Ebola disease outbreak caused by the Sudan virus in Uganda, 2022: a descriptive epidemiological study

Authors: Bosa, Henry Kyobe, Komakech, Allan, Gonahasa, Doreen Nsiimire, Bulage, Lilian, Kyamwine, Irene Byakatonda, Okethwangu, Denis, Kayiwa, Joshua, Nelson, Lisa J, Boore, Amy L, Nabatanzi, Sandra, Nsibambi, Thomas, Ntale, Jonathan, Mwangi, Christina, Fitzmaurice, Arthur G, Biribawa, Claire, Sande, Enos, Ojwang, Joseph, Choi, Mary, Lo, Terrence, Malefant, Jason, Shoemaker, Trevor, Montgomery, Joel M, Cossaboom, Caitlin M, Eggers, Carrie, Klena, John D, Whitmer, Shannon, Osinubi, Modupe O, Sadigh, Katrin S, Vosburgh, Waverly, Worrell, Mary-Claire, Fuller, James A, Lubwama, Bernard, Nabukenya, Immaculate, Okello, Paul Edward, Katana, Elizabeth Babirye, Morukileng, Job, Nansikombi, Hildah Tendo, Mbaka, Paul, Atuhaire, Immaculate, Asio, Alice, Elayeete, Sarah, Nsubuga, Edirisa Junior, Masanja, Veronica, Migamba, Stella Martha, Mwine, Patience, Nakamya, Petranilla, Nampeera, Rose, Kwiringira, Andrew, Komugisha, Mariam, Kibwika, Brian, Ssemanda, Innocent, Nuwamanya, Yasiini, Kamukama, Adams, Aanyu, Dorothy, Kizza, Dominic, Senyange, Shaban, Bakainaga, Andrew Niwagaba, Bwire, Godfrey, Ocom, Felix, Wetaka, Milton Makoba, Kyazze, Simon, Kisakye, Anita, Lamorde, Mohammed, Nakiire, Lydia, Ahabwe, Peter Babigumira, Mirembe, Bernadette Basuta, Muwanguzi, Esther Namukose, Ochien, Emmanuel, Komakech, Innocent, Nankya, Annet Martha, Byakika, Sarah, Nakinsinge, Anne, Okello, Daniel Ayen, Zalwango, Sarah K, Senyonga, Muzafalu, Okware, Solome, Bahatungire, Rony Reginald, Kimuli, Ivan, Rubangakene, Moses, Mafigiri, Richardson, Bulwadda, Daniel, Aujo, Deborah, Isabirye, Herbert Kiirya, Semanda, Judith Nanyondo, Kibanga, John-Baptist, Bbuye, Mudarshir, Baryamujura, Jovan, Akello, Grace, Balinandi, Stephen, Njuguna, Charles, Chimbaru, Alex, Bodo, Bongomin, Akera, Tonny, Kabagambe, Philimon, Natseri, Nasan, Mulei, Sophia, Nyakarahuka, Luke, Baluku, Jimmy, Kyondo, Jackson, Tumusiime, Alex, Lutwama, Julius Julian, Kaleebu, Pontiano, Masiira, Ben, Aliddeki, Dativa, Buhuguru, Remmy, Kasumba, Hakeem, Sendikadiwa, Bosco Vito, Kabanda, Joseph, Jacob, Shevin T, Fletcher, Tom E, Fischer II, William A, Youkee, Daniel, Lado, Marta, Lang, Hans-Joerg, Mugisha, Nathan Kenya, Namusisi, Olivia, Toliva, Bernard Opar, Mwaka, Savio, Nsereko, Christopher, Lukoya, Charles Okot, Ngabirano, Annet Alenyo, Waniaye, John- Baptist, Mwanga, Michael, Amone, Jackson, Apiyo, Paska, Kabanda, Richard, Mugerwa, Ibrahim, Ssewanyana, Isaac, Nabadda, Susan, Kabami, Zainah ^*, Ario, Alex R, Harris, Julie R, Ninsiima, Mackline, Ahirirwe, Sherry R, Ocero, Jane R Aceng, Atwine, Diana, Mwebesa, Henry G, Kyabayinze, Daniel J, Muruta, Allan N, Kagirita, Atek, Tegegn, Yonas, Nanyunja, Miriam, Kizito, Saudah N, Kadobera, Daniel, Kwesiga, Benon, Gidudu, Samuel, Migisha, Richard, Makumbi, Issa, Eurien, Daniel, Elyanu, Peter J, Ndyabakira, Alex, Naiga, Helen Nelly, Zalwango, Jane F, Agaba, Brian, Kawungezi, Peter C, Zalwango, Marie G, King, Patrick, Simbwa, Brenda N, Akunzirwe, Rebecca, Wanyana, Mercy W, Zavuga, Robert, Kiggundu, Thomas

