Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies

Authors: Sasca, Daniel ^{1, 2, 3}, Yun, Haiyang ^{1, 2}, Giotopoulos, George ^{1, 2}, Szybinski, Jakub ³, Evan, Theo ^{1, 2}, Wilson, Nicola K. ^{1, 2}, Gerstung, Moritz ⁴, Gallipoli, Paolo ^{1, 2}, Green, Anthony R. ^{1, 2}, Hills, Robert ⁵, Russell, Nigel ⁶, Osborne, Cameron S. ⁷, Papaemmanuil, Elli ⁸, Göttgens, Berthold ^{1, 2}, Campbell, Peter ⁹, Huntly, Brian J.P. ^{1, 2}

Source: In Blood 12 December 2019 134(24):2195-2208

RUNX1-ETO Depletion in t(8;21) AML Leads to C/EBPα- and AP-1-Mediated Alterations in Enhancer-Promoter Interaction

Authors: Ptasinska, Anetta, Pickin, Anna, Assi, Salam A., Chin, Paulynn Suyin, Ames, Luke, Avellino, Roberto, Gröschel, Stefan, Delwel, Ruud, Cockerill, Peter N., Osborne, Cameron S., Bonifer, Constanze

Source: Cell reports. 28(12):3022-3031.e7

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100091330405.0x000001&indx=1&recIds=ETOCvdc_100091330405.0x000001

Multi-omics and machine learning reveal context-specific gene regulatory activities of PML::RARA in acute promyelocytic leukemia.

Authors: Villiers, William, Kelly, Audrey, He, Xiaohan, Kaufman-Cook, James, Elbasir, Abdurrahman, Bensmail, Halima, Lavender, Paul, Dillon, Richard, Mifsud, Borbála, Osborne, Cameron S.

Source: Nature Communications; 2/9/2023, Vol. 14 Issue 1, p1-17, 17p

Subject Terms: ACUTE promyelocytic leukemia, GENETIC regulation, REGULATOR genes, MULTIOMICS, BINDING sites, MACHINE learning

Raising the curtains on interchromosomal interactions

Authors: Krueger, Christel, Osborne, Cameron S.

Source: In Trends in Genetics 2006 22(12):637-639

The Corfu δβ thalassemia deletion disrupts γ-globin gene silencing and reveals post-transcriptional regulation of HbF expression

Authors: Chakalova, Lyubomira, Osborne, Cameron S., Dai, Yan-Feng, Goyenechea, Beatriz, Metaxotou-Mavromati, Anna, Kattamis, Antonios, Kattamis, Christos, Fraser, Peter ^*

Source: In Blood 1 March 2005 105(5):2154-2160

Comparison of Capture Hi-C Analytical Pipelines.

Authors: Aljogol, Dina, Thompson, I. Richard, Osborne, Cameron S., Mifsud, Borbala

Source: Frontiers in Genetics; 1/28/2022, Vol. 13, p1-10, 10p

Subject Terms: CHROMATIN, FALSE positive error, ERROR rates

Generation of an Improved Luciferase Reporter Gene Plasmid That Employs a Novel Mechanism for High-Copy Replication

Authors: Bert, Andrew G., Burrows, Joanna, Osborne, Cameron S., Cockerill, Peter N.

Source: In Plasmid September 2000 44(2):173-182

Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression

Authors: Yun, Haiyang, Narayan, Nisha, Vohra, Shabana, Giotopoulos, George, Mupo, Annalisa, Madrigal, Pedro, Sasca, Daniel, Lara-Astiaso, David, Horton, Sarah J., Agrawal-Singh, Shuchi, Meduri, Eshwar, Basheer, Faisal, Marando, Ludovica, Gozdecka, Malgorzata, Dovey, Oliver M., Castillo-Venzor, Aracely, Wang, Xiaonan, Gallipoli, Paolo, Müller-Tidow, Carsten, Osborne, Cameron S., Vassiliou, George S., Huntly, Brian J. P.

Source: Nature Genetics; October 2021, Vol. 53 Issue: 10 p1443-1455, 13p

Meet the neighbours: tools to dissect nuclear structure and function.

Authors: Osborne, Cameron S.¹ cameron.osborne@bbsrc.ac.uk, Ewels, Philip A.², Young, Alice N.C.³

Source: Briefings in Functional Genomics. Jan2011, Vol. 10 Issue 1, p11-17. 7p.

Subject Terms: *NUCLEAR structure, *NUCLEOTIDE sequence, *EUKARYOTIC cells, *DNA synthesis, *GENOMICS, *MOLECULAR dynamics

Myc Dynamically and Preferentially Relocates to a Transcription Factory Occupied by Igh.

Authors: Osborne, Cameron S.¹ cameron.osborne@bbsrc.ac.uk, Chakalova, Lyubomira¹, Mitchell, Jennifer A.¹, Horton, Alice¹, Wood, Andrew L.¹, Bolland, Daniel J.¹, Corcoran, Anne E.¹, Fraser, Peter¹

Source: PLoS Biology. Aug2007, Vol. 5 Issue 8, p1763-1772. 10p. 1 Color Photograph, 2 Charts, 6 Graphs.

Subject Terms: *RNA polymerases, *TRANSFERASES, *GENES, *CELL nuclei, *LYMPHOMAS, *FLUORESCENCE in situ hybridization

Active genes dynamically colocalize to shared sites of ongoing transcription.

Authors: Osborne, Cameron S.¹, Chakalova, Lyubomira¹, Brown, Karen E.², Carter, David¹, Horton, Alice¹, Debrand, Emmanuel¹, Goyenechea, Beatriz¹, Mitchell, Jennifer A.¹, Lopes, Susana³, Reik, Wolf³, Fraser, Peter¹

Source: Nature Genetics. Oct2004, Vol. 36 Issue 10, p1065-1071. 7p.

Subject Terms: *GENE expression, *RNA polymerases, *GENETIC regulation, *TRANSCRIPTION factors, *RNA, *GENES

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An intergenic non-coding RNA promoter required for histone modifications in the human β-globin chromatin domain.

Authors: Debrand, Emmanuel, Chakalova, Lyubomira, Miles, Joanne, Dai, Yan-Feng, Goyenechea, Beatriz, Dye, Sandra, Osborne, Cameron S., Horton, Alice, Harju-Baker, Susanna, Pink, Ryan C., Caley, Daniel, Carter, David R. F., Peterson, Kenneth R., Fraser, Peter

Source: PLoS ONE; 8/14/2019, Vol. 14 Issue 8, p1-23, 23p

Subject Terms: LINCRNA, HUMAN chromatin, NON-coding RNA, FETAL hemoglobin, GLOBIN genes, EPIGENOMICS, GENE expression, CYTOLOGY

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