Inhibitors of dihydroorotate dehydrogenase synergize with the broad antiviral activity of 4′-fluorouridine

Authors: Schrell, Leon ^{a, 1}, Fuchs, Hannah L. ^{a, 1}, Dickmanns, Antje ^a, Scheibner, David ^b, Olejnik, Judith ^{c, d}, Hume, Adam J. ^{c, d}, Reineking, Wencke ^e, Störk, Theresa ^e, Müller, Martin ^f, Graaf-Rau, Annika ^g, Diederich, Sandra ^b, Finke, Stefan ^f, Baumgärtner, Wolfgang ^e, Mühlberger, Elke ^{c, d}, Balkema-Buschmann, Anne ^b, Dobbelstein, Matthias ^{a, h, ⁎}

Source: In Antiviral Research January 2025 233

Extracellular vimentin is an attachment factor that facilitates SARS-CoV-2 entry into human endothelial cells

Authors: Amraei, Razie, Xia, Chaoshuang, Olejnik, Judith, White, Mitchell R., Napoleon, Marc A., Lotfollahzadeh, Saran, Hauser, Blake M., Schmidt, Aaron G., Chitalia, Vipul, Mühlberger, Elke, Costello, Catherine E., Rahimi, Nader

Source: Proceedings of the National Academy of Sciences of the United States of America, 2022 Feb 01. 119(6), 1-9.

Access URL: https://www.jstor.org/stable/27118542

A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV-2 at the immune–epithelial interface

Authors: Leon, Juliette, Michelson, Daniel A., Olejnik, Judith, Chowdhary, Kaitavjeet, Oh, Hyung Suk, Hume, Adam J., Galván-Peña, Silvia, Zhu, Yangyang, Chen, Felicia, Vijaykumar, Brinda, Yang, Liang, Crestani, Elena, Yonker, Lael M., Knipe, David M., Mühlberger, Elke, Benoist, Christophe

Source: Proceedings of the National Academy of Sciences of the United States of America, 2022 Jan 01. 119(1), 1-11.

Access URL: https://www.jstor.org/stable/27112859

Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes

Authors: Scoon, Whitney A., Mancio-Silva, Liliana, Suder, Ellen L., Villacorta-Martin, Carlos, Lindstrom-Vautrin, Jonathan, Bernbaum, John G., Mazur, Steve, Johnson, Reed F., Olejnik, Judith, Flores, Elizabeth Y., Mithal, Aditya, Wang, Feiya, Hume, Adam J., Kaserman, Joseph E., March-Riera, Sandra, Wilson, Andrew A., Bhatia, Sangeeta N., Mühlberger, Elke, Mostoslavsky, Gustavo

Source: In Stem Cell Reports 11 October 2022 17(10):2286-2302

Human Pluripotent Stem Cell-Derived Intestinal Organoids Model SARS-CoV-2 Infection Revealing a Common Epithelial Inflammatory Response

Authors: Mithal, Aditya, Hume, Adam J., Lindstrom-Vautrin, Jonathan, Villacorta-Martin, Carlos, Olejnik, Judith, Bullitt, Esther, Hinds, Anne, Mühlberger, Elke, Mostoslavsky, Gustavo

Source: In Stem Cell Reports 13 April 2021 16(4):940-953

SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response

Authors: Huang, Jessie, Hume, Adam J., Abo, Kristine M., Werder, Rhiannon B., Villacorta-Martin, Carlos, Alysandratos, Konstantinos-Dionysios, Beermann, Mary Lou, Simone-Roach, Chantelle, Lindstrom-Vautrin, Jonathan, Olejnik, Judith, Suder, Ellen L., Bullitt, Esther, Hinds, Anne, Sharma, Arjun, Bosmann, Markus, Wang, Ruobing, Hawkins, Finn, Burks, Eric J., Saeed, Mohsan, Wilson, Andrew A., Mühlberger, Elke, Kotton, Darrell N.