Source: In The Lancet Global Health October 2024 12(10):e1684-e1692

HIV infection drives pro-inflammatory immunothrombotic pathway activation and organ dysfunction among adults with sepsis in Uganda

Authors: Cummings, Matthew J., Bakamutumaho, Barnabas, Price, Adam, Owor, Nicholas, Kayiwa, John, Namulondo, Joyce, Byaruhanga, Timothy, Jain, Komal, Postler, Thomas S., Muwanga, Moses, Nsereko, Christopher, Nayiga, Irene, Kyebambe, Stephen, Che, Xiaoyu, Sameroff, Stephen, Tokarz, Rafal, Shah, Shivang S., Larsen, Michelle H., Lipkin, W. Ian, Lutwama, Julius J., O'Donnell, Max R.

Source: AIDS. 37(2):233-245

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194419749.0x000001&indx=1&recIds=ETOCvdc_100194419749.0x000001

Brief Report: Detection of Urine Lipoarabinomannan Is Associated With Proinflammatory Innate Immune Activation, Impaired Host Defense, and Organ Dysfunction in Adults With Severe HIV-Associated Tuberculosis in Uganda

Authors: Cummings, Matthew J., Bakamutumaho, Barnabas, Jain, Komal, Price, Adam, Owor, Nicholas, Kayiwa, John, Namulondo, Joyce, Byaruhanga, Timothy, Muwanga, Moses, Nsereko, Christopher, Nayiga, Irene, Kyebambe, Stephen, Che, Xiaoyu, Sameroff, Stephen, Tokarz, Rafal, Wong, Wai, Postler, Thomas S., Larsen, Michelle H., Lipkin, W. Ian, Lutwama, Julius J., O'Donnell, Max R.

Source: Journal of acquired immune deficiency syndromes. 93(1):79-85

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189902615.0x000001&indx=1&recIds=ETOCvdc_100189902615.0x000001

Development of a Novel Clinicomolecular Risk Index to Enhance Mortality Prediction and Immunological Stratification of Adults Hospitalized with Sepsis in Sub-Saharan Africa: A Pilot Study from Uganda

Authors: Cummings, Matthew J., Bakamutumaho, Barnabas, Jain, Komal, Price, Adam, Owor, Nicholas, Kayiwa, John, Namulondo, Joyce, Byaruhanga, Timothy, Muwanga, Moses, Nsereko, Christopher

Source: American journal of tropical medicine and hygiene. 108(3):619-626

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631578789&indx=1&recIds=ETOCRN631578789

Spike protein is a key target for stronger and more persistent T-cell responses—a study of mild and asymptomatic SARS-CoV-2 infection

Authors: Ssali, Ivan, Mugaba, Susan, Watelo, Arthur Kalyebi, Bemanzi, Juliana, Katende, Joseph Ssebwana, Oluka, Gerald Kevin, Ankunda, Violet, Baine, Claire, Kato, Laban, Onyachi, Nathan, Muwanga, Moses, Jjuuko, Mark, Kayiwa, John, Nsereko, Christopher, Auma, Betty Oliver, Weiskopf, Daniela, Sette, Alessandro, Lutalo, Tom, Musenero, Monica, Kaleebu, Pontiano, Serwanga, Jennifer

Source: In International Journal of Infectious Diseases November 2023 136:49-56

Unsupervised Classification of the Host Response Identifies Dominant Pathobiological Signatures of Sepsis in Sub-Saharan Africa.

Authors: Cummings, Matthew J., Lutwama, Julius J., Owor, Nicholas, Tomoiaga, Alin S., Ross, Jesse E., Muwanga, Moses, Nsereko, Christopher, Nayiga, Irene, Kyebambe, Stephen, Shinyale, Joseph, Ochar, Thomas, Kiwubeyi, Moses, Nankwanga, Rittah, Nie, Kai, Xie, Hui, Miake-Lye, Sam, Villagomez, Bryan, Qi, Jingjing, Reynolds, Steven J., Nakibuuka, Martina Cathy

Source: American Journal of Respiratory & Critical Care Medicine; Mar2025, Vol. 211 Issue 3, p357-369, 13p

Subject Terms: BIOLOGICAL classification, RECEIVER operating characteristic curves, T-cell exhaustion, HIGH-income countries, MYELOID cells

