Hepatic SerpinA1 improves energy and glucose metabolism through regulation of preadipocyte proliferation and UCP1 expression.

Authors: Okagawa, Shota, Sakaguchi, Masaji, Okubo, Yuma, Takekuma, Yuri, Igata, Motoyuki, Kondo, Tatsuya, Takeda, Naoki, Araki, Kimi, Brandao, Bruna Brasil, Qian, Wei-Jun, Tseng, Yu-Hua, Kulkarni, Rohit N., Kubota, Naoto, Kahn, C. Ronald, Araki, Eiichi

Source: Nature Communications; 11/12/2024, Vol. 15 Issue 1, p1-19, 19p

Subject Terms: BROWN adipose tissue, ADIPOSE tissues, EPHRIN receptors, METABOLIC regulation, UNCOUPLING proteins, FAT cells

Phosphatase protector alpha4 (α4) is involved in adipocyte maintenance and mitochondrial homeostasis through regulation of insulin signaling.

Authors: Sakaguchi, Masaji, Okagawa, Shota, Okubo, Yuma, Otsuka, Yuri, Fukuda, Kazuki, Igata, Motoyuki, Kondo, Tatsuya, Sato, Yoshifumi, Yoshizawa, Tatsuya, Fukuda, Takaichi, Yamagata, Kazuya, Cai, Weikang, Tseng, Yu-Hua, Sakaguchi, Nobuo, Kahn, C. Ronald, Araki, Eiichi

Source: Nature Communications; 10/14/2022, Vol. 13, p1-19, 19p

Subject Terms: INSULIN receptors, INSULIN regulation, PHOSPHOPROTEIN phosphatases, PROTEIN-tyrosine phosphatase, CARRIER proteins, HOMEOSTASIS

29-OR: Regulatory Loop of IR Signaling for Adipocyte Mitochondrial Homeostasis.

Authors: SAKAGUCHI, MASAJI, OKAGAWA, SHOTA, OKUBO, YUMA, FUKUDA, KAZUKI, IGATA, MOTOYUKI, KAWASHIMA, JUNJI, KONDO, TATSUYA, ARAKI, EIICHI

Source: Diabetes; 2021 Supplement 1, Vol. 70, pN.PAG-N.PAG, 1p

1714-P: Regulation of Phosphorylation Status in Insulin Signaling via a4 Is Necessary for Adipocyte Maintenance and Lipid Dynamics.

Authors: SAKAGUCHI, MASAJI, OKAGAWA, SHOTA, OKUBO, YUMA, KITANO, SAYAKA, IGATA, MOTOYUKI, KONDO, TATSUYA, ARAKI, EIICHI

Source: Diabetes; 2020 Supplement, Vol. 69, pN.PAG-N.PAG, 1p