3D printing as a solution for tablet splitting challenges dedicated to the Chagas disease treatment

Authors: Bedogni, Giselle R. ^a, Lima, Ana Luiza ^b, Gross, Idejan P. ^b, Gratieri, Tais ^b, Gelfuso, Guilherme M. ^b, Lamas, María C. ^{a, c}, Cunha-Filho, Marcilio ^b, Salomon, Claudio J. ^{a, c, ⁎}

Source: In Journal of Drug Delivery Science and Technology April 2025 106

Impact of antiparasitic therapy on cardiovascular outcomes in chronic Chagas disease. A systematic review and meta-analysisResearch in context

Authors: Anis Rassi, Jr, Alyssa Grimshaw, Ashwin Sarwal, Ranjit Sah, Sangam Shah, Nelson I. Agudelo Higuita, Fabio Mahamed Rassi, Michaele Francesco Corbisiero, Hannah M. Kyllo, Jordan Stellern, Samantha Kaplan, Luis A. Marcos, Edgar A. Ramírez-García, Martin Casapia, Peter Hotez, Maria Elena Bottazzi, Shital Patel, Carlos Franco-Paredes, José Antonio Marin-Neto, Andrés F. Henao-Martínez

Source: EClinicalMedicine, Vol 79, Iss , Pp 102972- (2025)

Subject Terms: Chagas disease, Chagas cardiomyopathy, Trypanosoma cruzi, Antitrypanosomal therapy, Benznidazole, Nifurtimox, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589537024005510; https://doaj.org/toc/2589-5370

Access URL: https://doaj.org/article/7eb3c7fa6cb046c6ac461bf64bb1565f

Concomitant diagnosis of Trypanosoma cruzi and HIV in a patient with neurologic manifestations: A case report

Authors: Emmanuel Molina Solano, Mauricio Mora Díaz, Stephanie Montoya Madriz, Mauricio Lizano Calvo, Lissette Retana Moreira

Source: Brazilian Journal of Infectious Diseases, Vol 28, Iss 6, Pp 104478- (2024)

Subject Terms: Trypanosoma cruzi, HIV, neurologic, nifurtimox, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S141386702400761X; https://doaj.org/toc/1413-8670

Access URL: https://doaj.org/article/d3ac4a3fb8ad4377ab026482f8bab99f

First report of an acute case of Chagas disease in the municipality of Miraflores, Guaviare, Colombia

Authors: José Ziadé Benítez, Diana Cedeño Díaz, Luz Alba Colorado, Laureano Mosquera Murillo, María Trinidad Orozco, Sandra Vallecilla, Julio Cesar Padilla, Mario J. Olivera

Source: Revista Peruana de Medicina Experimental y Salud Pública, Pp 203-8 (2024)

Subject Terms: benznidazole, case reports, chagas disease, nifurtimox, trypanosoma cruzi, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/13271; https://doaj.org/toc/1726-4634; https://doaj.org/toc/1726-4642

Access URL: https://doaj.org/article/21767f5259b34e18aad2fd95c1fe78ed

Development and Characterization of Innovative Nifurtimox Formulations as Therapeutic Alternative for Chagas Disease

Authors: Ana Lia Mazzeti, Karolina Ribeiro Gonçalves, Patrícia Ferreira Boasquivis, Maria Terezinha Bahia, Vanessa Carla Furtado Mosqueira

Source: Tropical Medicine and Infectious Disease, Vol 10, Iss 2, p 50 (2025)

Subject Terms: trypanosomiasis, nifurtimox, self-emulsifying drug delivery systems, poly(ε-caprolactone), implants, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2414-6366/10/2/50; https://doaj.org/toc/2414-6366

Access URL: https://doaj.org/article/481e0c042f364f86ae9e60c9880d1827

3D-Printed Tablets of Nifurtimox: In Vitro and In Vivo Anti-Trypanosoma cruzi Studies

Authors: Giselle R. Bedogni, Ana Luiza Lima, Idejan P. Gross, Tatiana Prata Menezes, Andre Talvani, Marcilio Cunha-Filho, Claudio J. Salomon

Source: Pharmaceutics, Vol 17, Iss 1, p 80 (2025)

Subject Terms: nifurtimox, film casting, hot melt extrusion, 3D printing, fused deposition modeling, anti-T. cruzi activity, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/17/1/80; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/f9a2f7e8b5f8427b8a42009c132d6bc8

Exploring Quinazoline Nitro-Derivatives as Potential Antichagasic Agents: Synthesis and In Vitro Evaluation

