OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids

Authors: Evgeniya Mickols, Alina Meyer, Niklas Handin, Malin Stüwe, Jens Eriksson, Jakob Rudfeldt, Kristin Blom, Mårten Fryknäs, Mikael E. Sellin, Volker M. Lauschke, Maria Karlgren, Per Artursson

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Subject Terms: Hepatocyte, Liver, Uptake, ASP+, OCT1, Drug transport, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/14b6909630ac42c4af6b2cef75b8a422

Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates

Authors: Sook Wah Yee, Luis Ferrández-Peral, Pol Alentorn-Moron, Claudia Fontsere, Merve Ceylan, Megan L. Koleske, Niklas Handin, Virginia M. Artegoitia, Giovanni Lara, Huan-Chieh Chien, Xujia Zhou, Jacques Dainat, Arthur Zalevsky, Andrej Sali, Colin M. Brand, Finn D. Wolfreys, Jia Yang, Jason E. Gestwicki, John A. Capra, Per Artursson, John W. Newman, Tomàs Marquès-Bonet, Kathleen M. Giacomini

Source: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/a48ee6cda4514840ac818713e505c1b2

Proteome deconvolution of liver biopsies reveals hepatic cell composition as an important marker of fibrosis

Authors: Niklas Handin, Di Yuan, Magnus Ölander, Christine Wegler, Cecilia Karlsson, Rasmus Jansson-Löfmark, Jøran Hjelmesæth, Anders Åsberg, Volker M. Lauschke, Per Artursson

Source: Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 4361-4369 (2023)

Subject Terms: Fibrosis, Proteomics, Biomarker, Liver, Deconvolution, Computational Methods, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2001037023003136; https://doaj.org/toc/2001-0370

Access URL: https://doaj.org/article/398158ee84d44ea5b316e13587231791

Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis

Authors: Snehangshu Kundu, Muhammad Akhtar Ali, Niklas Handin, Louis P. Conway, Veronica Rendo, Per Artursson, Liqun He, Daniel Globisch, Tobias Sjöblom

Source: Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-19 (2021)

Subject Terms: Ras pathway, KRAS, BRAF, Colorectal cancer, Isogenic cell models, Integrative -omics analysis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/c6b41f70605140fe8ae77d5c5efb4251

Conditions for maintenance of hepatocyte differentiation and function in 3D cultures

Authors: Niklas Handin, Evgeniya Mickols, Magnus Ölander, Jakob Rudfeldt, Kristin Blom, Frida Nyberg, Wojciech Senkowski, Jozef Urdzik, Varun Maturi, Mårten Fryknäs, Per Artursson

Source: iScience, Vol 24, Iss 11, Pp 103235- (2021)

Subject Terms: Biological sciences, Proteomics, Methodology in biological sciences, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004221012037; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/6809c7fc5e7b425199479cb1e3e85b46

Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells

Authors: Snehangshu Kundu, Muhammad Akhtar Ali, Niklas Handin, Narendra Padhan, Jimmy Larsson, Maria Karoutsou, Kenneth Ban, Jacek R. Wiśniewski, Per Artursson, Liqun He, Mats Hellström, Tobias Sjöblom

Source: Genome Medicine, Vol 10, Iss 1, Pp 1-13 (2018)

Subject Terms: Forward genetics, piggyBac transposon, Colorectal cancer, Ras pathway, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13073-017-0511-4; https://doaj.org/toc/1756-994X

Access URL: https://doaj.org/article/e59e8395c9b944bfa4183f634a16c9e7