Borrelia PeptideAtlas: A proteome resource of common Borrelia burgdorferi isolates for Lyme research

Authors: Panga J. Reddy, Zhi Sun, Helisa H. Wippel, David H. Baxter, Kristian Swearingen, David D. Shteynberg, Mukul K. Midha, Melissa J. Caimano, Klemen Strle, Yongwook Choi, Agnes P. Chan, Nicholas J. Schork, Andrea S. Varela-Stokes, Robert L. Moritz

Source: Scientific Data, Vol 11, Iss 1, Pp 1-17 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2052-4463

Access URL: https://doaj.org/article/bd4e1e68f2674b299d11797f90ce48b7

Single‐Cell Patch‐Clamp/Proteomics of Human Alzheimer's Disease iPSC‐Derived Excitatory Neurons Versus Isogenic Wild‐Type Controls Suggests Novel Causation and Therapeutic Targets

Authors: Swagata Ghatak, Jolene K. Diedrich, Maria Talantova, Nivedita Bhadra, Henry Scott, Meetal Sharma, Matthew Albertolle, Nicholas J. Schork, John R. Yates III, Stuart A. Lipton

Source: Advanced Science, Vol 11, Iss 29, Pp n/a-n/a (2024)

Subject Terms: Alzheimer's disease, hiPSC‐derived neurons, patch clamp electrophysiology, single‐cell proteomics, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/7f4dd02cff274168ba32976ec18c4157

Lifespan-extending interventions induce consistent patterns of fatty acid oxidation in mouse livers

Authors: Kengo Watanabe, Tomasz Wilmanski, Priyanka Baloni, Max Robinson, Gonzalo G. Garcia, Michael R. Hoopmann, Mukul K. Midha, David H. Baxter, Michal Maes, Seamus R. Morrone, Kelly M. Crebs, Charu Kapil, Ulrike Kusebauch, Jack Wiedrick, Jodi Lapidus, Lance Pflieger, Christopher Lausted, Jared C. Roach, Gwênlyn Glusman, Steven R. Cummings, Nicholas J. Schork, Nathan D. Price, Leroy Hood, Richard A. Miller, Robert L. Moritz, Noa Rappaport

Source: Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/62bd4731cc7d4a7caaf5b70a9897021a

Emerging therapeutic drug monitoring technologies: considerations and opportunities in precision medicine

Authors: Winnie S. Liang, Brett Beaulieu-Jones, Susan Smalley, Michael Snyder, Laura H. Goetz, Nicholas J. Schork

Source: Frontiers in Pharmacology, Vol 15 (2024)

Subject Terms: therapeutic drug monitoring, N-of-1 clinical trials, biosensors, wearables, precision medicine, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1348112/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/8a5a3f2f07dd4f9082012862749da0d7

Early-stage multi-cancer detection using an extracellular vesicle protein-based blood test

Authors: Juan Pablo Hinestrosa, Razelle Kurzrock, Jean M. Lewis, Nicholas J. Schork, Gregor Schroeder, Ashish M. Kamat, Andrew M. Lowy, Ramez N. Eskander, Orlando Perrera, David Searson, Kiarash Rastegar, Jake R. Hughes, Victor Ortiz, Iryna Clark, Heath I. Balcer, Larry Arakelyan, Robert Turner, Paul R. Billings, Mark J. Adler, Scott M. Lippman, Rajaram Krishnan

Source: Communications Medicine, Vol 2, Iss 1, Pp 1-9 (2022)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2730-664X

Access URL: https://doaj.org/article/1d42a6ac983a4da48a2fb210e7baba4d

Author Correction: Lifespan-extending interventions induce consistent patterns of fatty acid oxidation in mouse livers

Authors: Kengo Watanabe, Tomasz Wilmanski, Priyanka Baloni, Max Robinson, Gonzalo G. Garcia, Michael R. Hoopmann, Mukul K. Midha, David H. Baxter, Michal Maes, Seamus R. Morrone, Kelly M. Crebs, Charu Kapil, Ulrike Kusebauch, Jack Wiedrick, Jodi Lapidus, Lance Pflieger, Christopher Lausted, Jared C. Roach, Gwênlyn Glusman, Steven R. Cummings, Nicholas J. Schork, Nathan D. Price, Leroy Hood, Richard A. Miller, Robert L. Moritz, Noa Rappaport

Source: Communications Biology, Vol 6, Iss 1, Pp 1-1 (2023)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/a9aff2da020c40e2bb53670b91526adc

Assessing brain and biological aging trajectories associated with Alzheimer’s disease

Authors: Winnie S. Liang, Laura H. Goetz, Nicholas J. Schork

Source: Frontiers in Neuroscience, Vol 16 (2022)

