Activating mutations in JAK2 and CALR differentially affect intracellular calcium flux in store operated calcium entry

Authors: Vikas Bhuria, Tobias Franz, Conny Baldauf, Martin Böttcher, Nicolas Chatain, Steffen Koschmieder, Tim H. Brümmendorf, Dimitrios Mougiakakos, Burkhart Schraven, Sascha Kahlfuß, Thomas Fischer

Source: Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-22 (2024)

Subject Terms: Calcium flux, EPO signaling, TPO signaling, MPNs, JAK2-V617F, CALR mutation, Medicine, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1478-811X

Access URL: https://doaj.org/article/db493b9498e045b9a9db0c8fc03508d6

Calreticulin and JAK2V617F driver mutations induce distinct mitotic defects in myeloproliferative neoplasms

Authors: Kristin Holl, Nicolas Chatain, Susanne Krapp, Julian Baumeister, Tiago Maié, Sarah Schmitz, Anja Scheufen, Nathalie Brock, Steffen Koschmieder, Daniel Moreno-Andrés

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/16908be3238c4f509fba9b2239b81661

Non-canonical Hedgehog signaling mediates profibrotic hematopoiesis-stroma crosstalk in myeloproliferative neoplasms

Authors: Jessica E. Pritchard, Juliette E. Pearce, Inge A.M. Snoeren, Stijn N.R. Fuchs, Katrin Götz, Fabian Peisker, Silke Wagner, Adam Benabid, Niklas Lutterbach, Vanessa Klöker, James S. Nagai, Monica T. Hannani, Anna K. Galyga, Ellen Sistemich, Bella Banjanin, Niclas Flosdorf, Eric Bindels, Kathrin Olschok, Katharina Biaesch, Nicolas Chatain, Neha Bhagwat, Andrew Dunbar, Rita Sarkis, Olaia Naveiras, Marie-Luise Berres, Steffen Koschmieder, Ross L. Levine, Ivan G. Costa, Hélène F.E. Gleitz, Rafael Kramann, Rebekka K. Schneider

Source: Cell Reports, Vol 43, Iss 1, Pp 113608- (2024)

Subject Terms: CP: Stem cell research, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124723016200; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/79a625e34918435f841f28673c9cdf62

The telomerase inhibitor imetelstat differentially targets JAK2V617F versus CALR mutant myeloproliferative neoplasm cells and inhibits JAK-STAT signaling

Authors: Kathrin Olschok, Bianca Altenburg, Marcelo A. S. de Toledo, Angela Maurer, Anne Abels, Fabian Beier, Deniz Gezer, Susanne Isfort, Katrin Paeschke, Tim H. Brümmendorf, Martin Zenke, Nicolas Chatain, Steffen Koschmieder

Source: Frontiers in Oncology, Vol 13 (2023)

Subject Terms: Myeloproliferative neoplasms (MPN), imetelstat (GRN163L), myelofibrosis (MF), induced pluripotent stem cells, telomere length (TL), JAK2V617F, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2023.1277453/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/22f86771bc0443b6890a712facd8c199

P1004: ACTIVATING MUTATIONS IN JAK2 AND CALR DIFFERENTIALLY AFFECT INTRACELLULAR CALCIUM LEVELS AND CALCIUM FLUX

Authors: Vikas Bhuria, Tobias Franz, Conny Baldauf, Martin Böttcher, Nicolas Chatain, Steffen Koschmieder, Tim H Brümmendorf, Dimitrios Mougiakakos, Burkhart Schraven, Sascha Kahlfuß, Thomas Fischer

Source: HemaSphere, Vol 7, p e21609c8 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000970920.21609.c8; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/5506c27cb8d042049a0c79cc874e1248

P988: MUTANT CALRETICULIN AND JAK2V617F DRIVER MUTATIONS INDUCE DISTINCT MITOTIC DEFECTS IN MYELOPROLIFERATIVE NEOPLASMS

Authors: Kristin Holl, Nicolas Chatain, Nathalie Brock, Susanne Krapp, Julian Baumeister, Steffen Koschmieder, Wolfram Antonin, Daniel Moreno-Andrés

Source: HemaSphere, Vol 7, p e061815f (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000970856.06181.5f; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/8d4c8814998043f9b9ab66e7861b741f

P653: CML LONG-TERM LEUKEMIC STEM CELL PERSISTENCE IS INFLUENCED BY MYELOFIBROSIS AT DIAGNOSIS

Authors: Henrike Jacobi, Margherita Vieri, Carolina Y. Namasu, Laura Flüter, Ivan G. Costa, Tiago Maié, Nicolas Chatain, Fabian Beier, Michael Huber, Martina Crysandt, Tim H. Brümmendorf, Mirle Schemionek-Reinders

