Targeting heterochromatin eliminates chronic myelomonocytic leukemia malignant stem cells through reactivation of retroelements and immune pathways

Authors: Donia Hidaoui, Audrey Porquet, Rabie Chelbi, Mathieu Bohm, Aikaterini Polyzou, Vincent Alcazer, Stéphane Depil, Aygun Imanci, Margot Morabito, Aline Renneville, Dorothée Selimoglu-Buet, Sylvain Thépot, Raphael Itzykson, Lucie Laplane, Nathalie Droin, Eirini Trompouki, Emilie Elvira-Matelot, Eric Solary, Françoise Porteu

Source: Communications Biology, Vol 7, Iss 1, Pp 1-18 (2024)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/d0d32ed0a4bf4fa2b5ee6523cd1a587f

DiPRO1 distinctly reprograms muscle and mesenchymal cancer cells

Authors: Jeremy Rich, Melanie Bennaroch, Laura Notel, Polina Patalakh, Julien Alberola, Fayez Issa, Paule Opolon, Olivia Bawa, Windy Rondof, Antonin Marchais, Philippe Dessen, Guillaume Meurice, Morgane Le-Gall, Melanie Polrot, Karine Ser-Le Roux, Kamel Mamchaoui, Nathalie Droin, Hana Raslova, Pascal Maire, Birgit Geoerger, Iryna Pirozhkova

Source: EMBO Molecular Medicine, Vol 16, Iss 8, Pp 1840-1885 (2024)

Subject Terms: DiPRO1, Mesenchymal Cancer, Muscle, Retrotransposable Repeats, Methylation, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/3399c70743a941bc831dd23135024135

Accelerated DNA replication fork speed due to loss of R-loops in myelodysplastic syndromes with SF3B1 mutation

Authors: David Rombaut, Carine Lefèvre, Tony Rached, Sabrina Bondu, Anne Letessier, Raphael M. Mangione, Batoul Farhat, Auriane Lesieur-Pasquier, Daisy Castillo-Guzman, Ismael Boussaid, Chloé Friedrich, Aurore Tourville, Magali De Carvalho, Françoise Levavasseur, Marjorie Leduc, Morgane Le Gall, Sarah Battault, Marie Temple, Alexandre Houy, Didier Bouscary, Lise Willems, Sophie Park, Sophie Raynaud, Thomas Cluzeau, Emmanuelle Clappier, Pierre Fenaux, Lionel Adès, Raphael Margueron, Michel Wassef, Samar Alsafadi, Nicolas Chapuis, Olivier Kosmider, Eric Solary, Angelos Constantinou, Marc-Henri Stern, Nathalie Droin, Benoit Palancade, Benoit Miotto, Frédéric Chédin, Michaela Fontenay

Source: Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/123566d884df484c9b7e6a5d549470f7

When monoclonal gammopathy‐associated chronic neutrophilic leukemia is a reactive process distinct from a clonal myeloproliferative neoplasm: Lessons from mistakes

Authors: Christophe Willekens, Claude Chahine, Matteo Dragani, Sabine Khalife‐Hachem, Camille Bigenwald, Julien Rossignol, Cristina Castilla‐Llorente, Alina Danu, Jean‐Marie Michot, Veronique Saada, Sophie Cotteret, Christophe Marzac, Aline Renneville, Isabelle Plo, Sophie Broutin, Nelly Bosselut, Bruno Cassinat, Julien Lazarovici, Nathalie Droin, Stephane De Botton

Source: eJHaem, Vol 4, Iss 3, Pp 823-826 (2023)

Subject Terms: chronic neutrophilic leukemia, leukemoid reaction, leukocytosis, MGUS, proteasome inhibitor, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/2688-6146

Access URL: https://doaj.org/article/e6046ba3ef504877ae667d93dacc1c70

Stepwise GATA1 and SMC3 mutations alter megakaryocyte differentiation in a Down syndrome leukemia model

