Auto-immunoproteomics analysis of COVID-19 ICU patients revealed increased levels of autoantibodies related to the male reproductive system

Authors: Frank Schmidt, Houari B. Abdesselem, Karsten Suhre, Nishant N. Vaikath, Muhammad U. Sohail, Maryam Al-Nesf, Ilham Bensmail, Fathima Mashod, Hina Sarwath, Joerg Bernhardt, Stephanie Schaefer-Ramadan, Ti-Myen Tan, Priscilla E. Morris, Edward J. Schenck, David Price, Vidya Mohamed-Ali, Mohammed Al-Maadheed, Abdelilah Arredouani, Julie Decock, Jonathan M. Blackburn, Augustine M. K. Choi, Omar M. El-Agnaf

Source: Frontiers in Physiology, Vol 14 (2023)

Subject Terms: COVID-19, autoantibodies, immunoproteomics, SPANXN4, Stk25, male reproductive system, Physiology, QP1-981

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphys.2023.1203723/full; https://doaj.org/toc/1664-042X

Access URL: https://doaj.org/article/cafc2cc0758a400281587d6a1c37112f

Uncovering a neurological protein signature for severe COVID-19

Authors: Omar El-Agnaf, Ilham Bensmail, Maryam A.Y. Al-Nesf, James Flynn, Mark Taylor, Nour K. Majbour, Ilham Y. Abdi, Nishant N. Vaikath, Abdulaziz Farooq, Praveen B. Vemulapalli, Frank Schmidt, Khalid Ouararhni, Heba H. Al-Siddiqi, Abdelilah Arredouani, Patrick Wijten, Mohammed Al-Maadheed, Vidya Mohamed-Ali, Julie Decock, Houari B. Abdesselem

Source: Neurobiology of Disease, Vol 182, Iss , Pp 106147- (2023)

Subject Terms: Severe COVID-19, Neurological complications, Olink proteomics, Protein signature, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996123001614; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/fd669ebb74b0473c81aeb3ab6179a51c

CSF total and oligomeric α-Synuclein along with TNF-α as risk biomarkers for Parkinson’s disease: a study in LRRK2 mutation carriers

Authors: Nour K. Majbour, Jan O. Aasly, Eldbjørg Hustad, Mercy A. Thomas, Nishant N. Vaikath, Naser Elkum, Wilma D. J. van de Berg, Takahiko Tokuda, Brit Mollenhauer, Henk W. Berendse, Omar M. A. El-Agnaf

Source: Translational Neurodegeneration, Vol 9, Iss 1, Pp 1-10 (2020)

Subject Terms: Parkinson’s disease, LRRK2 mutation carriers, Alpha-synuclein oligomers, Biomarkers, Inflammatory markers, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40035-020-00192-4; https://doaj.org/toc/2047-9158

Access URL: https://doaj.org/article/ee5ec5df964e4d5e95f941a5372ac1af

Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts

Authors: Mustafa T. Ardah, Simona S. Ghanem, Sara A. Abdulla, Guohua Lv, Mohamed M. Emara, Katerina E. Paleologou, Nishant N. Vaikath, Jia-Hong Lu, Min Li, Konstantinos Vekrellis, David Eliezer, Omar M. A. El-Agnaf

Source: BMC Complementary Medicine and Therapies, Vol 20, Iss 1, Pp 1-21 (2020)

Subject Terms: α-Synuclein, Parkinson’s disease, Seeded fibril formation, Amyloid fibrils, Salvianolic acid B, Dihydromyricetin, Other systems of medicine, RZ201-999

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12906-020-2849-1; https://doaj.org/toc/2662-7671

Access URL: https://doaj.org/article/20d1bd5274794f01b0343a5862a81e46

Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy

Authors: Jia-Zhen Wu, Mustafa Ardah, Caroline Haikal, Alexander Svanbergsson, Meike Diepenbroek, Nishant N. Vaikath, Wen Li, Zhan-You Wang, Tiago F. Outeiro, Omar M. El-Agnaf, Jia-Yi Li

Source: Translational Neurodegeneration, Vol 8, Iss 1, Pp 1-15 (2019)

Subject Terms: chaperone-mediated autophagy, macroautophagy, alpha-synuclein, protein aggregation, Parkinson disease, lysosomal-associated membrane protein, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40035-019-0159-7; https://doaj.org/toc/2047-9158

Access URL: https://doaj.org/article/5804e97c94bb42328dfc122517329af0

Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

Authors: Megan F. Duffy, Timothy J. Collier, Joseph R. Patterson, Christopher J. Kemp, Kelvin C. Luk, Malú G. Tansey, Katrina L. Paumier, Nicholas M. Kanaan, D. Luke Fischer, Nicole K. Polinski, Olivia L. Barth, Jacob W. Howe, Nishant N. Vaikath, Nour K. Majbour, Omar M. A. El-Agnaf, Caryl E. Sortwell