Geographic Terms: AFRICA

Evaluation of the performance of 25 SARS-CoV-2 serological rapid diagnostic tests using a reference panel of plasma specimens at the Uganda Virus Research Institute

Authors: Lutalo, Tom, Nalumansi, Aminah, Olara, Denis, Kayiwa, John, Ogwang, Bernard, Odwilo, Emmanuel, Watera, Christine, Balinandi, Stephen, Kiconco, Jocelyn, Nakaseegu, Joweria, Serwanga, Jennifer, Kikaire, Bernard, Ssemwanga, Deogratius, Abiko, Brendah, Nsereko, Christopher, Cotten, Matthew, Buule, Joshua, Lutwama, Julius, Downing, Robert, Kaleebu, Pontiano

Source: In International Journal of Infectious Diseases November 2021 112:281-287

Field evaluation of the performance of a SARS-CoV-2 antigen rapid diagnostic test in Uganda using nasopharyngeal samples

Authors: Nalumansi, Aminah, Lutalo, Tom, Kayiwa, John, Watera, Christine, Balinandi, Stephen, Kiconco, Jocelyn, Nakaseegu, Joweria, Olara, Denis, Odwilo, Emmanuel, Serwanga, Jennifer, Kikaire, Bernard, Ssemwanga, Deogratius, Nabadda, Susan, Ssewanyana, Isaac, Atwine, Diane, Mwebesa, Henry, Bosa, Henry Kyobe, Nsereko, Christopher, Cotten, Matthew, Downing, Robert, Lutwama, Julius, Kaleebu, Pontiano

Source: In International Journal of Infectious Diseases March 2021 104:282-286

Severe COVID-19 in Uganda across Two Epidemic Phases: A Prospective Cohort Study

Authors: Bakamutumaho, Barnabas, Cummings, Matthew J., Owor, Nicholas, Kayiwa, John, Namulondo, Joyce, Byaruhanga, Timothy, Muwanga, Moses, Nsereko, Christopher, Rwamutwe, Emmanuel, Mutonyi, Roselyn

Source: American journal of tropical medicine and hygiene. 105(3):740-744

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN627458320&indx=1&recIds=ETOCRN627458320

Lessons for Strengthening a Resilient Health System from the View of Health Facilities During the COVID-19 Pandemic: A Qualitative Study.

Authors: Komasawa, Makiko, Saito, Kiyoko, Sato, Miho, Ssekitoleko, Robert Tamale, Nsereko, Christopher, Isono, Mitsuo, Nantume, Jesca, Aung, Myo Nyein

Source: Risk Management & Healthcare Policy; Oct2024, Vol. 17, p2427-2441, 15p

Subject Terms: HEALTH facilities, COVID-19, COVID-19 pandemic, MEDICAL personnel, PUBLIC health

Geographic Terms: SUB-Saharan Africa

A Transcriptomic Classifier Model Identifies High-Risk Endotypes in a Prospective Study of Sepsis in Uganda.

Authors: Cummings, Matthew J., Bakamutumaho, Barnabas, Tomoiaga, Alin S., Owor, Nicholas, Jain, Komal, Price, Adam, Kayiwa, John, Namulondo, Joyce, Byaruhanga, Timothy, Muwanga, Moses, Nsereko, Christopher, Nayiga, Irene, Kyebambe, Stephen, Sameroff, Stephen, Che, Xiaoyu, Lutwama, Julius J., Lipkin, W. Ian, O'Donnell, Max R.

Source: Critical Care Medicine; Mar2024, Vol. 52 Issue 3, p475-482, 8p

Impact of Hospital Closure on Patients with Communicable and Non-Communicable Diseases During the COVID-19 Pandemic in Uganda: A Cross-Sectional and Mixed-Methods Study.

Authors: Komasawa, Makiko, Aung, Myo Nyein, Nsereko, Christopher, Ssekitoleko, Robert, Isono, Mitsuo, Saito, Kiyoko, Nantume, Jesca, Shirayama, Yoshihisa, Chandani, Shrestha, Yuasa, Motoyuki

Source: Risk Management & Healthcare Policy; Nov2023, Vol. 16, p2593-2607, 15p

Subject Terms: COMMUNICABLE diseases, COVID-19 pandemic, HOSPITAL patients, MEDICAL care, TUBERCULOSIS patients, HOSPITAL closures, NON-communicable diseases, PATELLA dislocation

Geographic Terms: UGANDA

Rapid, early, and potent Spike-directed IgG, IgM, and IgA distinguish asymptomatic from mildly symptomatic COVID-19 in Uganda, with IgG persisting for 28 months.