Source: In Cell Stem Cell 3 December 2020 27(6):962-973

Ebolavirus polymerase uses an unconventional genome replication mechanism

Authors: Deflubé, Laure R., Cressey, Tessa N., Hume, Adam J., Olejnik, Judith, Haddock, Elaine, Feldmann, Friederike, Ebihara, Hideki, Fearns, Rachel, Mühlberger, Elke

Source: Proceedings of the National Academy of Sciences of the United States of America, 2019 Apr . 116(17), 8535-8543.

Access URL: https://www.jstor.org/stable/26703536

A Comparative Assessment of the Pathogenic Potential of Newly Discovered Henipaviruses.

Authors: Meier, Kristina, Olejnik, Judith, Hume, Adam J., Mühlberger, Elke

Source: Pathogens; Jul2024, Vol. 13 Issue 7, p587, 22p

Subject Terms: HENDRA virus, HENIPAVIRUSES, NIPAH virus, VIRAL transmission, NUCLEOTIDE sequencing

Geographic Terms: GHANA

Low-Input, High-Resolution 5′ Terminal Filovirus RNA Sequencing with ViBE-Seq.

Authors: Ross, Stephen J., Hume, Adam J., Olejnik, Judith, Turcinovic, Jacquelyn, Honko, Anna N., McKay, Lindsay G. A., Connor, John H., Griffiths, Anthony, Mühlberger, Elke, Cifuentes, Daniel

Source: Viruses (1999-4915); Jul2024, Vol. 16 Issue 7, p1064, 17p

Subject Terms: MARBURG virus, RNA sequencing, EBOLA virus, NUCLEOTIDE sequencing, RNA viruses

CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responses.

Authors: Jalloh, Sallieu¹ (AUTHOR), Olejnik, Judith^1,2 (AUTHOR), Berrigan, Jacob¹ (AUTHOR), Nisa, Annuurun³ (AUTHOR), Suder, Ellen L.^1,2 (AUTHOR), Akiyama, Hisashi¹ (AUTHOR), Lei, Maohua¹ (AUTHOR), Ramaswamy, Sita¹ (AUTHOR), Tyagi, Sanjay³ (AUTHOR), Bushkin, Yuri³ (AUTHOR), Mühlberger, Elke^1,2 (AUTHOR), Gummuluru, Suryaram¹ (AUTHOR) rgummulu@bu.edu

Source: PLoS Pathogens. 10/24/2022, Vol. 18 Issue 10, p1-33. 33p.

Subject Terms: *MACROPHAGES, *SARS-CoV-2, *MONOCYTES, *PLANT lectins, *COVID-19, *VIRAL antigens, *MYELOID cells

Interferon‐alpha or ‐beta Facilitates SARS‐CoV‐2 Pulmonary Vascular Infection by Inducing ACE2

Authors: Yuan, Ke, Klouda, Timothy, Yuan, Hao, Kim, Hyunbum, Kim, Jiwon, Olejnik, Judith, Hume, Adam J., Melero‐Martin, Juan, Mühlberger, Elke, Jia, Hongpeng, Padera, Robert F., Raby, Benjamin A.

Source: FASEB journal. 36

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100196519462.0x000001&indx=1&recIds=ETOCvdc_100196519462.0x000001

Marburg virus outbreaks are increasing in frequency and geographic spread – three virologists explain

Authors: Hume Adam, Mühlberger Elke, Olejnik Judith

Source: The Conversation: An Independent Source of Analysis from Academic Researchers.

Availability: https://search.credoreference.com/content/entry/conversqauq/marburg_virus_outbreaks_are_increasing_in_frequency_and_geographic_spread_three_virologistsexplain/0

Modulations of Homeostatic ACE2, CD147, GRP78 Pathways Correlate with Vascular and Endothelial Performance Markers during Pulmonary SARS-CoV-2 Infection.

Authors: Nisa, Annuurun, Kumar, Ranjeet, Ramasamy, Santhamani, Kolloli, Afsal, Olejnik, Judith, Jalloh, Sallieu, Gummuluru, Suryaram, Subbian, Selvakumar, Bushkin, Yuri

Source: Cells (2073-4409); Mar2024, Vol. 13 Issue 5, p432, 22p

Subject Terms: COVID-19 pandemic, LUNG infections, ANGIOTENSIN converting enzyme, LUNGS, FLUORESCENCE in situ hybridization, GLUCOSE-regulated proteins, ENDOTHELIUM, HOMEOSTASIS

Heat Inactivation of Nipah Virus for Downstream Single-Cell RNA Sequencing Does Not Interfere with Sample Quality.

