USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development

Authors: Novellasdemunt, Laura, Kucharska, Anna, Baulies, Anna, Hutton, Colin, Vlachogiannis, Georgios, Repana, Dimitra, Rowan, Andrew, Suárez-Bonnet, A., Ciccarelli, Francesca, Valeri, Nicola, Li, Vivian S.W.

Source: Stem cell reports. 18(2):570-584

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182564985.0x000001&indx=1&recIds=ETOCvdc_100182564985.0x000001

The Transcription Co-Repressors MTG8 and MTG16 Regulate Exit of Intestinal Stem Cells From Their Niche and Differentiation Into Enterocyte vs Secretory Lineages

Authors: Baulies, Anna, Angelis, Nikolaos, Foglizzo, Valentina, Danielsen, E. Thomas, Patel, Harshil, Novellasdemunt, Laura, Kucharska, Anna, Carvalho, Joana, Nye, Emma, De Coppi, Paolo, Li, Vivian S.W.

Source: In Gastroenterology October 2020 159(4):1328-1341

Identifying strategies to target the metabolic flexibility of tumours

Authors: Méndez-Lucas, Andrés, Lin, Wei, Driscoll, Paul C., Legrave, Nathalie, Novellasdemunt, Laura, Xie, Chencheng, Charles, Mark, Wilson, Zena, Jones, Neil P., Rayport, Stephen, Rodríguez-Justo, Manuel, Li, Vivian, MacRae, James I., Hay, Nissim, Chen, Xin, Yuneva, Mariia

Source: Nature metabolism. 2(4):335-350

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100172055328.0x000001&indx=1&recIds=ETOCvdc_100172055328.0x000001

USP7 Is a Tumor-Specific WNT Activator for APC-Mutated Colorectal Cancer by Mediating β-Catenin Deubiquitination

Authors: Novellasdemunt, Laura, Foglizzo, Valentina, Cuadrado, Laura, Antas, Pedro, Kucharska, Anna, Encheva, Vesela, Snijders, Ambrosius P., Li, Vivian S.W.

Source: In Cell Reports 17 October 2017 21(3):612-627

Role of Akt/PKB and PFKFB isoenzymes in the control of glycolysis, cell proliferation and protein synthesis in mitogen-stimulated thymocytes

Authors: Houddane, Amina, Bultot, Laurent, Novellasdemunt, Laura, Johanns, Manuel, Gueuning, Marie-Agnès, Vertommen, Didier, Coulie, Pierre G., Bartrons, Ramon, Hue, Louis, Rider, Mark H.

Source: In Cellular Signalling June 2017 34:23-37

Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain.

Authors: Powell, Gareth T.^1,2, Faro, Ana¹, Yuguang Zhao³, yuguang.zhao@strubi.ox.ac.uk, Stickney, Heather^1,4,5, Novellasdemunt, Laura^6,7, Henriques, Pedro¹, Gestri, Gaia¹, White, Esther Redhouse¹, Jingshan Ren³, Weixian Lu³, Young, Rodrigo M.^1,8,9, Hawkins, Thomas A.¹, Cavodeassi, Florencia^1,10, Schwarz, Quenten⁸, Dreosti, Elena¹, Raible, David W.⁴, Li, Vivian S. W.⁶, Wright, Gavin J.^2,11, Jones, E. Yvonne³, yvonne.jones@strubi.ox.ac.uk, Wilson, Stephen W.¹, s.wilson@ucl.ac.uk

Source: Science; 5/3/2024, Vol. 384 Issue 6695, p573-579, 7p, 5 Diagrams

Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy

Authors: Tajan, Mylène, Hennequart, Marc, Cheung, Eric C., Zani, Fabio, Hock, Andreas K., Legrave, Nathalie, Maddocks, Oliver D. K., Ridgway, Rachel A., Athineos, Dimitris, Suárez-Bonnet, Alejandro, Ludwig, Robert L., Novellasdemunt, Laura, Angelis, Nikolaos, Li, Vivian S. W., Vlachogiannis, Georgios, Valeri, Nicola, Mainolfi, Nello, Suri, Vipin, Friedman, Adam, Manfredi, Mark, Blyth, Karen, Sansom, Owen J., Vousden, Karen H.

Source: Nature communications. 12(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191457775.0x000001&indx=1&recIds=ETOCvdc_100191457775.0x000001

Mitochondrial Phosphoenolpyruvate Carboxykinase (PEPCK-M) Is a Pro-survival, Endoplasmic Reticulum (ER) Stress Response Gene Involved in Tumor Cell Adaptation to Nutrient Availability

Authors: Méndez-Lucas, Andrés ^a, Hyroššová, Petra ^a, Novellasdemunt, Laura ^a, Viñals, Francesc ^a, Perales, Jose C. ^a

Source: In Journal of Biological Chemistry 8 August 2014 289(32):22090-22102

Akt-dependent Activation of the Heart 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase (PFKFB2) Isoenzyme by Amino Acids

Authors: Novellasdemunt, Laura, Tato, Irantzu, Navarro-Sabate, Aurea, Ruiz-Meana, Marisol, Méndez-Lucas, Andrés, Perales, Jose Carlos, Garcia-Dorado, David, Ventura, Francesc, Bartrons, Ramon, Rosa, Jose Luis