Source: HemaSphere, Vol 7, p e8231722 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000969516.82317.22; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/76f95e3c7a8948be84aeebe6a888ad80

P1008: THE TELOMERASE INHIBITOR IMETELSTAT DIFFERENTIALLY TARGETS JAK2V617F- VERSUS CALR-MUTANT MYELOPROLIFERATIVE NEOPLASM CELLS AND INHIBITS JAK-STAT SIGNALING

Authors: Kathrin Olschok, Bianca Altenburg, Marcelo A.S. de Toledo, Angela Maurer, Anne Abels, Fabian Beier, Deniz Gezer, Susanne Isfort, Tim H Brümmendorf, Martin Zenke, Nicolas Chatain, Steffen Koschmieder

Source: HemaSphere, Vol 7, p e661233c (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000970936.66123.3c; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/1d8c94f874454194b3139eb4534987b7

Myelofibrosis at diagnosis is associated with the failure of treatment-free remission in CML patients

Authors: Henrike Jacobi, Margherita Vieri, Marlena Bütow, Carolina Y. Namasu, Laura Flüter, Ivan G. Costa, Tiago Maié, Katharina Lindemann-Docter, Nicolas Chatain, Fabian Beier, Michael Huber, Wolfgang Wagner, Martina Crysandt, Tim H. Brümmendorf, Mirle Schemionek

Source: Frontiers in Pharmacology, Vol 14 (2023)

Subject Terms: CML, TFR, fibrosis, leukemic stem cells, LSC, MSc, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1212392/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/1bcfdb9e48a74693a9367baef6ba229c

Targeting cytokine-induced leukemic stem cell persistence in chronic myeloid leukemia by IKK2-inhibition

Authors: Marlena Bütow, Fabio J. Testaquadra, Julian Baumeister, Tiago Maié, Nicolas Chatain, Timo Jaquet, Stefan Tillmann, Martina Crysandt, Ivan G. Costa, Tim H. Brümmendorf, Mirle Schemionek

Source: Haematologica, Vol 108, Iss 4 (2022)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/10885; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/812b73c5e1934e12ae3523cb4a8c88ae

CRISPR/Cas9-engineered human ES cells harboring heterozygous and homozygous c-KIT knockout

Authors: Marcelo A.S. de Toledo, Xuhuang Fu, Frederick Kluge, Katrin Götz, Susanne Schmitz, Paul Wanek, Herdit M. Schüler, Kristina Pannen, Nicolas Chatain, Steffen Koschmieder, Tim H. Brümmendorf, Martin Zenke

Source: Stem Cell Research, Vol 60, Iss , Pp 102732- (2022)

Subject Terms: Embryonic stem cells, ES cells, c-KIT, CD117, Stem cell factor receptor, CRISPR, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1873506122000812; https://doaj.org/toc/1873-5061

Access URL: https://doaj.org/article/b4c89ee1dd1e4d999c46911c9926efdf

Differential roles of STAT1 and STAT2 in the sensitivity of JAK2V617F- vs. BCR-ABL-positive cells to interferon alpha

Authors: Claudia Schubert, Manuel Allhoff, Stefan Tillmann, Tiago Maié, Ivan G. Costa, Daniel B. Lipka, Mirle Schemionek, Kristina Feldberg, Julian Baumeister, Tim H. Brümmendorf, Nicolas Chatain, Steffen Koschmieder

Source: Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-16 (2019)

Subject Terms: IFNa, BCR-ABL, JAK2V617F, MPN, Polycythemia vera, Chronic myeloid leukemia, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13045-019-0722-9; https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/f04572cd8a7a47c1b8bb12f8129e168b

Evaluation of Chiral Organosulfur Compounds on Their Activity against the Malaria Parasite Plasmodium falciparum

Authors: Che Julius Ngwa, Rabea Stratmann, Jean Pierre Musabyimana, Kristina Pannen, Jan-Hendrik Schöbel, Marcus Frings, Ingo Schiffers, Calogero Quaranta, Steffen Koschmieder, Nicolas Chatain, Gabriele Pradel, Carsten Bolm

Source: Tropical Medicine and Infectious Disease, Vol 7, Iss 12, p 416 (2022)

Subject Terms: malaria, Plasmodium falciparum, organosulfur compounds, enantiomers, drugs, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2414-6366/7/12/416; https://doaj.org/toc/2414-6366

Access URL: https://doaj.org/article/14fb282cb32d460d82cccdcd5ace6e5d

CRISPR/Cas9 mediated CXCL4 knockout in human iPS cells of polycythemia vera patient with JAK2 V617F mutation

