Molecular basis of resistance to proteasome inhibitors in hematological malignancies

Authors: Niewerth, Denise, Jansen, Gerrit, Assaraf, Yehuda G., Zweegman, Sonja, Kaspers, Gertjan J.L., Cloos, Jacqueline

Source: In Drug Resistance Updates January 2015 18:18-35

Antileukemic Activity and Mechanism of Drug Resistance to the Marine Salinispora tropica Proteasome Inhibitor Salinosporamide A (Marizomib)

Authors: Niewerth, Denise, Jansen, Gerrit, Riethoff, Lesley F.V., van Meerloo, Johan, Kale, Andrew J., Moore, Bradley S., Assaraf, Yehuda G., Anderl, Janet L., Zweegman, Sonja, Kaspers, Gertjan J.L., Cloos, Jacqueline ^*

Source: In Molecular Pharmacology July 2014 86(1):12-19

Anti-leukemic activity and mechanisms underlying resistance to the novel immunoproteasome inhibitor PR-924

Authors: Niewerth, Denise, van Meerloo, Johan, Jansen, Gerrit, Assaraf, Yehuda G., Hendrickx, Tessa C., Kirk, Christopher J., Anderl, Janet L., Zweegman, Sonja, Kaspers, Gertjan J.L., Cloos, Jacqueline

Source: In Biochemical Pharmacology 1 May 2014 89(1):43-51

Proteasome inhibitors in acute leukemia

Authors: Niewerth, Denise, Dingjan, Ilse, Cloos, Jacqueline, Jansen, Gerrit, Kaspers, Gertjan

Source: Expert review of anticancer therapy. 13(3):327-337

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100106670761.0x000001&indx=1&recIds=ETOCvdc_100106670761.0x000001

A review on allogeneic stem cell transplantation for newly diagnosed pediatric acute myeloid leukemia

Authors: Niewerth, Denise, Creutzig, Ursula, Bierings, Marc B., Kaspers, Gertjan J.L. ^*

Source: In Blood 30 September 2010 116(13):2205-2214

Proteasome subunit expression analysis and chemosensitivity in relapsed paediatric acute leukaemia patients receiving bortezomib-containing chemotherapy.

Authors: Niewerth, Denise¹, Kaspers, Gertjan J. L.¹, van Meerloo, Johan^1,2, Cloos, Jacqueline^1,2, Jansen, Gerrit³, Zweegman, Sonja², Jenkins, Gaye⁴, Horton, Terzah M.⁴, Whitlock, James A.⁵, Hunger, Stephen P.⁶, Xiaomin Lu⁷, Alonzo, Todd A.⁸, van de Ven, Peter M.⁹

Source: Journal of Hematology & Oncology. 9/6/2016, Vol. 9, p1-9. 9p. 2 Charts, 4 Graphs.

Subject Terms: *LYMPHOCYTIC leukemia, *ACUTE leukemia, *BORTEZOMIB, *PROTEASOME inhibitors, *MYELOID leukemia

Overcoming bortezomib resistance in human B cells by anti-CD20/rituximab-mediated complement-dependent cytotoxicity and epoxyketone-based irreversible proteasome inhibitors

Authors: Verbrugge Sue Ellen, Al Marjon, Assaraf Yehuda G, Niewerth Denise, van Meerloo Johan, Cloos Jacqueline, van der Veer Michael, Scheffer George L, Peters Godefridus J, Chan Elena T, Anderl Janet L, Kirk Christopher J, Zweegman Sonja, Dijkmans Ben AC, Lems Willem F, Scheper Rik J, de Gruijl Tanja D, Jansen Gerrit

Source: Experimental Hematology & Oncology, Vol 2, Iss 1, p 2 (2013)

Subject Terms: Proteasome inhibitors, Anti-CD20/rituximab therapy, B cells, Autoimmune disorders, Resistance, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.ehoonline.org/content/2/1/2; https://doaj.org/toc/2162-3619

Access URL: https://doaj.org/article/a6fa0811b477498ca69c0bc081ec176b

Interferon-gamma-induced upregulation of immunoproteasome subunit assembly overcomes bortezomib resistance in human hematological cell lines.

Authors: Niewerth, Denise¹ d.niewerth@vumc.nl, Kaspers, Gertjan J. L.¹ gjl.kaspers@vumc.nl, Assaraf, Yehuda G.² assaraf@technion.ac.il, van Meerloo, Johan^1,3 j.vanmeerloo@vumc.nl, Kirk, Christopher J.⁴ ckirk@onyx.com, Anderl, Janet⁴ janderl@onyx.com, Blank, Jonathan L.⁵ jonathan.blank@mpi.com, Van de Ven, Peter M.⁶ p.vandeven@vumc.nl, Zweegman, Sonja³ s.zweegman@vumc.nl, Jansen, Gerrit⁷ g.jansen@vumc.nl, Cloos, Jacqueline^1,3 j.cloos@vumc.nl

Source: Journal of Hematology & Oncology. 2014, Vol. 7 Issue 1, p1-28. 28p.

