Permutation-based significance analysis reduces the type 1 error rate in bisulphite sequencing data analysis of human umbilical cord blood samples

Authors: Laajala, Essi, Halla-aho, Viivi, Grönroos, Toni, Kalim, Ubaid Ullah, Vähä-Mäkilä, Mari, Nurmio, Mirja, Kallionpää, Henna, Lietzén, Niina, Mykkänen, Juha, Rasool, Omid, Toppari, Jorma, Orešič, Matej, Knip, Mikael, Lund, Riikka, Lahesmaa, Riitta, Lähdesmäki, Harri

Source: Epigenetics. 17(12):1608-1627

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100163330609.0x000001&indx=1&recIds=ETOCvdc_100163330609.0x000001

The effects of perfluorooctanoic acid (PFOA) on fetal and adult rat testis

Authors: Eggert, Anna, Cisneros-Montalvo, Sheyla, Anandan, Sathyavathy, Musilli, Stefania, Stukenborg, Jan-Bernd, Adamsson, Annika, Nurmio, Mirja, Toppari, Jorma

Source: In Reproductive Toxicology December 2019 90:68-76

Developmental effects of imatinib mesylate on follicle assembly and early activation of primordial follicle pool in postnatal rat ovary

Authors: Asadi-Azarbaijani, Babak, Santos, Regiane R., Jahnukainen, Kirsi, Braber, Saskia, van Duursen, Majorie B.M., Toppari, Jorma, Saugstad, Ola D., Nurmio, Mirja, Oskam, Irma C.

Source: In Reproductive Biology March 2017 17(1):25-33

Hydroxysteroid (17β) dehydrogenase 1 expressed by Sertoli cells contributes to steroid synthesis and is required for male fertility

Authors: Hakkarainen, Janne, Zhang, Fu-Ping, Jokela, Heli, Mayerhofer, Artur, Behr, Rüdiger, Cisneros-Montalvo, Sheyla, Nurmio, Mirja, Toppari, Jorma, Ohlsson, Claes, Kotaja, Noora, Sipilä, Petra, Poutanen, Matti

Source: FASEB journal. 32(6):3229-3241

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103325061.0x000001&indx=1&recIds=ETOCvdc_100103325061.0x000001

Minimal residual disease of leukemia and the quality of cryopreserved human ovarian tissue in vitro

Authors: Asadi-Azarbaijani, Babak, Sheikhi, Mona, Nurmio, Mirja, Tinkanen, Helena, Juvonen, Vesa, Dunkel, Leo, Hovatta, Outi, Oskam, Irma C., Jahnukainen, Kirsi

Source: Leukemia & lymphoma. 57(3):700-707

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100067436124.0x000001&indx=1&recIds=ETOCvdc_100067436124.0x000001

Serum APOC1 levels are decreased in young autoantibody positive children who rapidly progress to type 1 diabetes.

Authors: Hirvonen, M. Karoliina, Lietzén, Niina, Moulder, Robert, Bhosale, Santosh D., Koskenniemi, Jaakko, Vähä-Mäkilä, Mari, Nurmio, Mirja, Orešič, Matej, Ilonen, Jorma, Toppari, Jorma, Veijola, Riitta, Hyöty, Heikki, Lähdesmäki, Harri, Knip, Mikael, Cheng, Lu, Lahesmaa, Riitta

Source: Scientific Reports; 11/18/2023, Vol. 13 Issue 1, p1-11, 11p

Subject Terms: TYPE 1 diabetes, AUTOANTIBODIES, APOLIPOPROTEIN C, PANCREATIC beta cells, PANEL analysis, PROTEOMICS

Receptor tyrosine kinase inhibition causes simultaneous bone loss and excess bone formation within growing bone in rats

Authors: Nurmio, Mirja, Joki, Henna, Kallio, Jenny, Määttä, Jorma A., Väänänen, H. Kalervo, Toppari, Jorma, Jahnukainen, Kirsi, Laitala-Leinonen, Tiina

Source: In Toxicology and Applied Pharmacology 2011 254(3):267-279

Testicular Function, Semen Quality, and Fertility in Young Men After Renal Transplantation During Childhood or Adolescence

Authors: Tainio, Juuso, Jahnukainen, Kirsi, Nurmio, Mirja, Pakarinen, Mikko, Jalanko, Hannu, Jahnukainen, Timo

Source: Transplantation. 98(9):987-993

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100050747401.0x000001&indx=1&recIds=ETOCvdc_100050747401.0x000001

Peritubular myoid cells have a role in postnatal testicular growth

Authors: Nurmio, Mirja, Kallio, Jenny, Adam, Marion, Mayerhofer, Artur, Toppari, Jorma, Jahnukainen, Kirsi

Source: Spermatogenesis. 2(2):79-87

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100050714728.0x000001&indx=1&recIds=ETOCvdc_100050714728.0x000001

Functional in vitro model to examine cancer therapy cytotoxicity in maturing rat testis

Authors: Nurmio, Mirja, Toppari, Jorma, Kallio, Jenny, Hou, Mi, Söder, Olle, Jahnukainen, Kirsi

Source: In Reproductive Toxicology 2009 27(1):28-34

Adult reproductive functions after early postnatal inhibition by imatinib of the two receptor tyrosine kinases, c-kit and PDGFR, in the rat testis

Authors: Nurmio, Mirja, Kallio, Jenny, Toppari, Jorma, Jahnukainen, Kirsi

Source: In Reproductive Toxicology 2008 25(4):442-446

Umbilical cord blood DNA methylation in children who later develop type 1 diabetes.

