Which is more important for predicting de novo DSA production in donor-sensitized kidney transplant recipients, B-cell epitope or T-cell epitope analysis?

Authors: Ashimine, Satoshi, Sakamoto, Shintaro, Tomosugi, Toshihide, Spierings, Eric, Niemann, Matthias, Shizuku, Masato, Okada, Manabu, Miwa, Yuko, Iwasaki, Kenta, Hiramitsu, Takahisa, Goto, Norihiko, Narumi, Shunji, Watarai, Yoshihiko, Ishiyama, Kohei, Kobayashi, Takaaki

Source: In Human Immunology November 2024 85(6)

High-resolution HLA genotyping improves PIRCHE-II assessment of molecular mismatching in kidney transplantation

Authors: Crane, Clarkson, Niemann, Matthias, Dale, Bethany, Gragert, Loren, Shah, Mita, Ingulli, Elizabeth, Morris, Gerald P.

Source: In Human Immunology May 2024 85(3)

Using cloud infrastructure to facilitate data collection and conversion of HLA diagnostic data for the 18th International HLA and Immunogenetics Workshop

Authors: Matern, Benedict M., Niemann, Matthias, Nemparis, Ioannis, Schimanski, Andreas, Peereboom, Emma T. M., Kramer, Cynthia S. M., Heidt, Sebastiaan, Spierings, Eric

Source: HLA. 101(5):484-495

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184878673.0x000001&indx=1&recIds=ETOCvdc_100184878673.0x000001

Repeated local ellipsoid protrusion supplements HLA surface characterization.

Authors: Niemann, Matthias¹ (AUTHOR) matthias.niemann@pirche.com, Matern, Benedict M.^1,2 (AUTHOR), Spierings, Eric^2,3 (AUTHOR)

Source: HLA: Immune Response Genetics. Jan2024, Vol. 103 Issue 1, p1-14. 14p.

Subject Terms: *SURFACE analysis, *ELLIPSOIDS, *MOLECULAR shapes, *WEB services, *GRAFT survival

Immunologic risk stratification of pediatric heart transplant patients by combining HLAMatchmaker and PIRCHE-II

Authors: Mangiola, Massimo, Ellison, Mitchell A., Marrari, Marilyn, Bentlejewski, Carol, Sadowski, John, Zern, Dwayne, Niemann, Matthias, Feingold, Brian, Webber, Steve A., Zeevi, Adriana

Source: Journal of heart and lung transplantation. 41(7):952-960

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100166592522.0x000001&indx=1&recIds=ETOCvdc_100166592522.0x000001

De Novo donor-specific anti-HLA antibody risk stratification in kidney transplantation using a combination of B cell and T cell molecular mismatch assessment.

Authors: Chou-Wu, Elaine, Niemann, Matthias, Youngs, Danny, Gimferrer, Idoia

Source: Frontiers in Immunology; 2025, p1-14, 14p

Advancing risk stratification in kidney transplantation: integrating HLA-derived T-cell epitope and B-cell epitope matching algorithms for enhanced predictive accuracy of HLA compatibility.

Authors: Niemann, Matthias, Matern, Benedict M., Gupta, Gaurav, Tanriover, Bekir, Halleck, Fabian, Budde, Klemens, Spierings, Eric

Source: Frontiers in Immunology; 2025, p1-14, 14p

Subject Terms: PROPORTIONAL hazards models, KIDNEY transplantation, B cells, T cells, GRAFT survival

Molecular matching tools for allocation and immunosuppression optimization. Ready for primetime?

Authors: Niemann, Matthias, Matern, Benedict M.

Source: Current Opinion in Organ Transplantation; Feb2025, Vol. 30 Issue 1, p30-36, 7p

Standard reference sequences for submission of HLA genotyping for the 18th International HLA and Immunogenetics Workshop

Authors: Matern, Benedict M., Mack, Steven J., Osoegawa, Kazutoyo, Maiers, Martin, Niemann, Matthias, Robinson, James, Heidt, Sebastiaan, Spierings, Eric

Source: HLA. 97(6):512-519

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100121122038.0x000001&indx=1&recIds=ETOCvdc_100121122038.0x000001

What happens after graft loss? A large, long‐term, single‐center observation

Authors: Schrezenmeier, Eva, Lehner, Lukas J., Merkel, Marina, Mayrdorfer, Manuel, Duettmann, Wiebke, Naik, Marcel G., Fröhlich, Felix, Liefeldt, Lutz, Pigorsch, Mareen, Friedersdorff, Frank, Schmidt, Danilo, Niemann, Matthias, Lachmann, Nils, Budde, Klemens, Halleck, Fabian

Source: Transplant international. 34(4):732-742

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100120688675.0x000001&indx=1&recIds=ETOCvdc_100120688675.0x000001

Combined Molecular Mismatch Approaches to Predict Immunological Events Within the First Year After Renal Transplantation.

