Focused ultrasound on the substantia nigra enables safe neurotensin-polyplex nanoparticle-mediated gene delivery to dopaminergic neurons intranasally and by blood circulation.

Authors: Mascotte-Cruz, Juan U.¹, Vera, Arturo², Leija, Lorenzo², Lopez-Salas, Francisco E.³, Gradzielski, Michael⁴, Koetz, Joachim⁵, Gatica-García, Bismark^1,6, Rodríguez-Oviedo, C. P.⁶, Valenzuela-Arzeta, Irais E.¹, Escobedo, Lourdes¹, Reyes-Corona, David⁶, Gutierrez-Castillo, ME.⁷, Maldonado-Berny, Minerva¹, Espadas-Alvarez, Armando J.⁷, Orozco-Barrios, Carlos E.⁸, Martinez-Fong, Daniel^1,6, daniel.martinezfong@cinvestav.mx

Source: Discover Nano; 4/2/2024, Vol. 19 Issue 1, p1-24, 24p

Demonstration of therapeutic effect of plasma-synthesized polypyrrole/iodine biopolymer in rhesus monkey with complete spinal cord section.

Authors: Ríos, Camilo¹, Salgado-Ceballos, Hermelinda^2,3, melisalce@yahoo.com, Grijalva, Israel^2,3, Morales-Guadarrama, Axayacatl^4,5, Diaz-Ruiz, Araceli⁶, Olayo, Roberto⁵, Morales-Corona, Juan⁵, Olayo, María G.⁷, Cruz, Guillermo J.⁷, Mondragón-Lozano, Rodrigo^3,8, Alvarez-Mejia, Laura^3,9, Orozco-Barrios, Carlos^3,8, Sánchez-Torres, Stephanie^3,8, Fabela-Sánchez, Omar¹⁰, Coyoy-Salgado, Angélica^3,8, Hernández-Godínez, Braulio¹¹, Ibáñez-Contreras, Alejandra¹¹, Mendez-Armenta, Marisela⁶

Source: Journal of Materials Science: Materials in Medicine; 2/17/2025, Vol. 36 Issue 1, p1-23, 23p

Enhanced neuronal differentiation using plasma synthesized amino polymers.

Authors: Alvarado Muñoz, Estephanny Jocelyn, Olayo González, Roberto, Olayo González, María Guadalupe, Cruz Cruz, Guillermo Jesús, Uribe Juárez, Omar Eduardo, Coyoy Salgado, Angélica, Martinez Fong, Daniel, Salgado Ceballos, Hermelinda, Orozco Barrios, Carlos Enrique, Morales Corona, Juan

Source: International Journal of Polymeric Materials & Polymeric Biomaterials; 2025, Vol. 74 Issue 1, p11-20, 10p

Subject Terms: NEURONAL differentiation, PLASMA polymerization, POLYPYRROLE, BIOPOLYMERS, CELL lines

Tibolone Improves Locomotor Function in a Rat Model of Spinal Cord Injury by Modulating Apoptosis and Autophagy.

Authors: Sánchez-Torres, Stephanie^1,2 (AUTHOR) stephanie.sanchez.torres@gmail.com, Orozco-Barrios, Carlos³ (AUTHOR) crls2878@gmail.com, Salgado-Ceballos, Hermelinda¹ (AUTHOR) melisalce@yahoo.com, Segura-Uribe, Julia J.⁴ (AUTHOR) jujeseur@gmail.com, Guerra-Araiza, Christian⁵ (AUTHOR) christianguerra2001@gmail.com, León-Cholula, Ángel¹ (AUTHOR) angelleon_28@outlook.com, Morán, Julio⁶ (AUTHOR) jmoran@ifc.unam.mx, Coyoy-Salgado, Angélica³ (AUTHOR) acoyoy@ifc.unam.mx

Source: International Journal of Molecular Sciences. Oct2023, Vol. 24 Issue 20, p15285. 19p.

Subject Terms: *SPINAL cord injuries, *AUTOPHAGY, *CELL death, *SPRAGUE Dawley rats, *APOPTOSIS, *ANIMAL disease models, *CELL communication

Evaluating Sex Steroid Hormone Neuroprotection in Spinal Cord Injury in Animal Models: Is It Promising in the Clinic?

