Action Mechanisms of Exosomes Derived from GD3/GD2-Positive Glioma Cells in the Regulation of Phenotypes and Intracellular Signaling: Roles of Integrins.

Authors: Hasnat, Mohammad Abul^1,2 (AUTHOR) lalon.hasnat@gmail.com, Ohmi, Yuhsuke³ (AUTHOR) ooumi82@isc.chubu.ac.jp, Yesmin, Farhana¹ (AUTHOR) farhana7779@gmail.com, Kaneko, Kei¹ (AUTHOR) ikekoneka@isc.chubu.ac.jp, Kambe, Mariko¹ (AUTHOR) kambem@isc.chubu.ac.jp, Kitaura, Yoko³ (AUTHOR) ykitaura@isc.chubu.ac.jp, Ito, Takako³ (AUTHOR) taca1021@isc.chubu.ac.jp, Imao, Yuka¹ (AUTHOR) imao@isc.chubu.ac.jp, Kano, Keiko⁴ (AUTHOR) kano.keiko.f4@f.mail.nagoya-u.ac.jp, Mishiro-Sato, Emi⁴ (AUTHOR) mishiro.emi.m5@f.mail.nagoya-u.ac.jp, Koyanagi, Hiroka¹ (AUTHOR) rb23004-0529@sti.chubu.ac.jp, Kawamoto, Yoshiyuki¹ (AUTHOR) ykawa@isc.chubu.ac.jp, Bhuiyan, Robiul Hasan⁵ (AUTHOR) biochemistrobi79@gmail.com, Ohkawa, Yuki⁶ (AUTHOR) yuki.ohkawa@oici.jp, Tajima, Orie¹ (AUTHOR) oriet@isc.chubu.ac.jp, Furukawa, Koichi¹ (AUTHOR) koichi@fsc.chubu.ac.jp, Furukawa, Keiko¹ (AUTHOR) koichi@fsc.chubu.ac.jp

Source: International Journal of Molecular Sciences. Dec2024, Vol. 25 Issue 23, p12752. 24p.

Subject Terms: *PROTEOMICS, *CELLULAR control mechanisms, *CELL communication, *EXTRACELLULAR vesicles, *GLYCOSPHINGOLIPIDS

Bidirectional signals generated by Siglec-7 and its crucial ligand tri-sialylated T to escape of cancer cells from immune surveillance

Authors: Hashimoto, Noboru ^{1, 2}, Ito, Shizuka ¹, Harazono, Akira ³, Tsuchida, Akiko ⁴, Mouri, Yasuhiro ⁵, Yamamoto, Akihito ², Okajima, Tetsuya ¹, Ohmi, Yuhsuke ⁶, Furukawa, Keiko ⁷, Kudo, Yasusei ⁵, Kawasaki, Nana ⁸, Furukawa, Koichi ^{1, 7, 9, ∗}

Source: In iScience 15 November 2024 27(11)

Disordered testosterone transport in mice lacking the ganglioside GM2/GD2 synthase gene

Authors: Furukawa, Koichi, Takamiya, Kogo, Ohmi, Yuhsuke, Bhuiyan, Robiul H., Tajima, Orie, Furukawa, Keiko

Source: FEBS open bio. 13(9):1615-1624

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191761213.0x000001&indx=1&recIds=ETOCvdc_100191761213.0x000001

Functional validation of novel variants in B4GALNT1 associated with early‐onset complex hereditary spastic paraplegia with impaired ganglioside synthesis

Authors: Alecu, Julian Emanuel, Ohmi, Yuhsuke, Bhuiyan, Robiul H., Inamori, Kei‐ichiro, Nitta, Takahiro, Saffari, Afshin, Jumo, Hellen, Ziegler, Marvin, Gusmao, Claudio Melo, Sharma, Nutan, Ohno, Shiho, Manabe, Noriyoshi, Yamaguchi, Yoshiki, Kambe, Mariko, Furukawa, Keiko, Sahin, Mustafa, Inokuchi, Jin‐ichi, Furakawa, Koichi, Ebrahimi‐Fakhari, Darius

Source: American journal of medical genetics.Part A. 188(9):2590-2598

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100166441853.0x000001&indx=1&recIds=ETOCvdc_100166441853.0x000001

