Oral administration of Bifidobacterium longum and Bifidobacterium infantis ameliorates cefcapene pivoxil-induced attenuation of anti-programmed cell death protein-1 antibody action in mice

Authors: Funayama, Eiji ^{a, b, c}, Hosonuma, Masahiro ^{b, c, d, e}, Tajima, Kohei ^{b, f}, Isobe, Junya ^{b, g}, Baba, Yuta ^b, Murayama, Masakazu ^{b, c, d, h}, Narikawa, Yoichiro ^{b, c, d, h}, Toyoda, Hitoshi ^{b, c, d, i}, Tsurui, Toshiaki ^{b, c, d, e}, Maruyama, Yuki ^{b, c, d, h}, Sasaki, Aya ^{b, c, d, q}, Amari, Yasunobu ^{j, k}, Yamazaki, Yoshitaka ^{c, l}, Nakashima, Rie ^{b, f}, Uchiyama, Jun ^b, Nakano, Ryota ⁿ, Shida, Midori ^b, Sasaki, Akiko ^{c, d}, Udaka, Yuko ^{c, d}, Oguchi, Tatsunori ^{c, d}, Sambe, Takehiko ^j, Kobayashi, Shinichi ^o, Tsuji, Mayumi ^c, Kiuchi, Yuji ^{c, d}, Kim, Yun-Gi ^m, Wada, Satoshi ^{e, p}, Tsunoda, Takuya ^e, Akiyama, Masahiro ^b, Nobe, Koji ^a, Kuramasu, Atsuo ^b, Yoshimura, Kiyoshi ^{b, e, ⁎}

Source: In Biomedicine & Pharmacotherapy January 2025 182

Isobutyric acid enhances the anti-tumour effect of anti-PD-1 antibody.

Authors: Murayama, Masakazu, Hosonuma, Masahiro, Kuramasu, Atsuo, Kobayashi, Sei, Sasaki, Akiko, Baba, Yuta, Narikawa, Yoichiro, Toyoda, Hitoshi, Isobe, Junya, Funayama, Eiji, Tajima, Kohei, Sasaki, Aya, Maruyama, Yuki, Yamazaki, Yoshitaka, Shida, Midori, Hamada, Kazuyuki, Hirasawa, Yuya, Tsurui, Toshiaki, Ariizumi, Hirotsugu, Ishiguro, Tomoyuki

Source: Scientific Reports; 5/17/2024, Vol. 14 Issue 1, p1-10, 10p

Subject Terms: SHORT-chain fatty acids, ORAL drug administration, IMMUNE checkpoint inhibitors, TUMOR microenvironment

Nivolumab receptor occupancy on effector regulatory T cells predicts clinical benefit.

Authors: Hosonuma, Masahiro, Hirasawa, Yuya, Kuramasu, Atsuo, Murayama, Masakazu, Narikawa, Yoichiro, Toyoda, Hitoshi, Baba, Yuta, Isobe, Junya, Funayama, Eiji, Tajima, Kohei, Shida, Midori, Hamada, Kazuyuki, Tsurui, Toshiaki, Ariizumi, Hirotsugu, Ishiguro, Tomoyuki, Suzuki, Risako, Ohkuma, Ryotaro, Kubota, Yutaro, Horiike, Atsushi, Sambe, Takehiko

Source: Cancer Science; Mar2024, Vol. 115 Issue 3, p752-762, 11p

Butyricimonas is a key gut microbiome component for predicting postoperative recurrence of esophageal cancer.

Authors: Otsuka, Koji, Isobe, Junya, Asai, Yoshiyuki, Nakano, Tomohisa, Hattori, Kouya, Ariyoshi, Tomotake, Yamashita, Takeshi, Motegi, Kentaro, Saito, Akira, Kohmoto, Masahiro, Hosonuma, Masahiro, Kuramasu, Atsuo, Baba, Yuta, Murayama, Masakazu, Narikawa, Yoichiro, Toyoda, Hitoshi, Funayama, Eiji, Tajima, Kohei, Shida, Midori, Hirasawa, Yuya

Source: Cancer Immunology, Immunotherapy; Feb2024, Vol. 73 Issue 2, p1-12, 12p

Subject Terms: ESOPHAGEAL cancer, CANCER relapse, GUT microbiome, SHOTGUN sequencing, STATISTICAL learning, NEOADJUVANT chemotherapy