Blood pressure‐independent renoprotective effects of small interference RNA targeting liver angiotensinogen in experimental diabetes

Authors: Cruz‐López, Edwyn O., Ren, Liwei, Uijl, Estrellita, Clahsen‐van Groningen, Marian C., Veghel, Richard, Garrelds, Ingrid M., Domenig, Oliver, Poglitsch, Marko, Zlatev, Ivan, Rooney, Timothy, Kasper, Anne, Nioi, Paul, Foster, Don, Danser, A. H. Jan

Source: British journal of pharmacology. 180(1):80-93

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100169047946.0x000001&indx=1&recIds=ETOCvdc_100169047946.0x000001

Rare coding variants in DNA damage repair genes associated with timing of natural menopause

Authors: Ward, Lucas D., Parker, Margaret M., Deaton, Aimee M., Tu, Ho-Chou, Flynn-Carroll, Alexander O., Hinkle, Gregory, Nioi, Paul

Source: In Human Genetics and Genomics Advances 14 April 2022 3(2)

Transthyretin-stabilising mutation T119M is not associated with protection against vascular disease or death in the UK Biobank

Authors: Parker, Margaret M., Ticau, Simina, Butler, James, Erbe, David, Merkel, Madeline, Aldinc, Emre, Hinkle, Gregory, Nioi, Paul

Source: Amyloid. 27(3):184-190

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123087061.0x000001&indx=1&recIds=ETOCvdc_100123087061.0x000001

Modernizing Human Cancer Risk Assessment of Therapeutics

Authors: Fielden, Mark R., Ward, Lucas D., Minocherhomji, Sheroy, Nioi, Paul, Lebrec, Herve, Jacobson-Kram, David

Source: In Trends in Pharmacological Sciences March 2018 39(3):232-247

Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects

Authors: Nguyen, Phuong, Born, David, Deaton, Aimee, Nioi, Paul, Ward, Lucas

Source: Nature communications. 10(1):1-11

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129227175.0x000001&indx=1&recIds=ETOCvdc_100129227175.0x000001

Rationalizing Secondary Pharmacology Screening Using Human Genetic and Pharmacological Evidence

Authors: Deaton, Aimee M, Fan, Fan, Zhang, Wei, Nguyen, Phuong A, Ward, Lucas D, Nioi, Paul

Source: Toxicological sciences. 167(2):593-603

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100078442473.0x000001&indx=1&recIds=ETOCvdc_100078442473.0x000001

A rare missense variant in NR1H4 associates with lower cholesterol levels

Authors: Deaton, Aimee, Sulem, Patrick, Nioi, Paul, Benonisdottir, Stefania, Ward, Lucas, Davidsson, Olafur, Lao, Socheata, Helgadottir, Anna, Fan, Fan, Jensson, Brynjar, Norddahl, Gudmundur, Jonasdottir, Aslaug, Jonasdottir, Adalbjorg, Sigurdsson, Asgeir, Kristjansson, Ragnar, Oddsson, Asmundur, Arnadottir, Gudny, Jonsson, Hakon, Olafsson, Isleifur, Eyjolfsson, Gudmundur, Sigurdardottir, Olof, Bjornsson, Einar, Olafsson, Sigurdur, Steingrimsdottir, Thora, Rafnar, Thorunn, Thorgeirsson, Gudmundur, Masson, Gisli, Thorleifsson, Gudmar, Gudbjartsson, Daniel, Holm, Hilma, Thorsteinsdottir, Unnur, Stefansson, Kari

Source: Communications biology. 1(1):1-9

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112264365.0x000001&indx=1&recIds=ETOCvdc_100112264365.0x000001

Time-dependent cellular and transcriptional changes in the osteoblast lineage associated with sclerostin antibody treatment in ovariectomized rats

Authors: Taylor, Scott, Ominsky, Michael S., Hu, Rong, Pacheco, Efrain, He, Yudong D., Brown, Danielle L., Aguirre, J. Ignacio, Wronski, Thomas J., Buntich, Sabina, Afshari, Cynthia A., Pyrah, Ian, Nioi, Paul, Boyce, Rogely Waite

Source: In Bone March 2016 84:148-159

Treatment response and neurofilament light chain levels with long-term patisiran in hereditary transthyretin-mediated amyloidosis with polyneuropathy: 24-month results of an open-label extension study.

