Distinct metabolic perturbations link liver steatosis and incident CVD in lean but not obese PWH

Authors: Louise E. van Eekeren, Nadira Vadaq, Marc J. T. Blaauw, Albert L. Groenendijk, Wilhelm A. J. W. Vos, Erni J. Nelwan, Annelies Verbon, Janneke E. Stalenhoef, Marvin A. H. Berrevoets, Jan van Lunzen, Mihai G. Netea, Gert Weijers, Niels P. Riksen, Joost H. W. Rutten, Quirijn de Mast, Eric T. T. L. Tjwa, Leo A. B. Joosten, André J. A. M. van der Ven

Source: BMC Medicine, Vol 23, Iss 1, Pp 1-17 (2025)

Subject Terms: HIV, CVD, MASLD, Steatosis, Fibrosis, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1741-7015

Access URL: https://doaj.org/article/9d7891bc896e4255aef85eeef1b371ba

Targeting mTOR in myeloid cells prevents infection-associated inflammation

Authors: Yohana C. Toner, Jazz Munitz, Geoffrey Prevot, Judit Morla-Folch, William Wang, Yuri van Elsas, Bram Priem, Jeroen Deckers, Tom Anbergen, Thijs J. Beldman, Eliane E.S. Brechbühl, Muhammed D. Aksu, Athanasios Ziogas, Sebastian A. Sarlea, Mumin Ozturk, Zhenhua Zhang, Wenchao Li, Yang Li, Alexander Maier, Jessica C. Fernandes, Glenn A.O. Cremers, Bas van Genabeek, Joost H.C.M. Kreijtz, Esther Lutgens, Niels P. Riksen, Henk M. Janssen, Serge H.M. Söntjens, Freek J.M. Hoeben, Ewelina Kluza, Gagandeep Singh, Evangelos J. Giamarellos-Bourboulis, Michael Schotsaert, Raphaël Duivenvoorden, Roy van der Meel, Leo A.B. Joosten, Lei Cai, Ryan E. Temel, Zahi A. Fayad, Musa M. Mhlanga, Mandy M.T. van Leent, Abraham J.P. Teunissen, Mihai G. Netea, Willem J.M. Mulder

Source: iScience, Vol 28, Iss 4, Pp 112163- (2025)

Subject Terms: Natural sciences, Biological sciences, Biochemistry, Immunology, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004225004249; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/42ac9256a7534f0d84459dcca42fb410

Single high-fat challenge and trained innate immunity: A randomized controlled cross-over trial

Authors: Julia van Tuijl, Julia I.P. van Heck, Harsh Bahrar, Wieteke Broeders, Johan Wijma, Yvonne M. ten Have, Martin Giera, Heidi Zweers-van Essen, Laura Rodwell, Leo A.B. Joosten, Mihai G. Netea, Lydia A. Afman, Siroon Bekkering, Niels P. Riksen

Source: iScience, Vol 27, Iss 11, Pp 111103- (2024)

Subject Terms: Health sciences, Human Physiology, Human metabolism, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004224023289; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/2cbb666c2b6342b7a4a95757c35a8009

Plasma proteomic signatures of liver steatosis and fibrosis in people living with HIV: a cross-sectional studyResearch in context

Authors: Louise E. van Eekeren, Quirijn de Mast, Elise M.G. Meeder, Adriana Navas, Albert L. Groenendijk, Marc J.T. Blaauw, Wilhelm A.J.W. Vos, Nadira Vadaq, Jéssica C. Dos Santos, Joost Rutten, Niels P. Riksen, Jan van Lunzen, Gert Weijers, Mihai G. Netea, André J.A.M. van der Ven, Eric T.T.L. Tjwa, Leo A.B. Joosten

Source: EBioMedicine, Vol 109, Iss , Pp 105407- (2024)

Subject Terms: HIV, MASLD, Steatosis, Fibrosis, Proteomics, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396424004432; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/ef271a81f9d744ecb5a25b46cb60e8f7

