Mosaic HIV-1 vaccine regimen in southern African women (Imbokodo/HVTN 705/HPX2008): a randomised, double-blind, placebo-controlled, phase 2b trial

Authors: Allagappen, Jon, Andriesen, Jessica, Ayres, Alison, Bekker, Linda-Gail, Borremans, Caroline, Brumskine, William, Chilengi, Roma, Dubula, Thozama, Garrett, Nigel, Gelderblom, Huub, Gill, Katherine, Hoosain, Zaheer, Hosseinipour, Mina, Hutter, Julia, Inambao, Mubiana, Innes, Craig, Kilembe, William, Kotze, Philippus, Kotze, Sheena, Laher, Fatima, Laszlo, Imre, Lazarus, Erica, Malahleha, Mookho, Mathebula, Matsontso, Matoga, Mitch, McClennen, Rachael, Mda, Pamela, Meerts, Peter, Naicker, Vimla, Naidoo, Logashvari, Philip, Tricia, Pitsi, Annah, Scheppler, Lorenz, Sopher, Carrie, Takuva, Simbarashe G., Viegas, Edna, Weijtens, Mo, Yuan, Olive, Gray, Glenda E ^*, Mngadi, Kathryn, Lavreys, Ludo, Nijs, Steven, Gilbert, Peter B, Hural, John, Hyrien, Ollivier, Juraska, Michal, Luedtke, Alex, Mann, Philipp, McElrath, M Juliana, Odhiambo, Jackline A, Stieh, Daniel J, van Duijn, Janine, Takalani, Azwidihwi N, Willems, Wouter, Tapley, Asa, Tomaras, Georgia D, Van Hoof, Johan, Schuitemaker, Hanneke, Swann, Edith, Barouch, Dan H, Kublin, James G, Corey, Lawrence, Pau, Maria G, Buchbinder, Susan, Tomaka, Frank

Source: In The Lancet Infectious Diseases November 2024 24(11):1201-1212

Immune correlates analysis of the Imbokodo (HVTN 705/HPX2008) efficacy trial of a mosaic HIV-1 vaccine regimen evaluated in Southern African people assigned female sex at birth: a two-phase case-control study

Authors: Allagappen, Jon, Andriesen, Jessica, Ayres, Alison, Baral, Saman, Bekker, Linda-Gail, Besethi, Asiphe, Borremans, Caroline, Braams, Esmee, Brackett, Caroline, Brumskine, William, Chilengi, Roma, Choi, Rachel, Dubula, Thozama, Dumas, Jaiden Seongmi, Dunn, Brooke, Etikala, Radhika, Euler, Zelda, Everett, Sarah, Garrett, Nigel, Gelderblom, Huub, Gill, Katherine, Gillespie, Kevin, Goedhart, Dimitri, Goosmann, Erik, Grant, Shannon, Hands, Ellie, Haynes, Barton, Herringer, Bronwill, Hoosain, Zaheer, Hosseinipour, Mina, Hunidzarira, Portia, Hutter, Julia, Inambao, Mubiana, Innes, Craig, Keyes, Taylor, Kilembe, William, Kotze, Philippus, Kotze, Sheena, Laher, Fatima, Laszlo, Imre, Lazarus, Erica, Liao, Hua-Xin, Lin, Yong, Lu, Helen, Lucas, Judith, Malahleha, Mookho, McNair, Tara, Meerts, Peter, Mgaga, Zinhle, Montlha, Mahlodi, Mosito, Boitumelo, Moultrie, Andrew, Mudrak, Sarah, Oriol-Mathieu, Valérie, Sarzotti-Kelsoe, Marcella, Mathebula, Matson Tso, Matoga, Mitch, McClennen, Rachael, Mda, Pamela, Naicker, Vimla, Naidoo, Logashvari, Okkers, Cindy-Ann, Omarjee, Saleha, Pasmans, Hella, Philip, Tricia, Pinter, Abraham, Pitsi, Annah, Ramos, Ornelia, Randhawa, April, Roels, Sanne, Rohith, Shamiska, Rutten, Lucy, Sadoff, Jerald, Salinas, Gabriela, Salzgeber, Yvonne, Scheppler, Lorenz, Schwedhelm, Katharine, Schuller, Nicolette, Sharak, Angelina, Stanfield-Oakley, Sherry, Sopher, Carrie, Tafatatha, Terence, Takuva, Simbarashe G., Tang, Chan, Vandebosch, An, Viegas, Edna, Voillet, Valentin, Wegmann, Frank, Weijtens, Mo, Wilcox, Stephany, Williams, Anthony, Yu, Chenchen, Yu, Pei-Chun, Yuan, Olive, Zhang, Xuehan, Kenny, Avi, van Duijn, Janine, Dintwe, One, Heptinstall, Jack, Burnham, Randy, Sawant, Sheetal, Zhang, Lu, Mielke, Dieter, Khuzwayo, Sharon, Omar, Faatima Laher, Goodman, Derrick, Fong, Youyi, Benkeser, David, Zou, Rodger, Hural, John, Hyrien, Ollivier, Juraska, Michal, Luedtke, Alex, van der Laan, Lars, Giorgi, Elena E., Magaret, Craig, Carpp, Lindsay N., Pattacini, Laura, van de Kerkhof, Tom, Korber, Bette, Willems, Wouter, Fisher, Leigh H., Schuitemaker, Hanneke, Swann, Edith, Kublin, James G., Pau, Maria G., Buchbinder, Susan, Tomaka, Frank, Nijs, Steven, Lavreys, Ludo, Gelderblom, Huub C., Corey, Lawrence, Mngadi, Kathryn, Gray, Glenda E., Borducchi, Erica, Hendriks, Jenny, Seaton, Kelly E., Zolla-Pazner, Susan, Barouch, Dan H., Ferrari, Guido, De Rosa, Stephen C., McElrath, M Juliana, Andersen-Nissen, Erica, Stieh, Daniel J., Tomaras, Georgia D., Gilbert, Peter B.

