Early detection of pancreatic cancer: Study design and analytical considerations in biomarker discovery and early phase validation studies

Authors: Smith, Lynette M., Mahoney, Douglas W., Bamlet, William R., Yu, Fang, Liu, Suyu, Goggins, Michael G., Darabi, Sourat, Majumder, Shounak, Wang, Qiao-Li, Coté, Gregory A., Demeure, Michael J., Zhang, Zhen, Srivastava, Sudhir, Chawla, Akhil, Izmirlian, Grant, Olson, Janet E., Wolpin, Brian M., Genkinger, Jeanine M., Zaret, Kenneth S., Brand, Randall, Koay, Eugene J., Oberg, Ann L.

Source: In Pancreatology December 2024 24(8):1265-1279

Artificial intelligence assisted whole organ pancreatic fat estimation on magnetic resonance imaging and correlation with pancreas attenuation on computed tomography

Authors: Janssens, Laurens P., Takahashi, Hiroaki, Nagayama, Hiroki, Nugen, Fred, Bamlet, William R., Oberg, Ann L., Fuemmeler, Eric, Goenka, Ajit H., Erickson, Bradley J., Takahashi, Naoki, Majumder, Shounak

Source: Pancreatology. 23(5):556-562

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194620345.0x000001&indx=1&recIds=ETOCvdc_100194620345.0x000001

Discordant risk factors between pancreatic neuroendocrine neoplasms and pancreatic ductal adenocarcinoma.

Authors: Chandra, Shruti, Halfdanarson, Thorvardur R., Carlson, Erin E., Rabe, Kari G., Mahipal, Amit, Majumder, Shounak, Bamlet, William R., Horibe, Masayasu, Tella, Sri Harsha, Shariq, Omair, Carr, Ryan M., Cleary, Sean P., Oberg, Ann L., Antwi, Samuel O.

Source: Endocrine-Related Cancer; Apr2025, Vol. 32 Issue 4, p11-21, 11p

Calcium sensing receptor expression is downregulated in gastroenteropancreatic neuroendocrine tumours via epigenetic mechanisms.

Authors: English, Katherine A., Goldsworthy, Michelle, Willis, Brittannie, Kooblall, Kreepa G., Birla, Shweta, Selberherr, Andreas, Stevenson, Mark, Shariq, Omair A., Oberg, Ann L., Wang, Tony, Carmichael, James, Mavrommatis, Konstantinos, Escoubet, Laure, Thakker, Rajesh V., Howles, Sarah A., Lines, Kate E.

Source: International Journal of Cancer; Mar2025, Vol. 156 Issue 5, p980-992, 13p

Subject Terms: IMMUNOSTAINING, NEUROENDOCRINE tumors, G proteins, CELL proliferation, DNA methylation

Investigation of the association of CTRB2 exon 6 deletion with time to progression and overall survival in pancreatic ductal adenocarcinoma.

Authors: Siddiqui, Zafar A, Jazieh, Khalid, Hoskins, Jason, Rabe, Kari G., Antwi, Samuel O, Sicotte, Hugues, Carlson, Erin E., Oberg, Ann L., Connellly, Katelyn, Carr, Ryan Michael, Amundadottir, Laufey

Source: Journal of Clinical Oncology; 2025 Supplement 4, Vol. 43, p770-770, 121p

Machine-learning aided in situ drug sensitivity screening predicts treatment outcomes in ovarian PDX tumors

Authors: Cotler, Max J., Ramadi, Khalil B., Hou, Xiaonan, Christodoulopoulos, Elena, Ahn, Sebastian, Bashyam, Ashvin, Ding, Huiming, Larson, Melissa, Oberg, Ann L., Whittaker, Charles, Jonas, Oliver, Kaufmann, Scott H., Weroha, S. John, Cima, Michael J.

Source: In Translational Oncology July 2022 21

Discovery and Validation of Methylated DNA Markers From Pancreatic Neuroendocrine Tumors

Authors: Majumder, Shounak, Halfdanarson, Thorvardur R., Berger, Calise K., Foote, Patrick H., Cao, Xiaoming, McGlinch, Maria C., Gysbers, Brianna J., de La Fuente, Jaime, Robran, Mariah J., Doering, Karen A., Burger, Kelli N., Bamlet, William E., Oberg, Ann L., Mahoney, Douglas W., Graham, Rondell P., Taylor, William R., Petersen, Gloria M., Kisiel, John B.

