Human pluripotent stem cell fate trajectories toward lung and hepatocyte progenitors

Authors: Ori, Chaido, Ansari, Meshal, Angelidis, Ilias, Olmer, Ruth, Martin, Ulrich, Theis, Fabian J., Schiller, Herbert B., Drukker, Micha

Source: In iScience 17 November 2023 26(11)

Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform

Authors: Bojkova, Denisa, Reus, Philipp, Panosch, Leona, Bechtel, Marco, Rothenburger, Tamara, Kandler, Joshua D., Pfeiffer, Annika, Wagner, Julian U.G., Shumliakivska, Mariana, Dimmeler, Stefanie, Olmer, Ruth, Martin, Ulrich, Vondran, Florian W.R., Toptan, Tuna, Rothweiler, Florian, Zehner, Richard, Rabenau, Holger F., Osman, Karen L., Pullan, Steven T., Carroll, Miles W., Stack, Richard, Ciesek, Sandra, Wass, Mark N., Michaelis, Martin, Cinatl, Jindrich, Jr.

Source: In iScience 17 February 2023 26(2)

Structure and function relationships of mucociliary clearance in human and rat airways.

Authors: Roth, Doris, Şahin, Ayşe Tuğçe, Ling, Feng, Tepho, Niels, Senger, Christiana N., Quiroz, Erik J., Calvert, Ben A., van der Does, Anne M., Güney, Tankut G., Glasl, Sarah, van Schadewijk, Annemarie, von Schledorn, Laura, Olmer, Ruth, Kanso, Eva, Nawroth, Janna C., Ryan, Amy L.

Source: Nature Communications; 3/12/2025, Vol. 16 Issue 1, p1-17, 17p

Subject Terms: CHRONIC obstructive pulmonary disease, MUCOCILIARY system, MEDICAL sciences, TRANSCRIPTOMES, RESPIRATORY diseases, ANIMAL models in research

High density bioprocessing of human pluripotent stem cells by metabolic control and in silico modeling

Authors: Manstein, Felix, Ullmann, Kevin, Kropp, Christina, Halloin, Caroline, Triebert, Wiebke, Franke, Annika, Farr, Clara‐Milena, Sahabian, Anais, Haase, Alexandra, Breitkreuz, Yannik, Peitz, Michael, Brüstle, Oliver, Kalies, Stefan, Martin, Ulrich, Olmer, Ruth, Zweigerdt, Robert

Source: Stem cells translational medicine. 10(7):1063-1080

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123842309.0x000001&indx=1&recIds=ETOCvdc_100123842309.0x000001

Systemic Type I IFN Inflammation in Human ISG15 Deficiency Leads to Necrotizing Skin Lesions

Authors: Martin-Fernandez, Marta, Bravo García-Morato, María, Gruber, Conor, Murias Loza, Sara, Malik, Muhammad Nasir Hayat, Alsohime, Fahad, Alakeel, Abdullah, Valdez, Rita, Buta, Sofija, Buda, Guadalupe, Marti, Marcelo A., Larralde, Margarita, Boisson, Bertrand, Feito Rodriguez, Marta, Qiu, Xueer, Chrabieh, Maya, Al Ayed, Mohammed, Al Muhsen, Saleh, Desai, Jigar V., Ferre, Elise M.N., Rosenzweig, Sergio D., Amador-Borrero, Blanca, Bravo-Gallego, Luz Yadira, Olmer, Ruth, Merkert, Sylvia, Bret, Montserrat, Sood, Amika K., Al-rabiaah, Abdulkarim, Temsah, Mohamad Hani, Halwani, Rabih, Hernandez, Michelle, Pessler, Frank, Casanova, Jean-Laurent, Bustamante, Jacinta, Lionakis, Michail S., Bogunovic, Dusan

Source: In Cell Reports 12 May 2020 31(6)

Generation of two human NRF2 knockout iPSC clones using CRISPR/Cas9 editing

Authors: Merkert, Sylvia, Haase, Alexandra, Dahlmann, Julia, Göhring, Gudrun, Waqas, Fakhar H., Pessler, Frank, Martin, Ulrich, Olmer, Ruth

Source: Stem cell research. 69

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191113210.0x000001&indx=1&recIds=ETOCvdc_100191113210.0x000001

Omicron‐induced interferon signaling prevents influenza A H1N1 and H5N1 virus infection

