1,25(OH)₂D₃ inhibits ferroptosis in nucleus pulposus cells via VDR signaling to mitigate lumbar intervertebral disc degeneration.

Authors: Li, Qiang¹ (AUTHOR), Peng, Jing² (AUTHOR), Ding, Fan¹ (AUTHOR) 307185039@qq.com

Source: Scientific Reports. 3/10/2025, Vol. 15 Issue 1, p1-13. 13p.

Subject Terms: *NUCLEUS pulposus, *INTERVERTEBRAL disk, *VITAMIN D receptors, *LUMBAR pain, *APOPTOSIS

Allelic frequency of 12-FGF4RG and the association between the genotype with number of calcified intervertebral discs visible on radiographs in Coton de Tuléar and French Bulldog breeds.

Authors: Reunanen, Vilma L. J.¹ (AUTHOR) vilma.reunanen@helsinki.fi, Jokinen, Tarja S.¹ (AUTHOR), Lilja-Maula, Liisa¹ (AUTHOR), Hytönen, Marjo K.^2,3,4 (AUTHOR), Lappalainen, Anu K.¹ (AUTHOR)

Source: BMC Veterinary Research. 3/4/2025, p1-8. 8p.

Subject Terms: *NUCLEUS pulposus, *GENETIC testing, *MEDICAL sciences, *YOUNG adults, *GENE frequency

The mTOR pathway is involved in the process of platelet-rich plasma improving intervertebral disc degeneration.

Authors: Jing Luan¹, Qi Wang², Wei Zheng¹, Yongjin He¹ heyongjin1996@126.com

Source: Iranian Journal of Basic Medical Sciences. Mar2025, Vol. 28 Issue 3, p393-400. 8p.

Subject Terms: *PLATELET-rich plasma, *NUCLEUS pulposus, *INTERVERTEBRAL disk, *EXTRACELLULAR matrix, *OXIDATIVE stress

The Pivotal Role of Thioredoxin-Interacting Protein in Joint Degenerative Diseases.

Authors: Alshorman, Jamal¹ Jamalking61@yahoo.com, Altahla, Ruba²

Source: Trends in Sciences. Mar2025, Vol. 22 Issue 3, p1-15. 15p.

Subject Terms: *THIOREDOXIN-interacting protein, *NUCLEUS pulposus, *INTERVERTEBRAL disk, *OSTEOARTHRITIS, *PYRIN (Protein)

Efficacy of Naringenin against aging and degeneration of nucleus pulposus cells through IGFBP3 inhibition.

Authors: Tang, Xiaokai^1,2,3 (AUTHOR), Zhong, Junlong² (AUTHOR), Luo, Hao^2,3 (AUTHOR), Zhou, Faxin^2,3 (AUTHOR), Wang, Lixia^2,3 (AUTHOR), Lin, Sijian⁴ (AUTHOR), Xiong, Jiachao² (AUTHOR), Lv, Hao^2,3 (AUTHOR), Zhou, Zhenhai² (AUTHOR), Yu, Honggui² (AUTHOR) xiatiantian0702@126.com, Cao, Kai^3,5 (AUTHOR) kaichaw@126.com

Source: Scientific Reports. 2/25/2025, Vol. 15 Issue 1, p1-19. 19p.

Subject Terms: *INSULIN-like growth factor-binding proteins, *NUCLEUS pulposus, *INTERVERTEBRAL disk, *REACTIVE oxygen species, *MOLECULAR docking

Exploring the correlation between magnetic resonance diffusion tensor imaging (DTI) parameters and aquaporin expression and biochemical composition content in degenerative intervertebral disc nucleus pulposus tissue: a clinical experimental study.

Authors: Chen, Shuang¹ (AUTHOR), Sun, Shenglu¹ (AUTHOR), Wang, Nan¹ (AUTHOR), Fang, Xiaoyang¹ (AUTHOR), Xie, Lin^1,2 (AUTHOR) xielin6508@163.com, Hu, Fei³ (AUTHOR) 18999583620@163.com, Xi, Zhipeng^1,3 (AUTHOR) xizhipeng1985@163.com

Source: BMC Musculoskeletal Disorders. 2/17/2025, Vol. 26 Issue 1, p1-13. 13p.

Subject Terms: *DIFFUSION tensor imaging, *NUCLEUS pulposus, *INTERVERTEBRAL disk, *AQUAPORINS, *MINIMALLY invasive procedures

Therapeutic potential of targeting the IRF2/POSTN/Notch1 axis in nucleus pulposus cells for intervertebral disc degeneration.

