SorCS2 binds progranulin to regulate motor neuron development

Authors: Thomasen, Pernille Bogetofte, Salasova, Alena, Kjaer-Sorensen, Kasper, Woloszczuková, Lucie, Lavický, Josef, Login, Hande, Tranberg-Jensen, Jeppe, Almeida, Sergio, Beel, Sander, Kavková, Michaela, Qvist, Per, Kjolby, Mads, Ovesen, Peter Lund, Nolte, Stella, Vestergaard, Benedicte, Udrea, Andreea-Cornelia, Nejsum, Lene Niemann, Chao, Moses V., Van Damme, Philip, Krivanek, Jan, Dasen, Jeremy, Oxvig, Claus, Nykjaer, Anders

Source: In Cell Reports 28 November 2023 42(11)

Carbamylated sortilin associates with cardiovascular calcification in patients with chronic kidney disease

Authors: Jankowski, Vera, Saritas, Turgay, Kjolby, Mads, Hermann, Juliane, Speer, Thimoteus, Himmelsbach, Anika, Mahr, Kerstin, Heuschkel, Marina Augusto, Schunk, Stefan J., Thirup, Soren, Winther, Simon, Bottcher, Morten, Nyegard, Mette, Nykjaer, Anders, Kramann, Rafael, Kaesler, Nadine, Jankowski, Joachim, Floege, Juergen, Marx, Nikolaus, Goettsch, Claudia

Source: Kidney international. 101(3):574-584

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100157341436.0x000001&indx=1&recIds=ETOCvdc_100157341436.0x000001

DiDBiT-TMT: A Novel Method to Quantify Changes in the Proteomic Landscape Induced by Neural Plasticity

Authors: Gamaleldin, Mariam, Yu, Nam-Kyung, Diedrich, Jolene K, Ma, Yuanhui, Wienand, Anne, McClatchy, Daniel B., Nykjaer, Anders, Nabavi, Sadegh, Yates, John R.

Source: Journal of Proteome Research; November 2024, Vol. 23 Issue: 11 p4878-4895, 18p

SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology

Authors: Malik, Anna R., Szydlowska, Kinga, Nizinska, Karolina, Asaro, Antonino, van Vliet, Erwin A., Popp, Oliver, Dittmar, Gunnar, Fritsche-Guenther, Raphaela, Kirwan, Jennifer A., Nykjaer, Anders, Lukasiuk, Katarzyna, Aronica, Eleonora, Willnow, Thomas E.

Source: In Cell Reports 5 March 2019 26(10):2792-2804

Biochemical and cognitive effects of docosahexaenoic acid differ in a developmental and SorLA dependent manner

Authors: Højland, Anne, Richner, Mette, Mølgaard, Simon, Dieu, Ruthe Storgaard, Eskelund, Amanda, Nykjær, Anders, Nyengaard, Jens Randel, Lykkesfeldt, Jens, Glerup, Simon, Nielsen, Morten Schallburg