Authors: Coyoy-Salgado, Angélica, Segura-Uribe, Julia, Salgado-Ceballos, Hermelinda, Castillo-Mendieta, Tzayaka, Sánchez-Torres, Stephanie, Freyermuth-Trujillo, Ximena, Orozco-Barrios, Carlos, Orozco-Suarez, Sandra, Feria-Romero, Iris, Pinto-Almazán, Rodolfo, Moralí de la Brena, Gabriela, Guerra-Araiza, Christian

Source: Biomedicines; Jul2024, Vol. 13 Issue 7, p1478, 30p

Subject Terms: SEX hormones, SPINAL cord injuries, HORMONE therapy, CEREBRAL circulation, BRAIN injuries

Regulation of human GDNF gene expression in nigral dopaminergic neurons using a new doxycycline-regulated NTS-polyplex nanoparticle system

Authors: Espadas-Alvarez, Armando J., Bannon, Michael J., Orozco-Barrios, Carlos E., Escobedo-Sanchez, Lourdes, Ayala-Davila, Jose, Reyes-Corona, David, Soto-Rodriguez, Guadalupe, Escamilla-Rivera, Vicente, De Vizcaya-Ruiz, Andrea, Eugenia Gutierrez-Castillo, M., Padilla-Viveros, America, Martinez-Fong, Daniel

Source: In Nanomedicine: Nanotechnology, Biology, and Medicine May 2017 13(4):1363-1375

Safety of the intravenous administration of neurotensin-polyplex nanoparticles in BALB/c mice

Authors: Hernandez, Maria E., Rembao, Jesus D., Hernandez-Baltazar, Daniel, Castillo-Rodriguez, Rosa A., Tellez-Lopez, Victor M., Flores-Martinez, Yazmin M., Orozco-Barrios, Carlos E., Rubio, Hector A., Sánchez-García, Aurora, Ayala-Davila, Jose, Arango-Rodriguez, Martha L., Pavón, Lenin, Mejia-Castillo, Teresa, Forgez, Patricia, Martinez-Fong, Daniel

Source: In Nanomedicine: Nanotechnology, Biology, and Medicine May 2014 10(4):745-754

Recovery of motor function after traumatic spinal cord injury by using plasma-synthesized polypyrrole/iodine application in combination with a mixed rehabilitation scheme.

Authors: Sánchez-Torres, Stephanie^1,2,3, Díaz-Ruíz, Araceli⁴, Ríos, Camilo⁴, Olayo, María G.⁵, Cruz, Guillermo J.⁵, Olayo, Roberto⁶, Morales, Juan⁶, Mondragón-Lozano, Rodrigo^3,7, Fabela-Sánchez, Omar^3,8,9, Orozco-Barrios, Carlos^3,7, Coyoy-Salgado, Angélica^3,7, Orozco-Suárez, Sandra¹, González-Ruiz, Cristian^3,10, Álvarez-Mejía, Laura^1,3,5, Morales-Guadarrama, Axayacatl⁶, Buzoianu-Anguiano, Vinnitsa¹, Damián-Matsumura, Pablo², Salgado-Ceballos, Hermelinda^1,3, melisalce@yahoo.com

Source: Journal of Materials Science: Materials in Medicine; Jul2020, Vol. 31 Issue 7, p1-18, 18p, 2 Color Photographs, 6 Graphs

Vitamin B12 Deficiency Reduces Proliferation and Promotes Differentiation of Neuroblastoma Cells and Up-Regulates PP2A, proNGF, and TACE

Authors: Battaglia-Hsu, Shyue-Fang, Akchiche, Nassila, Noel, Nicole, Alberto, Jean-Marc, Jeannesson, Elise, Orozco-Barrios, Carlos Enrique, Martinez-Fong, Daniel, Daval, Jean-Luc, Guéant, Jean-Louis, Clapham, David E.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2009 Dec 01. 106(51), 21930-21935.

Access URL: https://www.jstor.org/stable/40536198

Gene expression and locomotor recovery in adult rats with spinal cord injury and plasma-synthesized polypyrrole/iodine application combined with a mixed rehabilitation scheme.

Authors: Coyoy-Salgado, Angélica, Orozco-Barrios, Carlos, Sánchez-Torres, Stephanie, Olayo, María Guadalupe, Cruz, Guillermo Jesus, Morales-Corona, Juan, Olayo, Roberto, Diaz-Ruiz, Araceli, Ríos, Camilo, Alvarez-Mejia, Laura, Mondragón-Lozano, Rodrigo, Morales-Guadarrama, Axayacatl, Alonso-García, Ana Lucía, Fabela-Sánchez, Omar, Salgado-Ceballos, Hermelinda

Source: Frontiers in Neurology; 2023, p1-17, 17p

Subject Terms: SPINAL cord injuries, GENE expression, POLYPYRROLE, SYNAPTIC vesicles, NEURON development

LPS Triggers Acute Neuroinflammation and Parkinsonism Involving NLRP3 Inflammasome Pathway and Mitochondrial CI Dysfunction in the Rat.

