A conformational transition of the D′D3 domain primes von Willebrand factor for multimerization

Authors: Gruber, Sophia ^*, Löf, Achim ^*, Hausch, Adina, Kutzki, Fabian, Jöhr, Res, Obser, Tobias, König, Gesa, Schneppenheim, Reinhard, Aponte-Santamaría, Camilo, Gräter, Frauke, Brehm, Maria A., Benoit, Martin ^*, Lipfert, Jan ^*

Source: In Blood Advances 13 September 2022 6(17):5198-5209

Heparan sulfate dependent binding of plasmatic von Willebrand factor to blood circulating melanoma cells attenuates metastasis

Authors: Wang, Yuanyuan, Liu, Xiaobo, Obser, Tobias, Bauer, Alexander T., Heyes, Martin, Starzonek, Sarah, Zulal, Mina, Opitz, Karena, Ott, Leonie, Riethdorf, Sabine, Lange, Tobias, Pantel, Klaus, Bendas, Gerd, Schneider, Stefan W., Kusche-Gullberg, Marion, Gorzelanny, Christian

Source: In Matrix Biology August 2022 111:76-94

Shear-induced unfolding and enzymatic cleavage of full-length VWF multimers

Authors: Lippok, Svenja, Radtke, Matthias, Obser, Tobias, Kleemeier, Lars, Schneppenheim, Reinhard, Budde, Ulrich, Netz, Roland R., Rädler, Joachim O.

Subject Terms: Physics - Biological Physics

Access URL: http://arxiv.org/abs/1512.05127

Multiplexed protein force spectroscopy reveals equilibrium protein folding dynamics and the low-force response of von Willebrand factor

Authors: Löf, Achim, Walker, Philipp U., Sedlak, Steffen M., Gruber, Sophia, Obser, Tobias, Brehm, Maria A., Benoit, Martin, Lipfert, Jan

Source: Proceedings of the National Academy of Sciences of the United States of America, 2019 Sep . 116(38), 18798-18807.

Access URL: https://www.jstor.org/stable/26851632

Evidence for the Misfolding of the A1 Domain within Multimeric von Willebrand Factor in Type 2 von Willebrand Disease

Authors: Tischer, Alexander, Brehm, Maria A., Machha, Venkata R., Moon-Tasson, Laurie, Benson, Linda M., Nelton, Katelynn J., Leger, Rachel R., Obser, Tobias, Martinez-Vargas, Marina, Whitten, Steven T., Chen, Dong, Pruthi, Rajiv K., Bergen, H. Robert, III, Cruz, Miguel A., Schneppenheim, Reinhard, Auton, Matthew

Source: In Journal of Molecular Biology 17 January 2020 432(2):305-323

Shear-Induced Unfolding Activates von Willebrand Factor A2 Domain for Proteolysis

Authors: Baldauf, Carsten, Schneppenheim, Reinhard, Stacklies, Wolfram, Obser, Tobias, Pieconka, Antje, Schneppenheim, Sonja, Budde, Ulrich, Graeter, Frauke

Source: J. Thromb. Haemost. 2009 (7), 2096-2105

Subject Terms: Physics - Biological Physics, Quantitative Biology - Biomolecules

Access URL: http://arxiv.org/abs/0904.3951

Medulloblastoma in children with Fanconi anemia: Association with FA-D1/FA-N, SHH type and poor survival independent of treatment strategies.

Authors: Sönksen, Marthe, Obrecht-Sturm, Denise, Driever, Pablo Hernáiz, Sauerbrey, Axel, Graf, Norbert, Kontny, Udo, Reimann, Christian, Langhein, Mina, Kordes, Uwe R, Schwarz, Rudolf, Obser, Tobias, Boschann, Felix, Schüller, Ulrich, Altendorf, Lea, Goschzik, Tobias, Pietsch, Torsten, Mynarek, Martin, Rutkowski, Stefan

Source: Neuro-Oncology; Nov2024, Vol. 26 Issue 11, p2125-2139, 15p

The von Willebrand factor Tyr2561 allele is a gain-of-function variant and a risk factor for early myocardial infarction

Authors: Schneppenheim, Reinhard ^*, Hellermann, Natalie, Brehm, Maria A., Klemm, Ulrike, Obser, Tobias, Huck, Volker, Schneider, Stefan W., Denis, Cécile V., Tischer, Alexander, Auton, Matthew, März, Winfried, Xu, Emma-Ruoqi, Wilmanns, Matthias, Zotz, Rainer B.

Source: In Blood 24 January 2019 133(4):356-365

Structure and dynamics of the platelet integrin-binding C4 domain of von Willebrand factor

Authors: Xu, Emma-Ruoqi ^*, von Bülow, Sören ^*, Chen, Po-Chia, Lenting, Peter J., Kolšek, Katra, Aponte-Santamaría, Camilo, Simon, Bernd, Foot, Jaelle, Obser, Tobias, Schneppenheim, Reinhard, Gräter, Frauke, Denis, Cécile V., Wilmanns, Matthias ^*, Hennig, Janosch

Source: In Blood 24 January 2019 133(4):366-376

Enhanced Local Disorder in a Clinically Elusive von Willebrand Factor Provokes High-Affinity Platelet Clumping

Authors: Tischer, Alexander, Machha, Venkata R., Frontroth, Juan P., Brehm, Maria A., Obser, Tobias, Schneppenheim, Reinhard, Mayne, Leland, Walter Englander, S., Auton, Matthew

Source: In Journal of Molecular Biology 7 July 2017 429(14):2161-2177

Mutation G1629E Increases von Willebrand Factor Cleavage via a Cooperative Destabilization Mechanism

Authors: Aponte-Santamaría, Camilo, Lippok, Svenja, Mittag, Judith J., Obser, Tobias, Schneppenheim, Reinhard, Baldauf, Carsten, Gräter, Frauke, Budde, Ulrich, Rädler, Joachim O.

