High plasma concentration of tenofovir alafenamide in people living with HIV with ABCB1 genetic variants

Authors: Tsuchiya, Kiyoto ^{a, ⁎}, Tran, Hieu Trung ^{a, b}, Kawashima, Akira ^{a, b}, Watanabe, Koji ^a, Hamada, Akinobu ^c, Oka, Shinichi ^{a, b}, Gatanaga, Hiroyuki ^{a, b, ⁎⁎}

Source: In Journal of Infection and Chemotherapy February 2025 31(2)

Determination of intracellular tenofovir-diphosphate and emtricitabine-triphosphate concentrations in dried blood spots for pre-exposure prophylaxis adherence

Authors: Tsuchiya, Kiyoto ^{a, ⁎}, Hayashi, Yoshiharu ^{b, c}, Ryu, Shoraku ^b, Tran, Hieu Trung ^{a, d}, Takano, Misao ^a, Tanaka, Kazuko ^a, Mizushima, Daisuke ^a, Oka, Shinichi ^{a, d}, Gatanaga, Hiroyuki ^{a, d}, Hamada, Akinobu ^b

Source: In Journal of Infection and Chemotherapy September 2024 30(9):876-880

Switch to fixed-dose doravirine (100 mg) with islatravir (0·75 mg) once daily in virologically suppressed adults with HIV-1 on antiretroviral therapy: 48-week results of a phase 3, randomised, open-label, non-inferiority trial

Authors: Molina, Jean-Michel, Rizzardini, Giuliano, Orrell, Catherine, Afani, Alejandro, Calmy, Alexandra, Oka, Shinichi, Hinestrosa, Federico, Kumar, Princy, Tebas, Pablo, Walmsley, Sharon, Grandhi, Anjana, Klopfer, Stephanie, Gendrano, Isaias, Eves, Karen, Correll, Todd A, Fox, Michelle C, Kim, Jason ^*

Source: In The Lancet HIV June 2024 11(6):e369-e379

Intravenous infusion of auto-serum-expanded autologous mesenchymal stem cells into chronic severe brain injury patients

Authors: Yamaki, Tomohiro, Oka, Shinichi, Iyama, Satoshi, Sasaki, Masanori, Onodera, Rie, Kataoka-Sasaki, Yuko, Namioka, Takahiro, Namioka, Ai, Nakazaki, Masahito, Takemura, Mitsuhiro, Ukai, Ryo, Yokoyama, Takahiro, Sasaki, Yuichi, Yamashita, Tatsuro, Kobayashi, Masato, Yamaguchi, Misako, Fukino, Marina, Takazawa, Taro, Hayasaka, Megumi, Owaku, Takamitsu, Funakura, Mika, Onodera, Shinji, Ito, Yoichi M., Kobune, Masayoshi, Kato, Junji, Ishiai, Sumio, Kocsis, Jeffery D., Odaki, Masaru, Iwadate, Yasuo, Kobayashi, Shigeki, Honmou, Osamu

Source: In Interdisciplinary Neurosurgery: Advanced Techniques and Case Management June 2024 36

Rehabilitation facilitates functional improvement following intravenous infusion of mesenchymal stem cells in the chronic phase of cerebral ischemia in rats

Authors: Yamashita, Tatsuro ^{a, b}, Sasaki, Masanori ^{a, c, ⁎}, Sasaki, Yuichi ^{a, b}, Nagahama, Hiroshi ^{a, d}, Oka, Shinichi ^a, Kataoka-Sasaki, Yuko ^a, Ukai, Ryo ^a, Yokoyama, Takahiro ^a, Kobayashi, Masato ^{a, b}, Kakizawa, Masafumi ^b, Kocsis, Jeffery D. ^{c, e, f}, Honmou, Osamu ^{a, c}

Source: In Brain Research 15 February 2024 1825

Suppression of myeloid YAP antagonizes adverse cardiac remodeling during pressure overload stress

Authors: Francisco, Jamie, Guan, Jin, Zhang, Yu, Nakada, Yasuki, Mareedu, Satvik, Sung, Eun-Ah, Hu, Che-Ming, Oka, Shinichi, Zhai, Peiyong, Sadoshima, Junichi, Del Re, Dominic P.

