MnTnHex-2-PyP5+ Displays Anticancer Properties and Enhances Cisplatin Effects in Non-Small Cell Lung Cancer Cells

Authors: Rita B. Soares, Rita Manguinhas, João G. Costa, Nuno Saraiva, Nuno Gil, Rafael Rosell, Sérgio P. Camões, Ines Batinic-Haberle, Ivan Spasojevic, Matilde Castro, Joana P. Miranda, Filipa Amaro, Joana Pinto, Ana S. Fernandes, Paula Guedes de Pinho, Nuno G. Oliveira

Source: Antioxidants, Vol 11, Iss 11, p 2198 (2022)

Subject Terms: non-small cell lung cancer, SOD mimic, MnTnHex-2-PyP5+, metabolomics, cytotoxicity, cisplatin, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3921/11/11/2198; https://doaj.org/toc/2076-3921

Access URL: https://doaj.org/article/67a72876692d4ab0aff01917ce527f4b

A Critical Perspective on 3D Liver Models for Drug Metabolism and Toxicology Studies

Authors: Ana S. Serras, Joana S. Rodrigues, Madalena Cipriano, Armanda V. Rodrigues, Nuno G. Oliveira, Joana P. Miranda

Source: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Subject Terms: in vitro liver model, fit-for-purpose models, hepatotoxicity, paracetamol, diclofenac, troglitazone, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.626805/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/5c2ae96c668549b1be074ca02a296405

The manganese(III) porphyrin MnTnHex-2-PyP5+ modulates intracellular ROS and breast cancer cell migration: Impact on doxorubicin-treated cells

Authors: Ana Flórido, Nuno Saraiva, Sara Cerqueira, Nuno Almeida, Maddy Parsons, Ines Batinic-Haberle, Joana P. Miranda, João G. Costa, Guia Carrara, Matilde Castro, Nuno G. Oliveira, Ana S. Fernandes

Source: Redox Biology, Vol 20, Iss , Pp 367-378 (2019)

Subject Terms: Medicine (General), R5-920, Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2213231718308486; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/2187bc21422b4a2db5e3ceee7004d36e

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

Authors: Javier Egea, Isabel Fabregat, Yves M. Frapart, Pietro Ghezzi, Agnes Görlach, Thomas Kietzmann, Kateryna Kubaichuk, Ulla G. Knaus, Manuela G. Lopez, Gloria Olaso-Gonzalez, Andreas Petry, Rainer Schulz, Jose Vina, Paul Winyard, Kahina Abbas, Opeyemi S. Ademowo, Catarina B. Afonso, Ioanna Andreadou, Haike Antelmann, Fernando Antunes, Mutay Aslan, Markus M. Bachschmid, Rui M. Barbosa, Vsevolod Belousov, Carsten Berndt, David Bernlohr, Esther Bertrán, Alberto Bindoli, Serge P. Bottari, Paula M. Brito, Guia Carrara, Ana I. Casas, Afroditi Chatzi, Niki Chondrogianni, Marcus Conrad, Marcus S. Cooke, João G. Costa, Antonio Cuadrado, Pham My-Chan Dang, Barbara De Smet, Bilge Debelec–Butuner, Irundika H.K. Dias, Joe Dan Dunn, Amanda J. Edson, Mariam El Assar, Jamel El-Benna, Péter Ferdinandy, Ana S. Fernandes, Kari E. Fladmark, Ulrich Förstermann, Rashid Giniatullin, Zoltán Giricz, Anikó Görbe, Helen Griffiths, Vaclav Hampl, Alina Hanf, Jan Herget, Pablo Hernansanz-Agustín, Melanie Hillion, Jingjing Huang, Serap Ilikay, Pidder Jansen-Dürr, Vincent Jaquet, Jaap A. Joles, Balaraman Kalyanaraman, Danylo Kaminskyy, Mahsa Karbaschi, Marina Kleanthous, Lars-Oliver Klotz, Bato Korac, Kemal Sami Korkmaz, Rafal Koziel, Damir Kračun, Karl-Heinz Krause, Vladimír Křen, Thomas Krieg, João Laranjinha, Antigone Lazou, Huige Li, Antonio Martínez-Ruiz, Reiko Matsui, Gethin J. McBean, Stuart P. Meredith, Joris Messens, Verónica Miguel, Yuliya Mikhed, Irina Milisav, Lidija Milković, Antonio Miranda-Vizuete, Miloš Mojović, María Monsalve, Pierre-Alexis Mouthuy, John Mulvey, Thomas Münzel, Vladimir Muzykantov, Isabel T.N. Nguyen, Matthias Oelze, Nuno G. Oliveira, Carlos M. Palmeira, Nikoletta Papaevgeniou, Aleksandra Pavićević, Brandán Pedre, Fabienne Peyrot, Marios Phylactides, Gratiela G. Pircalabioru, Andrew R. Pitt, Henrik E. Poulsen, Ignacio Prieto, Maria Pia Rigobello, Natalia Robledinos-Antón, Leocadio Rodríguez-Mañas, Anabela P. Rolo, Francis Rousset, Tatjana Ruskovska, Nuno Saraiva, Shlomo Sasson, Katrin Schröder, Khrystyna Semen, Tamara Seredenina, Anastasia Shakirzyanova, Geoffrey L. Smith, Thierry Soldati, Bebiana C. Sousa, Corinne M. Spickett, Ana Stancic, Marie José Stasia, Holger Steinbrenner, Višnja Stepanić, Sebastian Steven, Kostas Tokatlidis, Erkan Tuncay, Belma Turan, Fulvio Ursini, Jan Vacek, Olga Vajnerova, Kateřina Valentová, Frank Van Breusegem, Lokman Varisli, Elizabeth A. Veal, A. Suha Yalçın, Olha Yelisyeyeva, Neven Žarković, Martina Zatloukalová, Jacek Zielonka, Rhian M. Touyz, Andreas Papapetropoulos, Tilman Grune, Santiago Lamas, Harald H.H.W. Schmidt, Fabio Di Lisa, Andreas Daiber