Authors: Janik Boehnke, Salim Atakhanov, Marcelo A.S. Toledo, Herdit M. Schüler, Stephanie Sontag, Nicolas Chatain, Steffen Koschmieder, Tim H. Brümmendorf, Rafael Kramann, Martin Zenke

Source: Stem Cell Research, Vol 55, Iss , Pp 102490- (2021)

Subject Terms: Induced pluripotent stem cell, iPS cells, Hematopoiesis, CXCL4, PF4, JAK2 V617F, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1873506121003378; https://doaj.org/toc/1873-5061

Access URL: https://doaj.org/article/d5201e98c76548fb80312315e5bbd47d

Human DC3 Antigen Presenting Dendritic Cells From Induced Pluripotent Stem Cells

Authors: Taiki Satoh, Marcelo A. S. Toledo, Janik Boehnke, Kathrin Olschok, Niclas Flosdorf, Katrin Götz, Caroline Küstermann, Stephanie Sontag, Kristin Seré, Steffen Koschmieder, Tim H. Brümmendorf, Nicolas Chatain, Yoh-ichi Tagawa, Martin Zenke

Source: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Subject Terms: induced pluripotent stem cell, iPS cells, hematopoiesis, dendritic cells, DC3, JAK2, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.667304/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/066bc1a8ca6f4f6981093117e628c953

Therapeutic Cancer Vaccination With a Peptide Derived From the Calreticulin Exon 9 Mutations Induces Strong Cellular Immune Responses in Patients With CALR-Mutant Chronic Myeloproliferative Neoplasms

Authors: Jacob Handlos Grauslund, Morten Orebo Holmström, Nicolai Grønne Jørgensen, Uffe Klausen, Stine Emilie Weis-Banke, Daniel El Fassi, Claudia Schöllkopf, Mette Borg Clausen, Lise Mette Rahbek Gjerdrum, Marie Fredslund Breinholt, Julie Westerlin Kjeldsen, Morten Hansen, Steffen Koschmieder, Nicolas Chatain, Guy Wayne Novotny, Jesper Petersen, Lasse Kjær, Vibe Skov, Özcan Met, Inge Marie Svane, Hans Carl Hasselbalch, Mads Hald Andersen

Source: Frontiers in Oncology, Vol 11 (2021)

Subject Terms: myeloproliferative neoplasms, cancer immune therapy, cancer vaccines, neo-antigen, calreticulin, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2021.637420/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/348bdbd7063d4ceeaa8716a415e505fe

Progression of Myeloproliferative Neoplasms (MPN): Diagnostic and Therapeutic Perspectives

Authors: Julian Baumeister, Nicolas Chatain, Alexandros Marios Sofias, Twan Lammers, Steffen Koschmieder

Source: Cells, Vol 10, Iss 12, p 3551 (2021)

Subject Terms: MPN, progression, diagnosis, therapy, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/10/12/3551; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/e9ae5e40eda04cac82bb818963aaa779

Inflammation and anti-inflammatory approaches in myeloproliferative neoplasm

Authors: Steffen Koschmieder, Nicolas Chatain

Source: HemaSphere, Vol 2, Pp 143-145 (2018)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/HS9.0000000000000106; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/baa2e74af1a449a48f1c9a3d8f86a7d0

Calreticulin-mutant proteins induce megakaryocytic signaling to transform hematopoietic cells and undergo accelerated degradation and Golgi-mediated secretion

Authors: Lijuan Han, Claudia Schubert, Johanna Köhler, Mirle Schemionek, Susanne Isfort, Tim H. Brümmendorf, Steffen Koschmieder, Nicolas Chatain

Source: Journal of Hematology & Oncology, Vol 9, Iss 1, Pp 1-14 (2016)

Subject Terms: Calreticulin, Frameshift mutants, del52, Myeloproliferative neoplasms, MPN, Megakaryopoiesis, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13045-016-0275-0; https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/05519d64505b4c6ebd53b93217bcc276

Dissecting Genomic Aberrations in Myeloproliferative Neoplasms by Multiplex-PCR and Next Generation Sequencing.

Authors: Martin M J Kirschner, Mirle Schemionek, Claudia Schubert, Nicolas Chatain, Stephanie Sontag, Susanne Isfort, Nadina Ortiz-Brüchle, Karla Schmitt, Luisa Krüger, Klaus Zerres, Martin Zenke, Tim H Brümmendorf, Steffen Koschmieder

Source: PLoS ONE, Vol 10, Iss 4, p e0123476 (2015)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/65a2ac84af5c42c4accf73cea7939b2f