Anti-CD19 chimeric antigen receptor T-cell therapy has less efficacy in Richter transformation than in de novo large B-cell lymphoma and transformed low-grade B-cell lymphoma

Authors: Ohad Benjamini, Shalev Fried, Roni Shouval, Jessica R. Flynn, Ofrat Beyar-Katz, Lori A Leslie, Tsilla Zucherman, Ronit Yerushalmi, Noga Shem-Tov, Maria Lia Palomba, Ivetta Danylesko, Inbal Sdayoor, Hila Malka, Orit Itzhaki, Hyung Suh, Sean M. Devlin, Ronit Marcus, Parastoo B Dahi, Elad Jacoby, Gunjan L Shah, Craig S Sauter, Andrew Ip, Miguel-Angel Perales, Arnon Nagler, Avichai Shimoni, Michael Scordo, Abraham Avigdor

Source: Haematologica, Vol 999, Iss 1 (2024)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/11652; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/446c107a98b1415f962e7e3be018edfa

P520: POINT OF CARE CD19 CHIMERIC ANTIGEN RECEPTOR (CAR) T-CELLS FOR RELAPSED/REFRACTORY ACUTE MYELOID LEUKEMIA (AML) WITH ABERRANT CD19 ANTIGEN EXPRESSION

Authors: Ivetta Danylesko, Noga Shem-Tov, Ronit Yerushalmi, Elad Jacoby, Amos Toren, Orit Itzhaki, Roni Shouval, Avichai Shimoni, Avigdor Abraham, Arnon Nagler

Source: HemaSphere, Vol 7, p e4369964 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000968988.43699.64; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/e68ac14296cc471fad149493a36eb6c7

P889: POINT-OF-CARE ANTI-BCMA CAR T-CELL THERAPY INDUCES ENCOURAGING RESPONSE RATES IN HIGH-RISK RELAPSE/REFRACTORY MULTIPLE MYELOMA

Authors: Hila Magen, Shalev Fried, Orit Itzhaki, Noga Shem-Tov, Ivetta Danylesko, Ronit Yerushalmi, Roni Shouval, Ronit Marcus, Lee Nevo, Ronnie Shapira-Frommer, Arnon Nagler, Avichai Shimoni, Eden Shkury, Avigdor Abraham

Source: HemaSphere, Vol 7, p e94543ab (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000970460.94543.ab; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/1d67fdbc161e4daf84b517bbc9b5b53a

P1400: THREE YEARS OUTCOMES OF PRIMARY MEDIASTINAL B CELL LYMPHOMA PATIENTS FOLLOWING ANTI CD19 CAR-T CELL THERAPY - A SINGLE CENTER EXPERIENCE

Authors: Mika Geva, Shalev Fried, Orit Itzhaki, Noga Shem-Tov, Ivetta Danylesko, Ronit Yerushalmi, Ronit Marcus, Inbal Sdayoor, Ronnie Shapira-Frommer, Meirav Kedmi, Roni Shouval, Arnon Nagler, Avichai Shimoni, Abraham Avigdor

Source: HemaSphere, Vol 7, p e62933fb (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000972488.62933.fb; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/e0575545a9cb4703885b16f12c06ef66

Impact of cryopreservation on CAR T production and clinical response

Authors: Karin Brezinger-Dayan, Orit Itzhaki, Jenny Melnichenko, Adva Kubi, Li-at Zeltzer, Elad Jacoby, Abraham Avigdor, Ronnie Shapira Frommer, Michal J. Besser

Source: Frontiers in Oncology, Vol 12 (2022)

Subject Terms: CAR T cells, cryopreservation, PBMC, CAR T manufacturing, clinical trial, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.1024362/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/28b30e0dcb6a46629daeb2902aaf9cab

Membrane anchored IL-18 linked to constitutively active TLR4 and CD40 improves human T cell antitumor capacities for adoptive cell therapy

Authors: Arpad Szoor, Gyorgy Vereb, Orit Itzhaki, Michal J Besser, Hinrich Abken, Dayana Blokon-Kogan, Maya Levi-Mann, Lior Malka-Levy, Yuval Shiftan, Gideon Gross, Hadas Weinstein-Marom

Source: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/10/9/e001544.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/5da24a6a92d74ac0a859adeb339173bd

Comparison of non-myeloablative lymphodepleting preconditioning regimens in patients undergoing adoptive T cell therapy

Authors: Ronnie Shapira-Frommer, Elad Jacoby, Orit Itzhaki, Abraham Nissani, Gal Markel, Jacob Schachter, Shaked Lev-Ari, Tomer Meirson, Nethanel Asher, Guy Ben-Betzalel, Michal J. Besser

Source: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/9/5/e001743.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/b123a9cc796845809ac8adf818ec97d0

Genetic Modification of Tumor-Infiltrating Lymphocytes via Retroviral Transduction

Authors: Hadas Weinstein-Marom, Gideon Gross, Michal Levi, Hadar Brayer, Jacob Schachter, Orit Itzhaki, Michal J. Besser

Source: Frontiers in Immunology, Vol 11 (2021)

Subject Terms: adoptive cell therapy, rapid expansion protocol, T cell subsets, T cell differentiation status, chimeric antigen receptors, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2020.584148/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/5ccd7f9fc772444f87e6289aac83f7e9

Gamma-Delta CAR-T Cells Show CAR-Directed and Independent Activity Against Leukemia

