PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate

Authors: Chessa, Tamara A.M., Jung, Piotr, Anwar, Arqum, Suire, Sabine, Anderson, Karen E., Barneda, David, Kielkowska, Anna, Sadiq, Barzan A., Lai, Ieng Wai, Felisbino, Sergio, Turnham, Daniel J., Pearson, Helen B., Phillips, Wayne A., Sasaki, Junko, Sasaki, Takehiko, Oxley, David, Spensberger, Dominik, Segonds-Pichon, Anne, Wilson, Michael, Walker, Simon, Okkenhaug, Hanneke, Cosulich, Sabina, Hawkins, Phillip T., Stephens, Len R.

Source: In Molecular Cell 17 August 2023 83(16):2991-3009

A cyclic peptide toolkit reveals mechanistic principles of peptidylarginine deiminase IV regulation.

Authors: Bertran, M. Teresa, Walmsley, Robert, Cummings, Thomas, Aramburu, Iker Valle, Benton, Donald J., Mora Molina, Rocio, Assalaarachchi, Jayalini, Chasampalioti, Maria, Swanton, Tessa, Joshi, Dhira, Federico, Stefania, Okkenhaug, Hanneke, Yu, Lu, Oxley, David, Walker, Simon, Papayannopoulos, Venizelos, Suga, Hiroaki, Christophorou, Maria A., Walport, Louise J.

Source: Nature Communications; 11/11/2024, Vol. 15 Issue 1, p1-20, 20p

Subject Terms: CYCLIC peptides, PEPTIDES, IMMUNE response, CELLULAR control mechanisms, AUTOIMMUNITY

An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis

Authors: Odle, Richard I., Walker, Simon A., Oxley, David, Kidger, Andrew M., Balmanno, Kathryn, Gilley, Rebecca, Okkenhaug, Hanneke, Florey, Oliver, Ktistakis, Nicholas T., Cook, Simon J.

Source: In Molecular Cell 16 January 2020 77(2):228-240

Aspirin prevents metastasis by limiting platelet TXA2suppression of T cell immunity

Authors: Yang, Jie, Yamashita-Kanemaru, Yumi, Morris, Benjamin I., Contursi, Annalisa, Trajkovski, Daniel, Xu, Jingru, Patrascan, Ilinca, Benson, Jayme, Evans, Alexander C., Conti, Alberto G., Al-Deka, Aws, Dahmani, Layla, Avdic-Belltheus, Adnan, Zhang, Baojie, Okkenhaug, Hanneke, Whiteside, Sarah K., Imianowski, Charlotte J., Wesolowski, Alexander J., Webb, Louise V., Puccio, Simone, Tacconelli, Stefania, Bruno, Annalisa, Di Berardino, Sara, De Michele, Alessandra, Welch, Heidi C. E., Yu, I-Shing, Lin, Shu-Wha, Mitra, Suman, Lugli, Enrico, van der Weyden, Louise, Okkenhaug, Klaus, Saeb-Parsy, Kourosh, Patrignani, Paola, Adams, David J., Roychoudhuri, Rahul

Source: Nature; 20250101, Issue: Preprints p1-10, 10p

A Critical Role of TET1/2 Proteins in Cell-Cycle Progression of Trophoblast Stem Cells

Authors: Chrysanthou, Stephanie, Senner, Claire E., Woods, Laura, Fineberg, Elena, Okkenhaug, Hanneke, Burge, Sarah, Perez-Garcia, Vicente, Hemberger, Myriam

Source: In Stem Cell Reports 10 April 2018 10(4):1355-1368

Calcium phosphate particles stimulate interleukin-1β release from human vascular smooth muscle cells: A role for spleen tyrosine kinase and exosome release

Authors: Dautova, Yana, Kapustin, Alexander N., Pappert, Kevin, Epple, Matthias, Okkenhaug, Hanneke, Cook, Simon J., Shanahan, Catherine M., Bootman, Martin D., Proudfoot, Diane

Source: In Journal of Molecular and Cellular Cardiology February 2018 115:82-93

Reporter cell lines to screen for inhibitors or regulators of the KRAS-RAF-MEK1/2-ERK1/2 pathway.

