Saturation mutagenesis-reinforced functional assays for disease-related genes

Authors: Ma, Kaiyue, Huang, Shushu, Ng, Kenneth K., Lake, Nicole J., Joseph, Soumya, Xu, Jenny, Lek, Angela, Ge, Lin, Woodman, Keryn G., Koczwara, Katherine E., Cohen, Justin, Ho, Vincent, O’Connor, Christine L., Brindley, Melinda A., Campbell, Kevin P., Lek, Monkol

Source: In Cell 14 November 2024 187(23):6707-6724

Wastewater Surveillance to Confirm Differences in Influenza A Infection between Michigan, USA, and Ontario, Canada, September 2022-March 2023.

Authors: Corchis-Scott, Ryland¹, corchisr@uwindsor.ca, Beach, Mackenzie¹, Qiudi Geng¹, Podadera, Ana¹, Corchis-Scott, Owen¹, Norton, John², Busch, Andrea², Faust, Russell A.³, McFarlane, Stacey⁴, Withington, Scott⁵, Irwin, Bridget⁶, Aloosh, Mehdi^6,7, Ng, Kenneth K. S.¹, McKay, R. Michael¹

Source: Emerging Infectious Diseases; Aug2024, Vol. 30 Issue 8, p1580-1588, 9p

Origin of the Phosphoprotein Phosphatase (PPP) sequence family in Bacteria: Critical ancestral sequence changes, radiation patterns and substrate binding features

Authors: Kerk, David, Valdés-Tresanco, Mario E., Toth, Ryan, Noskov, Sergei Yu., Ng, Kenneth K.-S., Moorhead, Greg B.

Source: In BBA Advances 2021 1

Detecting Glucose Fluctuations in the Campylobacter jejuni N-Glycan Structure

Authors: Nothaft, Harald, Bian, Xiaoming, Shajahan, Asif, Miller, William G., Bolick, David T., Guerrant, Richard L., Azadi, Parastoo, Ng, Kenneth K. S., Szymanski, Christine M.

Source: ACS chemical biology. 16(11):2690-2699

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN628095061&indx=1&recIds=ETOCRN628095061

Quantifying constraint in the human mitochondrial genome.

Authors: Lake, Nicole J., Ma, Kaiyue, Liu, Wei, Battle, Stephanie L., Laricchia, Kristen M., Tiao, Grace, Puiu, Daniela, Ng, Kenneth K., Cohen, Justin, Compton, Alison G., Cowie, Shannon, Christodoulou, John, Thorburn, David R., Zhao, Hongyu, Arking, Dan E., Sunyaev, Shamil R., Lek, Monkol

Source: Nature; Nov2024, Vol. 635 Issue 8038, p390-397, 8p

Two ubiquitous aldo-keto reductases in the genus Papaver support a patchwork model for morphine pathway evolution.

Authors: Carr, Samuel C., Rehman, Fasih, Hagel, Jillian M., Chen, Xue, Ng, Kenneth K. S., Facchini, Peter J.

Source: Communications Biology; 10/29/2024, Vol. 7 Issue 1, p1-18, 18p

Subject Terms: ALDO-keto reductases, GENE fusion, OPIUM poppy, CHROMOSOME duplication, BIOSYNTHESIS

Fibroblast Growth Factor 21 Mediates the Associations between Exercise, Aging, and Glucose Regulation

Authors: LEE, SHUEN YEE, BURNS, STEPHEN F., NG, KENNETH K. C., STENSEL, DAVID J., ZHONG, LIANG, TAN, FRANKIE H. Y., CHIA, KAR LING, FAM, KAI DENG, YAP, MARGARET M. C., YEO, KWEE POO, YAP, ERIC P. H., LIM, CHIN LEONG

Source: Medicine and science in sports and exercise. 52(2):370-380

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100096784620.0x000001&indx=1&recIds=ETOCvdc_100096784620.0x000001

Structural analysis of a ligand‐triggered intermolecular disulfide switch in a major latex protein from opium poppy.

Authors: Carr, Samuel C., Facchini, Peter J., Ng, Kenneth K. S.

Source: Acta Crystallographica: Section D, Structural Biology; Sep2024, Vol. 80 Issue 9, p675-685, 11p

Subject Terms: CONFORMATIONAL analysis, OPIUM poppy, MOLECULES, LIGANDS (Biochemistry), CRYSTAL structure

Structural and Functional Studies of Pavine N-Methyltransferase from Thalictrum flavum Reveal Novel Insights into Substrate Recognition and Catalytic Mechanism

Authors: Torres, Miguel A., Hoffarth, Elesha, Eugenio, Luiz, Savtchouk, Julia, Chen, Xue, Morris, Jeremy S., Facchini, Peter J., Ng, Kenneth K.-S.