Lack of GD3 synthase (St8sia1) attenuates malignant properties of gliomas in genetically engineered mouse model

Authors: Ohkawa, Yuki, Zhang, Pu, Momota, Hiroyuki, Kato, Akira, Hashimoto, Noboru, Ohmi, Yuhsuke, Bhuiyan, Robiul H., Farhana, Yesmin, Natsume, Atsushi, Wakabayashi, Toshihiko, Furukawa, Keiko, Furukawa, Koichi

Source: Cancer science. 112(9):3756-3768

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184363520.0x000001&indx=1&recIds=ETOCvdc_100184363520.0x000001

The ceramide moiety of disialoganglioside (GD3) is essential for GD3 recognition by the sialic acid–binding lectin SIGLEC7 on the cell surface

Alternate Title: Ceramide structures involved in the recognition of Siglec-7 (English)

Authors: Hashimoto, Noboru, Ito, Shizuka, Tsuchida, Akiko, Bhuiyan, Robiul H., Okajima, Tetsuya, Yamamoto, Akihito, Furukawa, Keiko, Ohmi, Yuhsuke, Furukawa, Koichi

Source: In Journal of Biological Chemistry July 2019 294(28):10833-10845

Loss of Enzyme Activity in Mutated B4GALNT1 Gene Products in Patients with Hereditary Spastic Paraplegia Results in Relatively Mild Neurological Disorders: Similarity with Phenotypes of B4galnt1 Knockout Mice

Authors: Bhuiyan, Robiul H., Ohmi, Yuhsuke, Ohkawa, Yuki, Zhang, Pu, Takano, Maiko, Hashimoto, Noboru, Okajima, Tetsuya, Furukawa, Keiko, Furukawa, Koichi

Source: In Neuroscience 15 January 2019 397:94-106

Effects of low temperature buffer on carbon nano wall’s growth

Authors: Singh, Rupesh, Kawahara, Toshio, Ohmi, Yuhsuke, Ohno, Yasuhide, Maehashi, Kenzo, Matsumoto, Kazuhiko, Okamoto, Kazumasa, Utsunomiya, Risa, Yoshimura, Masamichi

Source: In Materials Today Communications December 2018 17:94-99

Reduction of Fluctuation of the Binding Activity of SGP to Influenza Viruses

Authors: Kawahara, Toshio, Hiramatsu, Hiroaki, Ohmi, Yuhsuke, Suzuki, Yasuo, Hayashi, Kyoko, Nakakita, Shin-ichi, Watanabe, Yohei, Ohno, Yasuhide, Maehashi, Kenzo, Ono, Takao

Source: Vacuum and surface science. 62(8):470-475

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN621172588&indx=1&recIds=ETOCRN621172588

New era of research on cancer‐associated glycosphingolipids

Authors: Furukawa, Koichi, Ohmi, Yuhsuke, Ohkawa, Yuki, Bhuiyan, Robiul H., Zhang, Pu, Tajima, Orie, Hashimoto, Noboru, Hamamura, Kazunori, Furukawa, Keiko

Source: Cancer science. 110(5):1544-1551

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100083696303.0x000001&indx=1&recIds=ETOCvdc_100083696303.0x000001

Glycolipids: Essential regulator of neuro-inflammation, metabolism and gliomagenesis

Authors: Furukawa, Koichi, Ohmi, Yuhsuke, Ji, Shuting, Zhang, Pu, Bhuiyan, Robiul H., Ohkawa, Yuki, Tajima, Orie, Hashimoto, Noboru, Furukawa, Keiko

Source: In BBA - General Subjects October 2017 1861(10):2479-2484

Targeted insertion of conditional expression cassettes into the mouse genome using the modified i-PITT.

