Dynein light chains 1 and 2 are auxiliary proteins of pH-sensitive Kir4.1 channels

Authors: Lee, Sun-Joo ^{1, ∗}, Gao, Jian ¹, Thompson, Ellen ¹, Mount, Jonathan ², Nichols, Colin G. ¹

Source: In Journal of Biological Chemistry

Modulation of TMEM16B channel activity by the calcium-activated chloride channel regulator 4 (CLCA4) in human cells

Authors: Sala-Rabanal, Monica, Yurtsever, Zeynep, Berry, Kayla N., McClenaghan, Conor, Foy, Alyssa J., Hanson, Alex, Steinberg, Deborah F., Greven, Jessica A., Kluender, Colin E., Alexander-Brett, Jennifer M., Nichols, Colin G., Brett, Tom J.

Source: In Journal of Biological Chemistry July 2024 300(7)

Rapid Characterization of the Functional and Pharmacological Consequences of Cantú Syndrome KATP Channel Mutations in Intact Cells

Authors: Gao, Jian, McClenaghan, Conor ¹, Matreyek, Kenneth A., Grange, Dorothy K., Nichols, Colin G. ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics September 2023 386(3):298-309

ATP‐sensitive potassium channels in zebrafish cardiac and vascular smooth muscle

Authors: Singareddy, Soma S., Roessler, Helen I., McClenaghan, Conor, Ikle, Jennifer M., Tryon, Robert C., Haaften, Gijs, Nichols, Colin G.

Source: Journal of physiology. 600(2):299-312

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Genome-edited zebrafish model of ABCC8 loss-of-function disease

Authors: Ikle, Jennifer M., Tryon, Robert C., Singareddy, Soma S., York, Nathaniel W., Remedi, Maria S., Nichols, Colin G.

Source: Islets. 14(1):200-209

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167468693.0x000001&indx=1&recIds=ETOCvdc_100167468693.0x000001

Sulfonylurea-Insensitive Permanent Neonatal Diabetes Caused by a Severe Gain-of-Function Tyr330His Substitution in Kir6.2

Authors: McClenaghan, Conor, Rapini, Novella, De Rose, Domenico Umberto, Gao, Jian, Roeglin, Jacob, Bizzarri, Carla, Schiaffini, Riccardo, Tiberi, Eloisa, Mucciolo, Mafalda, Deodati, Annalisa, Perri, Alessandro, Vento, Giovanni, Barbetti, Fabrizio, Nichols, Colin G., Cianfarani, Stefano

Source: Hormone research in pædiatrics. 95(3):215-223

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100157415841.0x000001&indx=1&recIds=ETOCvdc_100157415841.0x000001

The T1‐tetramerisation domain of Kv1.2 rescues expression and preserves function of a truncated NaChBac sodium channel

Authors: D'Avanzo, Nazzareno, Miles, Andrew J., Powl, Andrew M., Nichols, Colin G., Wallace, B.A., O'Reilly, Andrias O.

Source: FEBS letters. 596(6):772-783

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100145692469.0x000001&indx=1&recIds=ETOCvdc_100145692469.0x000001

Loss of β-Cell KATP Reduces Ca²⁺ Sensitivity of Insulin Secretion and Trpm5 Expression.

Authors: York, Nathaniel W., Yan, Zihan, Osipovich, Anna B., Tate, Abbie, Patel, Sumit, Piston, David W., Magnuson, Mark A., Remedi, Maria S., Nichols, Colin G.

Source: Diabetes; Mar2025, Vol. 74 Issue 3, p376-383, 8p

Subject Terms: CALCIUM ions, GLUCOSE intolerance, INSULIN resistance, INSULIN sensitivity, INTRACELLULAR calcium

Large‐conductance calcium‐activated K+ channels, rather than KATP channels, mediate the inhibitory effects of nitric oxide on mouse lymphatic pumping

Authors: Kim, Hae Jin, Li, Min, Nichols, Colin G., Davis, Michael J.

Source: British journal of pharmacology. 178(20):4119-4136

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131022292.0x000001&indx=1&recIds=ETOCvdc_100131022292.0x000001

A novel ABCC9 variant in a Greek family with Cantu syndrome affecting multiple generations highlights the functional role of the SUR2B NBD1.