Unraveling interindividual variation of trimethylamine N‐oxide and its precursors at the population level

Authors: Sergio Andreu‐Sánchez, Shahzad Ahmad, Alexander Kurilshikov, Marian Beekman, Mohsen Ghanbari, Martijn vanFaassen, Inge C. L. van denMunckhof, Marinka Steur, Amy Harms, Thomas Hankemeier, M. Arfan Ikram, Maryam Kavousi, Trudy Voortman, Robert Kraaij, Mihai G. Netea, Joost H. W. Rutten, Niels P. Riksen, Alexandra Zhernakova, Folkert Kuipers, P. Eline Slagboom, Cornelia M. vanDuijn, Jingyuan Fu, Dina Vojinovic

Source: iMeta, Vol 3, Iss 3, Pp n/a-n/a (2024)

Subject Terms: diet, genetics, gut microbiome, meta‐analysis, population cohort, TMAO, Computer applications to medicine. Medical informatics, R858-859.7

File Description: electronic resource

Relation: https://doaj.org/toc/2770-596X

Access URL: https://doaj.org/article/8f4a85a05abd4322a6397015b41442e1

Increased innate immune responses in adolescents with obesity and its relation to subclinical cardiovascular measures: An exploratory study

Authors: Siroon Bekkering, Christoph Saner, Boris Novakovic, Toby Mansell, Danielle K. Longmore, Zoe McCallum, Anne-Louise Ponsonby, Markus Juonala, Mihai G. Netea, Matthew A. Sabin, Richard Saffery, Niels P. Riksen, David P. Burgner

Source: iScience, Vol 27, Iss 5, Pp 109762- (2024)

Subject Terms: Health sciences, Immunology, Pathophysiology, Disease, Risk factor, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004224009842; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/18ea2a93c6124c2c9822b1d8f3285792

Clonal hematopoiesis is associated with cardiovascular events in patients with stable coronary artery disease

Authors: Mihaela I. Dregoesc, Helin Tercan, Adrian B. Țigu, Siroon Bekkering, Leo AB. Joosten, Mihai G. Netea, Rosanne C. van Deuren, Alexander Hoischen, Niels P. Riksen, Adrian C. Iancu

Source: iScience, Vol 27, Iss 4, Pp 109472- (2024)

Subject Terms: Health sciences, Cardiovascular medicine, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S258900422400693X; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/f86bcc0f47134c969cae7c331a450621

Two‐Week Interruption of Statin Therapy Results in an Exaggerated Inflammatory Monocyte Phenotype in Young Patients With Myocardial Infarction Without Standard Modifiable Risk Factors

Authors: Jan‐Quinten Mol, Julia van Tuijl, Siroon Bekkering, Laura Rodwell, Gheorghe A. M. Pop, Mihai G. Netea, Niels van Royen, Niels P. Riksen, Saloua El Messaoudi

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 8 (2024)

Subject Terms: inflammation, monocytes, myocardial infarction, standard modifiable risk factors, statins, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/1a40ee6e9b894a50824cece00ad022d8

Association Between Clonal Hematopoiesis Driver Mutations, Immune Cell Function, and the Vasculometabolic Complications of Obesity

Authors: Helin Tercan, Benjamin C. Cossins, Rosanne C. van Deuren, Joost H. W. Rutten, Leo A. B. Joosten, Mihai G. Netea, Alexander Hoischen, Siroon Bekkering, Niels P. Riksen

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 2 (2024)

Subject Terms: atherosclerosis, clonal hematopoiesis, immunological parameters, obesity, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/386a3cf3b948494e8e35866013b4781d