Subject Terms: brain age, biological age, epigenetic clock, Alzheimer’s disease, epigenetic age, brain age gap, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnins.2022.1036102/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/5e4b09a9b686471288193fa58a0527cf

Improved methods for RNAseq-based alternative splicing analysis

Authors: Rebecca F. Halperin, Apurva Hegde, Jessica D. Lang, Elizabeth A. Raupach, C4RCD Research Group, Christophe Legendre, Winnie S. Liang, Patricia M. LoRusso, Aleksandar Sekulic, Jeffrey A. Sosman, Jeffrey M. Trent, Sampathkumar Rangasamy, Patrick Pirrotte, Nicholas J. Schork

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/a3220a92cf2645288aad59ed2f183636

A mRNA Vaccine Encoding for a RBD 60-mer Nanoparticle Elicits Neutralizing Antibodies and Protective Immunity Against the SARS-CoV-2 Delta Variant in Transgenic K18-hACE2 Mice

Authors: Pascal Brandys, Xavier Montagutelli, Irena Merenkova, Güliz T. Barut, Volker Thiel, Nicholas J. Schork, Bettina Trüeb, Laurine Conquet, Aihua Deng, Aleksandar Antanasijevic, Hyun-Ku Lee, Martine Valière, Anoop Sindhu, Gita Singh, Jens Herold

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: SARS-CoV-2, delta variant, mRNA vaccine, nanoparticle, receptor-binding domain, neutralizing antibody, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.912898/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/9ee8268a8ead4080ba8fda661152e7cb

Genetic and Protein Network Underlying the Convergence of Rett-Syndrome-like (RTT-L) Phenotype in Neurodevelopmental Disorders

Authors: Eric Frankel, Avijit Podder, Megan Sharifi, Roshan Pillai, Newell Belnap, Keri Ramsey, Julius Dodson, Pooja Venugopal, Molly Brzezinski, Lorida Llaci, Brittany Gerald, Gabrielle Mills, Meredith Sanchez-Castillo, Chris D. Balak, Szabolcs Szelinger, Wayne M. Jepsen, Ashley L. Siniard, Ryan Richholt, Marcus Naymik, Isabelle Schrauwen, David W. Craig, Ignazio S. Piras, Matthew J. Huentelman, Nicholas J. Schork, Vinodh Narayanan, Sampathkumar Rangasamy

Source: Cells, Vol 12, Iss 10, p 1437 (2023)

Subject Terms: Rett syndrome, atypical RTT syndrome, Rett-syndrome-like phenotype, methyl-CpG-binding protein 2, neurodevelopmental disorders, overlapping phenotype, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/12/10/1437; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/20acec46706042719162109c33744bd6

Transcriptomic evidence that von Economo neurons are regionally specialized extratelencephalic-projecting excitatory neurons

Authors: Rebecca D. Hodge, Jeremy A. Miller, Mark Novotny, Brian E. Kalmbach, Jonathan T. Ting, Trygve E. Bakken, Brian D. Aevermann, Eliza R. Barkan, Madeline L. Berkowitz-Cerasano, Charles Cobbs, Francisco Diez-Fuertes, Song-Lin Ding, Jamison McCorrison, Nicholas J. Schork, Soraya I. Shehata, Kimberly A. Smith, Susan M. Sunkin, Danny N. Tran, Pratap Venepally, Anna Marie Yanny, Frank J. Steemers, John W. Phillips, Amy Bernard, Christof Koch, Roger S. Lasken, Richard H. Scheuermann, Ed S. Lein

Source: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/78763ec182d74a1e969da1bbe56703f2

Rare variant phasing using paired tumor:normal sequence data

Authors: Alexandra R. Buckley, Trey Ideker, Hannah Carter, Nicholas J. Schork

Source: BMC Bioinformatics, Vol 20, Iss 1, Pp 1-11 (2019)

Subject Terms: Variant phasing, Cancer germline, Cancer genomics, Computer applications to medicine. Medical informatics, R858-859.7, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12859-019-2753-1; https://doaj.org/toc/1471-2105

Access URL: https://doaj.org/article/daab7d52caad4dc49cd6adbf28b52d31

Cross-Species and Human Inter-Tissue Network Analysis of Genes Implicated in Longevity and Aging Reveal Strong Support for Nutrient Sensing

Authors: Avijit Podder, Anish Raju, Nicholas J. Schork

Source: Frontiers in Genetics, Vol 12 (2021)

Subject Terms: human aging, cross-species orthologs, protein-protein interaction network, pathway enrichments, nutrient sensing, drug targets, Genetics, QH426-470

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fgene.2021.719713/full; https://doaj.org/toc/1664-8021