Source: Journal of molecular and cellular cardiology. 181:1-14

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195124270.0x000001&indx=1&recIds=ETOCvdc_100195124270.0x000001

Effect of tenofovir-based HIV pre-exposure prophylaxis against HBV infection in men who have sex with men

Authors: Mizushima, Daisuke, Takano, Misao, Aoki, Takahiro, Ando, Naokatsu, Uemura, Haruka, Yanagawa, Yasuaki, Watanabe, Koji, Gatanaga, Hiroyuki, Kikuchi, Yoshimi, Oka, Shinichi

Source: Hepatology. 77(6):2084-2092

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191135636.0x000001&indx=1&recIds=ETOCvdc_100191135636.0x000001

HIV-1 protective epitope-specific CD8+ T cells in HIV-1-exposed seronegative individuals

Authors: Chikata, Takayuki, Gatanaga, Hiroyuki, Nguyen, Hung The, Mizushima, Daisuke, Zhang, Yu, Kuse, Nozomi, Oka, Shinichi, Takiguchi, Masafumi

Source: In iScience 17 November 2023 26(11)

Efficacy, safety, and tolerability of switching to long-acting cabotegravir plus rilpivirine versus continuing fixed-dose bictegravir, emtricitabine, and tenofovir alafenamide in virologically suppressed adults with HIV, 12-month results (SOLAR): a randomised, open-label, phase 3b, non-inferiority trial

Authors: Ramgopal, Moti N, Castagna, Antonella, Cazanave, Charles, Diaz-Brito, Vicens, Dretler, Robin, Oka, Shinichi, Osiyemi, Olayemi, Walmsley, Sharon, Sims, James, Di Perri, Giovanni, Sutton, Kenneth, Sutherland-Phillips, Denise, Berni, Alessandro, Latham, Christine L, Zhang, Feifan, D'Amico, Ronald, Pascual Bernáldez, Miguel, Van Solingen-Ristea, Rodica, Van Eygen, Veerle, Patel, Parul, Chounta, Vasiliki, Spreen, William R, Garges, Harmony P, Smith, Kimberly, van Wyk, Jean ^*

Source: In The Lancet HIV September 2023 10(9):e566-e577

A practical protocol for high-spatial-resolution magnetic resonance angiography for cerebral arteries in rats

Authors: Nagahama, Hiroshi, Sasaki, Masanori, Komatsu, Katsuya, Sato, Kaori, Katagiri, Yoshimi, Kamagata, Masaki, Kataoka-Sasaki, Yuko, Oka, Shinichi, Ukai, Ryo, Yokoyama, Takahiro, Terada, Kojiro, Kobayashi, Masato, Kocsis, Jeffery D., Honmou, Osamu

Source: In Journal of Neuroscience Methods 15 February 2023 386

Asian participants' experience in phase 3/3b studies of long‐acting cabotegravir and rilpivirine: Efficacy, safety, pharmacokinetic, and virological outcomes through week 96.

Authors: Oka, Shinichi¹ oka@acc.ncgm.go.jp, Holohan, Vicki², Shirasaka, Takuma³, Choi, Jun Yong⁴, Kim, Yeon‐Sook⁵, Chamay, Nadine⁶, Patel, Parul⁷, Polli, Joseph W.⁷, Ford, Susan L.⁸, Crauwels, Herta⁹, Garside, Louise¹⁰, D'Amico, Ronald⁷, Latham, Christine⁷, van Solingen‐Ristea, Rodica⁹, Baugh, Bryan¹¹, van Wyk, Jean⁶

Source: HIV Medicine. Mar2024, Vol. 25 Issue 3, p381-390. 10p.

Subject Terms: *ANTI-HIV agents, *DRUG efficacy, *HIV infections, *STATISTICS, *HUMAN research subjects, *CLINICAL trials, *HIV integrase inhibitors, *DRUG tolerance, *COMBINATION drug therapy, *VIRAL load, *ASIANS, *TREATMENT effectiveness, *PATIENTS' attitudes, *PSYCHOSOCIAL factors, *NON-nucleoside reverse transcriptase inhibitors, *DESCRIPTIVE statistics, *RESEARCH funding, *DATA analysis, *DRUG side effects, *PATIENT safety, *SECONDARY analysis, *PHARMACODYNAMICS

Population-level Metagenomics Uncovers Distinct Effects of Multiple Medications on the Human Gut Microbiome

Authors: Nagata, Naoyoshi, Nishijima, Suguru, Miyoshi-Akiyama, Tohru, Kojima, Yasushi, Kimura, Moto, Aoki, Ryo, Ohsugi, Mitsuru, Ueki, Kohjiro, Miki, Kuniko, Iwata, Eri, Hayakawa, Kayoko, Ohmagari, Norio, Oka, Shinichi, Mizokami, Masashi, Itoi, Takao, Kawai, Takashi, Uemura, Naomi, Hattori, Masahira

Source: In Gastroenterology October 2022 163(4):1038-1052

Enhanced Network in Corticospinal Tracts after Infused Mesenchymal Stem Cells in Spinal Cord Injury

Authors: Hirota, Ryosuke, Sasaki, Masanori, Kataoka-Sasaki, Yuko, Oshigiri, Tsutomu, Kurihara, Kota, Fukushi, Ryunosuke, Oka, Shinichi, Ukai, Ryo, Yoshimoto, Mitsunori, Kocsis, Jeffery D., Yamashita, Toshihiko, Honmou, Osamu