Acid ceramidase regulates innate immune memory

Authors: Nils Rother, Cansu Yanginlar, Geoffrey Prévot, Inge Jonkman, Maaike Jacobs, Mandy M.T. van Leent, Julia van Heck, Vasiliki Matzaraki, Anthony Azzun, Judit Morla-Folch, Anna Ranzenigo, William Wang, Roy van der Meel, Zahi A. Fayad, Niels P. Riksen, Luuk B. Hilbrands, Rik G.H. Lindeboom, Joost H.A. Martens, Michiel Vermeulen, Leo A.B. Joosten, Mihai G. Netea, Willem J.M. Mulder, Johan van der Vlag, Abraham J.P. Teunissen, Raphaël Duivenvoorden

Source: Cell Reports, Vol 42, Iss 12, Pp 113458- (2023)

Subject Terms: CP: Immunology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124723014705; https://doaj.org/toc/2211-1247

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Systematic analysis of relationships between plasma branched-chain amino acid concentrations and cardiometabolic parameters: an association and Mendelian randomization study

Authors: Marwah Doestzada, Daria V. Zhernakova, Inge C. L. van den Munckhof, Daoming Wang, Alexander Kurilshikov, Lianmin Chen, Vincent W. Bloks, Martijn van Faassen, Joost H. W. Rutten, Leo A. B. Joosten, Mihai G. Netea, Cisca Wijmenga, Niels P. Riksen, Alexandra Zhernakova, Folkert Kuipers, Jingyuan Fu

Source: BMC Medicine, Vol 20, Iss 1, Pp 1-15 (2022)

Subject Terms: Branched-chain amino acids, Cardiometabolic diseases, Population-based studies, Mendelian randomization, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1741-7015

Access URL: https://doaj.org/article/6287de997c674451afb5910bbc9900d2

Traditional Cardiovascular Risk Factors Are Stronger Related to Carotid Intima‐Media Thickness Than to Presence of Carotid Plaques in People Living With HIV

Authors: Marc J. T. Blaauw, Marvin A. H. Berrevoets, Wilhelm A. J. W. Vos, Albert L. Groenendijk, Louise E. van Eekeren, Nadira Vadaq, Gert Weijers, Andre J. A. M. van der Ven, Joost H. W. Rutten, Niels P. Riksen

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 20 (2023)

Subject Terms: cardiovascular risk management, carotid atherosclerosis, carotid intima‐media thickness, carotid plaques, HIV, lipoproteins, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/150cdec6de574f6cb04fb4d4d5ed8fc2

A role for artificial intelligence in molecular imaging of infection and inflammation

Authors: Johannes Schwenck, Manfred Kneilling, Niels P. Riksen, Christian la Fougère, Douwe J. Mulder, Riemer J. H. A. Slart, Erik H. J. G. Aarntzen

Source: European Journal of Hybrid Imaging, Vol 6, Iss 1, Pp 1-16 (2022)

Subject Terms: Medical physics. Medical radiology. Nuclear medicine, R895-920

File Description: electronic resource

Relation: https://doaj.org/toc/2510-3636

Access URL: https://doaj.org/article/1010a0baffd24cc79a3cd66832c4813c

Cardiometabolic Differences in People Living with HIV Receiving Integrase Strand Transfer Inhibitors Compared to Non-nucleoside Reverse Transcriptase Inhibitors: Implications for Current ART Strategies

Authors: Wilhelm A. J. W. Vos, Nadira Vadaq, Vasiliki Matzaraki, Twan Otten, Albert L. Groenendijk, Marc J. T. Blaauw, Louise E. van Eekeren, Kees Brinkman, Quirijn de Mast, Niels P. Riksen, Anton F. H. Stalenhoef, Jan van Lunzen, Andre J. A. M. van der Ven, Willem L. Blok, Janneke E. Stalenhoef

Source: Viruses, Vol 16, Iss 4, p 582 (2024)

Subject Terms: metabolome, lipoproteome, integrase strand transfer inhibitor, non-nucleoside reverse transcriptase inhibitor, combination antiretroviral therapy, lipids, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/16/4/582; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/f709bcd454a146f98691dffd7cf32341

Clonal Hematopoiesis of Indeterminate Potential From a Heart Failure Specialist's Point of View