Source: In Gastro Hep Advances 2022 1(3):409-416

Hepcidin-regulating iron metabolism genes and pancreatic ductal adenocarcinoma: a pathway analysis of genome-wide association studies

Authors: Julián-Serrano, Sachelly, Yuan, Fangcheng, Wheeler, William, Benyamin, Beben, Machiela, Mitchell J, Arslan, Alan A, Beane-Freeman, Laura E, Bracci, Paige M, Duell, Eric J, Du, Mengmeng, Gallinger, Steven, Giles, Graham G, Goodman, Phyllis J, Kooperberg, Charles, Marchand, Loic Le, Neale, Rachel E, Shu, Xiao-Ou, Van Den Eeden, Stephen K, Visvanathan, Kala, Zheng, Wei, Albanes, Demetrius, Andreotti, Gabriella, Ardanaz, Eva, Babic, Ana, Berndt, Sonja I, Brais, Lauren K, Brennan, Paul, Bueno-de-Mesquita, Bas, Buring, Julie E, Chanock, Stephen J, Childs, Erica J, Chung, Charles C, Fabiánová, Eleonora, Foretová, Lenka, Fuchs, Charles S, Gaziano, J Michael, Gentiluomo, Manuel, Giovannucci, Edward L, Goggins, Michael G, Hackert, Thilo, Hartge, Patricia, Hassan, Manal M, Holcátová, Ivana, Holly, Elizabeth A, Hung, Rayjean I, Janout, Vladimir, Kurtz, Robert C, Lee, I-Min, Malats, Núria, McKean, David, Milne, Roger L, Newton, Christina C, Oberg, Ann L, Perdomo, Sandra, Peters, Ulrike, Porta, Miquel, Rothman, Nathaniel, Schulze, Matthias B, Sesso, Howard D, Silverman, Debra T, Thompson, Ian M, Wactawski-Wende, Jean, Weiderpass, Elisabete, Wenstzensen, Nicolas, White, Emily, Wilkens, Lynne R, Yu, Herbert, Zeleniuch-Jacquotte, Anne, Zhong, Jun, Kraft, Peter, Li, Dounghui, Campbell, Peter T, Petersen, Gloria M, Wolpin, Brian M, Risch, Harvey A, Amundadottir, Laufey T, Klein, Alison P, Yu, Kai, Stolzenberg-Solomon, Rachael Z ^*

Source: In The American Journal of Clinical Nutrition October 2021 114(4):1408-1417

Biomarker Discovery and Validation: Statistical Considerations

Authors: Ou, Fang-Shu, Michiels, Stefan, Shyr, Yu, Adjei, Alex A., Oberg, Ann L.

Source: In Journal of Thoracic Oncology April 2021 16(4):537-545

Co-expression patterns of chimeric antigen receptor (CAR)-T cell target antigens in primary and recurrent ovarian cancer

Authors: Banville, Allyson C., Wouters, Maartje C.A., Oberg, Ann L., Goergen, Krista M., Maurer, Matthew J., Milne, Katy, Ashkani, Jahanshah, Field, Emma, Ghesquiere, Chanel, Jones, Steven J.M., Block, Matthew S., Nelson, Brad H.

Source: In Gynecologic Oncology February 2021 160(2):520-529

Investigation of selective glucocorticoid receptor modulation in high-grade serous ovarian cancer PDX models.

Authors: Taya, Manisha, Xiaonan Hou, Veneris, Jennifer T., Kazi, Nina, Larson, Melissa C., Maurer, Matthew J., Heinzen, Ethan P., Hao Chen, Lastra, Ricardo, Oberg, Ann L., Weroha, S. John, Fleming, Gini F., Conzen, Suzanne D.