Authors: Ticau, Simina, Aldinc, Emre, Polydefkis, Michael, Adams, David, Coelho, Teresa, Ueda, Mitsuharu, Hale, Cecilia, Vest, John, Nioi, Paul

Source: Amyloid; Mar2024, Vol. 31 Issue 1, p1-11, 11p

Subject Terms: POLYNEUROPATHIES, AMYLOIDOSIS, CYTOPLASMIC filaments, THERAPEUTICS, NEUROPATHY

Geographic Terms: NORFOLK (England)

Combining hiPSCs and Human Genetics: Major Applications in Drug Development

Authors: Zhang, Jin, Li, Hu, Trounson, Alan, Wu, Joseph C., Nioi, Paul

Source: Cell stem cell. 21(2):161-165

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100063624176.0x000001&indx=1&recIds=ETOCvdc_100063624176.0x000001

Comment on 'Using Human 'Experiments of Nature' to Predict Drug Safety Issues: An Example with PCSK9 Inhibitors'

Authors: Ward, Lucas D., Moffat, Graeme J., Yuan, Jing, Nioi, Paul

Source: Drug safety. 41(11):1097-1099

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130226545.0x000001&indx=1&recIds=ETOCvdc_100130226545.0x000001

Plasma proteomic associations with genetics and health in the UK Biobank

Authors: Sun, Benjamin B., Chiou, Joshua, Traylor, Matthew, Benner, Christian, Hsu, Yi-Hsiang, Richardson, Tom G., Surendran, Praveen, Mahajan, Anubha, Robins, Chloe, Vasquez-Grinnell, Steven G., Hou, Liping, Kvikstad, Erika M., Burren, Oliver S., Davitte, Jonathan, Ferber, Kyle L., Gillies, Christopher E., Hedman, Åsa K., Hu, Sile, Lin, Tinchi, Mikkilineni, Rajesh, Pendergrass, Rion K., Pickering, Corran, Prins, Bram, Baird, Denis, Chen, Chia-Yen, Ward, Lucas D., Deaton, Aimee M., Welsh, Samantha, Willis, Carissa M., Lehner, Nick, Arnold, Matthias, Wörheide, Maria A., Suhre, Karsten, Kastenmüller, Gabi, Sethi, Anurag, Cule, Madeleine, Raj, Anil, Burkitt-Gray, Lucy, Melamud, Eugene, Black, Mary Helen, Fauman, Eric B., Howson, Joanna M. M., Kang, Hyun Min, McCarthy, Mark I., Nioi, Paul, Petrovski, Slavé, Scott, Robert A., Smith, Erin N., Szalma, Sándor, Waterworth, Dawn M., Mitnaul, Lyndon J., Szustakowski, Joseph D., Gibson, Bradford W., Miller, Melissa R., Whelan, Christopher D.

Source: Nature; October 2023, Vol. 622 Issue: 7982 p329-338, 10p

Author Correction: Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects

Authors: Nguyen, Phuong A., Born, David A., Deaton, Aimee M., Nioi, Paul, Ward, Lucas D.

Source: Nature communications. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130640122.0x000001&indx=1&recIds=ETOCvdc_100130640122.0x000001

SP021Identification and Phenotyping of a Healthy Human Deficient in HAO1 Supports Glycolate Oxidase Knockdown as a Potential Approach to Therapy for Primary Hyperoxaluria Type 1

Authors: Mcgregor, Tracy L, Hunt, Karen A, Nioi, Paul, Wright, John, Erbe, David, Van Heel, David

Source: Nephrology dialysis transplantation. 34(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100096851577.0x000001&indx=1&recIds=ETOCvdc_100096851577.0x000001

BLOOD PRESSURE-INDEPENDENT RENOPROTECTION IN DIABETIC RATS TREATED WITH SMALL INTERFERING RNA TARGETING LIVER ANGIOTENSINOGEN

Authors: Lopez, Edwyn Omar Cruz, Ren, Liwei, Uijl, Estrellita, Clahsen-Van Groningen, Marian C., Van Veghel, Richard, Garrelds, Ingrid M., Domenig, Oliver, Poglitsch, Marko, Zlatev, Ivan, Rooney, Timothy, Kasper, Anne, Nioi, Paul, Foster, Don, Danser, A.H. Jan

Source: Journal of hypertension. 40(1):e193-e193

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100156028590.0x000001&indx=1&recIds=ETOCvdc_100156028590.0x000001

Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals

Authors: Kosmicki, Jack A., Horowitz, Julie E., Banerjee, Nilanjana, Lanche, Rouel, Marcketta, Anthony, Maxwell, Evan, Bai, Xiaodong, Sun, Dylan, Backman, Joshua D., Sharma, Deepika, Kury, Fabricio S.P., Kang, Hyun M., O’Dushlaine, Colm, Yadav, Ashish, Mansfield, Adam J., Li, Alexander H., Watanabe, Kyoko, Gurski, Lauren, McCarthy, Shane E., Locke, Adam E., Khalid, Shareef, O’Keeffe, Sean, Mbatchou, Joelle, Chazara, Olympe, Huang, Yunfeng, Kvikstad, Erika, O’Neill, Amanda, Nioi, Paul, Parker, Meg M., Petrovski, Slavé, Runz, Heiko, Szustakowski, Joseph D., Wang, Quanli, Wong, Emily, Cordova-Palomera, Aldo, Smith, Erin N., Szalma, Sandor, Zheng, Xiuwen, Esmaeeli, Sahar, Davis, Justin W., Lai, Yi-Pin, Chen, Xing, Justice, Anne E., Leader, Joseph B., Mirshahi, Tooraj, Carey, David J., Verma, Anurag, Sirugo, Giorgio, Ritchie, Marylyn D., Rader, Daniel J., Povysil, Gundula, Goldstein, David B., Kiryluk, Krzysztof, Pairo-Castineira, Erola, Rawlik, Konrad, Pasko, Dorota, Walker, Susan, Meynert, Alison, Kousathanas, Athanasios, Moutsianas, Loukas, Tenesa, Albert, Caulfield, Mark, Scott, Richard, Wilson, James F., Baillie, J. Kenneth, Butler-Laporte, Guillaume, Nakanishi, Tomoko, Lathrop, Mark, Richards, J. Brent, Jones, Marcus, Balasubramanian, Suganthi, Salerno, William, Shuldiner, Alan R., Marchini, Jonathan, Overton, John D., Habegger, Lukas, Cantor, Michael N., Reid, Jeffrey G., Baras, Aris, Abecasis, Goncalo R., Ferreira, Manuel A.R.

Source: In The American Journal of Human Genetics 1 July 2021 108(7):1350-1355

Prediction of non-genotoxic carcinogenesis in rats using changes in gene expression following acute dosing

Authors: Nioi, Paul, Pardo, Ingrid D.R., Sherratt, Philip J., Snyder, Ronald D.

Source: In Chemico-Biological Interactions 2008 172(3):206-215

A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity

Authors: Nioi, Paul, Nguyen, Truyen

Source: In Biochemical and Biophysical Research Communications 2007 362(4):816-821

Conventional Vasopressor and Vasopressor-Sparing Strategies to Counteract the Blood Pressure-Lowering Effect of Small Interfering RNA Targeting Angiotensinogen.

Authors: Uijl, Estrellita, Dien Ye, Liwei Ren, Colafella, Katrina M. Mirabito, van Veghel, Richard, Garrelds, Ingrid M., Lu, Hong S., Daugherty, Alan, Hoorn, Ewout J., Nioi, Paul, Foster, Don, Danser, A. H. Jan, Ye, Dien, Ren, Liwei, Mirabito Colafella, Katrina M

Source: Journal of the American Heart Association; 8/2/2022, Vol. 11 Issue 15, p1-14, 14p

Rare loss of function variants in the hepatokine gene INHBE protect from abdominal obesity.

Authors: Deaton, Aimee M., Dubey, Aditi, Ward, Lucas D., Dornbos, Peter, Flannick, Jason, AMP-T2D-GENES Consortium, Yee, Elaine, Ticau, Simina, Noetzli, Leila, Parker, Margaret M., Hoffing, Rachel A., Willis, Carissa, Plekan, Mollie E., Holleman, Aaron M., Hinkle, Gregory, Fitzgerald, Kevin, Vaishnaw, Akshay K., Nioi, Paul

Source: Nature Communications; 7/27/2022, Vol. 13 Issue 1, p1-12, 12p

Subject Terms: GENETIC variation, ABDOMINAL adipose tissue, ACTIVIN receptors, CORONARY disease, HEART metabolism disorders, WAIST circumference, WAIST-hip ratio