Development and characterization of dendritic cell internalization and activation assays contributing to the immunogenicity risk evaluation of biotherapeutics

Authors: Michel Siegel, Aman Padamsey, Anna-Lena Bolender, Patrick Hargreaves, Johannes Fraidling, Axel Ducret, Katharina Hartman, Cary M. Looney, Cristina Bertinetti-Lapatki, Olivier Rohr, Timothy P. Hickling, Thomas E. Kraft, Céline Marban-Doran

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: immunogenicity, immunomodulation, biotherapeutics, dendritic cells, assay development, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1406804/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/7d40f92e19414c188759d42872e0dd4b

Internalization of therapeutic antibodies into dendritic cells as a risk factor for immunogenicity

Authors: Michel Siegel, Anna-Lena Bolender, Axel Ducret, Johannes Fraidling, Katharina Hartman, Cary M. Looney, Olivier Rohr, Timothy P. Hickling, Hubert Kettenberger, Martin Lechmann, Céline Marban-Doran, Thomas E. Kraft

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: immunogenicity, biotherapeutics, charge patches, internalization, dendritic cells, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1406643/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/c01676e863fb443ca2e5f23f30eb48a1

Corrigendum: Editorial: The relevance of molecular mechanisms in HIV-1 latency and reactivation from latency

Authors: Alexander O. Pasternak, Olivier Rohr, Carine Van Lint, Anna Kula-Pacurar

Source: Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)

Subject Terms: HIV-1, HIV-1 latency, HIV-1 reservoir, HIV-1 latency reversal, HIV-1 persistence, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcimb.2023.1213356/full; https://doaj.org/toc/2235-2988

Access URL: https://doaj.org/article/f2a4ed06a56d45e1a098877c3744d54d

Editorial: The relevance of molecular mechanisms in HIV-1 latency and reactivation from latency

Authors: Alexander O. Pasternak, Olivier Rohr, Carine Van Lint, Anna Kula-Pacurar

Source: Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)

Subject Terms: HIV-1, HIV-1 latency, HIV-1 reservoir, HIV-1 latency reversal, HIV-1 persistence, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcimb.2023.1190867/full; https://doaj.org/toc/2235-2988

Access URL: https://doaj.org/article/d69cf669970e4fc08ade52c715fb12df

Brain HIV-1 latently-infected reservoirs targeted by the suicide gene strategy

Authors: Sepideh Saeb, Mehrdad Ravanshad, Mahmoud Reza Pourkarim, Fadoua Daouad, Kazem Baesi, Olivier Rohr, Clémentine Wallet, Christian Schwartz

Source: Virology Journal, Vol 18, Iss 1, Pp 1-10 (2021)

Subject Terms: HIV-1, Microglial, Latent reservoirs, Suicide gene, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/1743-422X

Access URL: https://doaj.org/article/4449195b3c474c559af0e8447d7234fc

Inhibition of HIV-1 gene transcription by KAP1 in myeloid lineage

Authors: Amina Ait-Ammar, Maxime Bellefroid, Fadoua Daouad, Valérie Martinelli, Jeanne Van Assche, Clémentine Wallet, Anthony Rodari, Marco De Rovere, Birthe Fahrenkrog, Christian Schwartz, Carine Van Lint, Virginie Gautier, Olivier Rohr

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/fe46ec113a36484184b8fb43f3c5fa39

Novel role of UHRF1 in the epigenetic repression of the latent HIV-1

Authors: Roxane Verdikt, Maryam Bendoumou, Sophie Bouchat, Lorena Nestola, Alexander O. Pasternak, Gilles Darcis, Véronique Avettand-Fenoel, Caroline Vanhulle, Amina Aït-Ammar, Marion Santangelo, Estelle Plant, Valentin Le Douce, Nadège Delacourt, Aurelija Cicilionytė, Coca Necsoi, Francis Corazza, Caroline Pereira Bittencourt Passaes, Christian Schwartz, Martin Bizet, François Fuks, Asier Sáez-Cirión, Christine Rouzioux, Stéphane De Wit, Ben Berkhout, Virginie Gautier, Olivier Rohr, Carine Van Lint

Source: EBioMedicine, Vol 79, Iss , Pp 103985- (2022)

