Investigator-initiated phase I trial of an oligonucleotide therapeutic targeting long noncoding RNA TUG 1 for recurrent glioblastoma.

Authors: Deguchi, Shoichi¹ (AUTHOR), Ohka, Fumiharu¹ (AUTHOR), Shiba, Yoshiki¹ (AUTHOR), Yamaguchi, Junya¹ (AUTHOR), Sato, Aya¹ (AUTHOR), Shinjo, Keiko² (AUTHOR), Arakawa, Yoshiki³ (AUTHOR), Narita, Yoshitaka⁴ (AUTHOR), Kondo, Yutaka² (AUTHOR), Saito, Ryuta¹ (AUTHOR) saito.ryuta.b1@f.mail.nagoya-u.ac.jp

Source: BMC Cancer. 2/13/2025, Vol. 25 Issue 1, p1-9. 9p.

Subject Terms: *LINCRNA, *DRUG delivery systems, *MEDICAL sciences, *BRAIN tumors, *TUMOR growth, *DRUG formularies

Endoscopic Cystoventricular Stenting in Awake Patients with Electrical Stimulation Mapping for Convexity Cysts: Three Case Reports and a Systematic Review

Authors: Okumura, Eriko ¹, Takeuchi, Kazuhito ^{1, ∗}, Nagata, Yuichi ¹, Iwami, Kenichiro ¹, Motomura, Kazuya ², Ohka, Fumiharu ¹, Sato, Yoshiki ¹, Hirose, Toshiaki ¹, Saito, Ryuta ¹

Source: In World Neurosurgery January 2025 193:108-118

A multi-center, open-label, randomized clinical trial evaluating the preventive effect of perampanel on craniotomy-induced epileptogenesis in seizure-naive patients with supratentorial brain tumors: study protocol for a GRAMPAS trial.

Authors: Yamaguchi, Junya¹ (AUTHOR) yamaguchi.junya.c4@f.mail.nagoya-u.ac.jp, Ohka, Fumiharu¹ (AUTHOR) ooka.fumiharu.j7@f.mail.nagoya-u.ac.jp, Motomura, Kazuya¹ (AUTHOR) k.motomura@scchr.jp, Ishizaki, Tomotaka¹ (AUTHOR) tomotakaishizaki@gmail.com, Nakahara, Norimoto² (AUTHOR) noripitnmeh587@gmail.com, Fujitani, Shigeru³ (AUTHOR) shigeru.f717@gmail.com, Nagatani, Tetsuya⁴ (AUTHOR) nagatani4137@nagoya2.jrc.or.jp, Ohno, Masasuke⁵ (AUTHOR) m.ono@aichi-cc.jp, Ando, Masahiko⁶ (AUTHOR) mando@med.nagoya-u.ac.jp, Kuwatsuka, Yachiyo⁶ (AUTHOR) kuwatsuka.yachiyo.v1@f.mail.nagoya-u.ac.jp, Nishida, Kazuki⁶ (AUTHOR) nishida@med.nagoya-u.ac.jp, Saito, Ryuta¹ (AUTHOR) saito.ryuta.b1@f.mail.nagoya-u.ac.jp

Source: Trials. 12/24/2024, Vol. 25 Issue 1, p1-8. 8p.

Subject Terms: *MEDICAL sciences, *SURGICAL complications, *BRAIN tumors, *PERAMPANEL, *PUBLIC health

Isolation of ependymal cilia from mouse brain

Authors: Mizuno, Akihiro, Takeuchi, Kazuhito, Nagata, Yuichi, Harada, Hideyuki, Yamamoto, Taiki, Ishikawa, Takayuki, Maeda, Sachi, Ohka, Fumiharu, Ueno, Hironori, Saito, Ryuta

Source: In Journal of Neuroscience Methods September 2024 409

Rapid detection of the MYD88 L265P mutation for pre‐ and intra‐operative diagnosis of primary central nervous system lymphoma

Authors: Yamaguchi, Junya, Ohka, Fumiharu, Kitano, Yotaro, Maeda, Sachi, Motomura, Kazuya, Aoki, Kosuke, Takeuchi, Kazuhito, Nagata, Yuichi, Hattori, Hikaru, Tsujiuchi, Takashi, Motomura, Ayako, Nishikawa, Tomohide, Kibe, Yuji, Shinjo, Keiko, Kondo, Yutaka, Saito, Ryuta

