Organoid models of breathing disorders reveal patterning defect of hindbrain neurons caused by PHOX2B-PARMs

Authors: Lui, Kathy Nga-Chu, Li, Zhixin, Lai, Frank Pui-Ling, Lau, Sin-Ting, Ngan, Elly Sau-Wai

Source: In Stem Cell Reports 11 July 2023 18(7):1500-1515

New insights empowered by single-cell sequencing: From neural crest to enteric nervous system

Authors: Li, Zhixin, Ngan, Elly Sau-Wai

Source: In Computational and Structural Biotechnology Journal 2022 20:2464-2472

Activation of Hedgehog Signaling Promotes Development of Mouse and Human Enteric Neural Crest Cells, Based on Single-Cell Transcriptome Analyses

Authors: Lau, Sin-Ting, Li, Zhixin, Pui-Ling Lai, Frank, Nga-Chu Lui, Kathy, Li, Peng, Munera, Jorge O., Pan, Guangjin, Mahe, Maxime M., Hui, Chi-Chung, Wells, James M., Ngan, Elly Sau-Wai

Source: In Gastroenterology December 2019 157(6):1556-1571

Dual Regulatory Functions of SUFU and Targetome of GLI2 in SHH Subgroup Medulloblastoma

Authors: Yin, Wen-Chi, Satkunendran, Thevagi, Mo, Rong, Morrissy, Sorana, Zhang, Xiaoyun, Huang, Eunice Shiao, Uusküla-Reimand, Liis, Hou, Huayun, Son, Joe Eun, Liu, Weifan, Liu, Yulu C., Zhang, Jianing, Parker, Jessica, Wang, Xin, Farooq, Hamza, Selvadurai, Hayden, Chen, Xin, Ngan, Elly Sau-Wai, Cheng, Steven Y., Dirks, Peter B., Angers, Stephane, Wilson, Michael D., Taylor, Michael D., Hui, Chi-chung

Source: In Developmental Cell 28 January 2019 48(2):167-183

Identification of Genes Associated With Hirschsprung Disease, Based on Whole-Genome Sequence Analysis, and Potential Effects on Enteric Nervous System Development

Authors: Tang, Clara Sze-man, Li, Peng, Lai, Frank Pui-Ling, Fu, Alexander Xi, Lau, Sin-Ting, So, Man Ting, Lui, Kathy Nga-Chu, Li, Zhixin, Zhuang, Xuehan, Yu, Michelle, Liu, Xuelai, Ngo, Ngoc D., Miao, Xiaoping, Zhang, Xi, Yi, Bin, Tang, Shaotao, Sun, Xiaobing, Zhang, Furen, Liu, Hong, Liu, Qiji, Zhang, Ruizhong, Wang, Hualong, Huang, Liuming, Dong, Xiao, Tou, Jinfa, Cheah, Kathryn Song-Eng, Yang, Wanling, Yuan, Zhenwei, Yip, Kevin Yuk-lap, Sham, Pak-Chung, Tam, Paul Kwang-Hang, Garcia-Barcelo, Maria-Mercè, Ngan, Elly Sau-Wai

Source: In Gastroenterology December 2018 155(6):1908-1922

Human Pluripotent Stem Cell-Based Models for Hirschsprung Disease: From 2-D Cell to 3-D Organoid Model.

Authors: Lui, Kathy Nga-Chu¹ (AUTHOR), NGAN, Elly Sau-Wai¹ (AUTHOR) engan@hku.hk

Source: Cells (2073-4409). Nov2022, Vol. 11 Issue 21, p3428. 12p.

Subject Terms: *PLURIPOTENT stem cells, *HIRSCHSPRUNG'S disease, *INDUCED pluripotent stem cells, *ENTERIC nervous system, *DRUG discovery, *MEDICAL model

Correction of Hirschsprung-Associated Mutations in Human Induced Pluripotent Stem Cells Via Clustered Regularly Interspaced Short Palindromic Repeats/Cas9, Restores Neural Crest Cell Function

Authors: Lai, Frank Pui-Ling, Lau, Sin-Ting, Wong, John Kwong-Leong, Gui, Hongsheng, Wang, Reeson Xu, Zhou, Tingwen, Lai, Wing Hon, Tse, Hung-Fat, Tam, Paul Kwong-Hang, Garcia-Barcelo, Maria-Mercedes, Ngan, Elly Sau-Wai

Source: In Gastroenterology July 2017 153(1):139-153

Identification of GLI Mutations in Patients With Hirschsprung Disease That Disrupt Enteric Nervous System Development in Mice

Authors: Liu, Jessica Ai-Jia, Lai, Frank Pui-Ling, Gui, Hong-Sheng, Sham, Mai-Har, Tam, Paul Kwong-Hang, Garcia-Barcelo, Maria-Mercedes, Hui, Chi-Chung, Ngan, Elly Sau-Wai

Source: In Gastroenterology December 2015 149(7):1837-1848

Dysregulation of clathrin promotes thyroid cell growth and contributes to multinodular goiter pathogenesis

Authors: Lau, Sin-Ting, Zhou, Tingwen, Liu, Jessica Ai-jia, Fung, Eva Yi-Man, Che, Chi-Ming, Lang, Brian Hung-Hin, Ngan, Elly Sau-Wai

Source: In BBA - Molecular Basis of Disease August 2015 1852(8):1676-1686

Common genetic variants regulating ADD3 gene expression alter biliary atresia risk