Source: In Biophysical Journal 10 January 2017 112(1):57-65

Mutual A domain interactions in the force sensing protein von Willebrand factor

Authors: Posch, Sandra, Aponte-Santamaría, Camilo, Schwarzl, Richard, Karner, Andreas, Radtke, Matthias, Gräter, Frauke, Obser, Tobias, König, Gesa, Brehm, Maria A., Gruber, Hermann J., Netz, Roland R., Baldauf, Carsten, Schneppenheim, Reinhard, Tampé, Robert, Hinterdorfer, Peter

Source: In Journal of Structural Biology January 2017 197(1):57-64

The search for the underlying mutations causing VWD in 13 Venezuelan families

Authors: Marchi, Rita, Obser, Tobias, Oyen, Florian, Ruiz-Sáez, Arlette, Boadas, Apsara, Echenagucia, Marion, Schneppenheim, Sonja, Budde, Ulrich, Schneppenheim, Reinhard

Source: In Thrombosis Research March 2024 235:88-91

pH-Dependent Interactions in Dimers Govern the Mechanics and Structure of von Willebrand Factor

Authors: Müller, Jochen P., Löf, Achim, Mielke, Salomé, Obser, Tobias, Bruetzel, Linda K., Vanderlinden, Willem, Lipfert, Jan, Schneppenheim, Reinhard, Benoit, Martin

Source: In Biophysical Journal 26 July 2016 111(2):312-322

von Willebrand factor is dimerized by protein disulfide isomerase

Authors: Lippok, Svenja, Kolšek, Katra, Löf, Achim, Eggert, Dennis, Vanderlinden, Willem, Müller, Jochen P., König, Gesa, Obser, Tobias, Röhrs, Karoline, Schneppenheim, Sonja, Budde, Ulrich, Baldauf, Carsten, Aponte-Santamaría, Camilo, Gräter, Frauke, Schneppenheim, Reinhard, Rädler, Joachim O., Brehm, Maria A. ^*

Source: In Blood 3 March 2016 127(9):1183-1191

The activity of the intrinsically water-soluble enzyme ADAMTS13 correlates with the membrane state when bound to a phospholipid bilayer.

Authors: Kamenac, Andrej^1,2 (AUTHOR), Obser, Tobias³ (AUTHOR), Wixforth, Achim^1,2 (AUTHOR), Schneider, Matthias F.⁴ (AUTHOR), Westerhausen, Christoph^1,2,5 (AUTHOR) christoph.westerhausen@gmail.com

Source: Scientific Reports. 12/28/2021, Vol. 11 Issue 1, p1-9. 9p.

Subject Terms: *TRANSITION temperature, *ENZYMES, *PHASE transitions, *HEAT capacity, *PHOSPHOCHOLINE

Force sensing by the vascular protein von Willebrand factor is tuned by a strong intermonomer interaction

Authors: Müller, Jochen P., Mielke, Salomé, Löf, Achim, Obser, Tobias, Beer, Christof, Bruetzel, Linda K., Pippig, Diana A., Vanderlinden, Willem, Lipfert, Jan, Schneppenheim, Reinhard, Benoit, Martin

Source: Proceedings of the National Academy of Sciences of the United States of America, 2016 Feb 01. 113(5), 1208-1213.

Access URL: https://www.jstor.org/stable/26467581

Force-Sensitive Autoinhibition of the von Willebrand Factor Is Mediated by Interdomain Interactions

Authors: Aponte-Santamaría, Camilo, Huck, Volker, Posch, Sandra, Bronowska, Agnieszka K., Grässle, Sandra, Brehm, Maria A., Obser, Tobias, Schneppenheim, Reinhard, Hinterdorfer, Peter, Schneider, Stefan W., Baldauf, Carsten, Gräter, Frauke

Source: In Biophysical Journal 5 May 2015 108(9):2312-2321

Platelet-free shear flow assay facilitates analysis of shear-dependent functions of VWF and ADAMTS13

Authors: Kraus, Emma, Kraus, Kristina, Obser, Tobias, Oyen, Florian, Klemm, Ulrike, Schneppenheim, Reinhard, Brehm, Maria A.

Source: In Thrombosis Research December 2014 134(6):1285-1291

Identifying molecular markers for the sensitive detection of residual atypical teratoid rhabdoid tumor cells

Authors: Vu-Han, Tu-Lan, Frühwald, Michael C., Hasselblatt, Martin, Kerl, Kornelius, Nagel, Inga, Obser, Tobias, Oyen, Florian, Siebert, Reiner, Schneppenheim, Reinhard

Source: In Cancer Genetics September 2014 207(9):390-397