Authors: Citlali Vázquez, Audifás-Salvador Matus-Meza, Oswaldo Nuñez-Moreno, Brenda Michelle Barbosa-Sánchez, Victor Manuel Farías-Gutiérrez, Mariana Mendoza-Conde, Francisco Hernández-Luis, Emma Saavedra

Source: Molecules, Vol 29, Iss 18, p 4501 (2024)

Subject Terms: antiprotozoal agents, benznidazol, Chagas disease, nifurtimox, quinazoline, quinazoline-2,4-6-triamine, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/29/18/4501; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/e488dde8a68c43ef856b10cb9a865e79

Unveiling challenges in real-time PCR strategies for detecting treatment failure: observations from clinical trials on chronic Chagas disease

Authors: Alejandro G. Schijman

Source: Frontiers in Parasitology, Vol 2 (2023)

Subject Terms: polymerase chain reaction, Chagas disease, drug resistance, benznidazole, nifurtimox, dormancy, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fpara.2023.1260224/full; https://doaj.org/toc/2813-2424

Access URL: https://doaj.org/article/16a54e34577f44b6ae27d90238022087

Chagas disease treatment efficacy markers: experiences from a Phase III study with nifurtimox in children

Authors: Ulrike Grossmann, Maria-Luisa Rodriguez

Source: Frontiers in Parasitology, Vol 2 (2023)

Subject Terms: Chagas disease, pediatric patients, nifurtimox, ELISA, IHA, qPCR, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fpara.2023.1229467/full; https://doaj.org/toc/2813-2424

Access URL: https://doaj.org/article/581482a7b8ea4459b698dcde3910b82f

Critical analysis of Chagas disease treatment in different countries

Authors: Mendes, Fernanda de Souza Nogueira Sardinha, Perez-Molina, Jose Antonio, Angheben, Andrea, Meymandi, Sheba K, Sosa-Estani, Sergio, Molina, Israel

Source: Memórias do Instituto Oswaldo Cruz. January 2022 117

Subject Terms: Chagas disease, treatment, benznidazole, nifurtimox

File Description: text/html

Access URL: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762022000100212

Clinical, electrocardiographic and echocardiographic evolution of chronic Chagas disease treated with nifurtimox on prolonged follow‐up in Chile: observational study

Authors: Werner Apt, Marcelo Llancaqueo, Inés Zulantay, Mauricio Canals, Sergio Kara, Arturo Arribada, Gabriela Muñoz, Gabriela Martínez

Source: Journal of Global Antimicrobial Resistance, Vol 27, Iss , Pp 160-166 (2021)

Subject Terms: Chronic Chagas disease, Electrocardiogram, Echocardiogram, Nifurtimox, Cardiomyopathy, Microbiology, QR1-502

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213716521002046; https://doaj.org/toc/2213-7165

Access URL: https://doaj.org/article/c8f027428f144d7d959648eb423d1e46

Sensibilidad in vitro a benznidazol, nifurtimox y posaconazol de cepas de Trypanosoma cruzi de Paraguay

Authors: Nidia Acosta, Gloria Yaluff, Elsa López, Christopher Bobadilla, Analía Ramírez, Ivana Fernández, Patricia Escobar

Source: Biomédica: revista del Instituto Nacional de Salud, Vol 40, Iss 4, Pp 749-763 (2020)

Subject Terms: trypanosoma cruzi, enfermedad de chagas, nitroimidazoles, nifurtimox, triazoles, paraguay, Medicine, Arctic medicine. Tropical medicine, RC955-962

File Description: electronic resource

Relation: https://revistabiomedica.org/index.php/biomedica/article/view/5187; https://doaj.org/toc/0120-4157

Access URL: https://doaj.org/article/5f691d7fe7e4485f91e7aebd537de03e

Trypanosoma cruzi Mitochondrial Peroxiredoxin Promotes Infectivity in Macrophages and Attenuates Nifurtimox Toxicity

Authors: Gabriela Specker, Damián Estrada, Rafael Radi, Lucía Piacenza

Source: Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)

Subject Terms: T. cruzi, nifurtimox, mitochondrial peroxiredoxin, macrophage infection, holdase and peroxidase activities, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcimb.2022.749476/full; https://doaj.org/toc/2235-2988

Access URL: https://doaj.org/article/17a9eca0ed4a46ecbc643bcdf1ca83fc

Nifurtimox versus benznidazole or placebo for asymptomatic Trypanosoma cruzi infection (Equivalence of Usual Interventions for Trypanosomiasis - EQUITY): study protocol for a randomised controlled trial