Source: Cancer science. 114(6):2544-2551

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100192111211.0x000001&indx=1&recIds=ETOCvdc_100192111211.0x000001

Efficacy and safety of bevacizumab, irinotecan, and temozolomide combination for relapsed or refractory pediatric central nervous system embryonal tumor: a single-institution study

Authors: Shiba, Yoshiki, Motomura, Kazuya, Taniguchi, Rieko, Kurimoto, Michihiro, Mizutani, Kosuke, Ohka, Fumiharu, Aoki, Kosuke, Ito, Eiji, Nishikawa, Tomohide, Yamaguchi, Junya

Source: Journal of neurosurgery.Pediatrics. 31(6):624-632

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN632393603&indx=1&recIds=ETOCRN632393603

CD79BY196 mutation is a potent predictive marker for favorable response to R‐MPV in primary central nervous system lymphoma

Authors: Yamaguchi, Junya, Ohka, Fumiharu, Lushun, Chalise, Motomura, Kazuya, Aoki, Kosuke, Takeuchi, Kazuhito, Nagata, Yuichi, Ito, Satoshi, Mizutani, Nobuhiko, Ohno, Masasuke, Suzaki, Noriyuki, Takasu, Syuntaro, Seki, Yukio, Kano, Takahisa, Wakabayashi, Kenichi, Oyama, Hirofumi, Kurahashi, Shingo, Tanahashi, Kuniaki, Hirano, Masaki, Shimizu, Hiroyuki, Kitano, Yotaro, Maeda, Sachi, Yamazaki, Shintaro, Wakabayashi, Toshihiko, Kondo, Yutaka, Natsume, Atsushi, Saito, Ryuta

Source: Cancer medicine. 12(6):7116-7126

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185281274.0x000001&indx=1&recIds=ETOCvdc_100185281274.0x000001

Mutation detection of urinary cell-free DNA via catch-and-release isolation on nanowires for liquid biopsy

Authors: Takahashi, Hiromi, Yasui, Takao, Hirano, Masaki, Shinjo, Keiko, Miyazaki, Yusuke, Shinoda, Wataru, Hasegawa, Takeshi, Natsume, Atsushi, Kitano, Yotaro, Ida, Mikiko, Zhang, Min, Shimada, Taisuke, Paisrisarn, Piyawan, Zhu, Zetao, Ohka, Fumiharu, Aoki, Kosuke, Rahong, Sakon, Nagashima, Kazuki, Yanagida, Takeshi, Baba, Yoshinobu

Source: In Biosensors and Bioelectronics 15 August 2023 234

Endoscopic Trans-Mini-Cylinder Biopsy for Intraparenchymal Brain Lesions

Authors: Takeuchi, Kazuhito, Ohka, Fumiharu, Nagata, Yuichi, Maeda, Sachi, Tanahashi, Kuniaki, Araki, Yoshio, Yamamoto, Taiki, Sasaki, Hiroo, Mizuno, Akihiro, Harada, Hideyuki, Saito, Ryuta

Source: In World Neurosurgery November 2022 167:e1147-e1153

Imaging features and consideration of progression pattern of diffuse hemispheric gliomas, H3 G34-mutant.

Authors: Kibe, Yuji, Chalise, Lushun, Ohka, Fumiharu, Motomura, Kazuya, Nakahara, Norimoto, Aoki, Kosuke, Deguchi, Shoichi, Shiba, Yoshiki, Takeuchi, Kazuhito, Iwami, Kenichiro, Yamaguchi, Junya, Shimizu, Hiroki, Maeda, Sachi, Takido, Yuhei, Yamamoto, Ryo, Okuno, Yusuke, Sakai, Akihiro, Karube, Kennosuke, Saito, Ryuta

Source: Acta Neuropathologica Communications; 2/27/2025, Vol. 13 Issue 1, p1-11, 11p

Subject Terms: CENTRAL nervous system tumors, WHITE matter (Nerve tissue), MAGNETIC resonance imaging, MEDICAL sciences, SURGICAL excision, AUTOPSY

Neurod4 converts endogenous neural stem cells to neurons with synaptic formation after spinal cord injury

