Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection

Authors: Dong, Xintong, Limjunyawong, Nathachit, Sypek, Elizabeth I., Wang, Gaofeng, Ortines, Roger V., Youn, Christine, Alphonse, Martin P., Dikeman, Dustin, Wang, Yu, Lay, Mark, Kothari, Ruchita, Vasavda, Chirag, Pundir, Priyanka, Goff, Loyal, Miller, Lloyd S., Lu, Wuyuan, Garza, Luis A., Kim, Brian S., Archer, Nathan K., Dong, Xinzhong

Source: In Immunity 13 September 2022 55(9):1645-1662

IL-6R/Signal Transducer and Activator of Transcription 3 Signaling in Keratinocytes rather than in T Cells Induces Psoriasis-Like Dermatitis in Mice

Authors: Ravipati, Advaitaa, Nolan, Sabrina, Alphonse, Martin, Dikeman, Dustin, Youn, Christine, Wang, Yu, Orlando, Nicholas, Patrick, Garrett, Lee, Steven, Ortines, Roger V., Liu, Haiyun, Miller, Robert J., Dillen, Carly A., Marchitto, Mark, Cai, S. Sarah, Miller, Lloyd S., Archer, Nathan K.

Source: In Journal of Investigative Dermatology April 2022 142(4):1126-1135

CCR2 contributes to host defense against Staphylococcus aureus orthopedic implant‐associated infections in mice

Authors: Wang, Yu, Dikeman, Dustin, Zhang, Jeffrey, Ackerman, Nicole, Kim, Sophia, Alphonse, Martin P., Ortines, Roger V., Liu, Haiyun, Joyce, Daniel P., Dillen, Carly A., Thompson, John M., Thomas, Abigail A., Plaut, Roger D., Miller, Lloyd S., Archer, Nathan K.

Source: Journal of orthopaedic research. 40(2):409-419

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140092982.0x000001&indx=1&recIds=ETOCvdc_100140092982.0x000001

Neutrophil extracellular traps impair regeneration

Authors: Wier, Eric, Asada, Mayumi, Wang, Gaofeng, Alphonse, Martin P., Li, Ang, Hintelmann, Chase, Sweren, Evan, Youn, Christine, Pielstick, Brittany, Ortines, Roger, Lyu, Chenyi, Daskam, Maria, Miller, Lloyd S., Archer, Nathan K., Garza, Luis A.

Source: Journal of cellular and molecular medicine. 25(21):10008-10019

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138710485.0x000001&indx=1&recIds=ETOCvdc_100138710485.0x000001

Clonal Vγ6⁺Vδ4⁺ T cells promote IL-17–mediated immunity against Staphylococcus aureus skin infection

Authors: Marchitto, Mark C., Dillen, Carly A., Liu, Haiyun, Miller, Robert J., Archer, Nathan K., Ortines, Roger V., Alphonse, Martin P., Marusina, Alina I., Merleev, Alexander A., Wang, Yu, Pinsker, Bret L., Byrd, Angel S., Brown, Isabelle D., Ravipati, Advaitaa, Zhang, Emily, Cai, Shuting S., Limjunyawong, Nathachit, Dong, Xinzhong, Yeaman, Michael R., Simon, Scott I., Shen, Wei, Durum, Scott K., O’Brien, Rebecca L., Maverakis, Emanual, Miller, Lloyd S.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2019 May . 116(22), 10917-10926.

Access URL: https://www.jstor.org/stable/26707164

Theranostic biocomposite scaffold membrane

Authors: Roussakis, Emmanuel, Ortines, Roger V., Pinsker, Bret L., Mooers, Cavin T., Evans, Conor L., Miller, Lloyd S., Calderón-Colón, Xiomara

Source: In Biomaterials August 2019 212:17-27

Interleukin‐1β and tumor necrosis factor are essential in controlling an experimental orthopedic implant‐associated infection

Authors: Wang, Yu, Ashbaugh, Alyssa G., Dikeman, Dustin A., Zhang, Jeffrey, Ackerman, Nicole E., Kim, Sophie E., Falgons, Christian, Ortines, Roger V., Liu, Haiyun, Joyce, Daniel P., Alphonse, Martin Prince, Dillen, Carly A., Thompson, John M., Archer, Nathan K., Miller, Lloyd S.