Source: Journal of Gynecologic Oncology; Jan2025, Vol. 36 Issue 1, p1-14, 14p

Subject Terms: NUCLEAR receptors (Biochemistry), GLUCOCORTICOID receptors, TUMOR proteins, OVARIAN cancer, PROGRESSION-free survival

Experimental design of preclinical experiments: number of PDX lines vs subsampling within PDX lines

Authors: Eckel-Passow, Jeanette E, Kitange, Gaspar J, Decker, Paul A, Kosel, Matthew L, Burgenske, Danielle M, Oberg, Ann L, Sarkaria, Jann N

Source: Neuro-oncology. 23(12):2066-2075

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100136087838.0x000001&indx=1&recIds=ETOCvdc_100136087838.0x000001

Marked Up-Regulation of ACE2 in Hearts of Patients With Obstructive Hypertrophic Cardiomyopathy: Implications for SARS-CoV-2–Mediated COVID-19

Authors: Bos, J. Martijn, Hebl, Virginia B., Oberg, Ann L., Sun, Zhifu, Herman, Daniel S., Teekakirikul, Polakit, Seidman, Jonathan G., Seidman, Christine E., dos Remedios, Cristobal G., Maleszewski, Joseph J., Schaff, Hartzell V., Dearani, Joseph A., Noseworthy, Peter A., Friedman, Paul A., Ommen, Steve R., Brozovich, Frank V., Ackerman, Michael J.

Source: In Mayo Clinic Proceedings July 2020 95(7):1354-1368

Genes associated with bowel metastases in ovarian cancer

Authors: Mariani, Andrea, Wang, Chen, Oberg, Ann L., Riska, Shaun M., Torres, Michelle, Kumka, Joseph, Multinu, Francesco, Sagar, Gunisha, Roy, Debarshi, Jung, Deok–Beom, Zhang, Qing, Grassi, Tommaso, Visscher, Daniel W., Patel, Vatsal P., Jin, Ling, Staub, Julie K., Cliby, William A., Weroha, Saravut J., Kalli, Kimberly R., Hartmann, Lynn C., Kaufmann, Scott H., Goode, Ellen L., Shridhar, Viji

Source: In Gynecologic Oncology September 2019 154(3):495-504

Serum Proteomics on the Basis of Discovery of Predictive Biomarkers of Response to Androgen Deprivation Therapy in Advanced Prostate Cancer

Authors: Kohli, Manish, Oberg, Ann L., Mahoney, Douglas W., Riska, Shaun M., Sherwood, Robert, Zhang, Yuzi, Zenka, Roman M., Sahasrabudhe, Deepak, Qin, Rui, Zhang, Sheng

Source: In Clinical Genitourinary Cancer August 2019 17(4):248-253

Poly(adenosine diphosphate ribose) polymerase inhibitors induce autophagy‐mediated drug resistance in ovarian cancer cells, xenografts, and patient‐derived xenograft models

Authors: Santiago‐O'Farrill, Janice M., Weroha, S. John, Hou, Xiaonan, Oberg, Ann L., Heinzen, Ethan P., Maurer, Matthew J., Pang, Lan, Rask, Philip, Amaravadi, Ravi K., Becker, Sarah E., Romero, Ignacio, Rubio, Ma Jesús, Matias‐Guiu, Xavier, Santacana, Maria, Llombart‐Cussac, Antonio, Poveda, Andrés, Lu, Zhen, Bast, Robert C.

Source: Cancer. 126(4):894-907

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100097872703.0x000001&indx=1&recIds=ETOCvdc_100097872703.0x000001

A Transcriptome-Wide Association Study Identifies Novel Candidate Susceptibility Genes for Pancreatic Cancer