Authors: Zhu, Daxue^1,2 (AUTHOR), Wang, Zhaoheng^1,2 (AUTHOR), Chen, Shijie^1,2 (AUTHOR), Li, Yanhu^1,2 (AUTHOR), Kang, Xuewen^1,2 (AUTHOR) ery_kangxw@lzu.edu.cn

Source: Journal of Neuroinflammation. 1/22/2025, Vol. 22 Issue 1, p1-25. 25p.

Subject Terms: *NUCLEUS pulposus, *INTERFERON regulatory factors, *INTERVERTEBRAL disk, *LUMBAR pain, *MEDICAL sciences

MANF overexpression ameliorates oxidative stress-induced apoptosis of human nucleus pulposus cells by facilitating mitophagy through promoting MFN2 expression.

Authors: Ma, Liang^1,2 (AUTHOR), Meng, Xiangyu² (AUTHOR), Abudurexiti, Tuerhongjiang² (AUTHOR), Liu, Yuntao² (AUTHOR), Gao, Jiang² (AUTHOR), Sheng, Weibin¹ (AUTHOR) wbsheng@vip.sina.com

Source: Scientific Reports. 1/4/2025, Vol. 14 Issue 1, p1-11. 11p.

Subject Terms: *CYTOLOGY, *NUCLEUS pulposus, *INTERVERTEBRAL disk, *LIFE sciences, *RNA-binding proteins

Alginate vs. Hyaluronic Acid as Carriers for Nucleus Pulposus Cells: A Study on Regenerative Outcomes in Disc Degeneration.

Authors: Ogasawara, Shota¹ (AUTHOR) schol.jordy@gmail.com, Schol, Jordy^1,2 (AUTHOR) sato-m@is.icc.u-tokai.ac.jp, Sakai, Daisuke^1,2 (AUTHOR) daisakai@is.icc.u-tokai.ac.jp, Warita, Takayuki³ (AUTHOR) takayuki.warita@tunzpharma.co.jp, Susumu, Takano⁴ (AUTHOR) taka-0336@tokai-u.jp, Nakamura, Yoshihiko³ (AUTHOR) kahiko@is.icc.u-tokai.ac.jp, Sako, Kosuke¹ (AUTHOR), Tamagawa, Shota⁵ (AUTHOR) s-tamagawa@juntendo.ac.jp, Matsushita, Erika¹ (AUTHOR), Soma, Hazuki³ (AUTHOR) soma.hazuki@tunzpharma.co.jp, Sato, Masato^1,2 (AUTHOR), Watanabe, Masahiko^1,2 (AUTHOR)

Source: Cells (2073-4409). Dec2024, Vol. 13 Issue 23, p1984. 20p.

Subject Terms: *CHRONIC pain, *NUCLEUS pulposus, *INTERVERTEBRAL disk, *CELL transplantation, *HYALURONIC acid

Nuclear receptor Rev‐erbα alleviates intervertebral disc degeneration by recruiting NCoR–HDAC3 co‐repressor and inhibiting NLRP3 inflammasome.

Authors: Zhou, Qingshuang^1,2 (AUTHOR), Pu, Xiaojiang² (AUTHOR), Qian, Zhuang^1,2 (AUTHOR), Chen, Haojie² (AUTHOR), Wang, Nannan² (AUTHOR), Wang, Sinian² (AUTHOR), Feng, Zhenhua^1,2 (AUTHOR), Zhu, Zezhang^1,2 (AUTHOR), Wang, Bin^1,2 (AUTHOR), Qiu, Yong^1,2 (AUTHOR) scoliosis2002@sina.com, Sun, Xu^1,2 (AUTHOR) drsunxu@163.com

Source: Cell Proliferation. Dec2024, Vol. 57 Issue 12, p1-15. 15p.

Subject Terms: *NUCLEUS pulposus, *INTERVERTEBRAL disk, *HISTONE deacetylase, *NLRP3 protein, *STRAINS & stresses (Mechanics)

Procyanidin C1 ameliorates acidic pH stress induced nucleus pulposus degeneration through SIRT3/FOXO3-mediated mitochondrial dynamics.

Authors: Hua, Wenbin¹ (AUTHOR), Xie, Lin¹ (AUTHOR), Dong, Chenpeng¹ (AUTHOR), Yang, Guoyu¹ (AUTHOR), Chi, Shouyuan¹ (AUTHOR), Xu, Zhiqiang¹ (AUTHOR), Yang, Cao¹ (AUTHOR), Wang, Huiwen¹ (AUTHOR) 416919029@qq.com, Wu, Xinghuo¹ (AUTHOR) wuxinghuo@163.com

Source: Journal of Translational Medicine. 11/27/2024, Vol. 22 Issue 1, p1-16. 16p.

