ANGPTL4 silencing via antisense oligonucleotides reduces plasma triglycerides and glucose in mice without causing lymphadenopathy

Authors: Deng, Mingjuan, Kutrolli, Elda, Sadewasser, Anne, Michel, Sven, Joibari, Masoumeh Motamedi, Jaschinski, Frank, Olivecrona, Gunilla, Nilsson, Stefan K., Kersten, Sander

Source: In Journal of Lipid Research July 2022 63(7)

Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation

Authors: Fischer, Alexander W., Jaeckstein, Michelle Y., Gottschling, Kristina, Heine, Markus, Sass, Frederike, Mangels, Nils, Schlein, Christian, Worthmann, Anna, Bruns, Oliver T., Yuan, Yucheng, Zhu, Hua, Chen, Ou, Ittrich, Harald, Nilsson, Stefan K., Stefanicka, Patrik, Ukropec, Jozef, Balaz, Miroslav, Dong, Hua, Sun, Wenfei, Reimer, Rudolf, Scheja, Ludger, Heeren, Joerg

Source: In Cell Metabolism 2 March 2021 33(3):547-564

Liver-targeted Angptl4 silencing by antisense oligonucleotide treatment attenuates hyperlipidaemia and atherosclerosis development in APOE*3-Leiden.CETP mice.

Authors: Modder, Melanie, Panhuis, Wietse In het, Li, Mohan, Afkir, Salwa, Dorn, Alexandra L, Pronk, Amanda C M, Streefland, Trea C M, Lalai, Reshma A, Pierrou, Stefan, Nilsson, Stefan K, Olivecrona, Gunilla, Kooijman, Sander, Rensen, Patrick C N, Schönke, Milena

Source: Cardiovascular Research; Dec2024, Vol. 120 Issue 17, p2179-2190, 12p

Subject Terms: LOW density lipoproteins, BROWN adipose tissue, BLOOD lipids, LIPOPROTEIN lipase, KRA

Visualization of asymptomatic atherosclerotic disease for optimum cardiovascular prevention (VIPVIZA): a pragmatic, open-label, randomised controlled trial

Authors: Näslund, Ulf, Ng, Nawi, Lundgren, Anna, Fhärm, Eva, Grönlund, Christer, Johansson, Helene, Lindahl, Bernt, Lindahl, Bertil, Lindvall, Kristina, Nilsson, Stefan K, Nordin, Maria, Nordin, Steven, Nyman, Emma, Rocklöv, Joacim, Vanoli, Davide, Weinehall, Lars, Wennberg, Patrik, Wester, Per, Norberg, Margareta

Source: In The Lancet 12-18 January 2019 393(10167):133-142

Drug-target Mendelian randomization analysis supports lowering plasma ANGPTL3, ANGPTL4, and APOC3 levels as strategies for reducing cardiovascular disease risk.

Authors: Landfors, Fredrik, Henneman, Peter, Chorell, Elin, Nilsson, Stefan K, Kersten, Sander

Source: European Heart Journal Open; May2024, Vol. 4 Issue 3, p1-18, 18p

Subject Terms: APOLIPOPROTEIN C, CARDIOVASCULAR diseases, CARDIOVASCULAR diseases risk factors, GENOME-wide association studies, ANGIOPOIETIN-like proteins, TYPE 2 diabetes

FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues

Authors: Schlein, Christian, Talukdar, Saswata, Heine, Markus, Fischer, Alexander W., Krott, Lucia M., Nilsson, Stefan K., Brenner, Martin B., Heeren, Joerg, Scheja, Ludger

Source: In Cell Metabolism 8 March 2016 23(3):441-453

Structure–activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo

Authors: Caraballo, Rémi, Larsson, Mikael, Nilsson, Stefan K., Ericsson, Madelene, Qian, Weixing, Nguyen Tran, Nam Phuong, Kindahl, Tomas, Svensson, Richard, Saar, Valeria, Artursson, Per, Olivecrona, Gunilla, Enquist, Per-Anders, Elofsson, Mikael

Source: In European Journal of Medicinal Chemistry 20 October 2015 103:191-209

Apolipoprotein CIII links islet insulin resistance to β-cell failure in diabetes

Authors: Åvall, Karin, Ali, Yusuf, Leibiger, Ingo B., Leibiger, Barbara, Moede, Tilo, Paschen, Meike, Dicker, Andrea, Daré, Elisabetta, Köhler, Martin, Ilegems, Erwin, Abdulreda, Midhat H., Graham, Mark, Crooke, Rosanne M., Tay, Vanessa S. Y., Refai, Essam, Nilsson, Stefan K., Jacob, Stefan, Selander, Lars, Berggren, Per-Olof, Juntti-Berggren, Lisa

Source: Proceedings of the National Academy of Sciences of the United States of America, 2015 May . 112(20), E2611-E2619.

