Characterization of recombinant factor IX fusion proteins enabling subcutaneous administration

Authors: Schön, Kathrin ^{1, 2}, Pestel, Sabine ¹, Riedesel, Julia ¹, Seyfert-Brandt, Waltraud ³, Claar, Philipp ³, Herzog, Eva ⁴, Rezvani-Sharif, Alireza ⁵, Ponnuswamy, Padmapriya ^{1, ∗}, Nolte, Marc W. ¹

Source: In Journal of Thrombosis and Haemostasis October 2024 22(10):2713-2723

Pharmacological Inhibition of Factor XIIa Attenuates Abdominal Aortic Aneurysm, Reduces Atherosclerosis, and Stabilizes Atherosclerotic Plaques

Authors: Searle, Amy, Chen, Yung-Chih, Wallert, Maria, McFadyen, James, Maluenda, Ana, Noonan, Jonathan, Kanellakis, Peter, Zaldivia, Maria, Huang, Angela, Lioe, Hadi, Biondo, Mark, Nolte, Marc, Rossato, Paolo, Bobik, Alex, Panousis, Con, Wang, Xiaowei, Hosseini, Hamid, Peter, Karlheinz

Source: Thrombosis and haemostasis. 122(2):196-207

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191743090.0x000001&indx=1&recIds=ETOCvdc_100191743090.0x000001

Pharmacokinetic/pharmacodynamic modeling for dose selection for the first‐in‐human trial of the activated Factor XII inhibitor garadacimab (CSL312)

Authors: Pawaskar, Dipti, Chen, Xi, Glassman, Fiona, May, Frauke, Roberts, Anthony, Biondo, Mark, McKenzie, Andrew, Nolte, Marc W., Jusko, William J., Tortorici, Michael

Source: Clinical and translational science. 15(3):709-720

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100144447918.0x000001&indx=1&recIds=ETOCvdc_100144447918.0x000001

Generation of a humanized FXII knock‐in mouse—A powerful model system to test novel anti‐thrombotic agents

Authors: Beck, Sarah, Stegner, David, Loroch, Stefan, Baig, Ayesha A., Göb, Vanessa, Schumbrutzki, Cornelia, Eilers, Eva, Sickmann, Albert, May, Frauke, Nolte, Marc W., Panousis, Con, Nieswandt, Bernhard

Source: Journal of thrombosis and haemostasis. 19(11):2835-2840

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100151116036.0x000001&indx=1&recIds=ETOCvdc_100151116036.0x000001

C1-inhibitor to prevent intracerebral hemorrhage-related secondary brain injury.

Authors: Akeret, Kevin, Thomson, Bart R., Ghosh, Subhajit, Nolte, Marc, Fischer, Urs, Humar, Rok, Regli, Luca, Schaer, Dominik J., Hugelshofer, Michael, Buzzi, Raphael M.

Source: Fluids & Barriers of the CNS; 11/15/2024, Vol. 21 Issue 1, p1-5, 5p

Subject Terms: CHOROID plexus, HEMORRHAGIC stroke, BRAIN injuries, CEREBRAL hemorrhage, ISCHEMIC stroke

Tissue distribution of rIX‐FP after intravenous application to rodents

Authors: Herrmann, Sabrina, Doerr, Baerbel, May, Frauke, Kuehnemuth, Benjamin, Cherpokova, Deya, Herzog, Eva, Dickneite, Gerhard, Nolte, Marc W. ^*

Source: In Journal of Thrombosis and Haemostasis December 2020 18(12):3194-3202

C1-esterase inhibitor treatment: preclinical safety aspects on the potential prothrombotic risk

Authors: Schürmann, Daniel, Herzog, Eva, Raquet, Elmar, Nolte, Marc, May, Frauke, Müller-Cohrs, Jochen, Björkqvist, Jenny, Dickneite, Gerhard, Pragst, Ingo

Source: Thrombosis and haemostasis. 112(05):960-971

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183286211.0x000001&indx=1&recIds=ETOCvdc_100183286211.0x000001

Analysis of the safety and pharmacodynamics of human fibrinogen concentrate in animals

Authors: Beyerle, Andrea, Nolte, Marc W., Solomon, Cristina, Herzog, Eva, Dickneite, Gerhard

Source: In Toxicology and Applied Pharmacology 1 October 2014 280(1):70-77

Biodistribution of the recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) in rats

Authors: Herzog, Eva, Harris, Stephen, Henson, Claire, McEwen, Andrew, Schenk, Sabrina, Nolte, Marc W., Pragst, Ingo, Dickneite, Gerhard, Schulte, Stefan, Zollner, Sabine

Source: In Thrombosis Research May 2014 133(5):900-907

Composition comprising an active substance and a polyalkyleneoxide vinylester graft polymer

Composition comprising a pesticide, a surfactant and an alkoxylate of 2-propyheptylamine

Factor XII inhibitors for the treatment of silent brain ischemia and ischemia of other organs

Defective glycosylation of coagulation factor XII underlies hereditary angioedema type III

Authors: Björkqvist, Jenny, de Maat, Steven, Lewandrowski, Urs, Di Gennaro, Antonio, Oschatz, Chris, Schönig, Kai, Nöthen, Markus M., Drouet, Christian, Braley, Hal, Nolte, Marc W.

Source: Journal of clinical investigation. 125(8):3132-3214

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN602245820&indx=1&recIds=ETOCRN602245820

Inhibitory anti-factor XII/XIIA monoclonal antibodies and their uses

Factor XII inhibitors for the administration with medical procedures comprising contact with artificial surfaces

Modulation of Extravascular Binding of Recombinant Factor IX Impacts the Duration of Efficacy in Mouse Models.

Authors: Machado, Steffi Knoll, Peil, Hendrik, Kraushaar, Timo, Claar, Philipp, Mischnik, Marcel, Lind, Holger, Herzog, Eva, Bacher, Michael, Nolte, Marc Wolfgang, Bielohuby, Maximilian, Pestel, Sabine, Ponnuswamy, Padmapriya

Source: Thrombosis & Haemostasis; Aug2023, Vol. 123 Issue 8, p751-762, 12p

Selective Factor XIIa Inhibition Attenuates Silent Brain Ischemia: Application of Molecular Imaging Targeting Coagulation Pathway

Authors: Chen, John W., Figueiredo, Jose-Luiz, Wojtkiewicz, Gregory R., Siegel, Cory, Iwamoto, Yoshiko, Kim, Dong-Eog, Nolte, Marc W., Dickneite, Gerhard, Weissleder, Ralph, Nahrendorf, Matthias

Source: In JACC: Cardiovascular Imaging November 2012 5(11):1127-1138

Composition comprising a pesticide and an alkoxylate of iso-nonylamine

Method for enhancing the performance of a pesticide with guanidines

Method for controlling arthropods comprising the spot-wise application of a gel