Optimal risk-assessment scheduling for primary prevention of cardiovascular disease

Authors: Gasperoni, Francesca, Jackson, Christopher H., Wood, Angela M., Sweeting, Michael J., Newcombe, Paul J., Stevens, David, Barrett, Jessica K.

Subject Terms: Statistics - Applications

Access URL: http://arxiv.org/abs/2302.04992

Tailored Bayes: a risk modelling framework under unequal misclassification costs

Authors: Karapanagiotis, Solon, Benedetto, Umberto, Mukherjee, Sach, Kirk, Paul D. W., Newcombe, Paul J.

Subject Terms: Statistics - Methodology, Statistics - Applications

Access URL: http://arxiv.org/abs/2104.01822

Statistical Methods for cis-Mendelian Randomization with Two-sample Summary-level Data

Authors: Gkatzionis, Apostolos, Burgess, Stephen, Newcombe, Paul J.

Subject Terms: Quantitative Biology - Quantitative Methods, Quantitative Biology - Genomics, Statistics - Applications

Access URL: http://arxiv.org/abs/2101.04081

A Bayesian framework for case-cohort Cox regression: application to dietary epidemiology

Authors: Yiu, Andrew, Goudie, Robert J. B., Sharp, Stephen J., Newcombe, Paul J., Tom, Brian D. M.

Subject Terms: Statistics - Methodology, Statistics - Applications

Access URL: http://arxiv.org/abs/2007.12974

Conditional inference in cis-Mendelian randomization using weak genetic factors

Authors: Patel, Ashish, Gill, Dipender, Newcombe, Paul J., Burgess, Stephen

Subject Terms: Statistics - Methodology

Access URL: http://arxiv.org/abs/2005.01765

Two-Stage Penalized Regression Screening to Detect Biomarker-Treatment Interactions in Randomized Clinical Trials

Authors: Wang, Jixiong, Patel, Ashish, Wason, James M. S., Newcombe, Paul J.

Subject Terms: Statistics - Methodology, Computer Science - Machine Learning, Quantitative Biology - Quantitative Methods, Statistics - Machine Learning

Access URL: http://arxiv.org/abs/2004.12028

Statistical methods for cis‐Mendelian randomization with two‐sample summary‐level data

Authors: Gkatzionis, Apostolos, Burgess, Stephen, Newcombe, Paul J.

Source: Genetic epidemiology. 47(1):3-25

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100172918542.0x000001&indx=1&recIds=ETOCvdc_100172918542.0x000001

Two‐stage penalized regression screening to detect biomarker–treatment interactions in randomized clinical trials

Authors: Wang, Jixiong, Patel, Ashish, Wason, James M.S., Newcombe, Paul J.

Source: Biometrics. 78(1):141-150

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100145524901.0x000001&indx=1&recIds=ETOCvdc_100145524901.0x000001

Bayesian variable selection with a pleiotropic loss function in Mendelian randomization

Authors: Gkatzionis, Apostolos, Burgess, Stephen, Conti, David V., Newcombe, Paul J.

Source: Statistics in medicine. 40(23):5025-5045

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130156109.0x000001&indx=1&recIds=ETOCvdc_100130156109.0x000001

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Hierarchical joint analysis of marginal summary statistics—Part I: Multipopulation fine mapping and credible set construction.

Authors: Shen, Jiayi, Jiang, Lai, Wang, Kan, Wang, Anqi, Chen, Fei, Newcombe, Paul J., Haiman, Christopher A., Conti, David V.

Source: Genetic Epidemiology; Sep2024, Vol. 48 Issue 6, p241-257, 17p

Type I interferon blockade with anifrolumab in patients with systemic lupus erythematosus modulates key immunopathological pathways in a gene expression and proteomic analysis of two phase 3 trials.

Authors: Baker, Tina, Sharifian, Hoda, Newcombe, Paul J., Gavin, Patrick G., Lazarus, Mark N., Ramaswamy, Madhu, White, Wendy I., Ferrari, Nicola, Muthas, Daniel, Tummala, Raj, Morand, Eric F., Furie, Richard A., Vital, Edward M., Chamberlain, Chris, Platt, Adam, Al Mossawi, Hussein, Brohawn, Philip Z., Csomor, Eszter

Source: Annals of the Rheumatic Diseases; Aug2024, Vol. 83 Issue 8, p1018-1027, 10p

A flexible and parallelizable approach to genome‐wide polygenic risk scores

Authors: Newcombe, Paul J., Nelson, Christopher P., Samani, Nilesh J., Dudbridge, Frank

Source: Genetic epidemiology. 43(7):730-741

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100089397395.0x000001&indx=1&recIds=ETOCvdc_100089397395.0x000001

Accuracy of Gene Scores when Pruning Markers by Linkage Disequilibrium

Authors: Dudbridge, Frank, Newcombe, Paul J.