Source: In Journal of Biological Chemistry November 2016 291(45):23403-23415

A phase I trial of the Hedgehog inhibitor, sonidegib (LDE225), in combination with etoposide and cisplatin for the initial treatment of extensive stage small cell lung cancer

Authors: Pietanza, M. Catherine, Litvak, Anya M., Varghese, Anna M., Krug, Lee M., Fleisher, Martin, Teitcher, Jerrold B., Holodny, Andrei I., Sima, Cami S., Woo, Kaitlin M., Ng, Kenneth K., Won, Helen H., Berger, Michael F., Kris, Mark G., Rudin, Charles M.

Source: In Lung Cancer September 2016 99:23-30

Optimized Recombinant Expression and Purification of the SARS‐CoV‐2 Polymerase Complex.

Authors: Podadera, Ana, Campo, Lucas, Rehman, Fasih, Kolobaric, Nikola, Zutic, Adriana, Ng, Kenneth K‐S.

Source: Current Protocols; Mar2024, Vol. 4 Issue 3, p1-24, 24p

Editorial: Engineering antibodies and bacteriophages to manage and diagnose microbial infections.

Authors: Tanha, Jamshid, Ng, Kenneth K. S., Ling, Chang-Chun

Source: Frontiers in Microbiology; 2025, p1-2, 2p

Subject Terms: EXTRACELLULAR vesicles, EMERGING infectious diseases, CHEMICAL processes, IMMUNOTECHNOLOGY, VIRUS-like particles, PROTEIN-protein interactions

Synthesis of rationally designed tetrasaccharides for crystallographic and binding studies with Clostridium difficile toxins and unexpected partial N-methylations during catalytic hydrogenation of azides in methanol

Authors: Zhang, Ping, Ng, Kenneth K. S., Ling, Chang-Chun

Source: Canadian journal of chemistry. 94(11):961-968

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN609108860&indx=1&recIds=ETOCRN609108860

Screening Glycolipids Against Proteins in Vitro Using Picodiscs and Catch-and-Release Electrospray Ionization-Mass Spectrometry

Authors: Li, Jun, Fan, Xuxin, Kitova, Elena N., Zou, Chunxia, Cairo, Christopher W., Eugenio, Luiz, Ng, Kenneth K. S., Xiong, Zi Jian, Privé, Gilbert G., Klassen, John S.

Source: Analytical chemistry. 88(9):4742-4750

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN606239827&indx=1&recIds=ETOCRN606239827

Chlorosome-Inspired Synthesis of Templated Metallochlorin-Lipid Nanoassemblies for Biomedical Applications

Authors: Ng, Kenneth K., Takada, Misa, Harmatys, Kara, Chen, Juan, Zheng, Gang

Source: ACS nano. 10(4):4092-4101

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN606058492&indx=1&recIds=ETOCRN606058492

Engineering a disulfide-gated switch in streptavidin enables reversible binding without sacrificing binding affinity

Authors: Marangoni, Jesse M., Wu, Sau-Ching, Fogen, Dawson, Wong, Sui-Lam, Ng, Kenneth K. S.

Source: Scientific reports. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174728852.0x000001&indx=1&recIds=ETOCvdc_100174728852.0x000001

Organized Aggregation of Porphyrins in Lipid Bilayers for Third Harmonic Generation Microscopy

Authors: Cui, Liyang, Tokarz, Danielle, Cisek, Richard, Ng, Kenneth K., Wang, Fan, Chen, Juan, Barzda, Virginijus, Zheng, Gang

Source: Angewandte Chemie. 127(47):14134-14138

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100128626419.0x000001&indx=1&recIds=ETOCvdc_100128626419.0x000001

Self-Sensing Porphysomes for Fluorescence-Guided Photothermal Therapy

Authors: Ng, Kenneth K., Takada, Misa, Jin, Cheng C. S., Zheng, Gang

Source: Bioconjugate chemistry. 26(2):345-351

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631131734&indx=1&recIds=ETOCRN631131734

Molecular Interactions in Organic Nanoparticles for Phototheranostic Applications

Authors: Ng, Kenneth K., Zheng, Gang

Source: Chemical reviews. 115(19):11012-11042

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631152932&indx=1&recIds=ETOCRN631152932

Streptavidin mutein exhibiting reversible binding for biotin and streptavidin binding peptide tagged proteins