Source: In Journal of Biological Chemistry 12 April 2013 288(15):10640-10651

NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor

Authors: Novellasdemunt, Laura, Kucharska, Anna, Jamieson, Cara, Prange‐Barczynska, Maria, Baulies, Anna, Antas, Pedro, van der Vaart, Jelte, Gehart, Helmuth, Maurice, Madelon M, Li, Vivian SW

Source: EMBO journal. 39(3)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100099792163.0x000001&indx=1&recIds=ETOCvdc_100099792163.0x000001

Cooperation of Adenosine with Macrophage Toll-4 Receptor Agonists Leads to Increased Glycolytic Flux through the Enhanced Expression of PFKFB3 Gene

Authors: Ruiz-García, Almudena, Monsalve, Eva, Novellasdemunt, Laura, Navarro-Sabaté, Àurea, Manzano, Anna, Rivero, Samuel, Castrillo, Antonio, Casado, Marta, Laborda, Jorge, Bartrons, Ramón, Díaz-Guerra, María José M.

Source: In Journal of Biological Chemistry 3 June 2011 286(22):19247-19258

SH3BP4 Regulates Intestinal Stem Cells and Tumorigenesis by Modulating β-Catenin Nuclear Localization

Authors: Antas, Pedro, Novellasdemunt, Laura, Kucharska, Anna, Massie, Isobel, Carvalho, Joana, Oukrif, Dahmane, Nye, Emma, Novelli, Marco, Li, Vivian S.W.

Source: Cell reports. 26(9):2266-2273.e4

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100077458374.0x000001&indx=1&recIds=ETOCvdc_100077458374.0x000001

Metastatic recurrence in colorectal cancer arises from residual EMP1⁺ cells.

Authors: Cañellas-Socias, Adrià, Cortina, Carme, Hernando-Momblona, Xavier, Palomo-Ponce, Sergio, Mulholland, Eoghan J., Turon, Gemma, Mateo, Lidia, Conti, Sefora, Roman, Olga, Sevillano, Marta, Slebe, Felipe, Stork, Diana, Caballé-Mestres, Adrià, Berenguer-Llergo, Antonio, Álvarez-Varela, Adrián, Fenderico, Nicola, Novellasdemunt, Laura, Jiménez-Gracia, Laura, Sipka, Tamara, Bardia, Lidia

Source: Nature; Nov2022, Vol. 611 Issue 7936, p603-613, 11p

Metastatic recurrence in colorectal cancer arises from residual EMP1+cells

Authors: Cañellas-Socias, Adrià, Cortina, Carme, Hernando-Momblona, Xavier, Palomo-Ponce, Sergio, Mulholland, Eoghan J., Turon, Gemma, Mateo, Lidia, Conti, Sefora, Roman, Olga, Sevillano, Marta, Slebe, Felipe, Stork, Diana, Caballé-Mestres, Adrià, Berenguer-Llergo, Antonio, Álvarez-Varela, Adrián, Fenderico, Nicola, Novellasdemunt, Laura, Jiménez-Gracia, Laura, Sipka, Tamara, Bardia, Lidia, Lorden, Patricia, Colombelli, Julien, Heyn, Holger, Trepat, Xavier, Tejpar, Sabine, Sancho, Elena, Tauriello, Daniele V. F., Leedham, Simon, Attolini, Camille Stephan-Otto, Batlle, Eduard

Source: Nature; November 2022, Vol. 611 Issue: 7936 p603-613, 11p

Atypical cyclin P regulates cancer cell stemness through activation of the WNT pathway.

Authors: Sánchez-Botet, Abril, Quandt, Eva, Masip, Núria, Escribá, Rubén, Novellasdemunt, Laura, Gasa, Laura, Li, Vivian S. W., Raya, Ángel, Clotet, Josep, Ribeiro, Mariana P. C.

Source: Cellular Oncology (2211-3428); Dec2021, Vol. 44 Issue 6, p1273-1286, 14p

Subject Terms: CANCER stem cells, COLORECTAL cancer, CYCLINS, STEM cell culture, PROGNOSIS, MULTIDRUG resistance, CANCER cells

A brief history of organoids.

Authors: Corrò, Claudia¹ (AUTHOR), Novellasdemunt, Laura¹ (AUTHOR), Li, Vivian S.W.¹ (AUTHOR) vivian.li@crick.ac.uk

Source: American Journal of Physiology: Cell Physiology. Jul2020, Vol. 319 Issue 1, pC151-C165. 15p. 1 Chart, 2 Graphs.

Engineering transplantable jejunal mucosal grafts using patient-derived organoids from children with intestinal failure

Authors: Meran, Laween, Massie, Isobel, Campinoti, Sara, Weston, Anne E., Gaifulina, Riana, Tullie, Lucinda, Faull, Peter, Orford, Michael, Kucharska, Anna, Baulies, Anna, Novellasdemunt, Laura, Angelis, Nikolaos, Hirst, Elizabeth, König, Julia, Tedeschi, Alfonso Maria, Pellegata, Alessandro Filippo, Eli, Susanna, Snijders, Ambrosius P., Collinson, Lucy, Thapar, Nikhil, Thomas, Geraint M. H., Eaton, Simon, Bonfanti, Paola, De Coppi, Paolo, Li, Vivian S. W.

Source: Nature Medicine; October 2020, Vol. 26 Issue: 10 p1593-1601, 9p

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