New Epitopes for the Serodiagnosis of Human Borreliosis.

Authors: Alcón-Chino, Mônica E. T., Bonoldi, Virgínia L. N., Pereira, Rosa M. R., Gazeta, Gilberto S., Carvalho, João P. R. S., Napoleão-Pêgo, Paloma, Durans, Andressa M., Souza, André L. A., De-Simone, Salvatore G.

Source: Microorganisms; Nov2024, Vol. 12 Issue 11, p2212, 16p

Subject Terms: MEMBRANE proteins, PEPTIDES, LYME disease, BORRELIA burgdorferi, BANKING industry

High-Throughput IgG Epitope Mapping of Tetanus Neurotoxin: Implications for Immunotherapy and Vaccine Design.

Authors: De-Simone, Salvatore G.^1,2,3 (AUTHOR) pegopn@gmail.com, Napoleão-Pêgo, Paloma^1,2 (AUTHOR) gclechuga@gmail.com, Lechuga, Guilherme C.^1,2 (AUTHOR) larissagomesr@gmail.com, Carvalho, João P. R. S.^1,2,3 (AUTHOR), Gomes, Larissa R.^1,2 (AUTHOR), Cardozo, Sergian V.⁴ (AUTHOR) sergian.cardozo@unigranrio.edu.br, Morel, Carlos M.¹ (AUTHOR), Provance Jr., David W.^1,2 (AUTHOR), Silva, Flavio R. da^1,2 (AUTHOR)

Source: Toxins. Apr2023, Vol. 15 Issue 4, p239. 17p.

Subject Terms: *EXOTOXIN, *EPITOPES, *TETANUS, *CELL receptors, *VACCINATION of children, *HUMORAL immunity, *B cells, *IMMUNOGLOBULINS

B-Cell Epitope Mapping of the Vibrio cholera Toxins A, B, and P and an ELISA Assay.

Authors: De-Simone, Salvatore G.^1,2,3 (AUTHOR) dsimone@cdts.fiocruz.br, Napoleão-Pêgo, Paloma^1,2 (AUTHOR), Gonçalves, Priscilla S.^1,2,3 (AUTHOR), Lechuga, Guilherme C.^1,2 (AUTHOR), Cardoso, Sergian V.⁴ (AUTHOR), Provance Jr., David W.^1,2 (AUTHOR), Morel, Carlos M.¹ (AUTHOR), da Silva, Flavio R.^1,2 (AUTHOR)

Source: International Journal of Molecular Sciences. Jan2023, Vol. 24 Issue 1, p531. 13p.

Subject Terms: *CHOLERA toxin, *B cells, *VIBRIO cholerae, *PEPTIDES, *ENZYME-linked immunosorbent assay, *SERODIAGNOSIS, *B cell receptors

Chagas Disease Diagnosis with Trypanosoma cruzi -Exclusive Epitopes in GFP.

Authors: Durans, Andressa da M., Napoleão-Pêgo, Paloma, Reis, Flavia C. G., Dias, Evandro R., Machado, Luciana E. S. F., Lechuga, Guilherme C., Junqueira, Angela C. V., De-Simone, Salvatore G., Provance Jr., David W.

Source: Vaccines; Sep2024, Vol. 12 Issue 9, p1029, 17p

Subject Terms: GREEN fluorescent protein, SYNTHETIC proteins, FLUORESCENT proteins, CHAGAS' disease, SERODIAGNOSIS

Enhanced Assessment of Cross-Reactive Antigenic Determinants within the Spike Protein.

Authors: Lechuga, Guilherme C., Temerozo, Jairo R., Napoleão-Pêgo, Paloma, Carvalho, João P. R. S., Gomes, Larissa R., Bou-Habib, Dumith Chequer, Morel, Carlos M., Provance Jr., David W., Souza, Thiago M. L., De-Simone, Salvatore G.

Source: International Journal of Molecular Sciences; Aug2024, Vol. 25 Issue 15, p8180, 20p

Subject Terms: SARS-CoV-2, COVID-19, GLYCOPROTEIN synthesis, EPITOPES, CORONAVIRUSES

Patterns of Diversity and Humoral Immunogenicity for HIV-1 Antisense Protein (ASP).