Authors: Bojkova, Denisa, Bechtel, Marco, Rothenburger, Tamara, Kandler, Joshua D., Hayes, Lauren, Olmer, Ruth, Martin, Ulrich, Jonigk, Danny, Ciesek, Sandra, Wass, Mark N., Michaelis, Martin, Cinatl, Jindrich

Source: Journal of medical virology. 95(3)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182046199.0x000001&indx=1&recIds=ETOCvdc_100182046199.0x000001

High-Throughput Screening for Modulators of CFTR Activity Based on Genetically Engineered Cystic Fibrosis Disease-Specific iPSCs

Authors: Merkert, Sylvia, Schubert, Madline, Olmer, Ruth, Engels, Lena, Radetzki, Silke, Veltman, Mieke, Scholte, Bob J., Zöllner, Janina, Pedemonte, Nicoletta, Galietta, Luis J.V., von Kries, Jens P., Martin, Ulrich

Source: In Stem Cell Reports 11 June 2019 12(6):1389-1403

Alpha-1-antitrypsin improves anastomotic healing in intestinal epithelial cells model.

Authors: Schukfeh, Nagoud, Sivaraman, Kokilavani, Schmidt, Aileen, Vieten, Gertrud, Dingemann, Jens, Weidner, Johannes, Olmer, Ruth, Janciauskiene, Sabina

Source: Pediatric Surgery International; 9/30/2024, Vol. 40 Issue 1, p1-7, 7p

Subject Terms: SURGICAL site, PEDIATRIC surgery, WOUND healing, EPITHELIAL cells, IMAGING systems

Differentiation of Human Pluripotent Stem Cells into Functional Endothelial Cells in Scalable Suspension Culture

Authors: Olmer, Ruth, Engels, Lena, Usman, Abdulai, Menke, Sandra, Malik, Muhammad Nasir Hayat, Pessler, Frank, Göhring, Gudrun, Bornhorst, Dorothee, Bolten, Svenja, Abdelilah-Seyfried, Salim, Scheper, Thomas, Kempf, Henning, Zweigerdt, Robert, Martin, Ulrich

Source: In Stem Cell Reports 8 May 2018 10(5):1657-1672

Pharmacological inhibition of bromodomain and extra-terminal proteins induces an NRF-2-mediated antiviral state that is subverted by SARS-CoV-2 infection.

Authors: Mhlekude, Baxolele^1,2,3,4, Postmus, Dylan^1,2, Stenzel, Saskia^1,2, Weiner 3rd, January², Jansen, Jenny^1,2, Zapatero-Belinchón, Francisco J.^5,6,7, Olmer, Ruth⁸, Richter, Anja¹, Heinze, Julian¹, Heinemann, Nicolas¹, Mühlemann, Barbara¹, Schroeder, Simon¹, Jones, Terry C.^1,9, Müller, Marcel A.¹, Drosten, Christian¹, Pich, Andreas¹⁰, Thiel, Volker^11,12, Martin, Ulrich⁸, Niemeyer, Daniela¹, Gerold, Gisa^5,6,7

Source: PLoS Pathogens; 9/25/2023, Vol. 19 Issue 9, p1-37, 37p

NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner.

Authors: Waqas, Fakhar H.^1,2, Shehata, Mahmoud^3,4, Elgaher, Walid A. M.⁵, Lacour, Antoine^5,6, Kurmasheva, Naziia⁷, Begnini, Fabio⁸, Kiib, Anders E.⁸, Dahlmann, Julia^9,10, Chen, Chutao^1,2, Pavlou, Andreas⁶, Poulsen, Thomas B.⁸, Merkert, Sylvia^9,10, Martin, Ulrich^9,10, Olmer, Ruth^9,10, Olagnier, David⁷, Hirsch, Anna K. H.^5,11, Pleschka, Stephan^3,12, Pessler, Frank^1,2,13, frank.pessler@helmholtz-hzi.de

Source: PLoS Pathogens; 7/17/2023, Vol. 19 Issue 7, p1-24, 24p

Generation of two TMEM16A knockout iPSC clones each from a healthy human iPSC line, from a Cystic Fibrosis patient specific line with p.Phe508del mutation and from the gene corrected iPSC line

