PTP1B Antisense Oligonucleotide Lowers PTP1B Protein, Normalizes Blood Glucose, and Improves Insulin Sensitivity in Diabetic Mice

Authors: Zinker, Bradley A., Rondinone, Cristina M., Trevillyan, James M., Gum, Rebecca J., Clampit, Jill E., Waring, Jeffrey F., Xie, Nancy, Wilcox, Denise, Jacobson, Peer, Frost, Leigh, Kroeger, Paul E., Reilly, Regina M., Koterski, Sandra, Opgenorth, Terry J., Ulrich, Roger G., Crosby, Seth, Butler, Madeline, Murray, Susan F., McKay, Robert A., Bhanot, Sanjay, Monia, Brett P., Jirousek, Michael R.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2002 Aug . 99(17), 11357-11362.

Access URL: https://www.jstor.org/stable/3059573

Selective antagonism of the hepatic glucocorticoid receptor reduces hepatic glucose production

Authors: Edgerton, Dale S., Jacobson, Peer B., Opgenorth, Terry J., Zinker, Bradley, Beno, David, von Geldern, Tom, Ohman, Lars, Scott, Melanie, Neal, Doss, Cherrington, Alan D.

Source: In Metabolism 2006 55(9):1255-1262

Combination and use of drugs

Histamine-3 receptor ligands for diabetic conditions

Hepatic Glucocorticoid Receptor Antagonism Is Sufficient to Reduce Elevated Hepatic Glucose Output and Improve Glucose Control in Animal Models of Type 2 Diabetes

Authors: Jacobson, Peer B. ^*, von Geldern, Thomas W., Öhman, Lars, Österland, Marie, Wang, Jiahong, Zinker, Bradley, Wilcox, Denise, Nguyen, Phong T., Mika, Amanda, Fung, Steven, Fey, Thomas, Goos-Nilsson, Annika, Grynfarb, Marlena, Barkhem, Tomas, Marsh, Kennan, Beno, David W.A., Nga-Nguyen, Bach, Kym, Philip R., Link, James T., Tu, Noah, Edgerton, Dale S., Cherrington, Alan, Efendic, Suad, Lane, Benjamin C., Opgenorth, Terry J.

Source: In The Journal of Pharmacology and Experimental Therapeutics July 2005 314(1):191-200

Metabolic responses with endothelin antagonism in a model of insulin resistance

Authors: Berthiaume, Nathalie, Wessale, Jerry L., Opgenorth, Terry J., Zinker, Bradley A.

Source: In Metabolism 2005 54(6):735-740

Endothelin and ETA receptors in long-term arterial pressure homeostasis in conscious nonhuman primates.

Authors: Reinhart, Glenn A., Preusser, Lee C., Opgenorth, Terry J.

Source: American Journal of Physiology; November 2000 pt2, Vol. 279 Issue 5, pR1701-R1706, 6p

Endothelin converting enzyme inhibitors

Endothelin-1-evoked arachidonic acid release: a Ca2+-dependent pathway.

Authors: Wu-Wong, Jinshyun R., Dayton, Brian D., Opgenorth, Terry J.

Source: American Journal of Physiology; September 1996 pt 1, Vol. 271, pC869-C877, 9p

Atrial natriuretic peptide and glomerular hyperfiltration during onset of spontaneous diabetes mellitus.

Authors: Okwueze, Martina I., Opgenorth, Terry J., von Geldern, Thomas W.

Source: American Journal of Physiology; February 1994 pt2, Vol. 266, pR572-R577, 6p

Evidence for endothelin-induced renal vasoconstriction independent of ETA receptor activation.

Authors: Pollock, David M., Opgenorth, Terry J.

Source: American Journal of Physiology; January 1993 pt2, Vol. 264, pR222-R226, 5p

Direct determination of endothelin receptor antagonist levels in plasma using a scintillation proximity assay

Authors: Dayton, Brian D, Chiou, William J., Opgenorth, Terry J., Wu-Wong, Jinshyun R.

Source: In Life Sciences 2000 66(10):937-945

Selective Antagonism of the ETA Receptor, but Not the ETB Receptor, Is Protective Against Ischemic Acute Renal Failure in Rats

Authors: Kuro, Toshihiko ¹, Kohnou, Kaori ¹, Kobayashi, Yutaka ¹, Takaoka, Masanori ¹, Opgenorth, Terry J. ², Wessale, Jerry L. ², Matsumura, Yasuo ^{1, *}

Source: In Japanese Journal of Pharmacology 2000 82(4):307-316

ABT-627, an endothelin ET A receptor-selective antagonist, attenuates tactile allodynia in a diabetic rat model of neuropathic pain

Authors: Jarvis, Michael F ^*, Wessale, Jerry L, Zhu, Chang Z, Lynch, James J, III, Dayton, Brian D, Calzadilla, Samuel V, Padley, Robert J, Opgenorth, Terry J, Kowaluk, Elizabeth A

Source: In European Journal of Pharmacology 2000 388(1):29-35

New bone formation in an osteoblastic tumor model is increased by endothelin-1 overexpression and decreased by endothelin A receptor blockade

Authors: Nelson, Joel B ^*, Nguyen, Son H, Wu-Wong, Jinshyun R, Opgenorth, Terry J, Dixon, Douglas B, Chung, Leland W.K, Inoue, Nozomu

Source: In Urology May 1999 53(5):1063-1069

Discovery of a series of pyrrolidine-based endothelin receptor antagonists with enhanced ET A receptor selectivity

Authors: Boyd, Steven A ^{a, *}, Mantei, Robert A ^a, Tasker, Andrew S ^a, Liu, Gang ^a, Sorensen, Bryan K ^a, Henry Jr, Kenneth J ^a, von Geldern, Thomas W ^a, Winn, Martin ^a, Wu-Wong, Jinshyun R ^a, Chiou, William J ^a, Dixon, Douglas B ^a, Hutchins, Charles W ^b, Marsh, Kennan C ^c, Nguyen, Bach ^c, Opgenorth, Terry J ^a

Source: In Bioorganic & Medicinal Chemistry 1999 7(6):991-1002

Pharmacology of A-216546: a highly selective antagonist for endothelin ET A receptor

Authors: Wu-Wong, Jinshyun R ^*, Dixon, Douglas B, Chiou, William J, Dayton, Brian D, Novosad, Eugene I, Adler, Andrew L, Wessale, Jerry L, Calzadilla, Samuel V, Hernandez, Lisa, Marsh, Kennan C, Liu, Gang, Szczepankiewicz, Bruce, von Geldern, Thomas W, Opgenorth, Terry J

Source: In European Journal of Pharmacology 1999 366(2):189-201

Evidence for metalloprotease involvement in the in vivo effects of big endothelin 1.

Authors: Pollock, David M., Opgenorth, Terry J.

Source: American Journal of Physiology; July 1991 pt2, Vol. 261, pR257-R263, 7p

Effects of atrial natriuretic peptide on renin secretion in nonfiltering kidney.

Authors: Opgenorth, Terry J., Burnett, John C. Jr, Granger, Joey P.

Source: American Journal of Physiology; May 1986 pt2, Vol. 250, pF798-F801, 4p

Hepatic clearance of renin after angiotensin blockade.

Authors: Keiser, Joan A., Opgenorth, Terry J., Romero, Juan C.

Source: American Journal of Physiology; January 1985 pt2, Vol. 248, pR23-R28, 6p