Subject Terms: HIV-1 latency, Reactivation, UHRF1, Epigenetics, EGCG, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396422001694; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/b64342c7f9c945c392341ed58313d142

Validation of a Dendritic Cell and CD4+ T Cell Restimulation Assay Contributing to the Immunogenicity Risk Evaluation of Biotherapeutics

Authors: Michel Siegel, Guido Steiner, Linnea C. Franssen, Francesca Carratu, James Herron, Katharina Hartman, Cary M. Looney, Axel Ducret, Katharine Bray-French, Olivier Rohr, Timothy P. Hickling, Noel Smith, Céline Marban-Doran

Source: Pharmaceutics, Vol 14, Iss 12, p 2672 (2022)

Subject Terms: immunogenicity, immunomodulation, biotherapeutics, in vitro T cell assay, assay validation, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/14/12/2672; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/9163ac23f8bd4fae95f0bd210a951c5c

Flower power: Locking HIV in the gut with French lilac

Authors: Olivier Rohr

Source: EBioMedicine, Vol 66, Iss , Pp 103299- (2021)

Subject Terms: Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S235239642100092X; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/310f8c7634bc4c828a8cb9e8f9c17a37

Current Status of Latency Reversing Agents Facing the Heterogeneity of HIV-1 Cellular and Tissue Reservoirs

Authors: Amina Ait-Ammar, Anna Kula, Gilles Darcis, Roxane Verdikt, Stephane De Wit, Virginie Gautier, Patrick W. G. Mallon, Alessandro Marcello, Olivier Rohr, Carine Van Lint

Source: Frontiers in Microbiology, Vol 10 (2020)

Subject Terms: HIV-1, latency reversing agents, cure, latency, reservoirs, heterogeneity, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fmicb.2019.03060/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/0157bc9c5a4343be9f44024c01ba26bf

Microglial Cells: The Main HIV-1 Reservoir in the Brain

Authors: Clementine Wallet, Marco De Rovere, Jeanne Van Assche, Fadoua Daouad, Stéphane De Wit, Virginie Gautier, Patrick W. G. Mallon, Alessandro Marcello, Carine Van Lint, Olivier Rohr, Christian Schwartz

Source: Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)

Subject Terms: HIV-1, Ctip2, microglial cells, reservoirs, latency, brain, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fcimb.2019.00362/full; https://doaj.org/toc/2235-2988

Access URL: https://doaj.org/article/8efdf79cb1b04cf7a1b1cb29c1455cf1

Resveratrol Inhibits HCoV-229E and SARS-CoV-2 Coronavirus Replication In Vitro

Authors: Sébastien Pasquereau, Zeina Nehme, Sandy Haidar Ahmad, Fadoua Daouad, Jeanne Van Assche, Clémentine Wallet, Christian Schwartz, Olivier Rohr, Stéphanie Morot-Bizot, Georges Herbein

Source: Viruses, Vol 13, Iss 2, p 354 (2021)

Subject Terms: SARS-CoV-2, HCoV-229E, resveratrol, coronavirus, viral inhibition, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/13/2/354; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/ca09daa6e466433ea2d5ed19fab1d742

Sequential treatment with 5‐aza‐2′‐deoxycytidine and deacetylase inhibitors reactivates HIV‐1

Authors: Sophie Bouchat, Nadège Delacourt, Anna Kula, Gilles Darcis, Benoit Van Driessche, Francis Corazza, Jean‐Stéphane Gatot, Adeline Melard, Caroline Vanhulle, Kabamba Kabeya, Marion Pardons, Véronique Avettand‐Fenoel, Nathan Clumeck, Stéphane De Wit, Olivier Rohr, Christine Rouzioux, Carine Van Lint

Source: EMBO Molecular Medicine, Vol 8, Iss 2, Pp 117-138 (2015)

Subject Terms: demethylating agent, epigenetics, HDACIs, HIV latency, HIV reservoir, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/db67ed8a899c414c9c5e30cb5ab57e78

5 Inhibition of HIV-1 gene transcription by KAP1: a new CTIP2 interactant

Authors: Amina Ait Ammar, Virginie Gautier, Carine Van Lint, Christian Schwartz, Olivier Rohr

