Activity of Mesothelin-Specific Chimeric Antigen Receptor T Cells Against Pancreatic Carcinoma Metastases in a Phase 1 Trial

Authors: Beatty, Gregory L., O’Hara, Mark H., Lacey, Simon F., Torigian, Drew A., Nazimuddin, Farzana, Chen, Fang, Kulikovskaya, Irina M., Soulen, Michael C., McGarvey, Maureen, Nelson, Anne Marie, Gladney, Whitney L., Levine, Bruce L., Melenhorst, J. Joseph, Plesa, Gabriela, June, Carl H.

Source: In Gastroenterology July 2018 155(1):29-32

Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells

Authors: Fraietta, Joseph, Nobles, Christopher, Sammons, Morgan, Lundh, Stefan, Carty, Shannon, Reich, Tyler, Cogdill, Alexandria, Morrissette, Jennifer, DeNizio, Jamie, Reddy, Shantan, Hwang, Young, Gohil, Mercy, Kulikovskaya, Irina, Nazimuddin, Farzana, Gupta, Minnal, Chen, Fang, Everett, John, Alexander, Katherine, Lin-Shiao, Enrique, Gee, Marvin, Liu, Xiaojun, Young, Regina, Ambrose, David, Wang, Yan, Xu, Jun, Jordan, Martha, Marcucci, Katherine, Levine, Bruce, Garcia, K., Zhao, Yangbing, Kalos, Michael, Porter, David, Kohli, Rahul, Lacey, Simon, Berger, Shelley, Bushman, Frederic, June, Carl, Melenhorst, J.

Source: Nature. 558(7709):307-312

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100153455431.0x000001&indx=1&recIds=ETOCvdc_100153455431.0x000001

Persistence of long-lived plasma cells and humoral immunity in individuals responding to CD19-directed CAR T-cell therapy

Authors: Bhoj, Vijay G., Arhontoulis, Dimitrios, Wertheim, Gerald, Capobianchi, James, Callahan, Colleen A., Ellebrecht, Christoph T., Obstfeld, Amrom E., Lacey, Simon F., Melenhorst, Jan J., Nazimuddin, Farzana, Hwang, Wei-Ting, Maude, Shannon L., Wasik, Mariusz A., Bagg, Adam, Schuster, Stephen, Feldman, Michael D., Porter, David L., Grupp, Stephen A., June, Carl H., Milone, Michael C.

Source: In Blood 21 July 2016 128(3):360-370

Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies

Authors: Ruella, Marco, Barrett, David M., Kenderian, Saad S., Shestova, Olga, Hofmann, Ted J., Perazzelli, Jessica, Klichinsky, Michael, Aikawa, Vania, Nazimuddin, Farzana, Kozlowski, Miroslaw

Source: Journal of clinical investigation. 126(10):3814-3826

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN608298433&indx=1&recIds=ETOCRN608298433

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Checkpoint Inhibitors Augment CD19-Directed Chimeric Antigen Receptor (CAR) T Cell Therapy in Relapsed B-Cell Acute Lymphoblastic Leukemia

Authors: Li, Amanda M. ^*, Hucks, George E ^*, Dinofia, Amanda M. ^*, Seif, Alix E., Teachey, David T, Baniewicz, Diane ^*, Callahan, Colleen ^*, Fasano, Christina ^*, McBride, Beth ^*, Gonzalez, Vanessa ^*, Nazimuddin, Farzana ^*, Porter, David L., Lacey, Simon F, June, Carl H, Grupp, Stephan A., Maude, Shannon L.

Source: In Blood 29 November 2018 132 Supplement 1:556-556

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Clinical Evidence That Deficiency of the Methylcytosine Dioxygenase TET2 Gene Promotes the Clonal Expansion and Therapeutic Efficacy of CD19-Directed T Cells

Authors: Fraietta, Joseph A ^*, Nobles, Christopher L ^*, Sammons, Morgan A ^*, Carty, Shannon A., Lundh, Stefan M ^*, Reich, Tyler ^*, Cogdill, Alexandria P ^*, Gohil, Mercy ^*, Morrissette, Jennifer J.D. ^*, Kulikovskaya, Irina ^*, Nazimuddin, Farzana ^*, Gupta, Minnal ^*, Wang, Yan ^*, Liu, Xiaojun ^*, Young, Regina M ^*, Ambrose, David E ^*, Jordan, Martha S ^*, Marcucci, Katherine T ^*, Levine, Bruce L, Zhao, Yangbing ^*, Kalos, Michael ^*, Porter, David L, Lacey, Simon F, Berger, Shelley L ^*, Bushman, Frederic D ^*, June, Carl H, Melenhorst, J. Joseph

Source: In Blood 8 December 2017 130 Supplement 1:1909-1909

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Disruption of TET2promotes the therapeutic efficacy of CD19-targeted T cells

Authors: Fraietta, Joseph, Nobles, Christopher, Sammons, Morgan, Lundh, Stefan, Carty, Shannon, Reich, Tyler, Cogdill, Alexandria, Morrissette, Jennifer, DeNizio, Jamie, Reddy, Shantan, Hwang, Young, Gohil, Mercy, Kulikovskaya, Irina, Nazimuddin, Farzana, Gupta, Minnal, Chen, Fang, Everett, John, Alexander, Katherine, Lin-Shiao, Enrique, Gee, Marvin, Liu, Xiaojun, Young, Regina, Ambrose, David, Wang, Yan, Xu, Jun, Jordan, Martha, Marcucci, Katherine, Levine, Bruce, Garcia, K., Zhao, Yangbing, Kalos, Michael, Porter, David, Kohli, Rahul, Lacey, Simon, Berger, Shelley, Bushman, Frederic, June, Carl, Melenhorst, J.

Source: Nature; June 2018, Vol. 558 Issue: 7709 p307-312, 6p

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Efficacy and Safety of Humanized Chimeric Antigen Receptor (CAR)-Modified T Cells Targeting CD19 in Children with Relapsed/Refractory ALL

Authors: Maude, Shannon L, Barrett, David M. ^*, Ambrose, David E ^*, Rheingold, Susan R., Aplenc, Richard, Teachey, David T, Callahan, Colleen ^*, Barker, Christine S ^*, Mudambi, Maya ^*, Shaw, Pamela A ^*, Brogdon, Jennifer ^*, Young, Regina M ^*, Scholler, John ^*, Loew, Andreas ^*, Marcucci, Katherine T. ^*, Finklestein, Jeffrey ^*, Kulikovskaya, Irina ^*, Nazimuddin, Farzana ^*, Zheng, Zhaohui ^*, Levine, Bruce L., Porter, David L, Lacey, Simon F. ^*, Melenhorst, Jan J. ^*, June, Carl H., Grupp, Stephan A.

Source: In Blood 3 December 2015 126(23):683-683

Long-Term Functional Persistence, B Cell Aplasia and Anti-Leukemia Efficacy In Refractory B Cell Malignancies Following T Cell Immunotherapy Using CAR-Redirected T Cells Targeting CD19

Authors: Kalos, Michael, Nazimuddin, Farzana ^*, Finklestein, Jeffrey M. ^*, Gupta, Minnal ^*, Kulikovskaya, Irina ^*, Ambrose, David E. ^*, Gill, Saar, Lacey, Simon F., Zheng, Zhaohui ^*, Melenhorst, J. Joseph., Levine, Bruce L., Frey, Noelle V., Grupp, Stephan A., Porter, David L., June, Carl H.

Source: In Blood 15 November 2013 122(21):163-163

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