Enhancement of radio-sensitivity by inhibition of Janus kinase signaling with oclacitinib in canine tumor cell lines

Authors: Ryo Owaki, Kenji Hosoya, Tatsuya Deguchi, Satoru Konnai, Naoya Maekawa, Tomohiro Okagawa, Hironobu Yasui, Sangho Kim, Takafumi Sunaga, Masahiro Okumura

Source: Molecular Therapy: Oncology, Vol 33, Iss 1, Pp 200946- (2025)

Subject Terms: JAK inhibitor, dog, radiation, oncology, signaling pathway, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2950329925000153; https://doaj.org/toc/2950-3299

Access URL: https://doaj.org/article/b971edd1cc5241eeb1a482af45a36f21

Development of a high-affinity anti-bovine PD-1 rabbit–bovine chimeric antibody using an efficient selection and large production system

Authors: Tomohiro Okagawa, Satoru Konnai, Shinya Goto, Yamato Sajiki, Otgontuya Ganbaatar, Kei Watari, Hayato Nakamura, Cai-Xia Wang, Taro Tachibana, Yukinari Kato, Yayoi Kameda, Junko Kohara, Nobuhiro Terasaki, Manabu Kubota, Akira Takeda, Hirofumi Takahashi, Yasuhiko Suzuki, Naoya Maekawa, Shiro Murata, Kazuhiko Ohashi

Source: Veterinary Research, Vol 54, Iss 1, Pp 1-14 (2023)

Subject Terms: Monoclonal antibodies, programmed death-1, cattle, antibody production, Veterinary medicine, SF600-1100

File Description: electronic resource

Relation: https://doaj.org/toc/1297-9716

Access URL: https://doaj.org/article/d1e0e81c1ed349c095a5bc6af2dd26e6

Characterization of a Very Short Meq Protein Isoform in a Marek’s Disease Virus Strain in Japan

Authors: Yoshinosuke Motai, Shiro Murata, Jumpei Sato, Akihito Nishi, Naoya Maekawa, Tomohiro Okagawa, Satoru Konnai, Kazuhiko Ohashi

Source: Veterinary Sciences, Vol 11, Iss 1, p 43 (2024)

Subject Terms: Marek’s disease, Marek’s disease virus, meq gene, S-Meq, VS-Meq, deletion, Veterinary medicine, SF600-1100

File Description: electronic resource

Relation: https://www.mdpi.com/2306-7381/11/1/43; https://doaj.org/toc/2306-7381

Access URL: https://doaj.org/article/207e8a781a2146a1b133c0b73bd98d6e

In Vivo Characterization of the Anti-Glutathione S-Transferase Antibody Using an In Vitro Mite Feeding Model

Authors: Shwe Yee Win, Hikari Seo, Fumiya Horio, Sotaro Fujisawa, Jumpei Sato, Yoshinosuke Motai, Takumi Sato, Eiji Oishi, Akira Taneno, Lat Lat Htun, Saw Bawm, Tomohiro Okagawa, Naoya Maekawa, Satoru Konnai, Kazuhiko Ohashi, Shiro Murata

Source: Vaccines, Vol 12, Iss 2, p 148 (2024)

Subject Terms: poultry red mite, tropical fowl mite, northern fowl mite, glutathione S-transferase, vaccine, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-393X/12/2/148; https://doaj.org/toc/2076-393X

Access URL: https://doaj.org/article/cb77113d2ef0450a9f50d657494ebbd9

Exploration of serum biomarkers in dogs with malignant melanoma receiving anti-PD-L1 therapy and potential of COX-2 inhibition for combination therapy

Authors: Naoya Maekawa, Satoru Konnai, Yumie Asano, Yamato Sajiki, Tatsuya Deguchi, Tomohiro Okagawa, Kei Watari, Hiroto Takeuchi, Satoshi Takagi, Kenji Hosoya, Sangho Kim, Hiroshi Ohta, Yukinari Kato, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/9195edeb9fe7415f92cb3f8d09b03d7b

Suppressive modulation of host immune responses by Dermanyssus gallinae infestation

Authors: Sotaro Fujisawa, Shiro Murata, Masayoshi Isezaki, Shwe Yee Win, Takumi Sato, Eiji Oishi, Akira Taneno, Naoya Maekawa, Tomohiro Okagawa, Satoru Konnai, Kazuhiko Ohashi

