AID overexpression leads to aggressive murine CLL and nonimmunoglobulin mutations that mirror human neoplasms

Authors: Morande, Pablo Elías ^*, Yan, Xiao-Jie ^*, Sepulveda, Julieta, Seija, Noé, Marquez, María Elena, Sotelo, Natalia, Abreu, Cecilia, Crispo, Martina, Fernández-Graña, Gabriel, Rego, Natalia, Bois, Therence, Methot, Stephen P., Palacios, Florencia, Remedi, Victoria, Rai, Kanti R., Buschiazzo, Alejandro, Di Noia, Javier M., Navarrete, Marcelo A. ^***, Chiorazzi, Nicholas ^**, Oppezzo, Pablo ^*

Source: In Blood 22 July 2021 138(3):246-258

Docetaxel in chitosan-based nanocapsules conjugated with an anti-Tn antigen mouse/human chimeric antibody as a promising targeting strategy of lung tumors

Authors: Castro, Analía, Berois, Nora, Malanga, Antonio, Ortega, Claudia, Oppezzo, Pablo, Pristch, Otto, Mombrú, Alvaro W., Osinaga, Eduardo, Pardo, Helena

Source: In International Journal of Biological Macromolecules 1 July 2021 182:806-814

Ibrutinib therapy downregulates AID enzyme and proliferative fractions in chronic lymphocytic leukemia

Authors: Morande, Pablo Elías ^*, Sivina, Mariela ^*, Uriepero, Angimar, Seija, Noé, Berca, Catalina, Fresia, Pablo, Landoni, Ana Inés, Di Noia, Javier M., Burger, Jan A. ^**, Oppezzo, Pablo ^*

Source: In Blood 9 May 2019 133(19):2056-2068

S100-A9 protein in exosomes from chronic lymphocytic leukemia cells promotes NF-κB activity during disease progression

Authors: Prieto, Daniel ^*, Sotelo, Natalia ^*, Seija, Noé ^*, Sernbo, Sandra, Abreu, Cecilia, Durán, Rosario, Gil, Magdalena, Sicco, Estefanía, Irigoin, Victoria, Oliver, Carolina, Landoni, Ana Inés, Gabus, Raúl, Dighiero, Guillermo, Oppezzo, Pablo

Source: In Blood 10 August 2017 130(6):777-788

Noninfectious complications in patients with pediatric-onset common variable immunodeficiency correlated with defects in somatic hypermutation but not in class-switch recombination

Authors: Almejún, María Belén, Campos, Bárbara Carolina, Patiño, Virginia, Galicchio, Miguel, Zelazko, Marta, Oleastro, Matías, Oppezzo, Pablo, Danielian, Silvia

Source: In The Journal of Allergy and Clinical Immunology March 2017 139(3):913-922

Crystal structure of an enzymatically inactive trans-sialidase-like lectin from Trypanosoma cruzi: The carbohydrate binding mechanism involves residual sialidase activity

Authors: Oppezzo, Pablo, Obal, Gonzalo, Baraibar, Martín A., Pritsch, Otto, Alzari, Pedro M., Buschiazzo, Alejandro

Source: In BBA - Proteins and Proteomics September 2011 1814(9):1154-1161

High expression of AID and active class switch recombination might account for a more aggressive disease in unmutated CLL patients: link with an activated microenvironment in CLL disease

Authors: Palacios, Florencia ^*, Moreno, Pilar ^*, Morande, Pablo, Abreu, Cecilia, Correa, Agustín, Porro, Valentina, Landoni, Ana Ines, Gabus, Raul, Giordano, Mirta, Dighiero, Guillermo, Pritsch, Otto, Oppezzo, Pablo ^*

Source: In Blood 3 June 2010 115(22):4488-4496

Lipoprotein Lipase Expression in Chronic Lymphocytic Leukemia: New Insights into Leukemic Progression.

Authors: Prieto, Daniel¹ dprieto@fcien.edu.uy, Oppezzo, Pablo² poppezzo@pasteur.edu.uy

Source: Molecules. Dec2017, Vol. 22 Issue 12, p2083. 9p. 1 Diagram.

Subject Terms: *LIPOPROTEIN lipase, *CHRONIC lymphocytic leukemia treatment, *CHRONIC lymphocytic leukemia, *LIPID metabolism, *CATALYTIC activity, *PROGNOSIS

Antibody specific for the Tn antigen for the treatment of cancer

METHOD OF DIAGNOSIS/PROGNOSIS OF HUMAN CHRONIC LYMPHOCYTIC LEUKEMIA COMPRISING THE PROFILING OF LPL/ADAM GENES

Method of diagnosis/prognosis of human chronic lymphocytic leukemia comprising the profiling of LPL/ADAM genes

Structural and Kinetic Analysis of Two Covalent Sialosyl-Enzyme Intermediates on Trypanosoma rangeli Sialidase

Authors: Watts, Andrew G., Oppezzo, Pablo, Withers, Stephen G., Alzari, Pedro M., Buschiazzo, Alejandro

