Novel drug transporter substrates identification: An innovative approach based on metabolomic profiling, in silico ligand screening and biological validation

Authors: Nies, Anne T., König, Jörg, Leuthold, Patrick, Damme, Katja, Winter, Stefan, Haag, Mathias, Masuda, Satohiro, Kruck, Stephan, Daniel, Hannelore, Spanier, Britta, Fromm, Martin F., Bedke, Jens, Inui, Ken-ichi, Schwab, Matthias, Schaeffeler, Elke

Source: In Pharmacological Research October 2023 196

Targeting OCT3 attenuates doxorubicin-induced cardiac injury

Authors: Huang, Kevin M., Thomas, Megan Zavorka, Magdy, Tarek, Eisenmann, Eric D., Uddin, Muhammad Erfan, DiGiacomo, Duncan F., Pan, Alexander, Keiser, Markus, Otter, Marcus, Xia, Sherry H., Li, Yang, Jin, Yan, Fu, Qiang, Gibson, Alice A., Bonilla, Ingrid M., Carnes, Cynthia A., Corps, Kara N., Coppola, Vincenzo, Smith, Sakima A., Addison, Daniel, Nies, Anne T., Bundschuh, Ralf, Chen, Taosheng, Lustberg, Maryam B., Wang, Joanne, Oswald, Stefan, Campbell, Moray J., Yan, Pearlly S., Baker, Sharyn D., Hu, Shuiying, Burridge, Paul W., Sparreboom, Alex

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Feb 01. 118(5), 1-9.

Access URL: https://www.jstor.org/stable/27006166

Characterization of cytochrome P450 (CYP) 2D6 drugs as substrates of human organic cation transporters and multidrug and toxin extrusion proteins

Authors: Neul, Claudia, Hofmann, Ute, Schaeffeler, Elke, Winter, Stefan, Klein, Kathrin, Giacomini, Kathleen M., Eichelbaum, Michel, Schwab, Matthias, Nies, Anne T.

Source: British journal of pharmacology. 178(6):1459-1474

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123070928.0x000001&indx=1&recIds=ETOCvdc_100123070928.0x000001

Differential in vitro interactions of the Janus kinase inhibitor ruxolitinib with human SLC drug transporters

Authors: Bruyère, Arnaud, Le Vée, Marc, Jouan, Elodie, Molez, Stephanie, Nies, Anne T., Fardel, Olivier

Source: Xenobiotica. 51(4):467-478

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100116447590.0x000001&indx=1&recIds=ETOCvdc_100116447590.0x000001

Genetic and Epigenetic Regulation of Organic Cation Transporters

Authors: Kölz, Charlotte, Schaeffeler, Elke, Schwab, Matthias, Nies, Anne T.

Source: Handbook of experimental pharmacology. 266:81-100

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN627935801&indx=1&recIds=ETOCRN627935801

Inhibition of organic cation transporter 3 activity by tyrosine kinase inhibitors

Authors: Alim, Karima, Moreau, Amélie, Bruyère, Arnaud, Jouan, Elodie, Denizot, Claire, Nies, Anne T., Parmentier, Yannick, Fardel, Olivier

Source: Fundamental & clinical pharmacology. 35(5):919-929

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130131978.0x000001&indx=1&recIds=ETOCvdc_100130131978.0x000001

In silico and biological analyses of missense variants of the human biliary efflux transporter ABCC2: effects of novel rare missense variants.

Authors: Kölz, Charlotte, Gaugaz, Fabienne Z., Handin, Niklas, Schaeffeler, Elke, Tremmel, Roman, Winter, Stefan, Klein, Kathrin, Zanger, Ulrich M., Artursson, Per, Schwab, Matthias, Nies, Anne T.

Source: British Journal of Pharmacology; Nov2024, Vol. 181 Issue 22, p4593-4609, 17p

Subject Terms: MISSENSE mutation, GENETIC variation, MULTIDRUG resistance, DRUG therapy, XENOBIOTICS

Direct Automated MALDI Mass Spectrometry Analysis of Cellular Transporter Function: Inhibition of OATP2B1 Uptake by 294 Drugs

Authors: Unger, Melissa S., Schumacher, Lena, Enzlein, Thomas, Weigt, David, Zamek-Gliszczynski, Maciej J., Schwab, Matthias, Nies, Anne T., Drewes, Gerard, Schulz, Sandra, Reinhard, Friedrich B. M.