Authors: Serwanga, Jennifer, Ankunda, Violet, Sembera, Jackson, Kato, Laban, Oluka, Gerald Kevin, Baine, Claire, Odoch, Geoffrey, Kayiwa, John, Auma, Betty Oliver, Jjuuko, Mark, Nsereko, Christopher, Cotten, Matthew, Onyachi, Nathan, Muwanga, Moses, Lutalo, Tom, Fox, Julie, Musenero, Monica, Kaleebu, Pontiano

Source: Frontiers in Immunology; 3/16/2023, Vol. 14, p1-16, 16p

Subject Terms: IMMUNOGLOBULIN G, IMMUNOGLOBULIN A, ANTIBODY formation, COVID-19, ASYMPTOMATIC patients, HIV seroconversion

Geographic Terms: UGANDA

Epidemiology, Clinical Characteristics, and Mortality of Hospitalized Patients with Severe COVID-19 in Uganda, 2020-2021.

Authors: Bakamutumaho, Barnabas, Lutwama, Julius J., Owor, Nicholas, Kayiwa, John, Kiconco, Jocelyn, Haumba, Mercy, Muwanga, Moses, Nsereko, Christopher, Rwamutwe, Emmanuel, Nayiga, Irene, Kyebambe, Stephen, Bosa, Henry Kyobe, Ocom, Felix, Watyaba, Benjamin, Kikaire, Bernard, Kisaka, Stevens, Kiwanuka, Noah, O'Donnell, Max R., Cummings, Matthew J.

Source: Annals of the American Thoracic Society; Dec2022, Vol. 19 Issue 12, p2100-2104, 5p

Antiretroviral therapy initiation and outcomes of hospitalized HIV-infected patients in Uganda—An evaluation of the HIV test and treat strategy.

Authors: Katende, Andrew, Nakiyingi, Lydia, Andia-Biraro, Irene, Katairo, Thomas, Muhumuza, Richard, Ssemata, Andrew S., Nsereko, Christopher, Semitala, Fred C., Meya, David B.

Source: PLoS ONE; 8/19/2022, Vol. 17 Issue 8, p1-13, 13p

Subject Terms: HIV, HOSPITAL patients, ANTIRETROVIRAL agents, PUBLIC hospitals, MEDICAL personnel, HIV-positive children, HIV-positive persons

Geographic Terms: UGANDA

Field evaluation of the performance of seven Antigen Rapid diagnostic tests for the diagnosis of SARs-CoV-2 virus infection in Uganda.

Authors: Bwogi, Josephine, Lutalo, Tom, Tushabe, Phionah, Bukenya, Henry, Eliku, James Peter, Ssewanyana, Isaac, Nabadda, Susan, Nsereko, Christopher, Cotten, Matthew, Downing, Robert, Lutwama, Julius, Kaleebu, Pontiano

Source: PLoS ONE; 5/10/2022, Vol. 17 Issue 5, p1-14, 14p

Subject Terms: COVID-19 testing, SARS-CoV-2, DIAGNOSIS methods, HEALTH facilities, MEDICAL screening, VIRUS diseases

Geographic Terms: UGANDA

Multidimensional analysis of the host response reveals prognostic and pathogen-driven immune subtypes among adults with sepsis in Uganda.

Authors: Cummings, Matthew J., Bakamutumaho, Barnabas, Price, Adam, Owor, Nicholas, Kayiwa, John, Namulondo, Joyce, Byaruhanga, Timothy, Muwanga, Moses, Nsereko, Christopher, Sameroff, Stephen, Tokarz, Rafal, Wong, Wai, Shah, Shivang S., Larsen, Michelle H., Lipkin, W. Ian, Lutwama, Julius J., O'Donnell, Max R.

Source: Critical Care; 2/8/2022, Vol. 26 Issue 1, p1-15, 15p

Stratifying Sepsis in Uganda Using Rapid Pathogen Diagnostics and Clinical Data: A Prospective Cohort Study.

Authors: Cummings, Matthew J., Bakamutumaho, Barnabas, Owor, Nicholas, Kayiwa, John, Namulondo, Joyce, Byaruhanga, Timothy, Muwanga, Moses, Nsereko, Christopher, Baldwin, Matthew R., Lutwama, Julius J., O'Donnell, Max R.

Source: American Journal of Tropical Medicine & Hygiene; Aug2021, Vol. 105 Issue 2, p517-524, 8p

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