Source: Journal of neurotrauma. 39(23/24):1665-1677

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167524534.0x000001&indx=1&recIds=ETOCvdc_100167524534.0x000001

Metagenomic Identification of Microbial Signatures Predicting Pancreatic Cancer From a Multinational Study

Authors: Nagata, Naoyoshi, Nishijima, Suguru, Kojima, Yasushi, Hisada, Yuya, Imbe, Koh, Miyoshi-Akiyama, Tohru, Suda, Wataru, Kimura, Moto, Aoki, Ryo, Sekine, Katsunori, Ohsugi, Mitsuru, Miki, Kuniko, Osawa, Tsuyoshi, Ueki, Kohjiro, Oka, Shinichi, Mizokami, Masashi, Kartal, Ece, Schmidt, Thomas S.B., Molina-Montes, Esther, Estudillo, Lidia, Malats, Nuria, Trebicka, Jonel, Kersting, Stephan, Langheinrich, Melanie, Bork, Peer, Uemura, Naomi, Itoi, Takao, Kawai, Takashi

Source: Gastroenterology. 163(1):222-238

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100166480017.0x000001&indx=1&recIds=ETOCvdc_100166480017.0x000001

A four-year observation of HIV and sexually transmitted infections among men who have sex with men before and during pre-exposure prophylaxis in Tokyo

Authors: Mizushima, Daisuke, Takano, Misao, Ando, Naokatsu, Uemura, Haruka, Yanagawa, Yasuaki, Aoki, Takahiro, Watanabe, Koji, Ishizuka, Naoki, Oka, Shinichi

Source: Journal of infection and chemotherapy. 28(6):762-766

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100161594532.0x000001&indx=1&recIds=ETOCvdc_100161594532.0x000001

Repeated intravenous infusion of mesenchymal stem cells for enhanced functional recovery in a rat model of chronic cerebral ischemia

Authors: Takemura, Mitsuhiro, Sasaki, Masanori, Kataoka-Sasaki, Yuko, Kiyose, Ryo, Nagahama, Hiroshi, Oka, Shinichi, Ukai, Ryo, Yokoyama, Takahiro, Kocsis, Jeffery D., Ueba, Tetsuya

Source: Journal of neurosurgery. 137(2):402-411

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN629855530&indx=1&recIds=ETOCRN629855530

Detailed analysis of social support and proactive coping with depressive symptoms in Japanese HIV-infected individuals

Authors: Komatsu, Kensuke, Kimura, Sota, Kiryu, Yoko, Oka, Shinichi, Takahashi, Hidehiko, Matsushima, Eisuke, Takeuchi, Takashi

Source: AIDS care. 34(8):1022-1030

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100158336137.0x000001&indx=1&recIds=ETOCvdc_100158336137.0x000001

Pharmacological Difference Between Platelet Aggregations in Cardioembolic Stroke Patients with Direct Oral Anticoagulants: A Pilot Study

Authors: Nakazaki, Masahito, Oka, Shinichi, Magota, Hirotoshi, Kiyose, Ryo, Onodera, Rie, Ukai, Ryo, Kataoka-Sasaki, Yuko, Sasaki, Masanori, Honmou, Osamu

Source: In Journal of Stroke and Cerebrovascular Diseases July 2022 31(7)

Role of HLA-B*58:01–Restricted CD8⁺ T Cells in HIV-1 Subtype AE Infection.

Authors: Nguyen, Hung The, Chikata, Takayuki, Zhang, Yu, Tran, Giang Van, Gatanaga, Hiroyuki, Oka, Shinichi, Takiguchi, Masafumi

Source: Journal of Infectious Diseases; 1/15/2025, Vol. 231 Issue 1, p175-185, 11p

Subject Terms: VIETNAMESE people, HIV, T cells, EPITOPES, DISEASE progression

Geographic Terms: VIETNAM

Bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) in treatment-naïve and treatment-experienced people with HIV: 12-month virologic effectiveness and safety outcomes in the BICSTaR Japan cohort.

Authors: Yokomaku, Yoshiyuki, Teruya, Katsuji, Watanabe, Dai, Endo, Tomoyuki, Minami, Rumi, Taguchi, Nao, Cassidy, Tali, Marongiu, Andrea, Thorpe, David, Shirasaka, Takuma, Oka, Shinichi

Source: PLoS ONE; 1/8/2025, Vol. 20 Issue 1, p1-18, 18p

Subject Terms: CD4 lymphocyte count, HIV-positive persons, CLINICAL medicine, VERTIGO, TENOFOVIR, WEIGHT gain