Authors: Hume, Adam J., Olejnik, Judith, White, Mitchell R., Huang, Jessie, Turcinovic, Jacquelyn, Heiden, Baylee, Bawa, Pushpinder S., Williams, Christopher J., Gorham, Nickolas G., Alekseyev, Yuriy O., Connor, John H., Kotton, Darrell N., Mühlberger, Elke

Source: Pathogens; Jan2024, Vol. 13 Issue 1, p62, 17p

Subject Terms: NIPAH virus, RNA sequencing, BIOLOGICAL systems, VIRUS inactivation, CHEMICAL testing, RNA viruses

Filovirus Strategies to Escape Antiviral Responses

Authors: Olejnik, Judith, Hume, Adam J., Leung, Daisy W., Amarasinghe, Gaya K., Basler, Christopher F., Mühlberger, Elke

Source: Current topics in microbiology and immunology. 411:293-322

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN614610000&indx=1&recIds=ETOCRN614610000

Analyzing Apoptosis Induction and Evasion in Ebola Virus-Infected Cells

Authors: Olejnik, Judith, Nelson, Emily V.

Source: Methods in molecular biology. 1628:227-242

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN611677800&indx=1&recIds=ETOCRN611677800

The 3′ Untranslated Regions of Ebola Virus mRNAs Contain AU-Rich Elements Involved in Posttranscriptional Stabilization and Decay.

Authors: Nelson, Emily V, Ross, Stephen J, Olejnik, Judith, Hume, Adam J, Deeney, Dylan J, King, Emily, Grimins, Autumn O, Lyons, Shawn M, Cifuentes, Daniel, Mühlberger, Elke

Source: Journal of Infectious Diseases; 2023 Supplement, Vol. 228, pS488-S497, 10p

Subject Terms: EBOLA virus, RNA-binding proteins, MAMMALIAN embryos, REPORTER genes, PROTEIN expression

The L–VP35 and L–L interaction domains reside in the amino terminus of the Ebola virus L protein and are potential targets for antivirals

Authors: Trunschke, Martina, Conrad, Dominik, Enterlein, Sven, Olejnik, Judith, Brauburger, Kristina, Mühlberger, Elke

Source: In Virology 5 July 2013 441(2):135-145

Recombinant Lloviu virus as a tool to study viral replication and host responses.

Authors: Hume, Adam J.^1,2, hume@bu.edu, Heiden, Baylee^1,2, Olejnik, Judith^1,2, Suder, Ellen L.^1,2, Ross, Stephen^1,2,3, Scoon, Whitney A.^1,2, Bullitt, Esther⁴, Ericsson, Maria⁵, White, Mitchell R.^1,2, Turcinovic, Jacquelyn^1,2,6, Thao, Tran T. N.^7,8, Hekman, Ryan M.^3,9, Kaserman, Joseph E.^10,11, Huang, Jessie^10,11, Alysandratos, Konstantinos-Dionysios^10,11, Toth, Gabor E.^12,13, Jakab, Ferenc^12,13, Kotton, Darrell N.^10,11,14, Wilson, Andrew A.^10,11, Emili, Andrew^3,9,15

Source: PLoS Pathogens; 2/4/2022, Vol. 18 Issue 2, p1-25, 25p

Art of the Kill: Designing and Testing Viral Inactivation Procedures for Highly Pathogenic Negative Sense RNA Viruses.

Authors: Olejnik, Judith, Hume, Adam J., Ross, Stephen J., Scoon, Whitney A., Seitz, Scott, White, Mitchell R., Slutzky, Ben, Yun, Nadezhda E., Mühlberger, Elke

Source: Pathogens; Jul2023, Vol. 12 Issue 7, p952, 22p

Subject Terms: RNA viruses, PATHOGENIC viruses, CHEMICAL reagents, TEST design, EBOLA virus, SAFETY regulations