Authors: Jäger, Cäcilia¹ (AUTHOR), Niemann, Matthias² (AUTHOR), Hönger, Gideon^1,3,4 (AUTHOR), Wehmeier, Caroline¹ (AUTHOR), Hopfer, Helmut⁵ (AUTHOR), Menter, Thomas⁵ (AUTHOR), Amico, Patrizia¹ (AUTHOR), Dickenmann, Michael¹ (AUTHOR), Schaub, Stefan^1,3,4 (AUTHOR) stefan.schaub@usb.ch

Source: HLA: Immune Response Genetics. Nov2024, Vol. 104 Issue 5, p1-11. 11p.

Subject Terms: *GRAFT rejection, *KIDNEY transplantation, *HOMOGRAFTS, *CLASSIFICATION, *FORECASTING

Quantifying uncertainty of molecular mismatch introduced by mislabeled ancestry using haplotype-based HLA genotype imputation.

Authors: Matern, Benedict M., Spierings, Eric, Bandstra, Selle, Madbouly, Abeer, Schaub, Stefan, Weimer, Eric T., Niemann, Matthias

Source: Frontiers in Genetics; 2024, p1-13, 13p

Subject Terms: AMINO acid sequence, HAPLOTYPES, PROTEIN structure, GENOTYPES, LOCUS (Genetics), T cells

Exploring predicted indirectly recognizable HLA epitopes (PIRCHE-II) in liver transplant recipients on calcineurin inhibitor-free maintenance immunosuppression. A retrospective single center study

Authors: Meszaros, Magdalena, Niemann, Matthias, Ursic-Bedoya, José, Faure, Stéphanie, Meunier, Lucy, Rivière, Benjamin, Costes-Martineau, Valérie, Thevenin, Céline, Pageaux, Georges-Philippe

Source: In Transplant Immunology April 2020 59

Toward defining the immunogenicity of HLA epitopes: Impact of HLA class I eplets on antibody formation during pregnancy

Authors: Hönger, Gideon, Niemann, Matthias, Schawalder, Lara, Jones, James, Heck, Michelle R., Pasch, Loes A. L., Vendelbosch, Sanne, Rozemuller, Erik H., Hösli, Irene, Blümel, Sarah, Schaub, Stefan

Source: HLA. 96(5):589-600

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100110044335.0x000001&indx=1&recIds=ETOCvdc_100110044335.0x000001

Formation of donor‐specific antibodies depends on the epitope load of mismatched HLAs in lung transplant recipients: A retrospective single‐center study.

Authors: Lobashevsky, Andrew^1,2 (AUTHOR) alobashevsky@nrl.ae, Niemann, Matthias³ (AUTHOR), Kowinski, Brenda⁴ (AUTHOR), Higgins, Nancy¹ (AUTHOR), Abdel‐Wareth, Laila² (AUTHOR), Atrabulsi, Basel² (AUTHOR), Roe, David⁴ (AUTHOR), Hage, Chadi⁵ (AUTHOR)

Source: Clinical Transplantation. Sep2022, Vol. 36 Issue 9, p1-11. 11p.

Subject Terms: *LUNG transplantation, *ANTIBODY formation, *CYTOTOXIC T cells, *TRANSPLANTATION of organs, tissues, etc., *PLASMA cells

Positive Long-Term Outcome of Kidney Allocation via Acceptable Mismatch Program in Highly Sensitized Patients.

Authors: Strehler, Yara, Lachmann, Nils, Niemann, Matthias, Halleck, Fabian, Budde, Klemens, Pruß, Axel

Source: Transfusion Medicine & Hemotherapy; 2024, Vol. 51 Issue 3, p140-151, 12p

PIRCHE application major versions 3 and 4 lead to equivalent T cell epitope mismatch scores in solid organ and stem cell transplantation modules

Authors: Matern, Benedict M., Niemann, Matthias

Source: In Human Immunology May 2024 85(3)

Completion of HLA protein sequences by automated homology-based nearest-neighbor extrapolation of HLA database sequences

Authors: Geneugelijk, Kirsten, Niemann, Matthias, de Hoop, Talitha, Spierings, Eric

Source: In Human Immunology November 2016 77(11):1030-1036

Computational Eurotransplant kidney allocation simulations demonstrate the feasibility and benefit of T-cell epitope matching.

Authors: Niemann, Matthias¹ (AUTHOR) matthias.niemann@pirche.com, Lachmann, Nils² (AUTHOR), Geneugelijk, Kirsten³ (AUTHOR), Spierings, Eric³ (AUTHOR)

Source: PLoS Computational Biology. 7/27/2021, Vol. 17 Issue 7, p1-22. 22p. 2 Diagrams, 2 Charts, 6 Graphs.

Subject Terms: *MONTE Carlo method, *MARKOV chain Monte Carlo, *T cells, *KIDNEY exchange, *KIDNEYS, *GRAFT survival, *HAPLOTYPES

Donor selection in a pediatric stem cell transplantation cohort using PIRCHE and HLA‐DPB1 typing

Authors: Stenger, Wiebke, Künkele, Annette, Niemann, Matthias, Todorova, Kremena, Pruß, Axel, Schulte, Johannes H., Eggert, Angelika, Oevermann, Lena

Source: Pediatric blood & cancer. 67(3)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100150203682.0x000001&indx=1&recIds=ETOCvdc_100150203682.0x000001