Functional analysis of cell lines derived from SMAD3-related Loeys-Dietz syndrome patients provides insights into genotype-phenotype relation.

Authors: Wagenaar, Nathalie P de, Bersselaar, Lisa M van den, Odijk, Hanny J H M, Stefens, Sanne J M, Reinhardt, Dieter P, Roos-Hesselink, Jolien W, Kanaar, Roland, Verhagen, Judith M A, Brüggenwirth, Hennie T, Laar, Ingrid M B H van de, van der Pluijm, Ingrid, Essers, Jeroen

Source: Human Molecular Genetics; 6/15/2024, Vol. 33 Issue 12, p1090-1104, 15p

A mRad51-GFP antimorphic allele affects homologous recombination and DNA damage sensitivity

Authors: Uringa, Evert-Jan, Baldeyron, Céline, Odijk, Hanny, Wassenaar, Evelyne, van Cappellen, Wiggert A., Maas, Alex, Hoeijmakers, Jan H.J., Baarends, Willy M., Kanaar, Roland, Essers, Jeroen

Source: In DNA Repair January 2015 25:27-40

Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition

Authors: Krawczyk, Przemek M., Eppink, Berina, Essers, Jeroen, Stap, Jan, Rodermond, Hans, Odijk, Hanny, Zelensky, Alex, van Bree, Chris, Stalpers, Lukas J., Buist, Marrije R., Soullié, Thomas, Rens, Joost, Verhagen, Hence J. M., O'Connor, Mark J., Franken, Nicolaas A. P., Hagen, Timo L. M. ten, Kanaar, Roland, Aten, Jacob A.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2011 Jun . 108(24), 9851-9856.

Access URL: https://www.jstor.org/stable/25831324

Heat-induced BRCA2 degradation in human tumours provides rationale for hyperthermia-PARP-inhibitor combination therapies.

Authors: van den Tempel, Nathalie¹, Odijk, Hanny¹, van Holthe, Netteke², Naipal, Kishan¹, Raams, Anja¹, Eppink, Berina¹, van Gent, Dik C.¹, Hardillo, Jose³, Verduijn, Gerda M.², Drooger, Jan C.⁴, van Rhoon, Gerard C.², Smedts, Dineke (H.) P.M.⁵, van Doorn, Helena C.⁵, Boormans, Joost L.⁶, Jager, Agnes⁷, Franckena, Martine², Kanaar, Roland¹ r.kanaar@erasmusmc.nl

Source: International Journal of Hyperthermia. Jun2018, Vol. 34 Issue 4, p407-414. 8p.

Subject Terms: *FEVER, *CANCER chemotherapy, *CANCER treatment, *CANCER cells, *BRCA genes

HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis

Authors: Brandsma, Inger, Sato, Koichi, van Rossum-Fikkert, Sari E., van Vliet, Nicole, Sleddens, Esther, Reuter, Marcel, Odijk, Hanny, van den Tempel, Nathalie, Dekkers, Dick H.W., Bezstarosti, Karel, Demmers, Jeroen A.A., Maas, Alex, Lebbink, Joyce, Wyman, Claire, Essers, Jeroen, van Gent, Dik C., Baarends, Willy M., Knipscheer, Puck, Kanaar, Roland, Zelensky, Alex N.

Source: In Cell Reports 25 June 2019 27(13):3790-3798

The Structure of the Human ERCC1/XPF Interaction Domains Reveals a Complementary Role for the Two Proteins in Nucleotide Excision Repair

Authors: Tripsianes, Konstantinos, Folkers, Gert, AB, Eiso, Das, Devashish, Odijk, Hanny, Jaspers, Nicolaas G.J., Hoeijmakers, Jan H.J., Kaptein, Robert, Boelens, Rolf

Source: In Structure 2005 13(12):1849-1858

Ionizing radiation-induced foci formation of mammalian Rad51 and Rad54 depends on the Rad51 paralogs, but not on Rad52

Authors: van Veelen, Lieneke R., Essers, Jeroen, van de Rakt, Mandy W.M.M., Odijk, Hanny, Pastink, Albert, Zdzienicka, Małgorzata Z., Paulusma, Coen C., Kanaar, Roland ^*

Source: In Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 2005 574(1):34-49

Role of BRCA2 DNA-binding and C-terminal domain in its mobility and conformation in DNA repair.

Authors: Paul, Maarten W., Sidhu, Arshdeep, Yongxin Liang, van Rossum-Fikkert, Sarah E., Odijk, Hanny, Zelensky, Alex N., Kanaar, Roland, Wyman, Claire

Source: eLife; 7/30/2021, p1-23, 23p

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A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis.

Authors: Niedernhofer, Laura J., Garinis, George A., Raams, Anja, Lalai, Astrid S., Robinson, Andria Rasile, Appeldoorn, Esther, Odijk, Hanny, Oostendorp, Roos, Ahmad, Anwaar, van Leeuwen, Wibeke, Theil, Arjan F., Vermeulen, Wim, van der Horst, Gijsbertus T. J., Meinecke, Peter, Kleijer, Wim J., Vijg, Jan, Jaspers, Nicolaas G. J., Hoeijmakers, Jan H. J.

Source: Nature. 12/21/2006, Vol. 444 Issue 7122, p1038-1043. 6p. 1 Diagram, 4 Graphs.