Authors: Brahim Arkoun, Elie Robert, Fabien Boudia, Stefania Mazzi, Virginie Dufour, Aurélie Siret, Yasmine Mammasse, Zakia Aid, Matthieu Vieira, Aygun Imanci, Marine Aglave, Marie Cambot, Rachel Petermann, Sylvie Souquere, Philippe Rameau, Cyril Catelain, Romain Diot, Gérard Tachdjian, Olivier Hermine, Nathalie Droin, Najet Debili, Isabelle Plo, Sébastien Malinge, Eric Soler, Hana Raslova, Thomas Mercher, William Vainchenker

Source: The Journal of Clinical Investigation, Vol 132, Iss 14 (2023)

Subject Terms: Hematology, Oncology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1558-8238

Access URL: https://doaj.org/article/9c099ca48d754b06bdffe7e25037becf

ANKRD26 is a new regulator of type I cytokine receptor signaling in normal and pathological hematopoiesis

Authors: Francesca Basso-Valentina, Alessandro Donada, Vladimir T Manchev, Manuel Lisetto, Nathalie Balayn, Jean Edouard Martin, Delphine Muller, Cecilia Paola Marin Oyarzun, Hélène Duparc, Brahim Arkoun, Alessandro Cumin, Lionel Faivre, Nathalie Droin, Ida Biunno, Alessandro Pecci, Alessandra Balduini, Najet Debili, Iléana Antony-Debré, Caroline Marty, William Vainchenker, Isabelle Plo, Remi Favier, Hana Raslova

Source: Haematologica, Vol 108, Iss 8 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/10981; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/ea73fe6f815643c19db0d298819699a2

RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis

Authors: Ryan M. Carr, Denis Vorobyev, Terra Lasho, David L. Marks, Ezequiel J. Tolosa, Alexis Vedder, Luciana L. Almada, Andrey Yurcheko, Ismael Padioleau, Bonnie Alver, Giacomo Coltro, Moritz Binder, Stephanie L. Safgren, Isaac Horn, Xiaona You, Eric Solary, Maria E. Balasis, Kurt Berger, James Hiebert, Thomas Witzig, Ajinkya Buradkar, Temeida Graf, Peter Valent, Abhishek A. Mangaonkar, Keith D. Robertson, Matthew T. Howard, Scott H. Kaufmann, Christopher Pin, Martin E. Fernandez-Zapico, Klaus Geissler, Nathalie Droin, Eric Padron, Jing Zhang, Sergey Nikolaev, Mrinal M. Patnaik

Source: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/76c77b395be34b1d8dcd36a45fbde44e

Reprogramming monocyte-derived macrophages through caspase inhibition

Authors: Paul Chaintreuil, Lucie Laplane, Florian Esnault, Victoria Ghesquier, Coline Savy, Nathan Furstoss, Marie-Laure Arcangeli, Thomas Cluzeau, Guillaume Robert, Nathalie Droin, Eric Solary, Patrick Auberger, Arnaud Jacquel

Source: OncoImmunology, Vol 11, Iss 1 (2022)

Subject Terms: primary monocyte, monocyte-derived macrophages, differentiation, polarization, csf-1, caspases, emricasan, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/2e4cff75610744d89d531509ca632a79

378 Efficacy, safety and ancillary analyses of pembrolizumab in combination with nintedanib for the treatment of patients with relapsed advanced mesothelioma

Authors: Capucine Baldini, Francois-Xavier Danlos, Aurélien Marabelle, Jean-Charles Soria, Christophe Massard, Lydie Cassard, Julien Adam, David Planchard, Andreea Varga, Gérard Zalcman, Nathalie Chaput-Gras, Matthieu Texier, Severine Mouraud, Bastien Job, Diane Letourneur, Delphine Bredel, Salim Laghouati, Nathalie Droin, Aurelien Parpaleix, Audrey Rabeau