Source: Poultry Science, Vol 102, Iss 4, Pp 102532- (2023)

Subject Terms: Dermanyssus gallinae, poultry red mite, chicken, immunity, immunosuppression, Animal culture, SF1-1100

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0032579123000561; https://doaj.org/toc/0032-5791

Access URL: https://doaj.org/article/5e64bcc88bba4851a72371614482db91

In vitro evaluation of Lactiplantibacillus plantarum HOKKAIDO strain, effective lactic acid bacteria for calf diarrhea

Authors: Mari Ikehata, Satoru Konnai, Tomohiro Okagawa, Kentaro Abe, Mitsuru Honma, Toru Kitamura, Naoya Maekawa, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi

Source: Frontiers in Veterinary Science, Vol 10 (2023)

Subject Terms: Lactiplantibacillus plantarum HOKKAIDO strain, monocytes–cell, TLR2/4, antiviral effects, rotavirus, Veterinary medicine, SF600-1100

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fvets.2023.1145445/full; https://doaj.org/toc/2297-1769

Access URL: https://doaj.org/article/b1cf05cdd6024381a5df5ee2da20aa68

Potential of ferritin 2 as an antigen for the development of a universal vaccine for avian mites, poultry red mites, tropical fowl mites, and northern fowl mites

Authors: Shwe Yee Win, Shiro Murata, Sotaro Fujisawa, Hikari Seo, Jumpei Sato, Yoshinosuke Motai, Takumi Sato, Eiji Oishi, Akira Taneno, Lat Lat Htun, Saw Bawm, Tomohiro Okagawa, Naoya Maekawa, Satoru Konnai, Kazuhiko Ohashi

Source: Frontiers in Veterinary Science, Vol 10 (2023)

Subject Terms: poultry red mite, tropical fowl mite, northern fowl mite, ferritin 2, vaccine, Veterinary medicine, SF600-1100

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fvets.2023.1182930/full; https://doaj.org/toc/2297-1769

Access URL: https://doaj.org/article/3475bcac778149e187685f4e7f444c54

Hemangiosarcoma cells induce M2 polarization and PD-L1 expression in macrophages

Authors: Kevin Christian M. Gulay, Keisuke Aoshima, Naoya Maekawa, Tamami Suzuki, Satoru Konnai, Atsushi Kobayashi, Takashi Kimura

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/e75278cca0ad4ce29d8c97f45200d2f1

Molecular characterization of feline immune checkpoint molecules and establishment of PD-L1 immunohistochemistry for feline tumors

Authors: Naoya Maekawa, Satoru Konnai, Yumie Asano, Takumi Otsuka, Eri Aoki, Hiroto Takeuchi, Yukinari Kato, Mika K. Kaneko, Shinji Yamada, Yumiko Kagawa, Maki Nishimura, Satoshi Takagi, Tatsuya Deguchi, Hiroshi Ohta, Takayuki Nakagawa, Yasuhiko Suzuki, Tomohiro Okagawa, Shiro Murata, Kazuhiko Ohashi

Source: PLoS ONE, Vol 18, Iss 1 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879432/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/d7ae894061a347ccaa0954caf81ef8be

Characterization of SpsQ from Staphylococcus pseudintermedius as an affinity chromatography ligand for canine therapeutic antibodies

Authors: Hiroto Takeuchi, Chie Nakajima, Satoru Konnai, Naoya Maekawa, Tomohiro Okagawa, Masaru Usui, Yutaka Tamura, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi

Source: PLoS ONE, Vol 18, Iss 1 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879442/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/03138f4a64734f699d2f86eaaeec7a54

Safety and clinical efficacy of an anti-PD-L1 antibody (c4G12) in dogs with advanced malignant tumours.