Source: In eBioMedicine October 2024 108

Safety and immunogenicity of two heterologous HIV vaccine regimens in healthy, HIV-uninfected adults (TRAVERSE): a randomised, parallel-group, placebo-controlled, double-blind, phase 1/2a study

Authors: Ake, Julie A., Buchbinder, Susan, Buleza, Karen, Cohen, Kristen W., Crowell, Trevor A., Euler, Zelda, Frank, Ian, Goedhart, Dimitri, Keefer, Michael, Kelly, Colleen, Mayer, Ken, Nkolola, Joseph, Peter, Lauren, Robb, Merlin L., Rouphael, Nadine, Scheppler, Lorenz, Sobieszczyk, Magda, Van Tieu, Hong, Baden, Lindsey R ^{*, †}, Stieh, Daniel J ^†, Sarnecki, Michal, Walsh, Stephen R, Tomaras, Georgia D, Kublin, James G, McElrath, M Juliana, Alter, Galit, Ferrari, Guido, Montefiori, David, Mann, Philipp, Nijs, Steven, Callewaert, Katleen, Goepfert, Paul, Edupuganti, Srilatha, Karita, Etienne, Langedijk, Johannes P, Wegmann, Frank, Corey, Lawrence, Pau, Maria G, Barouch, Dan H, Schuitemaker, Hanneke, Tomaka, Frank

Source: In The Lancet HIV October 2020 7(10):e688-e698

Comparison of shortened mosaic HIV-1 vaccine schedules: a randomised, double-blind, placebo-controlled phase 1 trial (IPCAVD010/HPX1002) and a preclinical study in rhesus monkeys (NHP 17–22)

Authors: Stephenson, Kathryn E, Wegmann, Frank, Tomaka, Frank, Walsh, Stephen R, Tan, C Sabrina, Lavreys, Ludo, Ansel, Jessica L, Kanjilal, Diane G, Jaegle, Kate, Nkolola, Joseph P, Peter, Lauren, Fogel, Rachel, Bradshaw, Connor, Tyler, Anna, Makoni, Tatenda, Howe, Lisa, Quijada, Darla, Chandrashekar, Abishek, Bondzie, Esther A, Borducchi, Erica N, Yanosick, Katherine E, Hendriks, Jenny, Nijs, Steven, Truyers, Carla, Tolboom, Jeroen, Zahn, Roland C, Seaman, Michael S, Alter, Galit, Stieh, Daniel J, Pau, Maria Grazia, Schuitemaker, Hanneke, Barouch, Dan H ^*