Source: Human Heredity, 2015 Jan 01. 80(4), 178-186.

Access URL: https://www.jstor.org/stable/48513194

Predictive Models of Choroidal Neovascularization and Geographic Atrophy Incidence Applied to Clinical Trial Design

Authors: McCarthy, Linda C., Newcombe, Paul J., Whittaker, John C., Wurzelmann, John I., Fries, Michael A., Burnham, Nancy R., Cai, Gengqian, Stinnett, Sandra W., Trivedi, Trupti M., Xu, Chun-Fang

Source: In American Journal of Ophthalmology September 2012 154(3):568-578

Fine mapping chromatin contacts in capture Hi-C data

Authors: Eijsbouts, Christiaan Q, Burren, Oliver S, Newcombe, Paul J, Wallace, Chris

Source: BMC genomics. 20(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100127148913.0x000001&indx=1&recIds=ETOCvdc_100127148913.0x000001

Potential Impact of Adding Genetic Markers to Clinical Parameters in Predicting Prostate Biopsy Outcomes in Men Following an Initial Negative Biopsy: Findings from the REDUCE Trial

Authors: Kader, A. Karim, Sun, Jielin, Reck, Brian H., Newcombe, Paul J., Kim, Seong-Tae, Hsu, Fang-Chi, D'Agostino, Ralph B., Tao, Sha, Zhang, Zheng, Turner, Aubrey R., Platek, Greg T., Spraggs, Colin F., Whittaker, John C., Lane, Brian R., Isaacs, William B., Meyers, Deborah A., Bleecker, Eugene R., Torti, Frank M., Trent, Jeffery M., McConnell, John D., Zheng, S. Lilly, Condreay, Lynn D., Rittmaster, Roger S., Xu, Jianfeng

Source: European urology. 62(6):953-961

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100065625412.0x000001&indx=1&recIds=ETOCvdc_100065625412.0x000001

Multilocus Bayesian Meta-Analysis of Gene-Disease Associations

Authors: Newcombe, Paul J., Verzilli, Claudio, Casas, Juan P., Hingorani, Aroon D., Smeeth, Liam, Whittaker, John C.

