Characterization and inhibition of inflammasome responses in severe and non-severe asthma

Authors: Jay C. Horvat, Richard Y. Kim, Natasha Weaver, Christopher Augood, Alexandra C. Brown, Chantal Donovan, Pierrick Dupre, Lakshitha Gunawardhana, Jemma R. Mayall, Nicole G. Hansbro, Avril A. B. Robertson, Luke A. J. O’Neill, Matthew A. Cooper, Elizabeth G. Holliday, Philip M. Hansbro, Peter G. Gibson

Source: Respiratory Research, Vol 24, Iss 1, Pp 1-14 (2023)

Subject Terms: Asthma, Severe asthma, NLRP3 inflammasome, IL-1β, Inflammasome inhibition, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: https://doaj.org/toc/1465-993X

Access URL: https://doaj.org/article/60288ffe24fd40148d0b5a1960f9d444

TLR7 promotes smoke-induced experimental lung damage through the activity of mast cell tryptase

Authors: Gang Liu, Tatt Jhong Haw, Malcolm R. Starkey, Ashleigh M. Philp, Stelios Pavlidis, Christina Nalkurthi, Prema M. Nair, Henry M. Gomez, Irwan Hanish, Alan CY. Hsu, Elinor Hortle, Sophie Pickles, Joselyn Rojas-Quintero, Raul San Jose Estepar, Jacqueline E. Marshall, Richard Y. Kim, Adam M. Collison, Joerg Mattes, Sobia Idrees, Alen Faiz, Nicole G. Hansbro, Ryutaro Fukui, Yusuke Murakami, Hong Sheng Cheng, Nguan Soon Tan, Sanjay H. Chotirmall, Jay C. Horvat, Paul S. Foster, Brian GG. Oliver, Francesca Polverino, Antonio Ieni, Francesco Monaco, Gaetano Caramori, Sukhwinder S. Sohal, Ken R. Bracke, Peter A. Wark, Ian M. Adcock, Kensuke Miyake, Don D. Sin, Philip M. Hansbro

Source: Nature Communications, Vol 14, Iss 1, Pp 1-24 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/c49c73a4f4614f95ae1cab28b0686048

Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection

Authors: Tomalika R. Ullah, Matt D. Johansen, Katherine R. Balka, Rebecca L. Ambrose, Linden J. Gearing, James Roest, Julian P. Vivian, Sunil Sapkota, W. Samantha N. Jayasekara, Daniel S. Wenholz, Vina R. Aldilla, Jun Zeng, Stefan Miemczyk, Duc H. Nguyen, Nicole G. Hansbro, Rajan Venkatraman, Jung Hee Kang, Ee Shan Pang, Belinda J. Thomas, Arwaf S. Alharbi, Refaya Rezwan, Meredith O’Keeffe, William A. Donald, Julia I. Ellyard, Wilson Wong, Naresh Kumar, Benjamin T. Kile, Carola G. Vinuesa, Graham E. Kelly, Olivier F. Laczka, Philip M. Hansbro, Dominic De Nardo, Michael P. Gantier

Source: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/780fdb67fa074e35823aa88357231e9d

Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon

Authors: Tristram A. J. Ryan, Alexander Hooftman, Aisling M. Rehill, Matt D. Johansen, Eóin C. O’ Brien, Juliana E. Toller-Kawahisa, Mieszko M. Wilk, Emily A. Day, Hauke J. Weiss, Pourya Sarvari, Emilio G. Vozza, Fabian Schramm, Christian G. Peace, Alessia Zotta, Stefan Miemczyk, Christina Nalkurthi, Nicole G. Hansbro, Gavin McManus, Laura O’Doherty, Siobhan Gargan, Aideen Long, Jean Dunne, Clíona Ní Cheallaigh, Niall Conlon, Michael Carty, Padraic G. Fallon, Kingston H. G. Mills, Emma M. Creagh, James S. O’ Donnell, Paul J. Hertzog, Philip M. Hansbro, Rachel M. McLoughlin, Małgorzata Wygrecka, Roger J. S. Preston, Zbigniew Zasłona, Luke A. J. O’Neill