Subjects: XERODERMA pigmentosum, ENDONUCLEASES, DNA damage, CELL death, ANTIOXIDANTS, AGING

Ubiquitin ligase Rad18^Sc localizes to the XY body and to other chromosomal regions that are unpaired and transcriptionally silenced during male meiotic prophase.

Authors: van der Laan, Roald, Uringa, Evert-Jan, Wassenaar, Evelyne, Hoogerbrugge, Jos W., Sleddens, Esther, Odijk, Hanny, Roest, Henk P., de Boer, Peter, Hoeijmakers, Jan H., Grootegoed, J. Anton, Baarends, Willy M.

Source: Journal of Cell Science; 10/1/2004, Vol. 117 Issue 21, p5023-5033, 11p, 9 Diagrams

Subject Terms: UBIQUITIN, LIGASES, CHROMOSOMES, CELL nuclei, MEIOSIS, CELL division, CELL physiology, CYTOLOGY

The Structure-Specific Endonuclease Ercc1-Xpf Is Required To Resolve DNA Interstrand Cross-Link-Induced Double-Strand Breaks.

Authors: Niedernhofer, Laura J.¹ niedernhoferl@upmc.edu, Odijk, Hanny¹, Budzowska, Magda¹, Van Drunen, Ellen¹, Maas, Alex¹, Theil, Arjan F.¹, De Wit, Jan¹, Jaspers, N. G. J.¹, Beverloo, H. Berna¹, Hoeijmakers, Jan H. J.¹, Kanaar, Roland^1,2

Source: Molecular & Cellular Biology. Jul2004, Vol. 24 Issue 13, p5776-5787. 12p. 11 Diagrams, 1 Chart, 10 Graphs.

Subject Terms: *DNA damage, *DNA repair, *CELLS, *GENETIC mutation, *ANTINEOPLASTIC antibiotics, *MITOMYCIN C, *IMMUNOSUPPRESSIVE agents, *DNA replication, *CHROMOSOME replication

The structure-specific endonuclease Ercc1-Xpf is required for targeted gene replacement in embryonic stem cells.

Authors: Niedernhofer, Laura J., Essers, Jeroen, Weeda, Geert, Beverloo, Berna, de Wit, Jan, Muijtjens, Manja, Odijk, Hanny, Hoeijmakers, Jan H.J., Kanaar, Roland

Source: EMBO Journal; 11/15/2001, Vol. 20 Issue 22, p6540-6549, 10p

Subject Terms: DNA, GENES, NUCLEIC acids, GENETICS, EMBRYONIC stem cells, CELLS

Mapping of interaction domains between human repair proteins ERCC1 and XPF.

Authors: de Laat, Wouter L., Sijbers, Anneke M., Odijk, Hanny, Jaspers, Nicolaas G. J., Hoeijmakers, Jan H. J.

Source: Nucleic Acids Research; Sep1998, Vol. 26 Issue 18, p4146-4152, 7p

Mutational Analysis of the Human Nucleotide Excision Repair Gene ERCC1.

Authors: Sijbers, Anneke M., van der Spek, Peter J., Odijk, Hanny, van den Berg, Joke, van Duin, Marcel, Westerveld, Andries, Jaspers, Nicolaas G. J., Bootsma, Dirk, Hoeijmakers, Jan H. J.

Source: Nucleic Acids Research; 1996, Vol. 24 Issue 17, p3370-3380, 11p

Induction of a mutant phenotype in human repair proficient cells after overexpression of a mutated human DNA repair gene.

Authors: Belt, Peter B.G.M., Van Oosterwijk, Michiel F., Odijk, Hanny, Hoeijmakers, Jan H.J., Backendorf, Claude

Source: Nucleic Acids Research; 10/15/1991, Vol. 19 Issue 20, p5633-5637, 5p

Genomic characterization of the human DNA excision repair gene ERCC-1.

Authors: van Duin, Marcel, Koken, Marcel H.M., van den Tol, Jacolien, ten Dijke, Peter, Odijk, Hanny, Westerveld, Andries, Bootsma, Dirk, Hoeijmakers, Jan H.J.

Source: Nucleic Acids Research; 11/15/1987, Vol. 15 Issue 22, p9195-9214, 20p

On the Mechanism of Hyperthermia-Induced BRCA2 Protein Degradation.

Authors: van den Tempel, Nathalie, Zelensky, Alex N., Odijk, Hanny, Laffeber, Charlie, Schmidt, Christine K., Brandsma, Inger, Demmers, Jeroen, Krawczyk, Przemek M., Kanaar, Roland

Source: Cancers; Jan2019, Vol. 11 Issue 1, p97, 1p

Subject Terms: BIOCHEMISTRY, GENETICS, HEAT shock proteins, PHENOMENOLOGY, PROTEOLYTIC enzymes, THERMOTHERAPY, OXIDATIVE stress, BRCA genes, FREE radical scavengers

Molecular characterization of the human excision repair gene ERCC-1: cDNA cloning and amino acid homology with the yeast DNA repair gene RAD10

Authors: van Duin, Marcel, de Wit, Jan, Odijk, Hanny, Westerveld, Andries, Yasui, Akira, Koken, Marcel H.M., Hoeijmakers, Jan H.J., Bootsma, Dirk

Source: In Cell 1986 44(6):913-923

Differences between rodent and human cell lines in the amount of integrated DNA after transfection

Authors: Hoeijmakers, Jan H.J., Odijk, Hanny, Westerveld, Andries

Source: In Experimental Cell Research 1987 169(1):111-119