Source: In Behavioural Brain Research 1 August 2018 348:90-100

Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study

Authors: Pottier, Cyril, Zhou, Xiaolai, Perkerson, Ralph B, III, Baker, Matt, Jenkins, Gregory D, Serie, Daniel J, Ghidoni, Roberta, Benussi, Luisa, Binetti, Giuliano, López de Munain, Adolfo, Zulaica, Miren, Moreno, Fermin, Le Ber, Isabelle, Pasquier, Florence, Hannequin, Didier, Sánchez-Valle, Raquel, Antonell, Anna, Lladó, Albert, Parsons, Tammee M, Finch, NiCole A, Finger, Elizabeth C, Lippa, Carol F, Huey, Edward D, Neumann, Manuela, Heutink, Peter, Synofzik, Matthis, Wilke, Carlo, Rissman, Robert A, Slawek, Jaroslaw, Sitek, Emilia, Johannsen, Peter, Nielsen, Jørgen E, Ren, Yingxue, van Blitterswijk, Marka, DeJesus-Hernandez, Mariely, Christopher, Elizabeth, Murray, Melissa E, Bieniek, Kevin F, Evers, Bret M, Ferrari, Camilla, Rollinson, Sara, Richardson, Anna, Scarpini, Elio, Fumagalli, Giorgio G, Padovani, Alessandro, Hardy, John, Momeni, Parastoo, Ferrari, Raffaele, Frangipane, Francesca, Maletta, Raffaele, Anfossi, Maria, Gallo, Maura, Petrucelli, Leonard, Suh, EunRan, Lopez, Oscar L, Wong, Tsz H, van Rooij, Jeroen G J, Seelaar, Harro, Mead, Simon, Caselli, Richard J, Reiman, Eric M, Noel Sabbagh, Marwan, Kjolby, Mads, Nykjaer, Anders, Karydas, Anna M, Boxer, Adam L, Grinberg, Lea T, Grafman, Jordan, Spina, Salvatore, Oblak, Adrian, Mesulam, M-Marsel, Weintraub, Sandra, Geula, Changiz, Hodges, John R, Piguet, Olivier, Brooks, William S, Irwin, David J, Trojanowski, John Q, Lee, Edward B, Josephs, Keith A, Parisi, Joseph E, Ertekin-Taner, Nilüfer, Knopman, David S, Nacmias, Benedetta, Piaceri, Irene, Bagnoli, Silvia, Sorbi, Sandro, Gearing, Marla, Glass, Jonathan, Beach, Thomas G, Black, Sandra E, Masellis, Mario, Rogaeva, Ekaterina, Vonsattel, Jean-Paul, Honig, Lawrence S, Kofler, Julia, Bruni, Amalia C, Snowden, Julie, Mann, David, Pickering-Brown, Stuart, Diehl-Schmid, Janine, Winkelmann, Juliane, Galimberti, Daniela, Graff, Caroline, Öijerstedt, Linn, Troakes, Claire, Al-Sarraj, Safa, Cruchaga, Carlos, Cairns, Nigel J, Rohrer, Jonathan D, Halliday, Glenda M, Kwok, John B, van Swieten, John C, White, Charles L, III, Ghetti, Bernardino, Murell, Jill R, Mackenzie, Ian R A, Hsiung, Ging-Yuek R, Borroni, Barbara, Rossi, Giacomina, Tagliavini, Fabrizio, Wszolek, Zbigniew K, Petersen, Ronald C, Bigio, Eileen H, Grossman, Murray, Van Deerlin, Vivianna M, Seeley, William W, Miller, Bruce L, Graff-Radford, Neill R, Boeve, Bradley F, Dickson, Dennis W, Biernacka, Joanna M, Rademakers, Rosa

Source: In The Lancet Neurology June 2018 17(6):548-558

Neuronal Sorting Protein-Related Receptor sorLA/LR11 Regulates Processing of the Amyloid Precursor Protein

Authors: Andersen, Olav M., Reiche, Juliane, Schmidt, Vanessa, Gotthardt, Michael, Spoelgen, Robert, Behlke, Joachim, Breiderhoff, Tilman, Jansen, Pernille, Wu, Xin, Bales, Kelly R., Cappai, Roberto, Masters, Colin L., Gliemann, Jørgen, Mufson, Elliott J., Hyman, Bradley T., Paul, Steven M., Nykjær, Anders, Willnow, Thomas E., Ingram, Vernon Martin

Source: Proceedings of the National Academy of Sciences of the United States of America, 2005 Sep . 102(38), 13461-13466.

Access URL: https://www.jstor.org/stable/3376655

Hidden Twins: SorCS Neuroreceptors Form Stable Dimers

Authors: Januliene, Dovile, Manavalan, Arulmani, Ovesen, Peter Lund, Pedersen, Karen-Marie, Thirup, Søren, Nykjær, Anders, Moeller, Arne

Source: In Journal of Molecular Biology 15 September 2017 429(19):2907-2917

Cubilin Dysfunction Causes Abnormal Metabolism of the Steroid Hormone 25(OH) Vitamin D 3

Authors: Nykjaer, Anders, Fyfe, John C., Kozyraki, Renata, Leheste, Jörg-Robert, Jacobsen, Christian, Nielsen, Morten S., Verroust, Pierre J., Aminoff, Maria, de la Chapelle, Albert, Moestrup, Søren K., Ray, Rahul, Gliemann, Jørgen, Willnow, Thomas E., Christensen, Erik I.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2001 Nov . 98(24), 13895-13900.

Access URL: https://www.jstor.org/stable/3057191

Mannose 6-Phosphate/Insulin-Like Growth Factor-II Receptor Targets the Urokinase Receptor to Lysosomes via a Novel Binding Interaction

Authors: Nykjær, Anders, Christensen, Erik I., Vorum, Henrik, Hager, Henrik, Petersen, Claus M., Røigaard, Hans, Min, Hye Y., Vilhardt, Frederik, Møller, Lisbeth B., Kornfeld, Stuart, Gliemann, Jørgen

Source: The Journal of Cell Biology, 1998 May 01. 141(3), 815-828.