Subject Terms: *NUCLEUS pulposus, *MITOCHONDRIAL dynamics, *INTERVERTEBRAL disk, *EXTRACELLULAR matrix, *LABORATORY rats, *PROCYANIDINS

The Role of Microvascular Variations in the Process of Intervertebral Disk Degeneration and Its Regulatory Mechanisms: A Literature Review.

Authors: Zhang, Si‐Ping^1,2 (AUTHOR), Tong, Min^1,2 (AUTHOR), Li, Shi‐Da^1,2 (AUTHOR), Zhang, Bin^1,2 (AUTHOR), Zhang, Wenhao^1,2 (AUTHOR), Wang, Rong^1,2 (AUTHOR), Dong, Zhen‐Yu^1,2 (AUTHOR), Huang, Yi‐Fei^1,2 (AUTHOR) jerkhuang@163.com

Source: Orthopaedic Surgery. Nov2024, Vol. 16 Issue 11, p2587-2597. 11p.

Subject Terms: *INTERVERTEBRAL disk, *NUCLEUS pulposus, *ACQUISITION of manuscripts, *APOPTOSIS

The Role of the Bone Morphogenetic Protein Antagonist Noggin in Nucleus Pulposus Intervertebral Disc Cells.

Authors: Chen, Shuimu^1,2,3 (AUTHOR) sebastian.bigdon@insel.ch, Bigdon, Sebastian³ (AUTHOR) sonja.haeckel@insel.ch, Riether, Carsten^4,5 (AUTHOR) carsten.riether@unibe.ch, Ma, Xiaochi⁵ (AUTHOR) xiaoyi.niu@outlook.com, Niu, Xiaoyi⁵ (AUTHOR), Häckel, Sonja^3,6 (AUTHOR), Li, Zhen⁷ (AUTHOR) zhen.li@aofoundation.org, Gantenbein, Benjamin^1,3 (AUTHOR) benjamin.gantenbein@unibe.ch

Source: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 21, p11803. 13p.

Subject Terms: *NUCLEUS pulposus, *INTERVERTEBRAL disk, *BONE morphogenetic proteins, *LUMBAR pain, *GENE expression

Senescence in Intervertebral Disc Degeneration: A Comprehensive Analysis Based on Bioinformatic Strategies.

Authors: Zhao, Zijun¹ (AUTHOR), Wang, Yining² (AUTHOR), Wang, Zairan³ (AUTHOR), Zhang, Fan¹ (AUTHOR), Ding, Ze¹ (AUTHOR), Fan, Tao¹ (AUTHOR) fant@ccmu.edu.cn

Source: Immunity, Inflammation & Disease. Nov2024, Vol. 12 Issue 11, p1-18. 18p.

Subject Terms: *INTERVERTEBRAL disk, *NUCLEUS pulposus, *LUMBAR pain, *CELLULAR aging, *CELL analysis

Tetrahedral framework nucleic acids‐based delivery of microRNA‐155 alleviates intervertebral disc degeneration through targeting Bcl‐2/Bax apoptosis pathway.

Authors: Li, Zhuhai^1,2 (AUTHOR), Tang, Yuanlin³ (AUTHOR), Wang, Lihang^1,4 (AUTHOR), Wang, Kai¹ (AUTHOR), Huang, Shishu¹ (AUTHOR), Chen, Yu³ (AUTHOR) chen_yu55@hotmail.com

Source: Cell Proliferation. Nov2024, Vol. 57 Issue 11, p1-14. 14p.

Subject Terms: *NUCLEUS pulposus, *INTERVERTEBRAL disk, *CHRONIC pain, *NUCLEIC acids, *CELL proliferation

Selenium nanoparticles ameliorate lumbar disc degeneration by restoring GPX1-mediated redox homeostasis and mitochondrial function of nucleus pulposus cells.

Authors: He, Wei^1,2 (AUTHOR), Tian, Xin^1,2 (AUTHOR), Zhou, Quan^1,2 (AUTHOR), Lv, Jiaheng^1,2 (AUTHOR), Li, Yangfeng^1,2 (AUTHOR), Jin, Chenyang^2,3 (AUTHOR), Liu, Hao¹ (AUTHOR), Yang, Huiling^1,2 (AUTHOR), Xu, Yong^1,2 (AUTHOR) yxu1615@suda.edu.cn, He, Fan^1,2 (AUTHOR) fanhe@suda.edu.cn, Liu, Tao¹ (AUTHOR) liutao8250@suda.edu.cn

Source: Journal of Nanobiotechnology. 10/18/2024, Vol. 22 Issue 1, p1-23. 23p.