Authors: Jaboreck, Mark-Christian, Lühmann, Jonathan Lukas, Mielenz, Mia, Stanke, Frauke, Göhring, Gudrun, Martin, Ulrich, Olmer, Ruth, Merkert, Sylvia

Source: Stem cell research. 64

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100172785451.0x000001&indx=1&recIds=ETOCvdc_100172785451.0x000001

ISG15 deficiency features a complex cellular phenotype that responds to treatment with itaconate and derivatives

Authors: Waqas, Syed Fakhar‐ul‐Hassnain, Sohail, Aaqib, Nguyen, Ariane Hai Ha, Usman, Abdulai, Ludwig, Tobias, Wegner, Andre, Malik, Muhammad Nasir Hayat, Schuchardt, Sven, Geffers, Robert, Winterhoff, Moritz, Merkert, Sylvia, Martin, Ulrich, Olmer, Ruth, Lachmann, Nico, Pessler, Frank

Source: Clinical and translational medicine. 12(7)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100157765845.0x000001&indx=1&recIds=ETOCvdc_100157765845.0x000001

Generation of pulmonary arterial hypertension patient-specific induced pluripotent stem cell lines from three unrelated patients with a heterozygous missense mutation in exon 12, a heterozygous in-frame deletion in exon 3 and a missense mutation in exon 11 of the BMPR2 gene

Authors: Usman, Abdulai, Haase, Alexandra, Merkert, Sylvia, Göhring, Gudrun, Hansmann, Georg, Gall, Henning, Schermuly, Ralph, Martin, Ulrich, Olmer, Ruth

Source: Stem cell research. 55

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138921521.0x000001&indx=1&recIds=ETOCvdc_100138921521.0x000001

SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression.

Authors: Niemeyer, Daniela^1,2, Stenzel, Saskia^1,3, Veith, Talitha^1,2, Schroeder, Simon¹, Friedmann, Kirstin¹, Weege, Friderike¹, Trimpert, Jakob⁴, Heinze, Julian^1,2, Richter, Anja¹, Jansen, Jenny^1,3, Emanuel, Jackson¹, Kazmierski, Julia^1,3, Pott, Fabian^1,3, Jeworowski, Lara M.¹, Olmer, Ruth⁵, Jaboreck, Mark-Christian⁵, Tenner, Beate¹, Papies, Jan¹, Walper, Felix¹, Schmidt, Marie L.¹

Source: PLoS Biology; 11/16/2022, Vol. 20 Issue 11, p1-36, 36p, 2 Color Photographs, 5 Graphs

Controlling Expansion and Cardiomyogenic Differentiation of Human Pluripotent Stem Cells in Scalable Suspension Culture

Authors: Kempf, Henning, Olmer, Ruth, Kropp, Christina, Rückert, Michael, Jara-Avaca, Monica, Robles-Diaz, Diana, Franke, Annika, Elliott, David A., Wojciechowski, Daniel, Fischer, Martin, Roa Lara, Angelica, Kensah, George, Gruh, Ina, Haverich, Axel, Martin, Ulrich, Zweigerdt, Robert

Source: In Stem Cell Reports 9 December 2014 3(6):1132-1146

Cleavage of E-Cadherin and β-Catenin by Calpain Affects Wnt Signaling and Spheroid Formation in Suspension Cultures of Human Pluripotent Stem Cells

Authors: Konze, Sarah A. ^{‡, §}, van Diepen, Laura ^¶, Schröder, Anke ^‖, Olmer, Ruth ^{§, **}, Möller, Hanna ^{‡, §}, Pich, Andreas ^‖, Weißmann, Robert ^¶, Kuss, Andreas W. ^¶, Zweigerdt, Robert ^{§, **}, Buettner, Falk F.R. ^{‡, §, ‡‡}

Source: In Molecular & Cellular Proteomics April 2014 13(4):990-1007

Divorce Mediation in the United States

Authors: Brown Kristina, Olmer Ruth

Source: The Wiley Blackwell Encyclopedia of Family Studies.

Availability: https://search.credoreference.com/content/entry/wileyfamily/divorce_mediation_in_the_united_states/0

Childlessness, Involuntary

Authors: Brown Kristina, Olmer Ruth

Source: The Wiley Blackwell Encyclopedia of Family Studies.

Availability: https://search.credoreference.com/content/entry/wileyfamily/childlessness_involuntary/0