Source: Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-18 (2018)

Subject Terms: Neuroinflammation, Parkinson’s disease, Animal models, Synucleinopathy, Microglia, Major-histocompatibility complex-II, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12974-018-1171-z; https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/78b82214e6ad41e9bc7e34dc3be1cf71

Natural Alkaloid Compounds as Inhibitors for Alpha-Synuclein Seeded Fibril Formation and Toxicity

Authors: Simona S. Ghanem, Hend S. Fayed, Qi Zhu, Jia-Hong Lu, Nishant N. Vaikath, Janarthanan Ponraj, Said Mansour, Omar M. A. El-Agnaf

Source: Molecules, Vol 26, Iss 12, p 3736 (2021)

Subject Terms: α-synuclein, Parkinson’s disease, seeded fibril formation, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/26/12/3736; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/340f359f92b643dab08028d648431a56

RT-QuIC Using C-Terminally Truncated α-Synuclein Forms Detects Differences in Seeding Propensity of Different Brain Regions from Synucleinopathies

Authors: Ilaria Poggiolini, Daniel Erskine, Nishant N. Vaikath, Janarthanan Ponraj, Said Mansour, Christopher M. Morris, Omar M. A. El-Agnaf

Source: Biomolecules, Vol 11, Iss 6, p 820 (2021)

Subject Terms: synucleinopathies, Parkinson’s disease, dementia with Lewy bodies, RT-QuIC, α-synuclein, C-terminally truncated αSyn, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/11/6/820; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/3aef1def0d27483e8c7d9ec67aa016d9

Age, Disease Severity and Ethnicity Influence Humoral Responses in a Multi-Ethnic COVID-19 Cohort

Authors: Muneerah Smith, Houari B. Abdesselem, Michelle Mullins, Ti-Myen Tan, Andrew J. M. Nel, Maryam A. Y. Al-Nesf, Ilham Bensmail, Nour K. Majbour, Nishant N. Vaikath, Adviti Naik, Khalid Ouararhni, Vidya Mohamed-Ali, Mohammed Al-Maadheed, Darien T. Schell, Seanantha S. Baros-Steyl, Nur D. Anuar, Nur H. Ismail, Priscilla E. Morris, Raja N. R. Mamat, Nurul S. M. Rosli, Arif Anwar, Kavithambigai Ellan, Rozainanee M. Zain, Wendy A. Burgers, Elizabeth S. Mayne, Omar M. A. El-Agnaf, Jonathan M. Blackburn

Source: Viruses, Vol 13, Iss 5, p 786 (2021)

Subject Terms: immunoassay, SARS-CoV-2 nucleocapsid protein, epitope coverage, quantitative antibody binding, protein microarray, SARS-CoV-2 antibodies, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/13/5/786; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/7fc7a89e66c541788ef3f161fe3155b3

Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology

Authors: Nishant N. Vaikath, Nour K. Majbour, Katerina E. Paleologou, Mustafa T. Ardah, Esther van Dam, Wilma D.J. van de Berg, Shelley L. Forrest, Laura Parkkinen, Wei-Ping Gai, Nobutaka Hattori, Masashi Takanashi, Seung-Jae Lee, David M.A. Mann, Yuzuru Imai, Glenda M. Halliday, Jia-Yi. Li, Omar M.A. El-Agnaf

Source: Neurobiology of Disease, Vol 79, Iss , Pp 81-99 (2015)

Subject Terms: α-Synuclein, Conformation-specific monoclonal antibodies, Parkinson’s disease, Dementia with Lewy bodies, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996115001564; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/19a44523c3ba42558d9a4cf1d1828f27

Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

Authors: Megan F. Duffy, Timothy J. Collier, Joseph R. Patterson, Christopher J. Kemp, Kelvin C. Luk, Malú G. Tansey, Katrina L. Paumier, Nicholas M. Kanaan, D. Luke Fischer, Nicole K. Polinski, Olivia L. Barth, Jacob W. Howe, Nishant N. Vaikath, Nour K. Majbour, Omar M. A. El-Agnaf, Caryl E. Sortwell

Source: Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-1 (2018)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12974-018-1202-9; https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/be17cb9e75054c85be402f41c4ea1d84

This result is not displayed to guests.
Login for full access.

Expression, purification and characterization of α-synuclein fibrillar specific scFv from inclusion bodies.

Authors: Vijay Gupta, Indulekha P Sudhakaran, Zeyaul Islam, Nishant N Vaikath, Issam Hmila, Tamas Lukacsovich, Prasanna R Kolatkar, Omar M A El-Agnaf

Source: PLoS ONE, Vol 15, Iss 11, p e0241773 (2020)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/e6b990990aae455eb1b643413ba84c07