Authors: Maurits A. Sikking, Sophie L. V. M. Stroeks, Olivia J. Waring, Michiel T. H. M. Henkens, Niels P. Riksen, Alexander Hoischen, Stephane R. B. Heymans, Job A. J. Verdonschot

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 15 (2023)

Subject Terms: atherosclerotic cardiovascular disease, clonal hematopoiesis, heart failure, inflammation, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/23ac293c782343308b91a5c1bca21054

Peripheral blood mononuclear cell hyperresponsiveness in patients with premature myocardial infarction without traditional risk factors

Authors: Jan-Quinten Mol, Julia van Tuijl, Siroon Bekkering, Charlotte D.C.C. van der Heijden, Sander A.J. Damen, Benjamin C. Cossins, Liesbeth van Emst, Tim M. Nielen, Laura Rodwell, Yang Li, Gheorghe A.M. Pop, Mihai G. Netea, Niels van Royen, Niels P. Riksen, Saloua El Messaoudi

Source: iScience, Vol 26, Iss 7, Pp 107183- (2023)

Subject Terms: Cardiovascular medicine, Molecular mechanism of gene regulation, Components of the immune system, Transcriptomics, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004223012609; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/fc49a727a85442d1b19e4779f98bee00

Gut microbial co-abundance networks show specificity in inflammatory bowel disease and obesity

Authors: Lianmin Chen, Valerie Collij, Martin Jaeger, Inge C. L. van den Munckhof, Arnau Vich Vila, Alexander Kurilshikov, Ranko Gacesa, Trishla Sinha, Marije Oosting, Leo A. B. Joosten, Joost H. W. Rutten, Niels P. Riksen, Ramnik J. Xavier, Folkert Kuipers, Cisca Wijmenga, Alexandra Zhernakova, Mihai G. Netea, Rinse K. Weersma, Jingyuan Fu

Source: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/da603f99168743a3ba6b2f114c36782d

Relation Between Plasma Proteomics Analysis and Major Adverse Cardiovascular Events in Patients With Stable Coronary Artery Disease

Authors: Mihaela Ioana Dregoesc, Adrian Bogdan Ţigu, Siroon Bekkering, Charlotte D. C. C. van der Heijden, Sorana Daniela Bolboacǎ, Leo A. B. Joosten, Frank L. J. Visseren, Mihai G. Netea, Niels P. Riksen, Adrian Corneliu Iancu

Source: Frontiers in Cardiovascular Medicine, Vol 9 (2022)

Subject Terms: inflammation, biomarkers, proteomics, atherosclerosis, coronary artery disease, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcvm.2022.731325/full; https://doaj.org/toc/2297-055X

Access URL: https://doaj.org/article/4d767bf4e5124724861b43a9f5bb950f

An Explorative Study on Monocyte Reprogramming in the Context of Periodontitis In Vitro and In Vivo

Authors: Marlies P. Noz, Adelina S. Plachokova, Esther M.M. Smeets, Erik H. J. G. Aarntzen, Siroon Bekkering, Prya Vart, Leo A. B. Joosten, Mihai G. Netea, Niels P. Riksen

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: periodontitis, Porphyromonas gingivalis, trained immunity, inflammation, cardiovascular disease, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.695227/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/4f758402748d43c2af5f182ff74e45a4

Diversity and Ecology of Caudoviricetes Phages with Genome Terminal Repeats in Fecal Metagenomes from Four Dutch Cohorts

Authors: Anastasia Gulyaeva, Sanzhima Garmaeva, Alexander Kurilshikov, Arnau Vich Vila, Niels P. Riksen, Mihai G. Netea, Rinse K. Weersma, Jingyuan Fu, Alexandra Zhernakova

Source: Viruses, Vol 14, Iss 10, p 2305 (2022)

Subject Terms: human gut metagenome, Caudoviricetes, human phenotypes, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/14/10/2305; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/371e61bccdf54e19baa29a652b6e8f07