Access URL: https://www.jstor.org/stable/1618592

Absence of A Thyroid Phenotype in Sortilin-Deficient Mice

Authors: Lisi, Simonetta, Madsen, Peder, Botta, Roberta, Petersen, ClausMunck, Nykjær, Anders, Latrofa, Francesco, Vitti, Paolo, Marinò, Michele ^*

Source: In Endocrine Practice September 2015 21(9):981-985

Altered dopaminergic firing pattern and novelty response underlie ADHD-like behavior of SorCS2-deficient mice

Authors: Olsen, Ditte, Wellner, Niels, Kaas, Mathias, de Jong, Inge E. M., Sotty, Florence, Didriksen, Michael, Glerup, Simon, Nykjaer, Anders

Source: Translational psychiatry. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193132387.0x000001&indx=1&recIds=ETOCvdc_100193132387.0x000001

Progranulin gene variation affects serum progranulin levels differently in Danish bipolar individuals compared with healthy controls

Authors: Buttenschøn, Henriette N., Nielsen, Marit N., Thotakura, Gangadaar, Lee, Chris W., Nykjær, Anders, Mors, Ole, Glerup, Simon

Source: Psychiatric genetics. 27(3):89-95

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100043728813.0x000001&indx=1&recIds=ETOCvdc_100043728813.0x000001

SorCS2 Regulates Dopaminergic Wiring and Is Processed into an Apoptotic Two-Chain Receptor in Peripheral Glia

Authors: Glerup, Simon, Olsen, Ditte, Vaegter, Christian B., Gustafsen, Camilla, Sjoegaard, Susanne S., Hermey, Guido, Kjolby, Mads, Molgaard, Simon, Ulrichsen, Maj, Boggild, Simon, Skeldal, Sune, Fjorback, Anja N., Nyengaard, Jens R., Jacobsen, Jan, Bender, Dirk, Bjarkam, Carsten R., Sørensen, Esben S., Füchtbauer, Ernst-Martin, Eichele, Gregor, Madsen, Peder, Willnow, Thomas E., Petersen, Claus M., Nykjaer, Anders

Source: In Neuron 4 June 2014 82(5):1074-1087

Modulation of the VPS10p-domain receptor family for the treatment of mental and behavioural disorders

Soluble sortilin is present in excess and positively correlates with progranulin in CSF of aging individuals

Authors: Molgaard, Simon, Demontis, Ditte, Nicholson, Alexandra M., Finch, Nicole A., Petersen, Ronald C., Petersen, Claus M., Rademakers, Rosa, Nykjaer, Anders, Glerup, Simon

Source: Experimental gerontology. 84:96-100

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100059645945.0x000001&indx=1&recIds=ETOCvdc_100059645945.0x000001

Cubilin, a High Affinity Receptor for Fibroblast Growth Factor 8, Is Required for Cell Survival in the Developing Vertebrate Head

Authors: Cases, Olivier, Perea-Gomez, Aitana, Aguiar, Diego P., Nykjaer, Anders, Amsellem, Sabine, Chandellier, Jacqueline, Umbhauer, Muriel ^**, Cereghini, Silvia ^**, Madsen, Mette, Collignon, Jérôme, Verroust, Pierre, Riou, Jean-François ^**, Creuzet, Sophie E., Kozyraki, Renata

Source: In Journal of Biological Chemistry 7 June 2013 288(23):16655-16670

Gentamicin Binds to the Megalin Receptor as a Competitive Inhibitor Using the Common Ligand Binding Motif of Complement Type Repeats: INSIGHT FROM THE NMR STRUCTURE OF THE 10TH COMPLEMENT TYPE REPEAT DOMAIN ALONE AND IN COMPLEX WITH GENTAMICIN

Authors: Dagil, Robert, O'Shea, Charlotte, Nykjær, Anders, Bonvin, Alexandre M.J.J., Kragelund, Birthe B.

Source: In Journal of Biological Chemistry February 2013 288(6):4424-4435

SorLA Controls Neurotrophic Activity by Sorting of GDNF and Its Receptors GFRα1 and RET

Authors: Glerup, Simon, Lume, Maria, Olsen, Ditte, Nyengaard, Jens R., Vaegter, Christian B., Gustafsen, Camilla, Christensen, Erik I., Kjolby, Mads, Hay-Schmidt, Anders, Bender, Dirk, Madsen, Peder, Saarma, Mart, Nykjaer, Anders, Petersen, Claus M.

Source: In Cell Reports 31 January 2013 3(1):186-199

An alternative transcript of the Alzheimer's disease risk gene SORL1 encodes a truncated receptor

Authors: Blechingberg, Jenny, Poulsen, Annemarie Svane Aavild, Kjølby, Mads, Monti, Giulia, Allen, Mariet, Ivarsen, Anne Kathrine, Lincoln, Sarah J., Thotakura, Gangadaar, Vægter, Christian B., Ertekin-Taner, Nilüfer, Nykjær, Anders, Andersen, Olav M.

Source: In Neurobiology of Aging November 2018 71:266-266