Source: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/0df3d79819534a4786cd65226889c413

Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance

Authors: Gaetano Scaramuzzo, Francesco Nucera, Alessio Asmundo, Roberto Messina, Matilde Mari, Federica Montanaro, Matt D. Johansen, Francesco Monaco, Guido Fadda, Giovanni Tuccari, Nicole G. Hansbro, Philip M. Hansbro, Trevor T. Hansel, Ian M. Adcock, Antonio David, Paul Kirkham, Gaetano Caramori, Carlo Alberto Volta, Savino Spadaro

Source: Journal of Inflammation, Vol 20, Iss 1, Pp 1-24 (2023)

Subject Terms: COVID-19, SARS-CoV-2, ARDS, Biomarkers, Cytokines, Chemokines, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1476-9255

Access URL: https://doaj.org/article/09db15bec1ab49ba975346d548e55894

A single dose, BCG-adjuvanted COVID-19 vaccine provides sterilising immunity against SARS-CoV-2 infection

Authors: Claudio Counoupas, Matt D. Johansen, Alberto O. Stella, Duc H. Nguyen, Angela L. Ferguson, Anupriya Aggarwal, Nayan D. Bhattacharyya, Alice Grey, Owen Hutchings, Karishma Patel, Rezwan Siddiquee, Erica L. Stewart, Carl G. Feng, Nicole G. Hansbro, Umaimainthan Palendira, Megan C. Steain, Bernadette M. Saunders, Jason K. K. Low, Joel P. Mackay, Anthony D. Kelleher, Warwick J. Britton, Stuart G. Turville, Philip M. Hansbro, James A. Triccas

Source: npj Vaccines, Vol 6, Iss 1, Pp 1-10 (2021)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2059-0105

Access URL: https://doaj.org/article/54cf1269f483428f921decb5fa5ac562

Publisher Correction: Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon

Authors: Tristram A. J. Ryan, Alexander Hooftman, Aisling M. Rehill, Matt D. Johansen, Eóin C. O’ Brien, Juliana E. Toller-Kawahisa, Mieszko M. Wilk, Emily A. Day, Hauke J. Weiss, Pourya Sarvari, Emilio G. Vozza, Fabian Schramm, Christian G. Peace, Alessia Zotta, Stefan Miemczyk, Christina Nalkurthi, Nicole G. Hansbro, Gavin McManus, Laura O’Doherty, Siobhan Gargan, Aideen Long, Jean Dunne, Clíona Ní Cheallaigh, Niall Conlon, Michael Carty, Padraic G. Fallon, Kingston H. G. Mills, Emma M. Creagh, James S. O’ Donnell, Paul J. Hertzog, Philip M. Hansbro, Rachel M. McLoughlin, Małgorzata Wygrecka, Roger J. S. Preston, Zbigniew Zasłona, Luke A. J. O’Neill

Source: Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/3b72cd72017f45ae91810eb4f3826d16

Elastin is a key factor of tumor development in colorectal cancer

Authors: Jinzhi Li, Xiaoyue Xu, Yanyan Jiang, Nicole G. Hansbro, Philip M. Hansbro, Jincheng Xu, Gang Liu

Source: BMC Cancer, Vol 20, Iss 1, Pp 1-12 (2020)

Subject Terms: Colorectal cancer, Extracellular matrix protein, Elastin, epithelial-mesenchymal transition, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12885-020-6686-x; https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/0650710be90d4d678e9d4f68310c83de

Role of Lung Microbiome in Innate Immune Response Associated With Chronic Lung Diseases

Authors: Keshav Raj Paudel, Vivek Dharwal, Vyoma K. Patel, Izabela Galvao, Ridhima Wadhwa, Vamshikrishna Malyla, Sj Sijie Shen, Kurtis F. Budden, Nicole G. Hansbro, Annalicia Vaughan, Ian A. Yang, Maija R J Kohonen-Corish, Mary Bebawy, Kamal Dua, Philip M. Hansbro