Source: Journal of orthopaedic research. 38(8):1800-1809

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100107573716.0x000001&indx=1&recIds=ETOCvdc_100107573716.0x000001

Preclinical Models and Methodologies for Monitoring Staphylococcus aureus Infections Using Noninvasive Optical Imaging

Authors: Archer, Nathan K., Wang, Yu, Ortines, Roger V., Liu, Haiyun, Nolan, Sabrina J., Liu, Qi, Alphonse, Martin P., Dikeman, Dustin A., Mazhar, Momina, Miller, Robert J.

Source: Methods in molecular biology. 2069:197-228

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN621689507&indx=1&recIds=ETOCRN621689507

Injury, dysbiosis, and filaggrin deficiency drive skin inflammation through keratinocyte IL-1α release

Authors: Archer, Nathan K., Jo, Jay-Hyun, Lee, Steven K., Kim, Dongwon, Smith, Barbara, Ortines, Roger V., Wang, Yu, Marchitto, Mark C., Ravipati, Advaitaa, Cai, Shuting S., Dillen, Carly A., Liu, Haiyun, Miller, Robert J., Ashbaugh, Alyssa G., Uppal, Angad S., Oyoshi, Michiko K., Malhotra, Nidhi, Hoff, Sabine, Garza, Luis A., Kong, Heidi H., Segre, Julia A., Geha, Raif S., Miller, Lloyd S.

Source: In The Journal of Allergy and Clinical Immunology April 2019 143(4):1426-1443

Comparison of livestock-associated and community-associated Staphylococcus aureus pathogenicity in a mouse model of skin and soft tissue infection

Authors: Randad, Pranay, Dillen, Carly, Ortines, Roger, Mohr, David, Aziz, Maliha, Price, Lance, Kaya, Hülya, Larsen, Jesper, Carroll, Karen, Smith, Tara, Miller, Lloyd, Heaney, Christopher

Source: Scientific reports. 9(1):1-10

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100135458939.0x000001&indx=1&recIds=ETOCvdc_100135458939.0x000001

Development of a Staphylococcus aureus reporter strain with click beetle red luciferase for enhanced in vivo imaging of experimental bacteremia and mixed infections

Authors: Miller, Robert, Crosby, Heidi, Schilcher, Katrin, Wang, Yu, Ortines, Roger, Mazhar, Momina, Dikeman, Dustin, Pinsker, Bret, Brown, Isabelle, Joyce, Daniel, Zhang, Jeffrey, Archer, Nathan, Liu, Haiyun, Alphonse, Martin, Czupryna, Julie, Anderson, William, Bernthal, Nicholas, Fortuno-Miranda, Lea, Bulte, Jeff, Francis, Kevin, Horswill, Alexander, Miller, Lloyd

Source: Scientific reports. 9(1):1-19

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190973761.0x000001&indx=1&recIds=ETOCvdc_100190973761.0x000001

Mouse model of hematogenous implant-related Staphylococcus aureus biofilm infection reveals therapeutic targets

Authors: Wang, Yu, Cheng, Lily I., Helfer, David R., Ashbaugh, Alyssa G., Miller, Robert J., Tzomides, Alexander J., Thompson, John M., Ortines, Roger V., Tsai, Andrew S., Liu, Haiyun, Dillen, Carly A., Archer, Nathan K., Cohen, Taylor S., Tkaczyk, Christine, Stover, C. Kendall, Sellman, Bret R., Miller, Lloyd S.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2017 Jun . 114(26), E5094-E5102.

Access URL: https://www.jstor.org/stable/26485012

Staphylococcus aureus Epicutaneous Exposure Drives Skin Inflammation via IL-36-Mediated T Cell Responses

Authors: Liu, Haiyun, Archer, Nathan K., Dillen, Carly A., Wang, Yu, Ashbaugh, Alyssa G., Ortines, Roger V., Kao, Tracy, Lee, Steven K., Cai, Shuting S., Miller, Robert J., Marchitto, Mark C., Zhang, Emily, Riggins, Daniel P., Plaut, Roger D., Stibitz, Scott, Geha, Raif S., Miller, Lloyd S.