Authors: Caetano, Diogo Gama, Napoleão-Pêgo, Paloma, Villela, Larissa Melo, Côrtes, Fernanda Heloise, Cardoso, Sandra Wagner, Hoagland, Brenda, Grinsztejn, Beatriz, Veloso, Valdilea Gonçalves, De-Simone, Salvatore Giovanni, Guimarães, Monick Lindenmeyer

Source: Vaccines; Jul2024, Vol. 12 Issue 7, p771, 17p

Subject Terms: ANTISENSE peptides, HIV infections, PEPTIDES, UNCERTAINTY (Information theory), CELLULOSE synthase

MAPEAMENTO DOS PRINCIPAIS DETERMINANTES ANTIGÊNICOS(EPÍTOPOS) DOS AGENTES BACTERIANOS PARA O DESENVOLVIMENTO DE INSUMOS EM SAÚDE

Authors: da Silva, Flavio Rocha, de Simone, Salvatore Giovanni, Napoleão-Pêgo, Paloma, Gomes, Larissa R., Pina, Jorge S., Saísse, Alexandre de Oliveira

Source: BRAZILIAN JOURNAL OF INFECTIOUS DISEASES. 26(S1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100171548307.0x000001&indx=1&recIds=ETOCvdc_100171548307.0x000001

New Insights into Hemopexin-Binding to Hemin and Hemoglobin.

Authors: Lechuga, Guilherme C.^1,2 (AUTHOR) gclechuga@gmail.com, Napoleão-Pêgo, Paloma^1,2 (AUTHOR) pegopn@gmail.com, Morel, Carlos M.¹ (AUTHOR) carlos.morel@fiocruz.br, Provance, David W.^1,2 (AUTHOR) bill.provance@fiocruz.br, De-Simone, Salvatore G.^1,2,3 (AUTHOR) salvatore.simone@fiocruz.br

Source: International Journal of Molecular Sciences. Apr2022, Vol. 23 Issue 7, p3789-N.PAG. 11p.

Subject Terms: *HEMIN, *HEMOGLOBINS, *AMINO acid sequence, *HEMORRHAGIC diseases, *AMINO acids, *CELLULOSE synthase, *PROTEIN-protein interactions, *BLOOD coagulation factor IX

Humoral Immune Response to SARS-CoV-2 Spike Protein Receptor-Binding Motif Linear Epitopes.

Authors: Monteiro, Maria E. S., Lechuga, Guilherme C., Napoleão-Pêgo, Paloma, Carvalho, João P. R. S., Gomes, Larissa R., Morel, Carlos M., Provance, David W., De-Simone, Salvatore G.

Source: Vaccines; Apr2024, Vol. 12 Issue 4, p342, 12p

Subject Terms: HUMORAL immunity, SARS-CoV-2 Omicron variant, SARS-CoV-2, AMINO acid residues, EPITOPES, ANTIBODY titer

Performance assessment of a multi-epitope chimeric antigen for the serological diagnosis of acute Mayaro fever.

Authors: Napoleão-Pêgo, Paloma¹, Carneiro, Flávia R. G.^1,2, Durans, Andressa M.^1,2, Gomes, Larissa R.¹, Morel, Carlos M.¹, Provance Jr., David W.^1,2, De-Simone, Salvatore G.^1,3 dsimone@cdts.fiocruz.br

Source: Scientific Reports. 7/28/2021, Vol. 11 Issue 1, p1-10. 10p.

Subject Terms: *ARBOVIRUSES, *ANTIGENS, *IMMUNOGLOBULINS, *PROTEIN expression

Geographic Terms: SOUTH America

Identification of linear B epitopes of pertactin of Bordetella pertussis induced by immunization with whole and acellular vaccine

Authors: da Silva, Flavio R., Napoleão-Pego, Paloma, De-Simone, Salvatore G.

Source: In Vaccine 29 October 2014 32(47):6251-6258

IgE and IgG epitope mapping by microarray peptide-immunoassay reveals the importance and diversity of the immune response to the IgG3 equine immunoglobulin

Authors: De-Simone, Salvatore G., Napoleão-Pêgo, Paloma, Teixeira-Pinto, Luiz A.L., Melgarejo, Anibal R., Aguiar, Aniesse S., Provance, David W., Jr.

Source: In Toxicon February 2014 78:83-93

Spot Synthesis: An Optimized Microarray to Detect IgE Epitopes

Authors: De-Simone, Salvatore G., Napoleão-Pêgo, Paloma, De-Simone, Thatiane S.

Source: Methods in molecular biology. 1352:263-278

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN603615539&indx=1&recIds=ETOCRN603615539

Mapping IgA Epitope and Cross-Reactivity between Severe Acute Respiratory Syndrome-Associated Coronavirus 2 and DENV.

