N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry

Authors: Yung-Lin Wang, Chin-Yuan Chang, Ning-Shian Hsu, I-Wen Lo, Kuan-Hung Lin, Chun-Liang Chen, Chi-Fon Chang, Zhe-Chong Wang, Yasushi Ogasawara, Tohru Dairi, Chitose Maruyama, Yoshimitsu Hamano, Tsung-Lin Li

Source: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/d86e54a33b7e49ebbea9cb2bf226eb74

β-Hydroxylation of α-amino-β-hydroxylbutanoyl-glycyluridine catalyzed by a nonheme hydroxylase ensures the maturation of caprazamycin

Authors: Saeid Malek Zadeh, Mei-Hua Chen, Zhe-Chong Wang, Elahe K. Astani, I-Wen Lo, Kuan-Hung Lin, Ning-Shian Hsu, Kamal Adhikari, Syue-Yi Lyu, Hsin-Ying Tsai, Yuma Terasawa, Miyuki Yabe, Kazuki Yamamoto, Satoshi Ichikawa, Tsung-Lin Li

Source: Communications Chemistry, Vol 5, Iss 1, Pp 1-16 (2022)

Subject Terms: Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3669

Access URL: https://doaj.org/article/22746e753b0343b29bcee91137ebd8a5

KasQ an Epimerase Primes the Biosynthesis of Aminoglycoside Antibiotic Kasugamycin and KasF/H Acetyltransferases Inactivate Its Activity

Authors: Rajesh Rattinam, R. Sidick Basha, Yung-Lin Wang, Zhe-Chong Wang, Ning-Shian Hsu, Kuan-Hung Lin, Saeid Malek Zadeh, Kamal Adhikari, Jin-Ping Lin, Tsung-Lin Li

Source: Biomedicines, Vol 10, Iss 2, p 212 (2022)

Subject Terms: kasugamycin, kasugamine, antibiotic biosynthesis, epimerase and acetyltransferase, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/10/2/212; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/c5a65eb50fca418e88f21194a2510048

Structural and biochemical interrogation on transketolase from Pichia stipitis for new functionality.

Authors: Li-Jen Hsu^1,2, Ning-Shian Hsu¹, Yung-Lin Wang¹, Chang-Jer Wu³, Tsung-Lin Li^1,2,4 tlli@gate.sinica.edu.tw

Source: PEDS: Protein Engineering, Design & Selection. Nov2016, Vol. 29 Issue 11, p513-521. 9p.

Subject Terms: *PICHIA stipitis, *TRANSKETOLASE, *CRYSTAL structure, *MUTANT proteins, *XYLOSE

Multiple Complexes of Long Aliphatic N-Acyltransferases Lead to Synthesis of 2,6-Diacylated/2-Acyl-Substituted Glycopeptide Antibiotics, Effectively Killing Vancomycin-Resistant Enterococcus.

Authors: Syue-Yi Lyu^1,2, Yu-Chen Liu¹, Chin-Yuan Chang¹, Chuen-Jiuan Huang³, Ya-Huang Chiu⁴, Chun-Man Huang^1,2, Ning-Shian Hsu¹, Kuan-Hung Lin¹, Chang-Jer Wu⁴, Ming-Daw Tsai³, Tsung-Lin Li^1,3, tlli@gate.sinica.edu.tw

Source: Journal of the American Chemical Society; 8/6/2014, Vol. 136 Issue 31, p10989-10995, 7p, 5 Diagrams, 1 Chart, 1 Graph

A Unique Flavin Mononucleotide-Linked Primary Alcohol Oxidase for Glycopeptide A40926 Maturation.

Authors: Yi-Shan Li^1,2, Jin-Yuan Ho^1,3, Chia-Chi Huang^1,3, Syue-Yi Lyu^1,2, Chun-Yen Lee^1,2, Yu-Ting Huang^1,2, Chang-Jer Wu², Hsiu-Chien Chan^1,4, Chuan-Jiuan Huang^1,2, Ning-Shian Hsu^1,2, Ming-Daw Tsai^1,5, Tsung-Lin Li¹, tlli@gate.sinica.edu.tw, T

Source: Journal of the American Chemical Society; 11/7/2007, Vol. 129 Issue 44, p13384-13385, 2p, 2 Graphs