Source: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/88c4a66df07f4921b9789c2c5c470244

Dynamic gene regulation by nuclear colony-stimulating factor 1 receptor in human monocytes and macrophages

Authors: Laura Bencheikh, M’Boyba Khadija Diop, Julie Rivière, Aygun Imanci, Gerard Pierron, Sylvie Souquere, Audrey Naimo, Margot Morabito, Michaël Dussiot, Frédéric De Leeuw, Camille Lobry, Eric Solary, Nathalie Droin

Source: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/087012bf40e543c99b57671485f865ff

Acquisition of TCF3 and CCND3 Mutations and Transformation to Burkitt Lymphoma in a Case of B-Cell Prolymphocytic Leukemia

Authors: Florence Nguyen-Khac, Simon Bouzy, Damien Roos-Weil, Clotilde Bravetti, Agathe Maillon, M’boyba Diop, Cécile Doualle, Nathalie Droin, Olivier A. Bernard, Elise Chapiro

Source: HemaSphere, Vol 5, Iss 5, p e563 (2021)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/HS9.0000000000000563; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/269a6ee0258648f194be8c6d70604418

CD103+CD8+ TRM Cells Accumulate in Tumors of Anti-PD-1-Responder Lung Cancer Patients and Are Tumor-Reactive Lymphocytes Enriched with Tc17

Authors: Stéphanie Corgnac, Ines Malenica, Laura Mezquita, Edouard Auclin, Elodie Voilin, Jamila Kacher, Heloise Halse, Laetitia Grynszpan, Nicolas Signolle, Thibault Dayris, Marine Leclerc, Nathalie Droin, Vincent de Montpréville, Olaf Mercier, Pierre Validire, Jean-Yves Scoazec, Christophe Massard, Salem Chouaib, David Planchard, Julien Adam, Benjamin Besse, Fathia Mami-Chouaib

Source: Cell Reports Medicine, Vol 1, Iss 7, Pp 100127- (2020)

Subject Terms: CD8 TRM cells, CTL, Tc17, lung cancer, anti-PD-1 immunotherapy, tumor-infiltrating lymphocytes, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666379120301695; https://doaj.org/toc/2666-3791

Access URL: https://doaj.org/article/915c3d3910d847f0928d99be365b54ff

A miR-150/TET3 pathway regulates the generation of mouse and human non-classical monocyte subset

Authors: Dorothée Selimoglu-Buet, Julie Rivière, Hussein Ghamlouch, Laura Bencheikh, Catherine Lacout, Margot Morabito, M’boyba Diop, Guillaume Meurice, Marie Breckler, Aurélie Chauveau, Camille Debord, Franck Debeurme, Raphael Itzykson, Nicolas Chapuis, Christophe Willekens, Orianne Wagner-Ballon, Olivier A. Bernard, Nathalie Droin, Eric Solary

Source: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/5d55187610e84c0189ca6173abd8c67a

Prognostic Role of Gene Mutations in Chronic Myelomonocytic Leukemia Patients Treated With Hypomethylating Agents

Authors: Matthieu Duchmann, Fevzi F. Yalniz, Alessandro Sanna, David Sallman, Catherine C. Coombs, Aline Renneville, Olivier Kosmider, Thorsten Braun, Uwe Platzbecker, Lise Willems, Lionel Adès, Michaela Fontenay, Raajit Rampal, Eric Padron, Nathalie Droin, Claude Preudhomme, Valeria Santini, Mrinal M. Patnaik, Pierre Fenaux, Eric Solary, Raphael Itzykson

Source: EBioMedicine, Vol 31, Iss , Pp 174-181 (2018)

Subject Terms: Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396418301464; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/475ef9172ad444098b8af25c6b442881

Critical role of the HDAC6–cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect

Authors: Kahia Messaoudi, Ashfaq Ali, Rameez Ishaq, Alberta Palazzo, Dominika Sliwa, Olivier Bluteau, Sylvie Souquère, Delphine Muller, Khadija M. Diop, Philippe Rameau, Valérie Lapierre, Jean-Pierre Marolleau, Patrick Matthias, Isabelle Godin, Gérard Pierron, Steven G. Thomas, Stephen P. Watson, Nathalie Droin, William Vainchenker, Isabelle Plo, Hana Raslova, Najet Debili

Source: Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/e6244d22664d4e168a0d548e8a713d18

Engraftment of chronic myelomonocytic leukemia cells in immunocompromised mice supports disease dependency on cytokines

Authors: Yanyan Zhang, Liang He, Dorothée Selimoglu-Buet, Chloe Jego, Margot Morabito, Christophe Willekens, M'boyba Khadija Diop, Patrick Gonin, Valérie Lapierre, Nathalie Droin, Eric Solary, Fawzia Louache

Source: Blood Advances, Vol 1, Iss 14, Pp 972-979 (2017)

Subject Terms: Specialties of internal medicine, RC581-951

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2473952920302093; https://doaj.org/toc/2473-9529

Access URL: https://doaj.org/article/66dbe88188da4911846accf2d6be9a8a

Irrévérence et satire versus blasphème et christianophobie

Authors: Nathalie Droin

Source: Contextes, Vol 26 (2020)

Subject Terms: Polémique, Presse, Satire, Caricature, Droit, Injure, Literature (General), PN1-6790

File Description: electronic resource

Relation: https://journals.openedition.org/contextes/8762; https://doaj.org/toc/1783-094X

Access URL: https://doaj.org/article/2ced6293fc0342df9945ab831c1e8586

Multilayer intraclonal heterogeneity in chronic myelomonocytic leukemia

Authors: Allan Beke, Lucie Laplane, Julie Riviere, Qin Yang, Miguel Torres-Martin, Thibault Dayris, Philippe Rameau, Veronique Saada, Chrystèle Bilhou-Nabera, Ana Hurtado, Larissa Lordier, William Vainchenker, Maria E. Figueroa, Nathalie Droin, Eric Solary

Source: Haematologica, Vol 105, Iss 1 (2020)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/9481; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/5daedea10e974d1a8438031a1485653d

Downregulation of TREM-like transcript-1 and collagen receptor α2 subunit, two novel RUNX1-targets, contributes to platelet dysfunction in familial platelet disorder with predisposition to acute myelogenous leukemia

Authors: Ana C. Glembotsky, Dominika Sliwa, Dominique Bluteau, Nathalie Balayn, Cecilia P. Marin Oyarzún, Anna Raimbault, Marie Bordas, Nathalie Droin, Iryna Pirozhkova, Valance Washington, Nora P. Goette, Rosana F. Marta, Rémi Favier, Hana Raslova, Paula G. Heller

Source: Haematologica, Vol 104, Iss 6 (2019)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/8939; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/339e7f5175834da7a016b084f1a82957

Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents

Authors: Jane Merlevede, Nathalie Droin, Tingting Qin, Kristen Meldi, Kenichi Yoshida, Margot Morabito, Emilie Chautard, Didier Auboeuf, Pierre Fenaux, Thorsten Braun, Raphael Itzykson, Stéphane de Botton, Bruno Quesnel, Thérèse Commes, Eric Jourdan, William Vainchenker, Olivier Bernard, Noemie Pata-Merci, Stéphanie Solier, Velimir Gayevskiy, Marcel E. Dinger, Mark J. Cowley, Dorothée Selimoglu-Buet, Vincent Meyer, François Artiguenave, Jean-François Deleuze, Claude Preudhomme, Michael R. Stratton, Ludmil B. Alexandrov, Eric Padron, Seishi Ogawa, Serge Koscielny, Maria Figueroa, Eric Solary

Source: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/3d387d13bd0349019c8a2486e3d50c61