Source: Analytical chemistry. 92(17):11851-11859

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN624632757&indx=1&recIds=ETOCRN624632757

Clinically Relevant OATP2B1 Inhibitors in Marketed Drug Space

Authors: Unger, Melissa S., Mudunuru, Jennypher, Schwab, Matthias, Hopf, Carsten, Drewes, Gerard, Nies, Anne T., Zamek-Gliszczynski, Maciej J., Reinhard, Friedrich B. M.

Source: Molecular pharmaceutics. 17(2):488-498

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN623192415&indx=1&recIds=ETOCRN623192415

Sorafenib Activity and Disposition in Liver Cancer Does Not Depend on Organic Cation Transporter 1

Authors: Chen, Mingqing, Neul, Claudia, Schaeffeler, Elke, Frisch, Franziska, Winter, Stefan, Schwab, Matthias, Koepsell, Hermann, Hu, Shuiying, Laufer, Stefan, Baker, Sharyn D., Sparreboom, Alex, Nies, Anne T.

Source: Clinical pharmacology & therapeutics. 107(1):227-237

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100095987243.0x000001&indx=1&recIds=ETOCvdc_100095987243.0x000001

Pharmacoresponse in genetic generalized epilepsy: a genome-wide association study

Authors: Wolking, Stefan, Schulz, Herbert, Nies, Anne T, McCormack, Mark, Schaeffeler, Elke, Auce, Pauls, Avbersek, Andreja, Becker, Felicitas, Klein, Karl M, Krenn, Martin, Møller, Rikke S, Nikanorova, Marina, Weckhuysen, Sarah, Consortium, EpiPGx, Cavalleri, Gianpiero L, Delanty, Norman, Depondt, Chantal, Johnson, Michael R, Koeleman, Bobby PC, Kunz, Wolfram S, Marson, Anthony G, Sander, Josemir W, Sills, Graeme J, Striano, Pasquale, Zara, Federico, Zimprich, Fritz, Weber, Yvonne G, Krause, Roland, Sisodiya, Sanjay, Schwab, Matthias, Sander, Thomas, Lerche, Holger

Source: Pharmacogenomics. 21(5):325-335

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186575227.0x000001&indx=1&recIds=ETOCvdc_100186575227.0x000001

Testing association of rare genetic variants with resistance to three common antiseizure medications

Authors: Wolking, Stefan, Moreau, Claudia, Nies, Anne T., Schaeffeler, Elke, McCormack, Mark, Auce, Pauls, Avbersek, Andreja, Becker, Felicitas, Krenn, Martin, Møller, Rikke S., Nikanorova, Marina, Weber, Yvonne G., Weckhuysen, Sarah, Cavalleri, Gianpiero L., Delanty, Norman, Depondt, Chantal, Johnson, Michael R., Koeleman, Bobby P.C., Kunz, Wolfram S., Marson, Anthony G., Sander, Josemir W., Sills, Graeme J., Striano, Pasquale, Zara, Federico, Zimprich, Fritz, Schwab, Matthias, Krause, Roland, Sisodiya, Sanjay M., Cossette, Patrick, Girard, Simon L., Lerche, Holger

Source: Epilepsia. 61(4):657-666

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100106709981.0x000001&indx=1&recIds=ETOCvdc_100106709981.0x000001

Inhibition of organic cation transporter (OCT) activities by carcinogenic heterocyclic aromatic amines

Authors: Sayyed, Katia, Camillerapp, Christophe, Le Vée, Marc, Bruyère, Arnaud, Nies, Anne T., Abdel-Razzak, Ziad, Fardel, Olivier

Source: In Toxicology in Vitro February 2019 54:10-22

The fruit fly Drosophila melanogaster as an innovative preclinical ADME model for solute carrier membrane transporters, with consequences for pharmacology and drug therapy

Authors: Wang, Yiwen, Moussian, Bernard, Schaeffeler, Elke, Schwab, Matthias, Nies, Anne T.

Source: In Drug Discovery Today October 2018 23(10):1746-1760

Hepatic Expression of the Na + -Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation.