Authors: Gao, Jian^1,2, Ververi, Athina³, Thompson, Ellen^1,2, Tryon, Rob^1,2, Sotiriadis, Alexandros⁴, Rouvalis, Fotios⁵, Grange, Dorothy K.^2,6, Giannios, Christos⁷, giannioschris@yahoo.gr, Nichols, Colin G.^1,2, cnichols@wustl.edu

Source: American Journal of Medical Genetics. Part A; Dec2024, Vol. 194 Issue 12, p1-9, 9p

Skeletal muscle delimited myopathy and verapamil toxicity in SUR2 mutant mouse models of AIMS

Authors: McClenaghan, Conor, Mukadam, Maya A, Roeglin, Jacob, Tryon, Robert C, Grabner, Manfred, Dayal, Anamika, Meyer, Gretchen A, Nichols, Colin G

Source: EMBO molecular medicine. 15(6)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184656758.0x000001&indx=1&recIds=ETOCvdc_100184656758.0x000001

Kir6.1‐dependent KATP channels in lymphatic smooth muscle and vessel dysfunction in mice with Kir6.1 gain‐of‐function

Authors: Davis, Michael J., Kim, Hae Jin, Zawieja, Scott D., Castorena‐Gonzalez, Jorge A., Gui, Peichun, Li, Min, Saunders, Brian T., Zinselmeyer, Bernd H., Randolph, Gwendalyn J., Remedi, Maria S., Nichols, Colin G.

Source: Journal of physiology. 598(15):3107-3127

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100109341660.0x000001&indx=1&recIds=ETOCvdc_100109341660.0x000001

Glibenclamide reverses cardiovascular abnormalities of Cantu syndrome driven by K~A~T~P channel overactivity

Authors: McClenaghan, Conor, Huang, Yan, Yan, Zihan, Harter, Theresa, Halabi, Carmen M., Chalk, Rod, Kovacs, Attila, van Haaften, Gijs, Remedi, Maria S., Nichols, Colin G.

Source: Journal of clinical investigation. 130(3):1116-1121

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN623253671&indx=1&recIds=ETOCRN623253671

Electrophysiology of Human iPSC-derived Vascular Smooth Muscle Cells and Cell-autonomous Consequences of Cantú Syndrome Mutations.

Authors: Hanson, Alex, McClenaghan, Conor, Weng, Kuo-Chan, Colijn, Sarah, Stratman, Amber N, Halabi, Carmen M, Grange, Dorothy K, Silva, Jonathan R, Nichols, Colin G

Source: Function; 2024, Vol. 5 Issue 5, p1-12, 12p

Subject Terms: VASCULAR smooth muscle, VASCULAR resistance, GENE expression, CARDIOVASCULAR system, BLOOD pressure, POTASSIUM channels

Polyamines and potassium channels: A 25-year romance

Authors: Nichols, Colin G., Lee, Sun-joo

Source: In Journal of Biological Chemistry 30 November 2018 293(48):18779-18788

Superior diastolic function with KATP channel opener diazoxide in a novel mouse Langendorff model

Authors: Makepeace, Carol M., Suarez-Pierre, Alejandro, Kanter, Evelyn M., Schuessler, Richard B., Nichols, Colin G., Lawton, Jennifer S.

Source: In Journal of Surgical Research July 2018 227:186-193

Novel drug targets for ductus arteriosus manipulation: Looking beyond prostaglandins

Authors: Shelton, Elaine L., Singh, Gautam K., Nichols, Colin G.

Source: In Seminars in Perinatology June 2018 42(4):221-227

Cantu syndrome–associated SUR2 (ABCC9) mutations in distinct structural domains result in KATP channel gain-of-function by differential mechanisms

Authors: McClenaghan, Conor, Hanson, Alex, Sala-Rabanal, Monica, Roessler, Helen I., Josifova, Dragana, Grange, Dorothy K., van Haaften, Gijs, Nichols, Colin G.

Source: In Journal of Biological Chemistry 9 February 2018 293(6):2041-2052

Oxidation driven reversal of PIP2-dependent gating in GIRK2 channels

Authors: Joo Lee, Sun, Maeda, Shoji, Nichols, Colin G.

Source: Biophysical journal. 122(S1):391a-392a

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185949663.0x000001&indx=1&recIds=ETOCvdc_100185949663.0x000001

Pulmonary Hypertension and ATP-Sensitive Potassium Channels

Authors: McClenaghan, Conor, Woo, Kel Vin, Nichols, Colin G.

Source: Hypertension. 74(1):14-22

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100082887374.0x000001&indx=1&recIds=ETOCvdc_100082887374.0x000001