Mitotic abnormalities precede microsatellite instability in lynch syndrome-associated colorectal tumourigenesis

Authors: Pussila, Marjaana ^{a, ∗}, Laiho, Aleksi ^b, Törönen, Petri ^b, Björkbacka, Pauliina ^c, Nykänen, Sonja ^a, Pylvänäinen, Kirsi ^e, Holm, Liisa ^b, Mecklin, Jukka-Pekka ^{d, e}, Renkonen-Sinisalo, Laura ^{f, g}, Lehtonen, Taru ^f, Lepistö, Anna ^{f, g}, Linden, Jere ^c, Mäki-Nevala, Satu ^h, Peltomäki, Päivi ^{h, i}, Nyström, Minna ^a

Source: In eBioMedicine May 2024 103

Lynch Syndrome Genetics and Clinical Implications

Authors: Peltomäki, Päivi, Nyström, Minna, Mecklin, Jukka-Pekka, Seppälä, Toni T.

Source: Gastroenterology. 164(5):783-799

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186895918.0x000001&indx=1&recIds=ETOCvdc_100186895918.0x000001

DNA methylation changes and somatic mutations as tumorigenic events in Lynch syndrome-associated adenomas retaining mismatch repair protein expression

Authors: Mäki-Nevala, Satu, Valo, Satu, Ristimäki, Ari, Sarhadi, Virinder, Knuutila, Sakari, Nyström, Minna, Renkonen-Sinisalo, Laura, Lepistö, Anna, Mecklin, Jukka-Pekka, Peltomäki, Päivi

Source: In EBioMedicine January 2019 39:280-291

PMS2 expression decrease causes severe problems in mismatch repair

Authors: Kasela, Mariann, Nyström, Minna, Kansikas, Minttu

Source: Human mutation. 40(7):904-907

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100086722124.0x000001&indx=1&recIds=ETOCvdc_100086722124.0x000001

Western diet enhances intestinal tumorigenesis in Min/+ mice, associating with mucosal metabolic and inflammatory stress and loss of Apc heterozygosity

Authors: Niku, Mikael, Pajari, Anne-Maria, Sarantaus, Laura, Päivärinta, Essi, Storvik, Markus, Heiman-Lindh, Anu, Suokas, Santeri, Nyström, Minna, Mutanen, Marja

Source: In The Journal of Nutritional Biochemistry January 2017 39:126-133

Method to determine DNA mismatch repair function

Inherited cancer predisposition sensitizes colonic mucosa to address Western diet effects and putative cancer-predisposing changes on mouse proteome

Authors: Đermadi, Denis, Valo, Satu, Pussila, Marjaana, Reyhani, Nima, Sarantaus, Laura, Lalowski, Maciej, Baumann, Marc, Nyström, Minna

Source: In The Journal of Nutritional Biochemistry November 2014 25(11):1196-1206

Pathogenicity of MSH2 Missense Mutations Is Typically Associated With Impaired Repair Capability of the Mutated Protein

Authors: Ollila, Saara, Sarantaus, Laura, Kariola, Reetta, Chan, Philip, Hampel, Heather, Holinski–Feder, Elke, Macrae, Finlay, Kohonen–Corish, Maija, Gerdes, Anne–Marie, Peltomäki, Päivi, Mangold, Elisabeth, de la Chapelle, Albert, Greenblatt, Marc, Nyström, Minna

Source: In Gastroenterology 2006 131(5):1408-1417

Functional Significance and Clinical Phenotype of Nontruncating Mismatch Repair Variants of MLH1

Authors: Raevaara, Tiina E., Korhonen, Mari K., Lohi, Hannes, Hampel, Heather, Lynch, Elly, Lönnqvist, Karin E., Holinski-Feder, Elke, Sutter, Christian, McKinnon, Wendy, Duraisamy, Sekhar, Gerdes, Anne-Marie, Peltomäki, Päivi, Kohonen-Ccorish, Maija, Mangold, Elisabeth, MacRae, Finlay, Greenblatt, Marc, de la Chapelle, Albert, Nyström, Minna

Source: In Gastroenterology 2005 129(2):537-549

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DNA:n korjausmekanismien häiriöt ja niiden lääketieteellinen merkitys

Authors: Kansikas, Minttu, Nyström, Minna, Peltomäki, Päivi

Source: Duodecim. 133(3):259-259

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN609839932&indx=1&recIds=ETOCRN609839932

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Human DNA polymerase α interacts with mismatch repair proteins MSH2 and MSH6.

Authors: Itkonen, Harri M., Kantelinen, Jukka, Vaara, Markku, Parkkinen, Sinikka, Schlott, Bernhard, Grosse, Frank, Nyström, Minna, Syväoja, Juhani E., Pospiech, Helmut

Source: FEBS Letters; Dec2016, Vol. 590 Issue 23, p4233-4241, 9p

Subject Terms: DNA polymerases, DNA mismatch repair, PRIMASES, DNA replication, IMMUNOPRECIPITATION

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