Source: In The American Journal of Human Genetics 15 May 2009 84(5):567-580

Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants

Authors: Dadaev, Tokhir, Saunders, Edward J., Newcombe, Paul J., Anokian, Ezequiel, Leongamornlert, Daniel A., Brook, Mark N., Cieza-Borrella, Clara, Mijuskovic, Martina, Wakerell, Sarah, Olama, Ali Amin Al, Schumacher, Fredrick R., Berndt, Sonja I., Benlloch, Sara, Ahmed, Mahbubl, Goh, Chee, Sheng, Xin, Zhang, Zhuo, Muir, Kenneth, Govindasami, Koveela, Lophatananon, Artitaya, Stevens, Victoria L., Gapstur, Susan M., Carter, Brian D., Tangen, Catherine M., Goodman, Phyllis, Thompson, Ian M., Batra, Jyotsna, Chambers, Suzanne, Moya, Leire, Clements, Judith, Horvath, Lisa, Tilley, Wayne, Risbridger, Gail, Gronberg, Henrik, Aly, Markus, Nordström, Tobias, Pharoah, Paul, Pashayan, Nora, Schleutker, Johanna, Tammela, Teuvo L. J., Sipeky, Csilla, Auvinen, Anssi, Albanes, Demetrius, Weinstein, Stephanie, Wolk, Alicja, Hakansson, Niclas, West, Catharine, Dunning, Alison M., Burnet, Neil, Mucci, Lorelei, Giovannucci, Edward, Andriole, Gerald, Cussenot, Olivier, Cancel-Tassin, Géraldine, Koutros, Stella, Freeman, Laura E. Beane, Sorensen, Karina Dalsgaard, Orntoft, Torben Falck, Borre, Michael, Maehle, Lovise, Grindedal, Eli Marie, Neal, David E., Donovan, Jenny L., Hamdy, Freddie C., Martin, Richard M., Travis, Ruth C., Key, Tim J., Hamilton, Robert J., Fleshner, Neil E., Finelli, Antonio, Ingles, Sue Ann, Stern, Mariana C., Rosenstein, Barry, Kerns, Sarah, Ostrer, Harry, Lu, Yong-Jie, Zhang, Hong-Wei, Feng, Ninghan, Mao, Xueying, Guo, Xin, Wang, Guomin, Sun, Zan, Giles, Graham G., Southey, Melissa C., MacInnis, Robert J., FitzGerald, Liesel M., Kibel, Adam S., Drake, Bettina F., Vega, Ana, Gómez-Caamaño, Antonio, Fachal, Laura, Szulkin, Robert, Eklund, Martin, Kogevinas, Manolis, Llorca, Javier, Castaño-Vinyals, Gemma, Penney, Kathryn L., Stampfer, Meir, Park, Jong Y., Sellers, Thomas A., Lin, Hui-Yi, Stanford, Janet L., Cybulski, Cezary, Wokolorczyk, Dominika, Lubinski, Jan, Ostrander, Elaine A., Geybels, Milan S., Nordestgaard, Børge G., Nielsen, Sune F., Weisher, Maren, Bisbjerg, Rasmus, Røder, Martin Andreas, Iversen, Peter, Brenner, Hermann, Cuk, Katarina, Holleczek, Bernd, Maier, Christiane, Luedeke, Manuel, Schnoeller, Thomas, Kim, Jeri, Logothetis, Christopher J., John, Esther M., Teixeira, Manuel R., Paulo, Paula, Cardoso, Marta, Neuhausen, Susan L., Steele, Linda, Ding, Yuan Chun, De Ruyck, Kim, De Meerleer, Gert, Ost, Piet, Razack, Azad, Lim, Jasmine, Teo, Soo-Hwang, Lin, Daniel W., Newcomb, Lisa F., Lessel, Davor, Gamulin, Marija, Kulis, Tomislav, Kaneva, Radka, Usmani, Nawaid, Slavov, Chavdar, Mitev, Vanio, Parliament, Matthew, Singhal, Sandeep, Claessens, Frank, Joniau, Steven, Van den Broeck, Thomas, Larkin, Samantha, Townsend, Paul A., Aukim-Hastie, Claire, Gago-Dominguez, Manuela, Castelao, Jose Esteban, Martinez, Maria Elena, Roobol, Monique J., Jenster, Guido, van Schaik, Ron H. N., Menegaux, Florence, Truong, Thérèse, Koudou, Yves Akoli, Xu, Jianfeng, Khaw, Kay-Tee, Cannon-Albright, Lisa, Pandha, Hardev, Michael, Agnieszka, Kierzek, Andrzej, Thibodeau, Stephen N., McDonnell, Shannon K., Schaid, Daniel J., Lindstrom, Sara, Turman, Constance, Ma, Jing, Hunter, David J., Riboli, Elio, Siddiq, Afshan, Canzian, Federico, Kolonel, Laurence N., Le Marchand, Loic, Hoover, Robert N., Machiela, Mitchell J., Kraft, Peter, Freedman, Matthew, Wiklund, Fredrik, Chanock, Stephen, Henderson, Brian E., Easton, Douglas F., Haiman, Christopher A., Eeles, Rosalind A., Conti, David V., Kote-Jarai, Zsofia

Source: Nature communications. 9(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129914297.0x000001&indx=1&recIds=ETOCvdc_100129914297.0x000001

A Hierarchical Approach Using Marginal Summary Statistics for Multiple Intermediates in a Mendelian Randomization or Transcriptome Analysis.

Authors: Jiang, Lai, Xu, Shujing, Mancuso, Nicholas, Newcombe, Paul J, Conti, David V

Source: American Journal of Epidemiology; Jun2021, Vol. 190 Issue 6, p1148-1158, 11p

Subject Terms: SINGLE nucleotide polymorphisms, MYOCARDIAL infarction, GENE expression, TYPE 2 diabetes, CONCEPTUAL structures, GENE expression profiling, TRANSFERASES, STATISTICAL hypothesis testing, STATISTICAL models, BODY mass index, PROSTATE tumors, DISEASE risk factors