Authors: Tremmel, Roman^1,2 (AUTHOR) roman.tremmel@ikp-stuttgart.de, Nies, Anne T.^1,2,3 (AUTHOR) anne.nies@ikp-stuttgart.de, van Eijck, Barbara A. C.^1,2 (AUTHOR) B.vanEijck@gmx.de, Handin, Niklas⁴ (AUTHOR) niklas.handin@farmaci.uu.se, Haag, Mathias^1,2 (AUTHOR) mathias.haag@ikp-stuttgart.de, Winter, Stefan^1,2 (AUTHOR) stefan.winter@ikp-stuttgart.de, Büttner, Florian A.^1,2 (AUTHOR) florian.buettner@ikp-stuttgart.de, Kölz, Charlotte^1,2 (AUTHOR) charlotte.koelz@ikp-stuttgart.de, Klein, Franziska^1,2 (AUTHOR) franziska_frisch@online.de, Mazzola, Pascale^1,2 (AUTHOR) pascale.mazzola@med.uni-tuebingen.de, Hofmann, Ute^1,2 (AUTHOR) ute.hofmann@ikp-stuttgart.de, Klein, Kathrin^1,2 (AUTHOR) kathrin.klein@ikp-stuttgart.de, Hoffmann, Per^5,6 (AUTHOR) p.hoffmann@uni-bonn.de, Nöthen, Markus M.^5,7 (AUTHOR) markus.noethen@uni-bonn.de, Gaugaz, Fabienne Z.⁴ (AUTHOR) fabienne.gaugaz@gmx.net, Artursson, Per⁴ (AUTHOR) per.artursson@farmaci.uu.se, Schwab, Matthias^1,2,3,8 (AUTHOR) elke.schaeffeler@ikp-stuttgart.de, Schaeffeler, Elke^1,2,3 (AUTHOR)

Source: International Journal of Molecular Sciences. Jul2022, Vol. 23 Issue 13, p7468-N.PAG. 30p.

Subject Terms: *GENETIC variation, *GENE expression, *BILE salts, *GENOMICS, *DNA methylation, *ALCOHOL

Hepatic solute carrier transporters and drug therapy: Regulation of expression and impact of genetic variation

Authors: Nies, Anne T., Schaeffeler, Elke, Schwab, Matthias

Source: Pharmacology and therapeutics. 238

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100170597206.0x000001&indx=1&recIds=ETOCvdc_100170597206.0x000001

Characterization of the breast cancer resistance protein (BCRP/ABCG2) in clear cell renal cell carcinoma

Authors: Reustle, Anna, Fisel, Pascale, Renner, Olga, Büttner, Florian, Winter, Stefan, Rausch, Steffen, Kruck, Stephan, Nies, Anne T., Hennenlotter, Jörg, Scharpf, Marcus, Fend, Falko, Stenzl, Arnulf, Bedke, Jens, Schwab, Matthias, Schaeffeler, Elke

Source: International journal of cancer. 143(12):3181-3193

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100085061181.0x000001&indx=1&recIds=ETOCvdc_100085061181.0x000001

Impact of Membrane Drug Transporters on Resistance to Small-Molecule Tyrosine Kinase Inhibitors

Authors: Neul, Claudia, Schaeffeler, Elke, Sparreboom, Alex, Laufer, Stefan, Schwab, Matthias, Nies, Anne T.

Source: In Trends in Pharmacological Sciences November 2016 37(11):904-932

The importance of drug transporter characterization to precision medicine

Authors: Fisel, Pascale, Nies, Anne T., Schaeffeler, Elke, Schwab, Matthias

Source: Expert opinion on drug metabolism and toxicology. 13(4):361-365

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100106502640.0x000001&indx=1&recIds=ETOCvdc_100106502640.0x000001

Differential Expression of Drug Uptake and Efflux Transporters in Japanese Patients with Hepatocellular Carcinoma

Authors: Namisaki, Tadashi, Schaeffeler, Elke, Fukui, Hiroshi, Yoshiji, Hitoshi, Nakajima, Yoshiyuki, Fritz, Peter, Schwab, Matthias, Nies, Anne T. ^*

Source: In Drug Metabolism and Disposition December 2014 42(12):2033-2040