Subject Terms: *NUCLEUS pulposus, *INTERVERTEBRAL disk, *EXTRACELLULAR matrix, *REACTIVE oxygen species, *MATRIX effect

Double Cervical Adjacent Hydrated Nucleus Pulposus Extrusion (HNPE) in a Yorkshire Terrier.

Authors: Fugazzotto, Domenico^1,2 (AUTHOR) domenicofugazzotto@gmail.com, Tabbì, Marco¹ (AUTHOR) francesco.macri@unime.it, Lozano, Pilar Lorena² (AUTHOR) minatosimone81@gmail.com, Barillaro, Giuseppe³ (AUTHOR) info@cvsg.it, Macrì, Francesco¹ (AUTHOR), Minato, Simone² (AUTHOR)

Source: Animals (2076-2615). Oct2024, Vol. 14 Issue 19, p2889. 7p.

Subject Terms: *NUCLEUS pulposus, *INTERVERTEBRAL disk, *CERVICAL vertebrae, *CERVICAL cord, *SPINAL cord

Glucose deprivation-induced disulfidptosis in human nucleus pulposus cells: a novel pathological mechanism of intervertebral disc degeneration.

Authors: Wu, Shaobo¹ (AUTHOR), Wang, Jin^2,3 (AUTHOR), Wang, Minglin³ (AUTHOR), Zhou, Kaisheng¹ (AUTHOR), Huang, Dageng⁴ (AUTHOR) huangdageng@xjtu.edu.cn, Zhang, Yilei³ (AUTHOR) zhangyilei@xjtu.edu.cn, Zhang, Haihong¹ (AUTHOR) ery_zhanghher@lzu.edu.cn

Source: Biology Direct. 9/12/2024, Vol. 19 Issue 1, p1-15. 15p.

Subject Terms: *NUCLEUS pulposus, *INTERVERTEBRAL disk, *CYTOSKELETAL proteins, *WESTERN immunoblotting, *CELL death, *GLUCOSE transporters

A novel spherical GelMA-HAMA hydrogel encapsulating APET×2 polypeptide and CFIm25-targeting sgRNA for immune microenvironment modulation and nucleus pulposus regeneration in intervertebral discs.

Authors: Yu, Xiao-Jun^1,2 (AUTHOR), Zhao, Yuan-Ting^1,2 (AUTHOR), Abudouaini, Haimiti^1,2 (AUTHOR), Zou, Peng^1,2 (AUTHOR), Li, Tian-Qi^1,2 (AUTHOR), Bai, Xiao-Fan^1,2 (AUTHOR), Wang, Shan-Xi^1,2 (AUTHOR), Guan, Jian-Bin^1,2 (AUTHOR), Li, Meng-wei³ (AUTHOR), Wang, Xiao-dong^1,2 (AUTHOR), Wang, Ying-guang^1,2 (AUTHOR) d202082001@hust.edu.cn, Hao, Ding-Jun^1,2 (AUTHOR) haodingjun@mail.xjtu.edu.cn

Source: Journal of Nanobiotechnology. 9/12/2024, Vol. 22 Issue 1, p1-29. 29p.

Subject Terms: *NUCLEUS pulposus, *INTERVERTEBRAL disk, *GENE expression, *CELL death, *HEMATOXYLIN & eosin staining

HDAC/H3K27ac-mediated transcription of NDUFA3 exerts protective effects on high glucose-treated human nucleus pulposus cells through improving mitochondrial function.

Authors: Zheng, Cheng¹ (AUTHOR), Guo, Dongshuai² (AUTHOR), Zhang, Tong² (AUTHOR), Hu, Weiran² (AUTHOR), Zhang, Bo² (AUTHOR), Feng, Hang² (AUTHOR), Gao, Yanzheng² (AUTHOR), Yang, Guang² (AUTHOR) dryangguang@zzu.edu.cn

Source: Scientific Reports. 9/10/2024, Vol. 14 Issue 1, p1-12. 12p.

Subject Terms: *NUCLEUS pulposus, *INTERVERTEBRAL disk, *CELL survival, *GENETIC transcription, *REACTIVE oxygen species