Authors: Fukuoka, Toshiki, Kato, Akira, Hirano, Masaki, Ohka, Fumiharu, Aoki, Kosuke, Awaya, Takayuki, Adilijiang, Alimu, Sachi, Maeda, Tanahashi, Kuniaki, Yamaguchi, Junya, Motomura, Kazuya, Shimizu, Hiroyuki, Nagashima, Yoshitaka, Ando, Ryo, Wakabayashi, Toshihiko, Lee-Liu, Dasfne, Larrain, Juan, Nishimura, Yusuke, Natsume, Atsushi

Source: In iScience 19 February 2021 24(2)

Newly established patient-derived organoid model of intracranial meningioma

Authors: Yamazaki, Shintaro, Ohka, Fumiharu, Hirano, Masaki, Shiraki, Yukihiro, Motomura, Kazuya, Tanahashi, Kuniaki, Tsujiuchi, Takashi, Motomura, Ayako, Aoki, Kosuke, Shinjo, Keiko, Murofushi, Yoshiteru, Kitano, Yotaro, Maeda, Sachi, Kato, Akira, Shimizu, Hiroyuki, Yamaguchi, Junya, Adilijiang, Alimu, Wakabayashi, Toshihiko, Saito, Ryuta, Enomoto, Atsushi, Kondo, Yutaka, Natsume, Atsushi

Source: Neuro-oncology. 23(11):1936-1948

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100133219316.0x000001&indx=1&recIds=ETOCvdc_100133219316.0x000001

Intraoperative seizure outcome of levetiracetam combined with perampanel therapy in patients with glioma undergoing awake brain surgery

Authors: Motomura, Kazuya, Chalise, Lushun, Shimizu, Hiroyuki, Yamaguchi, Junya, Nishikawa, Tomohide, Ohka, Fumiharu, Aoki, Kosuke, Tanahashi, Kuniaki, Hirano, Masaki, Wakabayashi, Toshihiko

Source: Journal of neurosurgery. 135(4):998-1007

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN627646031&indx=1&recIds=ETOCRN627646031

Long-term survival in patients with primary intracranial germ cell tumors treated with surgery, platinum-based chemotherapy, and radiotherapy: a single-institution study

Authors: Shimizu, Hiroyuki, Motomura, Kazuya, Ohka, Fumiharu, Aoki, Kosuke, Tanahashi, Kuniaki, Hirano, Masaki, Chalise, Lushun, Nishikawa, Tomohide, Yamaguchi, Junya, Yoshida, Jun

Source: Journal of neurosurgery. 135(2):449-457

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN627167658&indx=1&recIds=ETOCRN627167658

Expression of programmed cell death ligand‐1 by immune cells in the microenvironment is a favorable prognostic factor for primary diffuse large B‐cell lymphoma of the central nervous system

Authors: Tsuyuki, Yuta, Ishikawa, Eri, Kohno, Kei, Shimada, Kazuyuki, Ohka, Fumiharu, Suzuki, Yuka, Mabuchi, Seiyo, Satou, Akira, Takahara, Taishi, Kato, Seiichi, Miyagi, Shohei, Ozawa, Hiroyuki, Kawano, Tasuku, Takagi, Yusuke, Hiraga, Junji, Wakabayashi, Toshihiko, Nakamura, Shigeo

Source: Neuropathology. 41(2):99-108

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100120166769.0x000001&indx=1&recIds=ETOCvdc_100120166769.0x000001

Trautmann-focused mastoidectomy for a simple, safe presigmoid approach: technical note

Authors: Tanahashi, Kuniaki, Uda, Kenji, Araki, Yoshio, Takeuchi, Kazuhito, Choo, Jungsu, Chalise, Lushun, Motomura, Kazuya, Ohka, Fumiharu, Wakabayashi, Toshihiko, Natsume, Atsushi

Source: Journal of neurosurgery. 134(3):843-847

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN625698957&indx=1&recIds=ETOCRN625698957

Increased Risk of Thyroid Dysfunction by PD-1 and CTLA-4 Blockade in Patients Without Thyroid Autoantibodies at Baseline