Access URL: https://doaj.org/article/79042f95c3c848caaa4f3a55ffa43b3c

Editorial: Creating Evidence From Real World Patient Digital Data

Authors: Jane Nikles, Eric J. Daza, Suzanne McDonald, Eric Hekler, Nicholas J. Schork

Source: Frontiers in Computer Science, Vol 2 (2021)

Subject Terms: N-of-1 clinical trials, single case experimental designs, digital health, real world data, single case designs, Electronic computers. Computer science, QA75.5-76.95

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcomp.2020.636996/full; https://doaj.org/toc/2624-9898

Access URL: https://doaj.org/article/95e416efdaf24e8eaa8cd3a0187c851a

Conserved Genomic Terminals of SARS-CoV-2 as Coevolving Functional Elements and Potential Therapeutic Targets

Authors: Agnes P. Chan, Yongwook Choi, Nicholas J. Schork

Source: mSphere, Vol 5, Iss 6 (2020)

Subject Terms: SARS-CoV-2, human microRNA, influenza A H1N1, virus 3′ untranslated region, COVID-19, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2379-5042

Access URL: https://doaj.org/article/662445f52d234fb598bc13e52424dfc0

Optimizing Aggregated N-Of-1 Trial Designs for Predictive Biomarker Validation: Statistical Methods and Theoretical Findings

Authors: Rebecca C. Hendrickson, Ronald G. Thomas, Nicholas J. Schork, Murray A. Raskind

Source: Frontiers in Digital Health, Vol 2 (2020)

Subject Terms: N-of-1 trials, crossover trials, posttraumatic stress disorder (PTSD), prazosin, biomarkers, personalized medicine, Medicine, Public aspects of medicine, RA1-1270, Electronic computers. Computer science, QA75.5-76.95

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fdgth.2020.00013/full; https://doaj.org/toc/2673-253X

Access URL: https://doaj.org/article/f0649e953119430d99b9b5c5c539c1c7

Exome-wide analysis of bi-allelic alterations identifies a Lynch phenotype in The Cancer Genome Atlas

Authors: Alexandra R. Buckley, Trey Ideker, Hannah Carter, Olivier Harismendy, Nicholas J. Schork

Source: Genome Medicine, Vol 10, Iss 1, Pp 1-15 (2018)

Subject Terms: Cancer genomics, Cancer germline, Cancer predisposition, TCGA, Microsatellite instability, Lynch syndrome, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13073-018-0579-5; https://doaj.org/toc/1756-994X

Access URL: https://doaj.org/article/a7bd11e3cd7f4d6fb987c17c68264726

Cell type discovery and representation in the era of high-content single cell phenotyping

Authors: Trygve Bakken, Lindsay Cowell, Brian D. Aevermann, Mark Novotny, Rebecca Hodge, Jeremy A. Miller, Alexandra Lee, Ivan Chang, Jamison McCorrison, Bali Pulendran, Yu Qian, Nicholas J. Schork, Roger S. Lasken, Ed S. Lein, Richard H. Scheuermann

Source: BMC Bioinformatics, Vol 18, Iss S17, Pp 7-16 (2017)

Subject Terms: Cell ontology, Single cell transcriptomics, Cell phenotype, Peripheral blood mononuclear cells, Neuron, Next generation sequencing, Computer applications to medicine. Medical informatics, R858-859.7, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12859-017-1977-1; https://doaj.org/toc/1471-2105

Access URL: https://doaj.org/article/a305d64a8be2415ebaf4f86a83546ebe

Pan-cancer analysis reveals technical artifacts in TCGA germline variant calls

Authors: Alexandra R. Buckley, Kristopher A. Standish, Kunal Bhutani, Trey Ideker, Roger S. Lasken, Hannah Carter, Olivier Harismendy, Nicholas J. Schork

Source: BMC Genomics, Vol 18, Iss 1, Pp 1-15 (2017)

Subject Terms: Cancer genomics, TCGA, Cancer germline, Whole exome sequencing, Variant calling, GATK, Biotechnology, TP248.13-248.65, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12864-017-3770-y; https://doaj.org/toc/1471-2164

Access URL: https://doaj.org/article/9526ab57f90745b687f38b890aedac4e

Comprehensive analysis of treatment response phenotypes in rheumatoid arthritis for pharmacogenetic studies

Authors: Kristopher A. Standish, C. Chris Huang, Mark E. Curran, Nicholas J. Schork

Source: Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-10 (2017)

Subject Terms: Rheumatoid arthritis, Pharmacogenetics, Genetics, Heritability, Phenotype, Placebo, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13075-017-1299-8; https://doaj.org/toc/1478-6362

Access URL: https://doaj.org/article/fee6f2188d2343a2b2ae080d83f9c2dd