Authors: Laajala, Essi, Kalim, Ubaid Ullah, Grönroos, Toni, Rasool, Omid, Halla-aho, Viivi, Konki, Mikko, Kattelus, Roosa, Mykkänen, Juha, Nurmio, Mirja, Vähä-Mäkilä, Mari, Kallionpää, Henna, Lietzén, Niina, Ghimire, Bishwa R., Laiho, Asta, Hyöty, Heikki, Elo, Laura L., Ilonen, Jorma, Knip, Mikael, Lund, Riikka J., Orešič, Matej

Source: Diabetologia; Sep2022, Vol. 65 Issue 9, p1534-1540, 7p

Expression and localization of androgen receptor-interacting protein-4 in the testis.

Authors: Domanskyi, Andrii, Zhang, Fu-Ping, Nurmio, Mirja

Source: American Journal of Physiology; February 2007 pt1, Vol. 292 Issue 2, pe513-e522, 10p

Type 1 Diabetes in Children With Genetic Risk May Be Predicted Very Early With a Blood miRNA.

Authors: Suomi, Tomi, Kalim, Ubaid Ullah, Rasool, Omid, Laiho, Asta, Kallionpää, Henna, Vähä-Mäkilä, Mari, Nurmio, Mirja, Mykkänen, Juha, Härkőnen, Taina, Hyőty, Heikki, Ilonen, Jorma, Veijola, Riitta, Toppari, Jorma, Knip, Mikael, Elo, Laura L., Lahesmaa, Riitta, Härkönen, Taina, Hyöty, Heikki

Source: Diabetes Care; Apr2022, Vol. 45 Issue 4, pe77-e79, 3p

Subject Terms: RESEARCH, RESEARCH methodology, RNA, TYPE 1 diabetes, EVALUATION research, TYPE 2 diabetes, COMPARATIVE studies

Imatinib decreases germ cell survival and germline stem cell proliferation in rodent testis ex vivo and in vitro.

Authors: Eggert, Anna^1,2 (AUTHOR) anvieg@utu.fi, Laasanen, Sini¹ (AUTHOR), Nurmio, Mirja¹ (AUTHOR), Wahlgren, Aida³ (AUTHOR), Jahnukainen, Kirsi^3,4 (AUTHOR), Eerola, Kim^1,5 (AUTHOR), Nieminen, Miisael¹ (AUTHOR), Olotu, Opeyemi¹ (AUTHOR), Kotaja, Noora¹ (AUTHOR), Mäkelä, Juho‐Antti¹ (AUTHOR), Toppari, Jorma^1,6,7,8 (AUTHOR) anvieg@utu.fi

Source: Andrology. Oct2024, p1. 17p. 6 Illustrations.

Subject Terms: *PROTEIN-tyrosine kinase inhibitors, *GERM cells, *SEMINIFEROUS tubules, *STEM cells, *DNA synthesis, *DASATINIB

Inhibition of tyrosine kinases PDGFR and C-Kit by imatinib mesylate interferes with postnatal testicular development in the rat.

Authors: Nurmio, Mirja¹ mirja.nurmio@utu.fi, Toppari, Jorma^1,2, Zaman, Farasat³, Andersson, Anna-Maria⁴, Paranko, Jorma⁵, Söder, Olle³, Jahnukainen, Kirsi^2,3

Source: International Journal of Andrology. Aug2007, Vol. 30 Issue 4, p366-376. 11p. 2 Black and White Photographs, 4 Charts, 1 Graph.

Subject Terms: *PROTEIN-tyrosine kinases, *GERM cells, *IMATINIB, *ANTINEOPLASTIC agents, *LABORATORY rats, *TESTIS

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Effect of Previous Alkylating Agent Exposure on Follicle Numbers in Cryopreserved Prepubertal and Young Adult Ovarian Tissue after Long-Term Xenografting.

Authors: Nurmio, Mirja^1,2 (AUTHOR) mihanu@utu.fi, Asadi-Azarbaijani, Babak³ (AUTHOR) babak.asadi@hotmail.com, Hou, Mi⁴ (AUTHOR) mi.hou@outlook.com, Kiviö, Ronja^1,2 (AUTHOR) ronja.kivio@nina.no, Toppari, Jorma^1,2,5 (AUTHOR) jortop@utu.fi, Tinkanen, Helena⁶ (AUTHOR) htinkanen@gmail.com, Laine, Tiina⁷ (AUTHOR) tiina.laine@hus.fi, Oskam, Irma C.⁸ (AUTHOR) irma.oskam@nmbu.no, Jahnukainen, Kirsi^4,9 (AUTHOR) kirsi.jahnukainen@hus.fi

Source: Cancers. Feb2022, Vol. 14 Issue 2, p399-399. 1p.

Subject Terms: *ANTHRACYCLINES, *XENOGRAFTS, *ANIMAL experimentation, *RATS, *FERTILITY preservation, *ALKYLATING agents, *OVARIAN follicle, *RESEARCH funding, *CRYOPRESERVATION of organs, tissues, etc., *ANIMALS

Retinoblastoma protein represses E2F3 to maintain Sertoli cell quiescence in mouse testis.

Authors: Rotgers, Emmi, Cisneros-Montalvo, Sheyla, Nurmio, Mirja, Toppari, Jorma

Source: Journal of Cell Science; 7/15/2019, Vol. 132 Issue 14, p1-16, 16p

Subject Terms: SERTOLI cells, RETINOBLASTOMA protein, TESTIS, TUMOR suppressor proteins, SPERMATOGENESIS, CELL physiology, OPHTHALMIC artery

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