Authors: Cheng, Guo, Tang, Clara Sze-Man, Wong, Emily Hoi-Man, Cheng, William Wai-Chun, So, Man-Ting, Miao, Xiaoping, Zhang, Ruizhong, Cui, Long, Liu, Xuelai, Ngan, Elly Sau-Wai, Lui, Vincent Chi-Hang, Chung, Patrick Ho-Yu, Chan, Ivy Hau-Yee, Liu, Juncheng, Zhong, Wei, Xia, Huimin, Yu, Jiakang, Qiu, Xiu, Wu, Xuan-Zhao, Wang, Bin, Dong, Xiao, Tou, Jinfa, Huang, Liuming, Yi, Bin, Ren, Hongxia, Chan, Edwin Kin-Wai, Ye, Kenny, O′Reilly, Paul F., Wong, Kenneth Kak-Yuen, Sham, Pak-Chung, Cherny, Stacey S., Tam, Paul Kwong-Hang, Garcia-Barceló, Maria-Mercè

Source: In Journal of Hepatology December 2013 59(6):1285-1291

Potential use of skin-derived precursors (SKPs) in establishing a cell-based treatment model for Hirschsprung's disease

Authors: Kwok, Carmen Ka-Man, Tam, Paul Kwong-Hang, Ngan, Elly Sau-Wai

Source: In Journal of Pediatric Surgery March 2013 48(3):619-628

Pluripotent stem cell for modeling neurological diseases

Authors: Yung, Jasmine Sum-Yee, Tam, Paul Kwong-Hang, Ngan, Elly Sau-Wai

Source: In Experimental Cell Research 15 January 2013 319(2):177-184

Genome-Wide Association Study Identifies NRG1 as a Susceptibility Locus for Hirschsprung's Disease

Authors: Garcia-Barcelo, Maria-Mercè, Tang, Clara Sze-man, Ngan, Elly Sau-wai, Lui, Vincent Chi-hang, Chen, Yan, So, Man-ting, Leon, Thomas Yuk-yu, Miao, Xiao-ping, Shum, Cathy Ka-yee, Liu, Feng-qin, Yeung, Ming-yiu, Yuan, Zhen-wei, Guo, Wei-hong, Liu, Lei, Sun, Xiao-bing, Huang, Liu-ming, Tou, Jin-fa, Song, You-qiang, Chan, Danny, Cheung, Kenneth M. C., Wong, Kenneth Kak-yuen, Cherny, Stacey S., Sham, Pak-chung, Tam, Paul Kwong-hang, Tsui, Lap-Chee

Source: Proceedings of the National Academy of Sciences of the United States of America, 2009 Feb . 106(8), 2694-2699.

Access URL: https://www.jstor.org/stable/40421771

Lack of association between nNOS −84G>A polymorphism and risk of infantile hypertrophic pyloric stenosis in a Chinese population

Authors: Miao, Xiaoping, Garcia-Barceló, Maria-Mercè, So, Man-ting, Tang, Wai-kiu, Dong, Xiao, Wang, Bin, Mao, Jianxiong, Ngan, Elly Sau-wai, Chen, Yan, Lui, Vincent Chi-hang, Wong, Kenneth Kak-yuen, Liu, Lei, Tam, Paul Kwong-hang

Source: In Journal of Pediatric Surgery 2010 45(4):709-713

MNX1 ( HLXB9) mutations in Currarino patients

Authors: Garcia-Barceló, Maria-Mercè, Lui, Vincent Chi-Hang, So, Man-ting, Miao, Xiaoping, Leon, Thomas Yuk-yu, Yuan, Zhen-wei, Ngan, Elly Sau-wai, Ehsan, Toufique, Chung, Patrick Ho-yu, Khong, Pek-lan, Wong, Kenneth Kak-yuen, Tam, Paul Kwong-hang

Source: In Journal of Pediatric Surgery 2009 44(10):1892-1898

Transcriptomics of Hirschsprung disease patient-derived enteric neural crest cells reveals a role for oxidative phosphorylation.

Authors: Li, Zhixin, Lui, Kathy Nga-Chu, Lau, Sin-Ting, Lai, Frank Pui-Ling, Li, Peng, Chung, Patrick Ho-Yu, Wong, Kenneth Kak-Yuen, Tam, Paul Kwong-Hing, Garica-Barcelo, Maria-Mercedes, Hui, Chi-Chung, Sham, Pak Chung, Ngan, Elly Sau-Wai

Source: Nature Communications; 4/15/2023, Vol. 14 Issue 1, p1-19, 19p

Subject Terms: HIRSCHSPRUNG'S disease, NEURAL crest, OXIDATIVE phosphorylation, ALTERNATIVE RNA splicing, RNA splicing, DEVELOPMENTAL neurobiology

Whole genome sequencing reveals epistasis effects within RET for Hirschsprung disease.

Authors: Wang, Yanbing, Mak, Timothy Shin Heng, Dattani, Saloni, Garcia-Barcelo, Maria-Merce, Fu, Alexander Xi, Yip, Kevin Y., Ngan, Elly Sau-Wai, Tam, Paul Kwang-Hang, Tang, Clara Sze-Man, Sham, Pak Chung

Source: Scientific Reports; 11/28/2022, Vol. 12 Issue 1, p1-10, 10p

Subject Terms: WHOLE genome sequencing, HIRSCHSPRUNG'S disease, GENETIC variation, HERITABILITY, LINKAGE disequilibrium, CONGENITAL disorders

BACE2 variant identified from HSCR patient causes AD-like phenotypes in hPSC-derived brain organoids.

Authors: Luo, Juan, Zou, Hailin, Guo, Yibo, Huang, Ke, Ngan, Elly Sau-Wai, Li, Peng

Source: Cell Death Discovery; 2/2/2022, Vol. 8 Issue 1, p1-8, 8p

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