Authors: Iwama, Shintaro, Kobayashi, Tomoko, Yasuda, Yoshinori, Okuji, Takayuki, Ito, Masaaki, Ando, Masahiko, Zhou, Xin, Yamagami, Ayana, Onoue, Takeshi, Kawaguchi, Yohei, Miyata, Takashi, Sugiyama, Mariko, Takagi, Hiroshi, Hagiwara, Daisuke, Suga, Hidetaka, Banno, Ryoichi, Hase, Tetsunari, Morise, Masahiro, Wakahara, Keiko, Yokota, Kenji, Kato, Masashi, Nishio, Naoki, Tanaka, Chie, Miyata, Kazushi, Ogura, Atsushi, Ito, Takanori, Sawada, Tsunaki, Shimokata, Tomoya, Niimi, Kaoru, Ohka, Fumiharu, Ishigami, Masatoshi, Gotoh, Momokazu, Hashimoto, Naozumi, Saito, Ryuta, Kiyoi, Hitoshi, Kajiyama, Hiroaki, Ando, Yuichi, Hibi, Hideharu, Sone, Michihiko, Akiyama, Masashi, Kodera, Yasuhiro, Arima, Hiroshi

Source: Journal of clinical endocrinology & metabolism. 107(4):e1620-e1630

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100152521059.0x000001&indx=1&recIds=ETOCvdc_100152521059.0x000001

Neurocognitive and functional outcomes in patients with diffuse frontal lower-grade gliomas undergoing intraoperative awake brain mapping

Authors: Motomura, Kazuya, Chalise, Lushun, Ohka, Fumiharu, Aoki, Kosuke, Tanahashi, Kuniaki, Hirano, Masaki, Nishikawa, Tomohide, Yamaguchi, Junya, Shimizu, Hiroyuki, Wakabayashi, Toshihiko

Source: Journal of neurosurgery. 132(6):1683-1691

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN624027873&indx=1&recIds=ETOCRN624027873

Genetic analysis in patients with newly diagnosed glioblastomas treated with interferon-beta plus temozolomide in comparison with temozolomide alone

Authors: Natsume, Atsushi, Aoki, Kosuke, Ohka, Fumiharu, Maeda, Sachi, Hirano, Masaki, Adilijiang, Alimu, Motomura, Kazuya, Sumi, Minako, Nishikawa, Ryo, Narita, Yoshitaka, Muragaki, Yoshihiro, Maruyama, Takashi, Ito, Tamio, Beppu, Takaaki, Nakamura, Hideo, Kayama, Takamasa, Sato, Shinya, Nagane, Motoo, Mishima, Kazuhiko, Nakasu, Yoko, Kurisu, Kaoru, Yamasaki, Fumiyuki, Sugiyama, Kazuhiko, Onishi, Takanori, Iwadate, Yasuo, Terasaki, Mizuhiko, Kobayashi, Hiroyuki, Matsumura, Akira, Ishikawa, Eiichi, Sasaki, Hikaru, Mukasa, Akitake, Matsuo, Takayuki, Hirano, Hirofumi, Kumabe, Toshihiro, Shinoura, Nobusada, Hashimoto, Naoya, Aoki, Tomokazu, Asai, Akio, Abe, Tatsuya, Yoshino, Atsuo, Arakawa, Yoshiki, Asano, Kenichiro, Yoshimoto, Koji, Shibui, Soichiro, Okuno, Yusuke, Wakabayashi, Toshihiko

Source: Journal of neuro-oncology. 148(1):17-27

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100171688930.0x000001&indx=1&recIds=ETOCvdc_100171688930.0x000001

Dual phenotypes in recurrent astrocytoma, IDH-mutant; coexistence of IDH-mutant and IDH-wildtype components: a case report with genetic and epigenetic analysis.

Authors: Yamaguchi, Junya¹ (AUTHOR), Ohka, Fumiharu¹ (AUTHOR) ooka.fumiharu.j7@f.mail.nagoya-u.ac.jp, Seki, Masafumi² (AUTHOR), Motomura, Kazuya¹ (AUTHOR), Deguchi, Shoichi¹ (AUTHOR), Shiba, Yoshiki¹ (AUTHOR), Okumura, Yuka² (AUTHOR), Kibe, Yuji¹ (AUTHOR), Shimizu, Hiroki¹ (AUTHOR), Maeda, Sachi¹ (AUTHOR), Takido, Yuhei¹ (AUTHOR), Yamamoto, Ryo¹ (AUTHOR), Nakamura, Akihiro¹ (AUTHOR), Karube, Kennosuke² (AUTHOR), Saito, Ryuta¹ (AUTHOR)

Source: Acta Neuropathologica Communications. 10/26/2024, Vol. 12 Issue 1, p1-7. 7p.

Subject Terms: *ISOCITRATE dehydrogenase, *TUMOR growth, *ASTROCYTOMAS, *GLIOMAS, *GLIOBLASTOMA multiforme