Secreted IgM deficiency alters the retinal landscape enhancing neurodegeneration associated with aging

Authors: Sarah E. Webster, Sydney M. Les, Nico Deleon, Daken M. Heck, Naomi L. Tsuj, Michael J. Clemente, Prentiss Jones, Nichol E. Holodick

Source: Immunity & Ageing, Vol 22, Iss 1, Pp 1-18 (2025)

Subject Terms: IgM, Immunoglobulin, Aging, Retina, Retinal degeneration, Cataracts, Immunologic diseases. Allergy, RC581-607, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/1742-4933

Access URL: https://doaj.org/article/8b81fa920b6d4049bf7eb9730a8fda87

B cell extracellular vesicles contain monomeric IgM that binds antigen and enters target cells

Authors: Michael F. Gutknecht, Nichol E. Holodick, Thomas L. Rothstein

Source: iScience, Vol 26, Iss 9, Pp 107526- (2023)

Subject Terms: Immunology, Cell biology, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004223016036; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/0d2bc1d3962a4d529f2b5b7edbaf261a

Age-related changes in antigen-specific natural antibodies are influenced by sex

Authors: Sarah E. Webster, Naomi L. Tsuji, Michael J. Clemente, Nichol E. Holodick

Source: Frontiers in Immunology, Vol 13 (2023)

Subject Terms: B-1 cell, natural antibody, phosphatidylcholine, aging, biological sex, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1047297/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/146f74f9a2dc4d50a61b8e248159c0e8

B-1b Cells Have Unique Functional Traits Compared to B-1a Cells at Homeostasis and in Aged Hyperlipidemic Mice With Atherosclerosis

Authors: Prasad Srikakulapu, Tanyaporn Pattarabanjird, Aditi Upadhye, Sai Vineela Bontha, Victoria Osinski, Melissa A. Marshall, James Garmey, Justine Deroissart, Thomas A. Prohaska, Joseph L. Witztum, Christoph J. Binder, Nichol E. Holodick, Thomas L. Rothstein, Coleen A. McNamara

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: B-1 cells, IgM antibodies, IgHV sequencing, aging, CCR6, atherosclerosis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.909475/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/286501d5bfa64c20ac2f25408827ca76

B-1a cells protect mice from sepsis-induced acute lung injury

Authors: Monowar Aziz, Yasumasa Ode, Mian Zhou, Mahendar Ochani, Nichol E. Holodick, Thomas L. Rothstein, Ping Wang

Source: Molecular Medicine, Vol 24, Iss 1, Pp 1-12 (2018)

Subject Terms: B-1a cells, Sepsis, Acute lung injury, Inflammation, Neutrophils, IL-10, Therapeutics. Pharmacology, RM1-950, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s10020-018-0029-2; https://doaj.org/toc/1076-1551; https://doaj.org/toc/1528-3658

Access URL: https://doaj.org/article/2d16342f825443bb97ea654ec6889b6f

Editorial: Natural Antibodies in Health and Disease

Authors: Ana Maria Hernandez, Nichol E. Holodick

Source: Frontiers in Immunology, Vol 8 (2017)

Subject Terms: natural antibodies, B cells, B-1 cells, antibodies, natural antibodies repertoire, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fimmu.2017.01795/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/a294905c42794c29bb0dcac16f6571bc

Defining Natural Antibodies

Authors: Nichol E. Holodick, Nely Rodríguez-Zhurbenko, Ana María Hernández

Source: Frontiers in Immunology, Vol 8 (2017)

Subject Terms: natural antibody, antibodies, natural antibody repertoire, B-1 cells, B cell subsets, B cells, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fimmu.2017.00872/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/fbf62f0a84bb4f88ae41f35599785451

CD25+ B-1a Cells Express Aicda

Authors: Hiroaki Kaku, Nichol E. Holodick, Joseph R. Tumang, Thomas L. Rothstein

Source: Frontiers in Immunology, Vol 8 (2017)

Subject Terms: AID, B-1a cells, CD25, B-1 cell subset, peritoneal cavity, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fimmu.2017.00672/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/0ab3307d121340608f610d4b4196848f

B-CD8+ T Cell Interactions in the Anti-Idiotypic Response against a Self-Antibody

Authors: Darel Martínez, Amaury Pupo, Lianet Cabrera, Judith Raymond, Nichol E. Holodick, Ana María Hernández

Source: Journal of Immunology Research, Vol 2017 (2017)

Subject Terms: Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/2314-8861; https://doaj.org/toc/2314-7156

Access URL: https://doaj.org/article/4bc5ddab6ff3485db5da05270d54eb98

A CD25-positive population of activated B1 cells expresses LIFR and responds to LIF

Authors: Joseph R. Tumang, Nichol E. Holodick, Teresa C. Vizconde, Hiroaki eKaku, Ruben eFrances, Thomas L Rothstein

Source: Frontiers in Immunology, Vol 2 (2011)

Subject Terms: signaling, B1 Cells, CD25, LIF receptor, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://journal.frontiersin.org/Journal/10.3389/fimmu.2011.00006/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/603148fd441d4a4189b6d5541bba49d2

Natural Antibodies in Health and Disease

Authors: Ana Maria Hernandez, Nichol E. Holodick

Subject Terms: R5-920, RC581-607, innate immunity, immunoglobulin, Antibodies, B cells, IgM, natural antibodies, B-1 cells, Medicine and Nursing

File Description: image/jpeg

Relation: Frontiers Research Topics

Access URL: https://directory.doabooks.org/handle/20.500.12854/54349
https://www.frontiersin.org/research-topics/3612/natural-antibodies-in-health-and-disease

Expansion of B-1a cells with germline heavy chain sequence in lupus mice

Authors: Nichol E Holodick, Leilani Sanchez Zeumer, Thomas L Rothstein, Laurence eMorel

Source: Frontiers in Immunology, Vol 7 (2016)

Subject Terms: Autoimmunity, Lupus Erythematosus, Systemic, B cells, B-1 cells, mouse model, natural antibodies, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00108/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/24c19b5297124232825114577a4c6691

Splenic B-1a Cells Expressing CD138 Spontaneously Secrete Large Amounts of Immunoglobulin in Naïve Mice

Authors: Nichol E Holodick, Teresa eVizconde, Thomas L Rothstein

Source: Frontiers in Immunology, Vol 5 (2014)

Subject Terms: B-1 cells, repertoire, Splenic B-1 cells, CD5+ B-1 cells, natural IgM, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00129/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/b815619daf4e4e97846e7091e4c96612

Atypical response of B-1 cells to BCR Ligation: A speculative model

Authors: Nichol E Holodick, Thomas L Rothstein

Source: Frontiers in Immunology, Vol 4 (2013)

Subject Terms: NF-kappa B, Phosphates, B-1 cells, BCR signaling, murine, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00457/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/e9d649cecdbb47c593d366ab0be6b26b