Authors: De-Simone, Salvatore G., Napoleão-Pêgo, Paloma, Lechuga, Guilherme C., Carvalho, João P. R. S., Monteiro, Maria E., Morel, Carlos M., Provance Jr., David W.

Source: Vaccines; Dec2023, Vol. 11 Issue 12, p1749, 17p

Subject Terms: IMMUNOGLOBULIN A, CORONAVIRUSES, SARS-CoV-2 Omicron variant, CROSS reactions (Immunology), COVID-19 testing, IMMUNOGLOBULIN M, CORONAVIRUS diseases, POLYPEPTIDES

Geographic Terms: WUHAN (China)

Linear B-cell epitopes in BthTX-1, BthTX-II and BthA-1, phospholipase A2's from Bothrops jararacussu snake venom, recognized by therapeutically neutralizing commercial horse antivenom

Authors: De-Simone, Salvatore G., Napoleão-Pego, Paloma, Teixeira-Pinto, Luiz A.L., Santos, Jonathas D.L., De-Simone, Thatiane S., Melgarejo, Anibal R., Aguiar, Aniesse S., Marchi-Salvador, Daniela P.

Source: In Toxicon 15 September 2013 72:90-101

Angiostrongylus cantonensis an Atypical Presenilin: Epitope Mapping, Characterization, and Development of an ELISA Peptide Assay for Specific Diagnostic of Angiostrongyliasis.

Authors: De-Simone, Salvatore G.^1,2,3 (AUTHOR) dsimone@cdts.fiocruz.br, Napoleão-Pêgo, Paloma¹ (AUTHOR) priscilla.desimone@cdts.fiocruz.br, Gonçalves, Priscila S.^1,3 (AUTHOR) guilherme.lechuga@cdts.fiocruz.br, Lechuga, Guilherme C.¹ (AUTHOR) bill.provance@cdts.fiocruz.br, Mandonado Jr., Arnaldo⁴ (AUTHOR) maldonado@ioc.fiocruz.br, Graeff-Teixeira, Carlos⁵ (AUTHOR) carlos.teixeira@ufes.br, Provance Jr., David W.¹ (AUTHOR)

Source: Membranes. Feb2022, Vol. 12 Issue 2, pN.PAG-N.PAG. 1p.

A Pencil-Lead Immunosensor for the Rapid Electrochemical Measurement of Anti-Diphtheria Toxin Antibodies.

Authors: Ameku, Wilson A.¹, akira.ameku@gmail.com, Ataide, Vanessa N.², vanneiva@usp.br, Costa, Eric T.², eric.costa@usp.br, Gomes, Larissa R.¹, larissa.gomes@cdts.fiocruz.br, Napoleão-Pêgo, Paloma¹, paloma.pego@cdts.fiocruz.br, William Provance Jr., David¹, bill.provance@cdts.fiocruz.br, Paixão, Thiago R. L. C.^2,3, trlcp@iq.usp.br, Salles, Maiara O.⁴, maiara@iq.ufrj.br, De-Simone, Salvatore Giovanni^1,5,6, dsimone@cdts.fiocruz.br

Source: Biosensors (2079-6374); Dec2021, Vol. 11 Issue 12, p489-489, 1p

Trypanosoma cruzi Presenilin-Like Transmembrane Aspartyl Protease: Characterization and Cellular Localization.

Authors: Lechuga, Guilherme C.^1,2 (AUTHOR) guilherme.lechuga@yahoo.com.br, Napoleão-Pêgo, Paloma¹ (AUTHOR) paloma.pego@cdts.fiocruz.br, Bottino, Carolina C. G.¹ (AUTHOR) carolina.bottino.bio@gmail.com, Pinho, Rosa T.³ (AUTHOR) rospinho@ioc.fiocruz.br, Provance-Jr, David W.^1,4 (AUTHOR) bill.provance@cdts.fiocruz.br, De-Simone, Salvatore G.^1,5 (AUTHOR) salvatore.dsimone@cdts.fiocruz.br

Source: Biomolecules (2218-273X). Nov2020, Vol. 10 Issue 11, p1564-1564. 1p.

Subject Terms: *TRYPANOSOMA cruzi, *CHAGAS' disease, *PRESENILINS, *ENDOPLASMIC reticulum, *DRUG development, *IMMUNE serums, *PROTEOLYTIC enzymes

Geographic Terms: LATIN America

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