Authors: Weatherdon, Laura, Stuart, Kate, Cassidy, Megan, de la Gándara, Alberto Moreno, Okkenhaug, Hanneke, Muellener, Markus, Mckenzie, Grahame, Cook, Simon J., Gilley, Rebecca

Source: Biochemical Journal; Mar2024, Vol. 481 Issue 6, p405-422, 18p

Subject Terms: CELL lines, RAS proteins, GENE expression, SMALL molecules, DRUG discovery, RAS oncogenes

Visualization of Endogenous ERK½ in Cells with a Bioorthogonal Covalent Probe

Authors: Sipthorp, James, Lebraud, Honorine, Gilley, Rebecca, Kidger, Andrew M., Okkenhaug, Hanneke, Saba-El-Leil, Marc, Meloche, Sylvain, Caunt, Christopher J., Cook, Simon J., Heightman, Tom D.

Source: Bioconjugate chemistry. 28(6):1677-1683

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631358479&indx=1&recIds=ETOCRN631358479

The Rac-GEF Tiam1 controls integrin-dependent neutrophil responses.

Authors: Hornigold, Kirsti, Baker, Martin J., Machin, Polly A., Chetwynd, Stephen A., Johnsson, Anna-Karin, Pantarelli, Chiara, Islam, Priota, Stammers, Melanie, Crossland, Laraine, Oxley, David, Okkenhaug, Hanneke, Walker, Simon, Walker, Rachael, Segonds-Pichon, Anne, Fukui, Yoshinori, Malliri, Angeliki, Welch, Heidi C. E.

Source: Frontiers in Immunology; 2023, p1-27, 27p

Subject Terms: NEUTROPHILS, REACTIVE oxygen species, STREPTOCOCCUS pneumoniae, LUNG infections

Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch

Authors: Lehmann, Laura C., Bacic, Luka, Hewitt, Graeme, Brackmann, Klaus, Sabantsev, Anton, Gaullier, Guillaume, Pytharopoulou, Sofia, Degliesposti, Gianluca, Okkenhaug, Hanneke, Tan, Song, Costa, Alessandro, Skehel, J. Mark, Boulton, Simon J., Deindl, Sebastian

Source: Cell reports. 33(12)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100117582598.0x000001&indx=1&recIds=ETOCvdc_100117582598.0x000001

Follicular Regulatory T Cells Can Access the Germinal Center Independently of CXCR5

Authors: Vanderleyden, Ine, Fra-Bido, Sigrid C., Innocentin, Silvia, Stebegg, Marisa, Okkenhaug, Hanneke, Evans-Bailey, Nicola, Pierson, Wim, Denton, Alice E., Linterman, Michelle A.

Source: Cell reports. 30(3):611-619.e4

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100096897289.0x000001&indx=1&recIds=ETOCvdc_100096897289.0x000001

A cell-based bioluminescence assay reveals dose-dependent and contextual repression of AP-1-driven gene expression by BACH2

Authors: Vardaka, Panagiota, Lozano, Teresa, Bot, Christopher, Ellery, Jonathan, Whiteside, Sarah K., Imianowski, Charlotte J., Farrow, Stuart, Walker, Simon, Okkenhaug, Hanneke, Yang, Jie, Okkenhaug, Klaus, Kuo, Paula, Roychoudhuri, Rahul

Source: Scientific reports. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183675358.0x000001&indx=1&recIds=ETOCvdc_100183675358.0x000001

Smarcad1 mediates microbiota-induced inflammation in mouse and coordinates gene expression in the intestinal epithelium

Authors: Kazakevych, Juri, Denizot, Jérémy, Liebert, Anke, Portovedo, Mariana, Mosavie, Mia, Jain, Payal, Stellato, Claudia, Fraser, Claire, Corrêa, Renan Oliveira, Célestine, Marina, Mattiuz, Raphaël, Okkenhaug, Hanneke, Miller, J. Ross, Vinolo, Marco Aurélio Ramirez, Veldhoen, Marc, Varga-Weisz, Patrick

Source: Genome biology. 21(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164911157.0x000001&indx=1&recIds=ETOCvdc_100164911157.0x000001

The GPCR adaptor protein Norbin regulates S1PR1 trafficking and the morphology, cell cycle and survival of PC12 cells.