Authors: Juan Carlos Villar, Víctor Mauricio Herrera, Juan Guillermo Pérez Carreño, Eliana Váquiro Herrera, Yeny Zulay Castellanos Domínguez, Skarlet Marcell Vásquez, Zulma Milena Cucunubá, Nilda Graciela Prado, Yolanda Hernández

Source: Trials, Vol 20, Iss 1, Pp 1-10 (2019)

Subject Terms: Nifurtimox, Benznidazole, Trypanosoma cruzi, Chagas disese, Randomized controlled trial, Medicine (General), R5-920

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13063-019-3423-3; https://doaj.org/toc/1745-6215

Access URL: https://doaj.org/article/c33cd2861e594b3fbbba6b1c8570339a

Chagas Disease

Authors: Kaminstein David, Mertz Leslie

Source: Gale Encyclopedia of Public Health.

Availability: https://search.credoreference.com/content/entry/galegph/chagas_disease/0

Systematic Review and Meta-Analysis on Human African Trypanocide Resistance

Authors: Keneth Iceland Kasozi, Ewan Thomas MacLeod, Susan Christina Welburn

Source: Pathogens, Vol 11, Iss 10, p 1100 (2022)

Subject Terms: human African trypanosomiasis, trypanosomes, drug resistance, pentamidines, nifurtimox/eflornithine combination therapy, fexinidazole, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-0817/11/10/1100; https://doaj.org/toc/2076-0817

Access URL: https://doaj.org/article/ca6e561e031e402cac88c2efc052ced6

Solid Nanomedicines of Nifurtimox and Benznidazole for the Oral Treatment of Chagas Disease

Authors: Miriam Rolon, Eustine Hanna, Celeste Vega, Cathia Coronel, Maria Auxiliadora Dea-Ayuela, Dolores R. Serrano, Aikaterini Lalatsa

Source: Pharmaceutics, Vol 14, Iss 9, p 1822 (2022)

Subject Terms: chagas disease, trypanosomiasis, self-nanoemulsifying drug delivery systems (SNEDDS), nifurtimox, benznidazole, silicon dioxide (silica), Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/14/9/1822; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/5d50965395e04135a8860b6f9af42f02

Nifurtimox response of Trypanosoma cruzi isolates from an outbreak of Chagas disease in Caracas, Venezuela

Authors: Arturo Munoz-Calderon, Zoraida Díaz-Bello, José Luis Ramírez, Oscar Noya, Belkisyolé Alarcón de Noya

Source: Journal of Vector Borne Diseases, Vol 56, Iss 3, Pp 237-243 (2019)

Subject Terms: caracas, chagas disease, nifurtimox, oral transmission, resistance, susceptibility assay, trypanosoma cruzi, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://www.jvbd.org/article.asp?issn=0972-9062;year=2019;volume=56;issue=3;spage=237;epage=243;aulast=Munoz-Calderon; https://doaj.org/toc/0972-9062

Access URL: https://doaj.org/article/c85784d1697942689746cba494dff666

Dipyridamole potentiated the trypanocidal effect of nifurtimox and improved the cardiac function in NMRI mice with acute chagasic myocarditis

Authors: Santeliz, Sonia, Caicedo, Peter, Giraldo, Elidiosmar, Alvarez, Carmen, Yustiz, María-Daniela, Rodríguez-Bonfante, Claudina, Bonfante-Rodríguez, Romina, Bonfante-Cabarcas, Rafael

Source: Memórias do Instituto Oswaldo Cruz. September 2017 112(9)

Subject Terms: Chagas disease, nifurtimox, dipyridamole, Trypanosoma cruzi, treatment

File Description: text/html

Access URL: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017000900596

A multicentre, randomised, non-inferiority clinical trial comparing a nifurtimox-eflornithine combination to standard eflornithine monotherapy for late stage Trypanosoma brucei gambiense human African trypanosomiasis in Uganda

Authors: Freddie Kansiime, Seraphine Adibaku, Charles Wamboga, Franklin Idi, Charles Drago Kato, Lawrence Yamuah, Michel Vaillant, Deborah Kioy, Piero Olliaro, Enock Matovu

Source: Parasites & Vectors, Vol 11, Iss 1, Pp 1-11 (2018)

Subject Terms: Human African trypanosomiasis (HAT), Meningo-encephalitic stage, Second-stage HAT, Nifurtimox-eflornithine combination treatment (NECT), Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13071-018-2634-x; https://doaj.org/toc/1756-3305

Access URL: https://doaj.org/article/33f300c5f0b040eba2e37e2a412bc704