Access URL: https://www.jstor.org/stable/26462858

Structural and functional analysis of APOA5 mutations identified in patients with severe hypertriglyceridemia

Authors: Mendoza-Barberá, Elena ^*, Julve, Josep ^{*, †}, Nilsson, Stefan K. ^§, Lookene, Aivar ^**, Martín-Campos, Jesús M. ^*, Roig, Rosa ^*, Lechuga-Sancho, Alfonso M. ^††, Sloan, John H. ^§§, Fuentes-Prior, Pablo ^*, Blanco-Vaca, Francisco ^{*, †, ***}

Source: In Journal of Lipid Research March 2013 54(3):649-661

Triacylglycerol-rich lipoproteins protect lipoprotein lipase from inactivation by ANGPTL3 and ANGPTL4

Authors: Nilsson, Stefan K., Anderson, Fredrick, Ericsson, Madelene, Larsson, Mikael, Makoveichuk, Elena, Lookene, Aivar, Heeren, Joerg, Olivecrona, Gunilla

Source: In BBA - Molecular and Cell Biology of Lipids October 2012 1821(10):1370-1378

Apolipoprotein A-V; a potent triglyceride reducer

Authors: Nilsson, Stefan K., Heeren, Joerg, Olivecrona, Gunilla, Merkel, Martin

Source: In Atherosclerosis November 2011 219(1):15-21

SPINK9: A Selective, Skin-Specific Kazal-Type Serine Protease Inhibitor

Authors: Brattsand, Maria ^*, Stefansson, Kristina, Hubiche, Thomas, Nilsson, Stefan K., Egelrud, Torbjörn

Source: In Journal of Investigative Dermatology July 2009 129(7):1656-1665

Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice

Authors: Heine, Markus, Fischer, Alexander W., Schlein, Christian, Jung, Caroline, Straub, Leon G., Gottschling, Kristina, Mangels, Nils, Yuan, Yucheng, Nilsson, Stefan K., Liebscher, Gudrun, Chen, Ou, Schreiber, Renate, Zechner, Rudolf, Scheja, Ludger, Heeren, Joerg

Source: Cell metabolism. 28(4):644-655.e4

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100081560276.0x000001&indx=1&recIds=ETOCvdc_100081560276.0x000001

Endocytosis of Apolipoprotein A-V by Members of the Low Density Lipoprotein Receptor and the Vps10p Domain Receptor Families

Authors: Nilsson, Stefan K., Christensen, Stine, Raarup, Merete K., Ryan, Robert O., Nielsen, Morten S., Olivecrona, Gunilla

Source: In Journal of Biological Chemistry 19 September 2008 283(38):25920-25927

Apolipoprotein A-V Interaction with Members of the Low Density Lipoprotein Receptor Gene Family.

Authors: Nilsson, Stefan K., Lookene, Aivar, Beckstead, Jennifer A.

Source: Biochemistry; March 27 2007, Vol. 46 Issue 12, p3896-3904, 9p

Role of Endothelial Cell Lipoprotein Lipase for Brown Adipose Tissue Lipid and Glucose Handling.

Authors: Thiemann, Ellen, Schwaerzer, Gerburg K., Evangelakos, Ioannis, Fuh, Marceline M., Jaeckstein, Michelle Y., Behrens, Janina, Nilsson, Stefan K., Kumari, Manju, Scheja, Ludger, Pfeifer, Alexander, Heeren, Joerg, Heine, Markus

Source: Frontiers in Physiology; 3/29/2022, Vol. 13, p1-11, 11p

Subject Terms: LIPOPROTEIN lipase, BROWN adipose tissue, ENDOTHELIAL cells, LIPID metabolism, LIPIDS

Time course of decompensation after angiotensin II and high-salt diet in Balb/CJ mice suggests pulmonary hypertension-induced cardiorenal syndrome.

Authors: Becirovic-Agic, Mediha, Jönsson, Sofia, Tveitarås, Maria K., Skogstrand, Trude, Karlsen, Tine V., Lidén, Åsa, Leh, Sabine, Ericsson, Madelene, Nilsson, Stefan K., Reed, Rolf K., Hultström, Michael

Source: American Journal of Physiology: Regulatory, Integrative & Comparative Physiology; May2019, Vol. 316 Issue 5, pR563-R570, 8p

Subject Terms: ANGIOTENSIN II, HIGH-salt diet, EDEMA, HEART failure, SYSTOLIC blood pressure, VASCULAR resistance, CARDIAC output, CARDIO-renal syndrome

Angiotensin II and salt-induced decompensation in Balb/CJ mice is aggravated by fluid retention related to low oxidative stress.

Authors: Jönsson, Sofia, Becirovic-Agic, Mediha, Isackson, Henrik, Tveitarås, Maria K., Skogstrand, Trude, Narfström, Fredrik, Karlsen, Tine V., Lidén, Åsa, Leh, Sabine, Ericsson, Madelene, Nilsson, Stefan K., Reed, Rolf K., Hultström, Michael

Source: American Journal of Physiology: Renal Physiology; May2019, Vol. 316 Issue 5, pF914-F933, 20p

Subject Terms: ANGIOTENSIN II, OXIDATIVE stress, GLUTATHIONE transferase, MICE, GLOMERULAR filtration rate

Identification of a small molecule that stabilizes lipoprotein lipase in vitro and lowers triglycerides in vivo

Authors: Larsson, Mikael, Caraballo, Rémi, Ericsson, Madelene, Lookene, Aivar, Enquist, Per-Anders, Elofsson, Mikael, Nilsson, Stefan K., Olivecrona, Gunilla

Source: In Biochemical and Biophysical Research Communications 25 July 2014 450(2):1063-1069

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