Incretin-like effects of small molecule trace amine-associated receptor 1 agonists

Authors: Raab, Susanne, Wang, Haiyan, Uhles, Sabine, Cole, Nadine, Alvarez-Sanchez, Ruben, Künnecke, Basil, Ullmer, Christoph, Matile, Hugues, Bedoucha, Marc, Norcross, Roger D., Ottaway-Parker, Nickki, Perez-Tilve, Diego, Conde Knape, Karin, Tschöp, Matthias H., Hoener, Marius C., Sewing, Sabine

Source: In Molecular Metabolism January 2016 5(1):47-56

A UGT2B10 Splicing Polymorphism Common in African Populations May Greatly Increase Drug Exposure

Authors: Fowler, Stephen, Kletzl, Heidemarie, Finel, Moshe, Manevski, Nenad ¹, Schmid, Paul, Tuerck, Dietrich, Norcross, Roger D., Hoener, Marius C., Spleiss, Olivia, Iglesias, Victor A. ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics February 2015 352(2):358-367

Trace Amine-Associated Receptor 1 Partial Agonism Reveals Novel Paradigm for Neuropsychiatric Therapeutics

Authors: Revel, Florent G., Moreau, Jean-Luc, Gainetdinov, Raul R., Ferragud, Antonio, Velázquez-Sánchez, Clara, Sotnikova, Tatyana D., Morairty, Stephen R., Harmeier, Anja, Groebke Zbinden, Katrin, Norcross, Roger D., Bradaia, Amyaouch, Kilduff, Thomas S., Biemans, Barbara, Pouzet, Bruno, Caron, Marc G., Canales, Juan J., Wallace, Tanya L., Wettstein, Joseph G., Hoener, Marius C.

Source: In Biological Psychiatry 1 December 2012 72(11):934-942

The Selective Antagonist EPPTB Reveals TAAR1-Mediated Regulatory Mechanisms in Dopaminergic Neurons of the Mesolimbic System

Authors: Bradaia, Amyaouch, Trube, Gerhard, Stalder, Henri, Norcross, Roger D., Ozmen, Laurence, Wettstein, Joseph G., Pinard, Audrée, Buchy, Danièle, Gassmann, Martin, Hoener, Marius C., Bettler, Bernhard

Source: Proceedings of the National Academy of Sciences of the United States of America, 2009 Nov . 106(47), 20081-20086.

Access URL: https://www.jstor.org/stable/25593327

New vistas in quinoline synthesis

Authors: Atechian, Sarkis, Nock, Nadine, Norcross, Roger D., Ratni, Hassen, Thomas, Andrew W., Verron, Julien, Masciadri, Raffaello

Source: In Tetrahedron 2007 63(13):2811-2823

Studies in macrolide synthesis: a stereocontrolled synthesis of oleandolide employing reagent- and substrate-controlled aldol reactions of (S)-1-(benzyloxy)-2-methylpentan-3-one.

Authors: Paterson, Ian, Norcross, Roger D., Ward, Richard A.

Source: Journal of the American Chemical Society; December 14 1994, Vol. 116, p11287-11314, 28p

Total synthesis of bioactive marine macrolides.

Authors: Norcross, Roger D., Paterson, Ian

Source: Chemical Reviews; September/October 1995, Vol. 95, p2041-2114, 74p

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Optimisation of imidazole compounds as selective TAAR1 agonists: Discovery of RO5073012

Authors: Galley, Guido, Stalder, Henri, Goergler, Annick, Hoener, Marius C., Norcross, Roger D.

Source: In Bioorganic & Medicinal Chemistry Letters 15 August 2012 22(16):5244-5248

Selective antagonists of mouse trace amine-associated receptor 1 (mTAAR1): Discovery of EPPTB ( RO5212773)

Authors: Stalder, Henri, Hoener, Marius C., Norcross, Roger D.

Source: In Bioorganic & Medicinal Chemistry Letters 2011 21(4):1227-1231

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4-Substituted-7-N-alkyl-N-acetyl 2-aminobenzothiazole amides: Drug-like and non-xanthine based A2B adenosine receptor antagonists

Authors: Cheung, Adrian Wai-Hing, Brinkman, John, Firooznia, Fariborz, Flohr, Alexander, Grimsby, Joseph, Gubler, Mary Lou, Guertin, Kevin, Hamid, Rachid, Marcopulos, Nicholas, Norcross, Roger D., Qi, Lida, Ramsey, Gwendolyn, Tan, Jenny, Wen, Yang, Sarabu, Ramakanth

Source: In Bioorganic & Medicinal Chemistry Letters 15 July 2010 20(14):4140-4146

Discovery of benzoylisoindolines as a novel class of potent, selective and orally active GlyT1 inhibitors

Authors: Pinard, Emmanuel, Alberati, Daniela, Bender, Markus, Borroni, Edilio, Brom, Virginie, Burner, Serge, Fischer, Holger, Hainzl, Dominik, Halm, Remy, Hauser, Nicole, Jolidon, Synèse, Lengyel, Judith, Marty, Hans-Peter, Meyer, Thierry, Moreau, Jean-Luc, Mory, Roland, Narquizian, Robert, Norcross, Roger D., Schmid, Philipp, Wermuth, Roger, Zimmerli, Daniel

Source: In Bioorganic & Medicinal Chemistry Letters 2010 20(23):6960-6965

Synthesis of enantiomerically pure [¹⁴C]-labelled morpholine derivatives for a class of trace amine-associate receptor 1 agonists.

Authors: Edelmann, Martin R., Hartung, Thomas, Trussardi, René, Iding, Hans, Galley, Guido, Pflieger, Philippe, Norcross, Roger D.

Source: Journal of Labelled Compounds & Radiopharmaceuticals; Dec2016, Vol. 59 Issue 14, p635-639, 5p

Subject Terms: MORPHOLINE, AMINE synthesis, RADIOCHEMICAL purification, RADIOCARBON dating, SUBSTITUENTS (Chemistry), BIOCATALYSIS

Discovery of benzoylpiperazines as a novel class of potent and selective GlyT1 inhibitors

Authors: Pinard, Emmanuel, Alberati, Daniela, Borroni, Edilio, Fischer, Holger, Hainzl, Dominik, Jolidon, Synèse, Moreau, Jean-Luc, Narquizian, Robert, Nettekoven, Matthias, Norcross, Roger D., Stalder, Henri, Thomas, Andrew W.

Source: In Bioorganic & Medicinal Chemistry Letters 2008 18(18):5134-5139

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Brain-Specific Overexpression of Trace Amine-Associated Receptor 1 Alters Monoaminergic Neurotransmission and Decreases Sensitivity to Amphetamine.

Authors: Revel, Florent G, Meyer, Claas A, Bradaia, Amyaouch, Jeanneau, Karine, Calcagno, Eleonora, André, Cédric B, Haenggi, Markus, Miss, Marie-Thérèse, Galley, Guido, Norcross, Roger D, Invernizzi, Roberto W, Wettstein, Joseph G, Moreau, Jean-Luc, Hoener, Marius C

Source: Neuropsychopharmacology; Nov2012, Vol. 37 Issue 12, p2580-2592, 13p, 1 Chart, 6 Graphs

Subject Terms: NEURAL transmission, SCHIZOPHRENIA, MENTAL illness, LOCUS (Genetics), SEROTONIN