Source: In Cell Host & Microbe 8 November 2017 22(5):653-666

Noninvasive optical and nuclear imaging of Staphylococcus-specific infection with a human monoclonal antibody-based probe

Authors: Romero Pastrana, Francisco, Thompson, John M., Heuker, Marjolein, Hoekstra, Hedzer, Dillen, Carly A., Ortines, Roger V., Ashbaugh, Alyssa G., Pickett, Julie E., Linssen, Matthijs D., Bernthal, Nicholas M., Francis, Kevin P., Buist, Girbe, van Oosten, Marleen, van Dam, Gooitzen M., Thorek, Daniel L. J., Miller, Lloyd S., van Dijl, Jan Maarten

Source: Virulence. 9(1):262-272

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100074575483.0x000001&indx=1&recIds=ETOCvdc_100074575483.0x000001

Dry and liquid formulations of IBT-V02, a novel multi-component toxoid vaccine, are effective against Staphylococcus aureus isolates from low-to-middle income countries.

Authors: Yu Wang, Mukherjee, Ipsita, Venkatasubramaniam, Arundhathi, Dikeman, Dustin, Orlando, Nicholas, Jing Zhang, Ortines, Roger, Mednikov, Mark, Sherchand, Shardulendra P., Kanipakala, Tulasikumari, Thao Le, Shukla, Sanjay, Ketner, Mark, Adhikari, Rajan P., Karauzum, Hatice, Aman, M. Javad, Archer, Nathan K.

Source: Frontiers in Immunology; 2024, p1-15, 15p

Subject Terms: STAPHYLOCOCCUS aureus, SOFT tissue infections, SURGICAL site infections, OSTEOMYELITIS, METHICILLIN-resistant staphylococcus aureus, RABBIT diseases, VACCINES

Geographic Terms: CONGO (Democratic Republic), PALESTINE, CAMBODIA

Author Correction: Comparison of livestock-associated and community-associated Staphylococcus aureus pathogenicity in a mouse model of skin and soft tissue infection

Authors: Randad, Pranay R., Dillen, Carly A., Ortines, Roger V., Mohr, David, Aziz, Maliha, Price, Lance B., Kaya, Hülya, Larsen, Jesper, Carroll, Karen C., Smith, Tara C., Miller, Lloyd S., Heaney, Christopher D.

Source: Scientific reports. 9(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131462967.0x000001&indx=1&recIds=ETOCvdc_100131462967.0x000001

Hyperimmune Targeting Staphylococcal Toxins Effectively Protect Against USA 300 MRSA Infection in Mouse Bacteremia and Pneumonia Models.

Authors: Han, Xiaobing, Ortines, Roger, Mukherjee, Ipsita, Kanipakala, Tulasikumari, Kort, Thomas, Sherchand, Shardulendra P., Liao, Grant, Mednikov, Mark, Chenine, Agnes L., Aman, M. Javad, Nykiforuk, Cory L., Adhikari, Rajan P.

Source: Frontiers in Immunology; 5/17/2022, Vol. 13, p1-16, 16p

Subject Terms: METHICILLIN-resistant staphylococcus aureus, TOXINS, MULTIDRUG resistance, BACTEREMIA, BACTERIAL toxins

Company/Entity: UNITED States. Food & Drug Administration

Pan-caspase inhibition as a potential host-directed immunotherapy against MRSA and other bacterial skin infections.

Authors: Alphonse, Martin P., Rubens, Jessica H., Ortines, Roger V., Orlando, Nicholas A., Patel, Aman M., Dikeman, Dustin, Wang, Yu, Vuong, Ivan, Joyce, Daniel P., Zhang, Jeffrey, Mumtaz, Mohammed, Liu, Haiyun, Liu, Qi, Youn, Christine, Patrick, Garrett J., Ravipati, Advaitaa, Miller, Robert J., Archer, Nathan K., Miller, Lloyd S.

Source: Science Translational Medicine; 7/7/2021, Vol. 13 Issue 601, p1-15, 15p

IBT-V02: A Multicomponent Toxoid Vaccine Protects Against Primary and Secondary Skin Infections Caused by Staphylococcus aureus.

Authors: Karauzum, Hatice, Venkatasubramaniam, Arundhathi, Adhikari, Rajan P., Kort, Tom, Holtsberg, Frederick W., Mukherjee, Ipsita, Mednikov, Mark, Ortines, Roger, Nguyen, Nhu T. Q., Doan, Thien M. N., Diep, Binh An, Lee, Jean C., Aman, M. Javad

Source: Frontiers in Immunology; 3/10/2021, Vol. 11, pN.PAG-N.PAG, 15p

Subject Terms: STAPHYLOCOCCUS aureus infections, SKIN infections, TOXIC shock syndrome, SURGICAL site infections, CELLULITIS, INFECTION, DISEASE risk factors

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