Source: In Journal of Biological Chemistry 17 February 2006 281(7):4149-4155

The LPL/ADAM29 expression ratio is a novel prognosis indicator in chronic lymphocytic leukemia

Authors: Oppezzo, Pablo, Vasconcelos, Yuri, Settegrana, Catherine, Jeannel, Dominique, Vuillier, Françoise, Legarff-Tavernier, Magali, Kimura, Eliza Yuriko, Bechet, Stéphane, Dumas, Gérard, Brissard, Martine, Merle-Béral, Hélène, Yamamoto, Mihoko, Dighiero, Guillaume, Davi, Frédéric ^*

Source: In Blood 15 July 2005 106(2):650-657

Lower levels of surface B-cell-receptor expression in chronic lymphocytic leukemia are associated with glycosylation and folding defects of the μ and CD79a chains

Authors: Vuillier, Françoise ^*, Dumas, Gérard, Magnac, Christian, Prevost, Marie-Christine, Lalanne, Ana Inés, Oppezzo, Pablo, Melanitou, Evie, Dighiero, Guillaume, Payelle-Brogard, Béatrice

Source: In Blood 1 April 2005 105(7):2933-2940

Different isoforms of BSAP regulate expression of AID in normal and chronic lymphocytic leukemia B cells

Authors: Oppezzo, Pablo ^*, Dumas, Gérard, Lalanne, Ana Inés, Payelle-Brogard, Béatrice, Magnac, Christian, Pritsch, Otto, Dighiero, Guillaume, Vuillier, Françoise

Source: In Blood 15 March 2005 105(6):2495-2503

TGF-β/SMAD Pathway Is Modulated by miR-26b-5p: Another Piece in the Puzzle of Chronic Lymphocytic Leukemia Progression.

Authors: Marquez, Maria Elena, Sernbo, Sandra, Payque, Eugenia, Uria, Rita, Tosar, Juan Pablo, Querol, Juliana, Berca, Catalina, Uriepero, Angimar, Prieto, Daniel, Alvarez-Saravia, Diego, Oliver, Carolina, Irigoin, Victoria, Dos Santos, Gimena, Guillermo, Cecilia, Landoni, Ana Inés, Navarrete, Marcelo, Palacios, Florencia, Oppezzo, Pablo

Source: Cancers; Apr2022, Vol. 14 Issue 7, p1676, 16p

Subject Terms: CHRONIC lymphocytic leukemia, DISEASE progression, GENETIC mutation, GROWTH factors, ONCOGENES, PROTEIN kinase inhibitors, MICRORNA, CELLULAR signal transduction, TUMOR necrosis factors

Targeting Inflammatory Pathways to Reverse Immunosuppressive Tumor Microenvironment in Chronic Lymphocytic Leukemia

Authors: Uriepero, Angimar ^*, Mediavilla-Varela, Melanie ^*, Maharaj, Kamira, Gamal, Wael, Marquez, Maria Elena ^*, Powers, John J. ^*, Kunta, Vishaal ^*, Sahakian, Eva ^*, Oppezzo, Pablo ^*, Pinilla Ibarz, Javier

Source: In Blood 15 November 2022 140 Supplement 1:6988-6989

Unbiased NGS Approach for IGHV Mutational Status, Clonal Space and Immune Repertoire Assessment in Chronic Lymphocytic Leukemia

Authors: Gonzalez-Puelma, Jorge ^*, Sepulveda-Yanez, Julieta ^*, Torres-Almonacid, Jorge ^*, Alvarez-Saravia, Diego ^*, Marquez, Maria Elena ^*, Alvarez-Ojeda, Hermy ^*, Cardemil, Daniela ^*, Uribe-Paredes, Roberto ^*, Oppezzo, Pablo ^*, Navarrete, Marcelo

Source: In Blood 15 November 2022 140 Supplement 1:6979-6980

Somatic hypermutation profiles in stereotyped IGHV4-34 receptors from South American chronic lymphocytic leukemia patients.

Authors: Stanganelli, Carmen, Torres, Davi Coe, Ortega, Claudia, Márquez, María Elena, Remedi, Victoria, Cabrera, Juana, Mardaraz, Claudia, Galvano, Camila, Krzywinski, Andrea, Lang, Cecilia, Zanella, Lorena, Agriello, Evangelina, Bezares, Raimundo, Pavlovsky, Astrid, Pavlovsky, Miguel A., Oppezzo, Pablo, Slavutsky, Irma

Source: Annals of Hematology; Feb2022, Vol. 101 Issue 2, p341-348, 8p

Subject Terms: CHRONIC lymphocytic leukemia, PROGNOSIS

AID in Chronic Lymphocytic Leukemia: Induction and Action During Disease Progression.

Authors: Oppezzo, Pablo, Navarrete, Marcelo, Chiorazzi, Nicholas

Source: Frontiers in Oncology; 5/10/2021, Vol. 11, pN.PAG-N.PAG, 19p

Subject Terms: CHRONIC lymphocytic leukemia, IMMUNOGLOBULIN class switching, DISEASE progression, CYTIDINE deaminase, MOUSE leukemia