Authors: Meir Rozenbaum, Amilia Meir, Yarden Aharony, Orit Itzhaki, Jacob Schachter, Ilan Bank, Elad Jacoby, Michal J. Besser

Source: Frontiers in Immunology, Vol 11 (2020)

Subject Terms: gamma-delta T cells, chimeric antigen receptor, leukemia, immuno oncology, B cell malignancies, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2020.01347/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/8067043762c649a48b16f18b0e8d3ff8

Head-to-head comparison of in-house produced CD19 CAR-T cell in ALL and NHL patients

Authors: Elad Jacoby, Orit Itzhaki, Abraham Nissani, Michal Levi, Arnon Nagler, Adva Kubi, Karin Brezinger, Hadar Brayer, Li-at Zeltzer, Meir Rozenbaum, Helly Vernitsky, Amos Toren, Abraham Avigdor

Source: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/8/1/e000148.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/c3d688963adb46cfae5f74024ca43fb3

Molecular and Functional Signatures Associated with CAR T Cell Exhaustion and Impaired Clinical Response in Patients with B Cell Malignancies

Authors: Katia Beider, Orit Itzhaki, Jacob Schachter, Ania Hava Grushchenko-Polaq, Valeria Voevoda-Dimenshtein, Evgenia Rosenberg, Olga Ostrovsky, Olivia Devillers, Ronnie Shapira Frommer, Li-at Zeltzer, Amos Toren, Elad Jacoby, Avichai Shimoni, Abraham Avigdor, Arnon Nagler, Michal J. Besser

Source: Cells, Vol 11, Iss 7, p 1140 (2022)

Subject Terms: CAR T, B cell malignancies, exhaustion, resistance, molecular signature, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/11/7/1140; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/02514ef3cdbe4b41b2bc1bbc9123ee34

Immune co-culture cell microarray – a feasible tool for high-throughput functional investigation of lymphocyte–cancer interactions

Authors: Erez Nissim Baruch, Rona Ortenberg, Camila Avivi, Liat Anafi, Daniela Dick-Necula, Chani Stossel, Yonatan Moshkovits, Orit Itzhaki, Michal Judith Besser, Jacob Schachter, Iris Barshack, Gal Markel

Source: OncoImmunology, Vol 9, Iss 1 (2020)

Subject Terms: immunotherapy, melanoma, immunological cytotoxicity test, functional protein expression, omics validation, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/97011e2deb4142d48b96ebe2f8f2005d

Tumor-infiltrating lymphocytes from human prostate tumors reveal anti-tumor reactivity and potential for adoptive cell therapy

Authors: Sharon Yunger, Assaf Bar El, Li-at Zeltzer, Eddie Fridman, Gil Raviv, Menachem Laufer, Jacob Schachter, Gal Markel, Orit Itzhaki, Michal J Besser

Source: OncoImmunology, Vol 8, Iss 12 (2019)

Subject Terms: adoptive cell therapy (act), tumor infiltrating lymphocyte (til), prostate cancer (pca), immunotherapy, primary prostate cancer cultures, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/307d8f06fe994a62a0389ee50e8bdb01

Selection of Shared and Neoantigen-Reactive T Cells for Adoptive Cell Therapy Based on CD137 Separation

Authors: Sivan Seliktar-Ofir, Efrat Merhavi-Shoham, Orit Itzhaki, Sharon Yunger, Gal Markel, Jacob Schachter, Michal J. Besser

Source: Frontiers in Immunology, Vol 8 (2017)

Subject Terms: adoptive cell therapy, melanoma, tumor infiltrating lymphocytes (TIL), CD137, neoantigen, tumor antigen, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fimmu.2017.01211/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/d7d294fb92b74aa58b01f05c3cb0fbea

Differential regulation of aggressive features in melanoma cells by members of the miR-17-92 complex

Authors: Eyal Greenberg, Steven Hajdu, Yael Nemlich, Ronit Cohen, Orit Itzhaki, Jasmine Jacob-Hirsch, Michal J. Besser, Jacob Schachter, Gal Markel

Source: Open Biology, Vol 4, Iss 6 (2014)

Subject Terms: mir-17, mir-20a, melanoma, mir-17-92 cluster, proliferation, differential regulation, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2046-2441

Access URL: https://doaj.org/article/68e7dfb435a645eab4bc88a37fb7c1c2

Nicotinamide inhibits vasculogenic mimicry, an alternative vascularization pathway observed in highly aggressive melanoma.

Authors: Orit Itzhaki, Eyal Greenberg, Bruria Shalmon, Adva Kubi, Avraham J Treves, Ronnie Shapira-Frommer, Camilla Avivi, Rona Ortenberg, Eytan Ben-Ami, Jacob Schachter, Michal J Besser, Gal Markel

Source: PLoS ONE, Vol 8, Iss 2, p e57160 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3581583?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/0534320b2f49433a87561bc72c1473b3

Regulation of cancer aggressive features in melanoma cells by microRNAs.

Authors: Eyal Greenberg, Liat Hershkovitz, Orit Itzhaki, Steven Hajdu, Yael Nemlich, Rona Ortenberg, Nir Gefen, Liat Edry, Shira Modai, Yona Keisari, Michal J Besser, Jacob Schachter, Noam Shomron, Gal Markel

Source: PLoS ONE, Vol 6, Iss 4, p e18936 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21541354/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/c83c8eb018fb4a90a218b7a8494a17e4