Authors: Valenzuela-Arzeta, Irais E., Soto-Rojas, Luis O., Flores-Martinez, Yazmin M., Delgado-Minjares, Karen M., Gatica-Garcia, Bismark, Mascotte-Cruz, Juan U., Nava, Porfirio, Aparicio-Trejo, Omar Emiliano, Reyes-Corona, David, Martínez-Dávila, Irma A., Gutierrez-Castillo, M. E., Espadas-Alvarez, Armando J., Orozco-Barrios, Carlos E., Martinez-Fong, Daniel

Source: International Journal of Molecular Sciences; Mar2023, Vol. 24 Issue 5, p4628, 22p

Subject Terms: NLRP3 protein, NEUROINFLAMMATION, INFLAMMASOMES, PARKINSON'S disease, PARKINSONIAN disorders, DOPAMINE, DEEP brain stimulation

Inflammation: A Target for Treatment in Spinal Cord Injury.

Authors: Freyermuth-Trujillo, Ximena, Segura-Uribe, Julia J., Salgado-Ceballos, Hermelinda, Orozco-Barrios, Carlos E., Coyoy-Salgado, Angélica

Source: Cells (2073-4409); Sep2022, Vol. 11 Issue 17, p2692, 34p

Subject Terms: SPINAL cord injuries, INFLAMMATION

Synthetic Monopartite Peptide That Enables the Nuclear Import of Genes Delivered by the Neurotensin-Polyplex Vector.

Authors: Lopez-Salas, Francisco E., Nadella, Rasajna, Maldonado-Berny, Minerva, Escobedo-Sanchez, Maria L., Fiorentino-Pérez, Rosana, Gatica-García, Bismark, Fernandez-Parrilla, Manuel A., Mario Gil, Moreno, Reyes-Corona, David, García, Ubaldo, Orozco-Barrios, Carlos E., Gutierrez-Castillo, Maria E., Martinez-Fong, Daniel

Source: Molecular Pharmaceutics; 12/7/2020, Vol. 17 Issue 12, p4572-4588, 17p

Vitamin B12-Impaired Metabolism Produces Apoptosis and Parkinson Phenotype in Rats Expressing the Transcobalamin-Oleosin Chimera in Substantia Nigra.

Authors: Orozco-Barrios, Carlos Enrique^1,2, Battaglia-Hsu, Shyue-Fang², Arango-Rodriguez, Martha Ligia¹, Ayala-Davila, Jose¹, Chery, Celine², Alberto, Jean-Marc², Schroeder, Henry³, Daval, Jean-Luc², Martinez-Fong, Daniel¹, Gueant, Jean-Louis² jean-louis.gueant@medecine.uhp-nancy.fr

Source: PLoS ONE. 2009, Vol. 4 Issue 12, p1-11. 11p.

Subject Terms: *VITAMIN B12, *BRAIN function localization, *CYTOSOL, *ADENOSYLMETHIONINE, *APOPTOSIS, *LABORATORY rats, *GENE expression, *MOSAICISM, *SUBSTANTIA nigra

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The Importance of Natural Antioxidants in the Treatment of Spinal Cord Injury in Animal Models: An Overview.

Authors: Coyoy-Salgado, Angélica, Segura-Uribe, Julia J., Guerra-Araiza, Christian, Orozco-Suárez, Sandra, Salgado-Ceballos, Hermelinda, Feria-Romero, Iris A., Gallardo, Juan Manuel, Orozco-Barrios, Carlos E.

Source: Oxidative Medicine & Cellular Longevity; 11/12/2019, p1-22, 22p

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Vitamin B12 deficiency reduces proliferation and promotes differentiation of neuroblastoma cells and up-regulates PP2A, proNGF, and TACE.

Authors: Shyue-fang BattagIia-Hsu, Akchiche, Nassila, Noel, Nicole, Alberto, Jean-Marc, Jeannesson, Elise, Orozco-Barrios, Carlos Enrique, Martinez-Fong, Daniel, Daval, Jean-Luc, Guéant, Jean-Louis

Source: Proceedings of the National Academy of Sciences of the United States of America; 12/22/2009, Vol. 106 Issue 51, p21930-21935, 6p, 6 Graphs

Subject Terms: VITAMIN B12 deficiency, CELL proliferation -- Molecular aspects, PERNICIOUS anemia, NEUROLOGICAL disorders, HOMOCYSTEINE, GENETICS, DISEASE risk factors