Authors: Zhong, Jun, Jermusyk, Ashley, Wu, Lang, Hoskins, Jason W, Collins, Irene, Mocci, Evelina, Zhang, Mingfeng, Song, Lei, Chung, Charles C, Zhang, Tongwu, Xiao, Wenming, Albanes, Demetrius, Andreotti, Gabriella, Arslan, Alan A, Babic, Ana, Bamlet, William R, Beane-Freeman, Laura, Berndt, Sonja, Borgida, Ayelet, Bracci, Paige M, Brais, Lauren, Brennan, Paul, Bueno-de-Mesquita, Bas, Buring, Julie, Canzian, Federico, Childs, Erica J, Cotterchio, Michelle, Du, Mengmeng, Duell, Eric J, Fuchs, Charles, Gallinger, Steven, Gaziano, J Michael, Giles, Graham G, Giovannucci, Edward, Goggins, Michael, Goodman, Gary E, Goodman, Phyllis J, Haiman, Christopher, Hartge, Patricia, Hasan, Manal, Helzlsouer, Kathy J, Holly, Elizabeth A, Klein, Eric A, Kogevinas, Manolis, Kurtz, Robert J, LeMarchand, Loic, Malats, Núria, Männistö, Satu, Milne, Roger, Neale, Rachel E, Ng, Kimmie, Obazee, Ofure, Oberg, Ann L, Orlow, Irene, Patel, Alpa V, Peters, Ulrike, Porta, Miquel, Rothman, Nathaniel, Scelo, Ghislaine, Sesso, Howard D, Severi, Gianluca, Sieri, Sabina, Silverman, Debra, Sund, Malin, Tjønneland, Anne, Thornquist, Mark D, Tobias, Geoffrey S, Trichopoulou, Antonia, Van Den Eeden, Stephen K, Visvanathan, Kala, Wactawski-Wende, Jean, Wentzensen, Nicolas, White, Emily, Yu, Herbert, Yuan, Chen, Zeleniuch-Jacquotte, Anne, Hoover, Robert, Brown, Kevin, Kooperberg, Charles, Risch, Harvey A, Jacobs, Eric J, Li, Donghui, Yu, Kai, Shu, Xiao-Ou, Chanock, Stephen J, Wolpin, Brian M, Stolzenberg-Solomon, Rachael Z, Chatterjee, Nilanjan, Klein, Alison P, Smith, Jill P, Kraft, Peter, Shi, Jianxin, Petersen, Gloria M, Zheng, Wei, Amundadottir, Laufey T

Source: Journal of the National Cancer Institute. 112(10):1003-1012

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112153811.0x000001&indx=1&recIds=ETOCvdc_100112153811.0x000001

53BP1 as a potential predictor of response in PARP inhibitor-treated homologous recombination-deficient ovarian cancer

Authors: Hurley, Rachel M., Wahner Hendrickson, Andrea E., Visscher, Daniel W., Ansell, Peter, Harrell, Maria I., Wagner, Jill M., Negron, Vivian, Goergen, Krista M., Maurer, Matthew J., Oberg, Ann L., Meng, X. Wei, Flatten, Karen S., De Jonge, Maja J.A., Van Herpen, Carla D., Gietema, Jourik A., Koornstra, Rutger H.T., Jager, Agnes, den Hollander, Martha W., Dudley, Matthew, Shepherd, Stacie P., Swisher, Elizabeth M., Kaufmann, Scott H.

Source: In Gynecologic Oncology April 2019 153(1):127-134

Proapoptotic activity of JNK-sensitive BH3-only proteins underpins ovarian cancer response to replication checkpoint inhibitors.

Authors: Venkatachalam, Annapoorna, Correia, Cristina, Peterson, Kevin L., Hou, Xianon, Schneider, Paula A., Strathman, Annabella R., Flatten, Karen S., Sine, Chance C., Balczewski, Emily A., McGehee, Cordelia D., Larson, Melissa C., Duffield, Laura N., Meng, X. Wei, Vincelette, Nicole D., Ding, Husheng, Oberg, Ann L., Couch, Fergus J., Swisher, Elizabeth M., Li, Hu, Weroha, S. John

Source: Molecular Cancer; 10/7/2024, Vol. 23 Issue 1, p1-16, 16p

Subject Terms: HOMOLOGOUS recombination, OVARIAN cancer, CELL cycle, CHECKPOINT kinase 1, CYCLIN-dependent kinases

Identify Non-mutational p53 Functional Deficiency in Human Cancers.

Authors: Li, Qianpeng, Zhang, Yang, Luo, Sicheng, Zhang, Zhang, Oberg, Ann L, Kozono, David E, Lu, Hua, Sarkaria, Jann N, Ma, Lina, Wang, Liguo

Source: Genomics, Proteomics & Bioinformatics; Oct2024, Vol. 22 Issue 5, p1-14, 14p