Subject Terms: *INTERLEUKIN-18, *BORTEZOMIB, *ANTINEOPLASTIC agents, *INTERFERONS, *GLYCOPROTEINS, *CELL lines

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Marcks Marks Resistance to Proteasome Inhibitors: Exocytosis of Polyubiquitinated Proteins in Bortezomib-Resistant Leukemia Cells

Authors: Franke, Niels ^*, Kaspers, Gertjan J.L., Assaraf, Yehuda G ^*, Van Meerloo, Johan ^*, Niewerth, Denise ^*, Horton, Terzah M., Chng, Wee Joo, Bi, Chonglei ^*, Menezes, Rene X. ^*, Musters, Renée J. ^*, Poddighe, Pino J. ^*, Kessler, Floortje ^*, Smeets, Serge ^*, Ylstra, Bauke ^*, Zweegman, Sonja, Jansen, Gerrit ^*, Cloos, Jacqueline ^*

Source: In Blood 3 December 2015 126(23):3712-3712

Phase II Study on Bortezomib (BTZ) in Multiple Relapsed or Refractory Pediatric Acute Lymphoblastic Leukemia (rALL): High Response Rate with a Modestly Intensive Regimen Including BTZ, Not Related to Pharmacokinetics

Authors: Kaspers, Gertjan J.L., Niewerth, Denise ^*, Wilhelm, Bram ^*, Ramnarain, Satianand ^*, Berkhof, Hans ^*, De Haas, Valerie, Mathôt, Ron A.A. ^*, Attarbaschi, Andishe ^*, Baruchel, Andre, de Bont, Eveline S., Fagioli, Franca ^*, Rossig, Claudia, Klingebiel, Thomas, De Moerloose, Barbara ^*, Nelken, Brigitte ^*, Palumbo, Giuseppe ^*, Reinhardt, Dirk, Rohrlich, Pierre Simon ^*, Simon, Pauline ^*, Stackelberg, Arend ^*, Zwaan, C. Michel

Source: In Blood 3 December 2015 126(23):2501-2501

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Pharmacodynamic monitoring of (immuno)proteasome inhibition during bortezomib treatment of a critically ill patient with lupus nephritis and myocarditis.

Authors: de Groot, Karina A., Sjoe, Michel Tsang a., Niewerth, Denise, Cloos, Jacqueline, Blank, Jonathan L., Niessen, Hans W. M., Zweegman, Sonja, Voskuyl, Alexandre E., Jansen, Gerrit, van der Heijden, Joost W.

Source: Lupus Science & Medicine; Jun2015, Vol. 2 Issue 1, p1-5, 5p

Preclinical Studies on the Molecular Basis of Bortezomib Resistance and Modalities to Overcome Resistance in Hematological Malignancies.

Authors: Cloos, Jacqueline, Niewerth, Denise, Jansen, Gerrit

Source: Resistance to Proteasome Inhibitors in Cancer; 2014, p181-204, 24p

Results of a Feasibility and Phase II Study on Bortezomib (BTZ) in Pediatric Multiply Relapsed or Refractory Acute Lymphoblastic Leukemia: Complete Hematological Responses with a Modestly Intensive Regimen Including BTZ

Authors: Kaspers, Gertjan, Niewerth, Denise ^*, Ramnarain, Satianand ^*, Attarbaschi, Andishe ^*, Baruchel, André, De Bont, Evelina S, Fagioli, Franca ^*, De Moerloose, Barbara ^*, Nysom, Karsten ^*, Palumbo, Giuseppe ^*, Reinhardt, Dirk, Rohrlich, Pierre-Simon ^*, Simon, Pauline ^*, von Stackelberg, Arend ^*, Zwaan, C. Michel

Source: In Blood 6 December 2014 124(21):2290-2290

The Novel Immunoproteasome Inhibitor PR-924: Anti-Leukemic Activity and Mechanisms Of Resistance

Authors: Niewerth, Denise ^*, van Meerloo, Johan ^*, Assaraf, Yehuda ^*, Jansen, Gerrit ^*, Hendrickx, Tessa C ^*, Kirk, Christopher J. ^*, Anderl, Janet ^*, Zweegman, Sonja, Cloos, Jacqueline ^*, Kaspers, Gertjan

Source: In Blood 15 November 2013 122(21):3841-3841

Pharmacokinetic Results Of a Feasibility and Phase II Study (ITCC 021) On Bortezomib (BTZ) In Pediatric Relapsed ALL: Lack Of Significant Penetration Of BTZ In The Cerebrospinal Fluid

Authors: Kaspers, Gertjan, Mathot, Ron ^*, Ramnarain, Satianand ^*, Niewerth, Denise ^*, Locatelli, Franco, De Bont, Eveline S.J.M, Fagioli, Franca ^*, Rohrlich, Pierre ^*, von Stackelberg, Arend, Zwaan, Michel

Source: In Blood 15 November 2013 122(21):1439-1439

Interferon-γ-Induced Upregulation of Immunoproteasome Subunit Assembly Overcomes Bortezomib Resistance of Leukemia Cell Lines Harbouring Bortezomib-Induced Mutations in Constitutive PSMB5

Authors: Niewerth, Denise ^*, Franke, Niels ^*, Jansen, Gerrit ^*, Assaraf, Yehuda ^*, van Meerloo, Johan ^*, Kirk, Christopher J ^*, Zweegman, Sonja, Kaspers, Gertjan J.L., Cloos, Jacqueline ^*

Source: In Blood 16 November 2012 120(21):1346-1346

Sensitivity of Pediatric Acute Leukemia Cells to Bortezomib and Epoxyketone-Based Proteasome Inhibitors: Correlations with Proteasome Subunit Expression

Authors: Niewerth, Denise ^*, Franke, Niels ^*, Jansen, Gerrit ^*, van Meerloo, Johan ^*, Assaraf, Yehuda ^*, Kirk, Christopher J ^*, Chan, Elena T ^*, Zweegman, Sonja, Kaspers, Gertjan J., Cloos, Jacqueline ^*

Source: In Blood 18 November 2011 118(21):1513-1513