Source: Frontiers in Medicine, Vol 7 (2020)

Subject Terms: asthma, chronic obstructive pulmonary disease, lung fibrosis, lung cancer, microbiome, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fmed.2020.00554/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/3437a43fcf1641e8a6facfec95f7cc3e

Epigenetic changes associated with disease progression in a mouse model of childhood allergic asthma

Authors: Adam Collison, Jessica S. Siegle, Nicole G. Hansbro, Chau-To Kwok, Cristan Herbert, Joerg Mattes, Megan Hitchins, Paul S. Foster, Rakesh K. Kumar

Source: Disease Models & Mechanisms, Vol 6, Iss 4, Pp 993-1000 (2013)

Subject Terms: Medicine, Pathology, RB1-214

File Description: electronic resource

Relation: http://dmm.biologists.org/content/6/4/993; https://doaj.org/toc/1754-8403; https://doaj.org/toc/1754-8411

Access URL: https://doaj.org/article/329730ceb18d4a199498b2b335ceab9b

Development of asthmatic inflammation in mice following early-life exposure to ambient environmental particulates and chronic allergen challenge

Authors: Cristan Herbert, Jessica S. Siegle, Alexander M. Shadie, Stina Nikolaysen, Linda Garthwaite, Nicole G. Hansbro, Paul S. Foster, Rakesh K. Kumar

Source: Disease Models & Mechanisms, Vol 6, Iss 2, Pp 479-488 (2013)

Subject Terms: Medicine, Pathology, RB1-214

File Description: electronic resource

Relation: http://dmm.biologists.org/content/6/2/479; https://doaj.org/toc/1754-8403; https://doaj.org/toc/1754-8411

Access URL: https://doaj.org/article/1191b337f88245718e0dda4328f753f7

The complex interplay between endoplasmic reticulum stress and the NLRP3 inflammasome: a potential therapeutic target for inflammatory disorders

Authors: Wai Chin Chong, Madhur D Shastri, Gregory M Peterson, Rahul P Patel, Prabuddha S Pathinayake, Kamal Dua, Nicole G Hansbro, Alan C Hsu, Peter A Wark, Shakti Dhar Shukla, Matt D Johansen, Kate Schroder, Philip M Hansbro

Source: Clinical & Translational Immunology, Vol 10, Iss 2, Pp n/a-n/a (2021)

Subject Terms: endoplasmic reticulum stress, inflammasome, inflammatory disorder, NLRP3, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/2050-0068

Access URL: https://doaj.org/article/bdb4a50c1be642b2b15a84d8a1bd9e01

TLR2, TLR4 AND MyD88 Mediate Allergic Airway Disease (AAD) and Streptococcus pneumoniae-Induced Suppression of AAD.

Authors: Alison N Thorburn, Hsin-Yi Tseng, Chantal Donovan, Nicole G Hansbro, Andrew G Jarnicki, Paul S Foster, Peter G Gibson, Philip M Hansbro

Source: PLoS ONE, Vol 11, Iss 6, p e0156402 (2016)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4911048?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/9082f3d2b79d4844b7c1b01afcf1a77c

LF-15 & T7, synthetic peptides derived from tumstatin, attenuate aspects of airway remodelling in a murine model of chronic OVA-induced allergic airway disease.

Authors: Karryn T Grafton, Lyn M Moir, Judith L Black, Nicole G Hansbro, Philip M Hansbro, Janette K Burgess, Brian G Oliver

Source: PLoS ONE, Vol 9, Iss 1, p e85655 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24454912/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/059d0ec733d9435892adfc513cf752be

Fibulin-1 is increased in asthma--a novel mediator of airway remodeling?

Authors: Justine Y Lau, Brian G Oliver, Melissa Baraket, Emma L Beckett, Nicole G Hansbro, Lyn M Moir, Steve D Wilton, Carolyn Williams, Paul S Foster, Philip M Hansbro, Judith L Black, Janette K Burgess

Source: PLoS ONE, Vol 5, Iss 10, p e13360 (2010)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2954173?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/ddc794eb15104c2bb96d4b448d663262