Source: In The Lancet HIV June 2020 7(6):e410-e421

First-in-Human Randomized, Controlled Trial of Mosaic HIV-1 Immunogens Delivered via a Modified Vaccinia Ankara Vector

Authors: IPCAVD006/RV380/HIV-V-A002 Study Group, Baden, Lindsey R., Walsh, Stephen R., Seaman, Michael S., Cohen, Yehuda Z., Johnson, Jennifer A., Licona, J. Humberto, Filter, Rachel D., Kleinjan, Jane A., Gothing, Jon A., Jennings, Julia, Peter, Lauren, Nkolola, Joseph, Abbink, Peter, Borducchi, Erica N., Kirilova, Marinela, Stephenson, Kathryn E., Pegu, Poonam, Eller, Michael A., Trinh, Hung V., Rao, Mangala, Ake, Julie A., Sarnecki, Michal, Nijs, Steven, Callewaert, Katleen, Schuitemaker, Hanneke, Hendriks, Jenny, Pau, Maria G., Tomaka, Frank, Korber, Bette T., Alter, Galit, Dolin, Raphael, Earl, Patricia L., Moss, Bernard, Michael, Nelson L., Robb, Merlin L., Barouch, Dan H.

Source: The Journal of Infectious Diseases, 2018 Aug . 218(4), 633-644.

Access URL: https://www.jstor.org/stable/26495603

Evaluation of a mosaic HIV-1 vaccine in a multicentre, randomised, double-blind, placebo-controlled, phase 1/2a clinical trial (APPROACH) and in rhesus monkeys (NHP 13-19)

Authors: Barouch, Dan H, Tomaka, Frank L, Wegmann, Frank, Stieh, Daniel J, Alter, Galit, Robb, Merlin L, Michael, Nelson L, Peter, Lauren, Nkolola, Joseph P, Borducchi, Erica N, Chandrashekar, Abishek, Jetton, David, Stephenson, Kathryn E, Li, Wenjun, Korber, Bette, Tomaras, Georgia D, Montefiori, David C, Gray, Glenda, Frahm, Nicole, McElrath, M Juliana, Baden, Lindsey, Johnson, Jennifer, Hutter, Julia, Swann, Edith, Karita, Etienne, Kibuuka, Hannah, Mpendo, Juliet, Garrett, Nigel, Mngadi, Kathy, Chinyenze, Kundai, Priddy, Frances, Lazarus, Erica, Laher, Fatima, Nitayapan, Sorachai, Pitisuttithum, Punnee, Bart, Stephan, Campbell, Thomas, Feldman, Robert, Lucksinger, Gregg, Borremans, Caroline, Callewaert, Katleen, Roten, Raphaele, Sadoff, Jerald, Scheppler, Lorenz, Weijtens, Mo, Feddes-de Boer, Karin, van Manen, Daniëlle, Vreugdenhil, Jessica, Zahn, Roland, Lavreys, Ludo, Nijs, Steven, Tolboom, Jeroen, Hendriks, Jenny, Euler, Zelda, Pau, Maria G, Schuitemaker, Hanneke

Source: In The Lancet 21-27 July 2018 392(10143):232-243

Safety and Immunogenicity of Ad26-vectored HIV Vaccine with Mosaic Immunogens and a Novel Mosaic Envelope Protein in HIV-uninfected Adults: A Phase 1/2a Study.

Authors: Stieh, Daniel J, Barouch, Dan H, Comeaux, Christy, Sarnecki, Michal, Stephenson, Kathryn E, Walsh, Stephen R, Sawant, Sheetal, Heptinstall, Jack, Tomaras, Georgia D, Kublin, James G, McElrath, M Juliana, Cohen, Kristen W, Rosa, Stephen C De, Alter, Galit, Ferrari, Guido, Montefiori, David, Mann, Philipp, Nijs, Steven, Callewaert, Katleen, Goepfert, Paul A

Source: Journal of Infectious Diseases; 4/15/2023, Vol. 227 Issue 8, p939-950, 12p

Subject Terms: AIDS vaccines, IMMUNE response, C++, CLINICAL trial registries, HIV infections

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