Source: Redox Biology, Vol 13, Iss C, Pp 94-162 (2017)

Subject Terms: Reactive oxygen species, Reactive nitrogen species, Redox signaling, Oxidative stress, Antioxidants, Redox therapeutics, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231717303373; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/637c0e34ca5240b4924d5b20463b39fc

Impact of the APE1 Redox Function Inhibitor E3330 in Non-Small Cell Lung Cancer Cells Exposed to Cisplatin: Increased Cytotoxicity and Impairment of Cell Migration and Invasion

Authors: Rita Manguinhas, Ana S. Fernandes, João G. Costa, Nuno Saraiva, Sérgio P. Camões, Nuno Gil, Rafael Rosell, Matilde Castro, Joana P. Miranda, Nuno G. Oliveira

Source: Antioxidants, Vol 9, Iss 6, p 550 (2020)

Subject Terms: non-small cell lung cancer, cisplatin, apurinic/apyrimidinic endonuclease 1, E3330, cytotoxicity, apoptosis, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3921/9/6/550; https://doaj.org/toc/2076-3921

Access URL: https://doaj.org/article/46f20bc6e47f419a90aa09ab839afbab

The SOD Mimic MnTnHex-2-PyP5+ Reduces the Viability and Migration of 786-O Human Renal Cancer Cells

Authors: João G. Costa, Nuno Saraiva, Ines Batinic-Haberle, Matilde Castro, Nuno G. Oliveira, Ana S. Fernandes

Source: Antioxidants, Vol 8, Iss 10, p 490 (2019)

Subject Terms: sod mimic, mntnhex-2-pyp5+, reactive oxygen species, cell migration, clear-cell renal carcinoma, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3921/8/10/490; https://doaj.org/toc/2076-3921

Access URL: https://doaj.org/article/dfffa1ff28b040a7834903b3bdd9e947

[15]aneN4S: Synthesis, Thermodynamic Studies and Potential Applications in Chelation Therapy

Authors: Nuno Torres, Sandrina Gonçalves, Ana S. Fernandes, J. Franco Machado, Maria J. Villa de Brito, Nuno G. Oliveira, Matilde Castro, Judite Costa, Maria F. Cabral

Source: Molecules, Vol 19, Iss 1, Pp 550-567 (2014)

Subject Terms: macrocyclic compounds, thiatetraaza, stability constants, spectroscopic studies, chelation therapy, mercury(II) chelator, copper(II) chelator, Organic chemistry, QD241-441

File Description: electronic resource

Relation: http://www.mdpi.com/1420-3049/19/1/550; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/992cc1b9ab644357a50ed48c31da2fd8

Synthesis and Biological Activity of 6-Selenocaffeine: Potential Modulator of Chemotherapeutic Drugs in Breast Cancer Cells

Authors: Inês L. Martins, Joana P. Miranda, Nuno G. Oliveira, Ana S. Fernandes, Sandrina Gonçalves, Alexandra M. M. Antunes

Source: Molecules, Vol 18, Iss 5, Pp 5251-5264 (2013)

Subject Terms: organoselenium compounds, caffeine, modulator of the cytoxicity, oxaliplatin, doxorubicin, cancer therapy, Organic chemistry, QD241-441

File Description: electronic resource

Relation: http://www.mdpi.com/1420-3049/18/5/5251; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/3a0474ceb2c145adb39a74421f51e0f5

Cytogenetic Damage Induced by Acrylamide and Glycidamide in Mammalian Cells: Correlation with Specific Glycidamide-DNA Adducts.

Authors: Célia Martins¹, Nuno G. Oliveira¹

Source: Toxicological Sciences. Feb2007, Vol. 95 Issue 2, p383-390. 8p.

Subject Terms: *CYTOGENETICS, *DNA damage, *DNA adducts, *ACRYLAMIDE