Authors: Johansen, Valdemar B. I., Hampson, Elizabeth, Tsonou, Elpida, Pantarelli, Chiara, Chu, Julia Y., Crossland, Laraine, Okkenhaug, Hanneke, Massey, Andrew J., Hornigold, David C., Welch, Heidi C. E., Chetwynd, Stephen A.

Source: Scientific Reports; 10/25/2023, Vol. 13 Issue 1, p1-13, 13p

Subject Terms: CELL cycle, ADAPTOR proteins, CELL survival, CELL physiology, G protein coupled receptors

Rhabdomere Biogenesis in Drosophila Photoreceptors Is Acutely Sensitive to Phosphatidic Acid Levels

Authors: Raghu, Padinjat, Coessens, Elise, Manifava, Maria, Georgiev, Plamen, Pettitt, Trevor, Wood, Eleanor, Garcia-Murillas, Isaac, Okkenhaug, Hanneke, Trivedi, Deepti, Zhang, Qifeng, Razzaq, Azam, Zaid, Ola, Wakelam, Michael, O'Kane, Cahir J., Ktistakis, Nicholas

Source: The Journal of Cell Biology, 2009 Apr 01. 185(1), 129-145.

Access URL: https://www.jstor.org/stable/20537235

Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues to enable adaptation to high temperatures in C. elegans.

Authors: Chauve, Laetitia¹, Hodge, Francesca¹, Murdoch, Sharlene¹, Masoudzadeh, Fatemah¹, Mann, Harry-Jack², Lopez-Clavijo, Andrea², Okkenhaug, Hanneke², West, Greg², Sousa, Bebiana C.², Segonds-Pichon, Anne², Li, Cheryl¹, Wingett, Steven², Kienberger, Hermine³, Kleigrewe, Karin³, De Bono, Mario⁴, Wakelam, Michael⁵, Casanueva, Olivia¹, moc771@gmail.com

Source: PLoS Biology; 11/1/2021, Vol. 19 Issue 11, p1-33, 33p, 1 Color Photograph, 1 Diagram, 1 Chart, 4 Graphs

TRPM Channels Mediate Zinc Homeostasis and Cellular Growth during Drosophila Larval Development

Authors: Georgiev, Plamen, Okkenhaug, Hanneke, Drews, Anna, Wright, David, Lambert, Sachar, Flick, Melanie, Carta, Valentina, Martel, Cecile, Oberwinkler, Johannes, Raghu, Padinjat

Source: In Cell Metabolism 6 October 2010 12(4):386-397

Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits

Authors: Whyte, Carly E., Singh, Kailash, Burton, Oliver T., Aloulou, Meryem, Kouser, Lubna, Veiga, Rafael Valente, Dashwood, Amy, Okkenhaug, Hanneke, Benadda, Samira, Moudra, Alena

Source: Journal of experimental medicine. 219(7):e20212391-e20212391

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN629761937&indx=1&recIds=ETOCRN629761937

lazaro Encodes a Lipid Phosphate Phosphohydrolase that Regulates Phosphatidylinositol Turnover during Drosophila Phototransduction

Authors: Garcia-Murillas, Isaac, Pettitt, Trevor, Macdonald, Elaine, Okkenhaug, Hanneke, Georgiev, Plamen, Trivedi, Deepti, Hassan, Bassam, Wakelam, Michael, Raghu, Padinjat

Source: In Neuron 2006 49(4):533-546

Satellite repeat transcripts modulate heterochromatin condensates and safeguard chromosome stability in mouse embryonic stem cells.

Authors: Novo, Clara Lopes, Wong, Emily V., Hockings, Colin, Poudel, Chetan, Sheekey, Eleanor, Wiese, Meike, Okkenhaug, Hanneke, Boulton, Simon J., Basu, Srinjan, Walker, Simon, Kaminski Schierle, Gabriele S., Narlikar, Geeta J., Rugg-Gunn, Peter J.

Source: Nature Communications; 6/20/2022, Vol. 13 Issue 1, p1-16, 16p

Subject Terms: EMBRYONIC stem cells, HETEROCHROMATIN, CHROMOSOMES, MICE, PHASE separation