Authors: Miura, Hiromi, Nakamura, Ayaka, Kurosaki, Aki, Kotani, Ai, Motojima, Masaru, Tanaka, Keiko, Kakuta, Shigeru, Ogiwara, Sanae, Ohmi, Yuhsuke, Komaba, Hirotaka, Schilit, Samantha L.P., Morton, Cynthia C., Gurumurthy, Channabasavaiah B., Ohtsuka, Masato

Source: BMC Genomics; 6/5/2024, Vol. 25 Issue 1, p1-11, 11p

Subject Terms: GENE expression, TRANSGENE expression, LABOR costs, MICE, TRANSGENES

Neogenin, Defined as a GD3-associated Molecule by Enzyme-mediated Activation of Radical Sources, Confers Malignant Properties via Intracytoplasmic Domain in Melanoma Cells

Authors: Kaneko, Kei, Ohkawa, Yuki, Hashimoto, Noboru, Ohmi, Yuhsuke, Kotani, Norihiro, Honke, Koichi, Ogawa, Mitsutaka, Okajima, Tetsuya, Furukawa, Keiko, Furukawa, Koichi

Source: In Journal of Biological Chemistry 5 August 2016 291(32):16630-16643

A therapeutic trial of human melanomas with combined small interfering RNAs targeting adaptor molecules p130Cas and paxillin activated under expression of ganglioside GD3

Authors: Makino, Yusuke, Hamamura, Kazunori, Takei, Yoshifumi, Bhuiyan, Robiul Hasan, Ohkawa, Yuki, Ohmi, Yuhsuke, Nakashima, Hideyuki, Furukawa, Keiko, Furukawa, Koichi

Source: In BBA - General Subjects August 2016 1860(8):1753-1763

Ganglioside GD3 Enhances Invasiveness of Gliomas by Forming a Complex with Platelet-derived Growth Factor Receptor α and Yes Kinase

Authors: Ohkawa, Yuki, Momota, Hiroyuki, Kato, Akira, Hashimoto, Noboru, Tsuda, Yusuke, Kotani, Norihiro, Honke, Koichi ^**, Suzumura, Akio, Furukawa, Keiko, Ohmi, Yuhsuke, Natsume, Atsushi, Wakabayashi, Toshihiko, Furukawa, Koichi

Source: In Journal of Biological Chemistry 26 June 2015 290(26):16043-16058

Regulatory function of glycosphingolipids in the inflammation and degeneration

Authors: Furukawa, Koichi, Ohmi, Yuhsuke, Kondo, Yuji, Ohkawa, Yuki, Tajima, Orie, Furukawa, Keiko

Source: In Archives of Biochemistry and Biophysics 1 April 2015 571:58-65

Sialyltransferases in autoimmune diseases

Authors: Ohmi, Yuhsuke, Furukawa, Kouichi

Source: Seikagaku. 89(5):666-672

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN613784339&indx=1&recIds=ETOCRN613784339

Increased a-series gangliosides positively regulate leptin/Ob receptor-mediated signals in hypothalamus of GD3 synthase-deficient mice

Authors: Ji, Shuting, Tokizane, Kyohei, Ohkawa, Yuki, Ohmi, Yuhsuke, Banno, Ryoichi, Okajima, Tetsuya, Kiyama, Hiroshi, Furukawa, Koichi, Furukawa, Keiko

Source: Biochemical and biophysical research communications. 479(3):453-460

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100066169863.0x000001&indx=1&recIds=ETOCvdc_100066169863.0x000001

B-series gangliosides crucially regulate leptin secretion in adipose tissues

Authors: Ji, Shuting, Ohkawa, Yuki, Tokizane, Kyohei, Ohmi, Yuhsuke, Banno, Ryoichi, Furukawa, Keiko, Kiyama, Hiroshi, Furukawa, Koichi

Source: Biochemical and biophysical research communications. 459(2):189-195

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100081640896.0x000001&indx=1&recIds=ETOCvdc_100081640896.0x000001

Gangliosides Play Pivotal Roles in the Regulation of Complement Systems and in the Maintenance of Integrity in Nerve Tissues

Authors: Ohmi, Yuhsuke, Tajima, Orie, Ohkawa, Yuki, Mori, Atsushi, Sugiura, Yasuo, Furukawa, Keiko, Furukawa, Koichi, Hakomon, Sen-Itiroh

Source: Proceedings of the National Academy of Sciences of the United States of America, 2009 Dec 01. 106(52), 22405-22410.

Access URL: https://www.jstor.org/stable/40536457