Source: Journal of Virus Eradication, Vol 3, Iss , Pp 7- (2017)

Subject Terms: Microbiology, QR1-502, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S205566402030710X; https://doaj.org/toc/2055-6640

Access URL: https://doaj.org/article/bd3f78974a5c41be92186d6269edf534

O6 Reactivation capacity by latency reversing agents ex vivo correlates with the size of the HIV-1 reservoir

Authors: Gilles Darcis, Sophie Bouchat, Anna Kula, Benoit Van Driessche, Nadège Delacourt, Caroline Vanhulle, Stéphane De Wit, Olivier Rohr, Christine Rouzioux, Carine Van Lint

Source: Journal of Virus Eradication, Vol 2, Iss , Pp 2- (2016)

Subject Terms: Microbiology, QR1-502, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2055664020310852; https://doaj.org/toc/2055-6640

Access URL: https://doaj.org/article/72f63ea132bf4742add074eb56eb0555

O7 Implication of DNA methylation in HIV-1 post-integration latency.

Authors: Roxane Verdikt, Sophie Bouchat, Nadège Delacourt, Gilles Darcis, Caroline Vanhulle, Christian Schwartz, Olivier ROHR, Carine Van Lint

Source: Journal of Virus Eradication, Vol 2, Iss , Pp 3- (2016)

Subject Terms: Microbiology, QR1-502, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2055664020310864; https://doaj.org/toc/2055-6640

Access URL: https://doaj.org/article/7d44ffb8acb64c508c5e89bde08feed0

Targeting the brain reservoirs: towards an HIV cure

Authors: Celine Marban, Faezeh Forouzanfar, Amina Ait-Ammar, Faiza Fahmi, Hala El Mekdad, Fadoua Daouad, Olivier Rohr, Christian Schwartz

Source: Frontiers in Immunology, Vol 7 (2016)

Subject Terms: Brain, Cure, latency, CART, reservoirs, HIV tran, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00397/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/4559365b304f41deb3ce04bc66207d37

Reactivation capacity by latency reversing agents ex vivo correlates with the size of the HIV-1 reservoir

Authors: Gilles Darcis, Sophie Bouchat, Anna Kula, Benoit Van Driessche, Nadège Delacourt, Caroline Vanhulle, Stéphane De Wit, Olivier Rohr, Christine Rouzioux, Carine Van Lint

Source: Journal of Virus Eradication, Vol 2, Iss , Pp 10- (2016)

Subject Terms: Microbiology, QR1-502, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2055664020311286; https://doaj.org/toc/2055-6640

Access URL: https://doaj.org/article/b09383f18e274eed8f2ee458d313115f

An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression.

Authors: Gilles Darcis, Anna Kula, Sophie Bouchat, Koh Fujinaga, Francis Corazza, Amina Ait-Ammar, Nadège Delacourt, Adeline Melard, Kabamba Kabeya, Caroline Vanhulle, Benoit Van Driessche, Jean-Stéphane Gatot, Thomas Cherrier, Luiz F Pianowski, Lucio Gama, Christian Schwartz, Jorge Vila, Arsène Burny, Nathan Clumeck, Michel Moutschen, Stéphane De Wit, B Matija Peterlin, Christine Rouzioux, Olivier Rohr, Carine Van Lint

Source: PLoS Pathogens, Vol 11, Iss 7, p e1005063 (2015)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4520688?pdf=render; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/46911b3af13e4e1dbee7dd349246f43b

The level of DING proteins is increased in HIV-infected patients: in vitro and in vivo studies.

Authors: Ahmed Djeghader, Gerard Aragonès, Nune Darbinian, Mikael Elias, Daniel Gonzalez, Anabel García-Heredia, Raúl Beltrán-Debón, Rafal Kaminski, Guillaume Gotthard, Julien Hiblot, Anna Rull, Olivier Rohr, Christian Schwartz, Carlos Alonso-Villaverde, Jorge Joven, Jordi Camps, Eric Chabriere

Source: PLoS ONE, Vol 7, Iss 3, p e33062 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3302901?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/53648f3bdf1d403daf9cd80c32b98f6a