Authors: Naoya Maekawa, Satoru Konnai, Kenji Hosoya, Sangho Kim, Ryohei Kinoshita, Tatsuya Deguchi, Ryo Owaki, Yurika Tachibana, Madoka Yokokawa, Hiroto Takeuchi, Yumiko Kagawa, Satoshi Takagi, Hiroshi Ohta, Yukinari Kato, Satoshi Yamamoto, Keiichi Yamamoto, Yasuhiko Suzuki, Tomohiro Okagawa, Shiro Murata, Kazuhiko Ohashi

Source: PLoS ONE, Vol 18, Iss 10, p e0291727 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/295c408651194fcf866d2177d2d31e14

Programmed death‐ligand 1 expression in swine chronic infections and enhancement of interleukin‐2 production via programmed death‐1/programmed death‐ligand 1 blockade

Authors: Otgontuya Ganbaatar, Satoru Konnai, Tomohiro Okagawa, Yutaro Nojima, Naoya Maekawa, Yoshiki Ichikawa, Atsushi Kobayashi, Tomoyuki Shibahara, Yojiro Yanagawa, Hidetoshi Higuchi, Yukinari Kato, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi

Source: Immunity, Inflammation and Disease, Vol 9, Iss 4, Pp 1573-1583 (2021)

Subject Terms: interleukin‐2, PD‐1, PD‐L1, swine diseases, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/2050-4527

Access URL: https://doaj.org/article/c1781704b73940e2bfc77036577955b1

Diagnosis and Early Prediction of Lymphoma Using High-Throughput Clonality Analysis of Bovine Leukemia Virus-Infected Cells

Authors: Tomohiro Okagawa, Honami Shimakura, Satoru Konnai, Masumichi Saito, Takahiro Matsudaira, Naganori Nao, Shinji Yamada, Kenji Murakami, Naoya Maekawa, Shiro Murata, Kazuhiko Ohashi

Source: Microbiology Spectrum, Vol 10, Iss 6 (2022)

Subject Terms: bovine leukemia virus, cattle, clinical diagnosis, high-throughput analysis, lymphoma, retrovirus, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2165-0497

Access URL: https://doaj.org/article/5012ee7b3a9d4f4cbd51adb898d7acad

Necroptosis of neuronal cells is related to the neuropathology of tick-borne encephalitis

Authors: Dai Tsujino, Kentaro Yoshii, Misa Kajiyama, Yuji Takahashi, Naoya Maekawa, Hiroaki Kariwa, Shintaro Kobayashi

Source: Virus Research, Vol 321, Iss , Pp 198914- (2022)

Subject Terms: Tick-borne encephalitis virus, Programmed cell death, Necroptosis, Microbiology, QR1-502, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0168170222002428; https://doaj.org/toc/1872-7492

Access URL: https://doaj.org/article/7388caf70c0545f4876009162eaee1d8

Clarifying expression patterns by renal lesion using transcriptome analysis and vanin-1 as a potential novel biomarker for renal injury in chickens

Authors: Chihiro Ishii, Yusuke K. Kawai, Yoshinori Ikenaka, Naoya Maekawa, Osamu Ichii, Shouta M.M. Nakayama, Mayumi Ishizuka

Source: Poultry Science, Vol 101, Iss 9, Pp 102011- (2022)

Subject Terms: acute interstitial nephritis (AIN), acute tubular necrosis (ATN), bird, VNN1 (vanin-1), renal biomarker, Animal culture, SF1-1100

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0032579122003029; https://doaj.org/toc/0032-5791

Access URL: https://doaj.org/article/7977951a083e461f93a11823a886696f

PD-L1 immunohistochemistry for canine cancers and clinical benefit of anti-PD-L1 antibody in dogs with pulmonary metastatic oral malignant melanoma

Authors: Naoya Maekawa, Satoru Konnai, Maki Nishimura, Yumiko Kagawa, Satoshi Takagi, Kenji Hosoya, Hiroshi Ohta, Sangho Kim, Tomohiro Okagawa, Yusuke Izumi, Tatsuya Deguchi, Yukinari Kato, Satoshi Yamamoto, Keiichi Yamamoto, Mikihiro Toda, Chie Nakajima, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi

Source: npj Precision Oncology, Vol 5, Iss 1, Pp 1-9 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2397-768X

Access URL: https://doaj.org/article/33eb1d45a3ba4b309dbca6e1d44f59bf

Tick saliva-induced programmed death-1 and PD-ligand 1 and its related host immunosuppression

Authors: Yamato Sajiki, Satoru Konnai, Yoshinori Ikenaka, Kevin Christian Montecillo Gulay, Atsushi Kobayashi, Luís Fernando Parizi, Benvindo Capela João, Kei Watari, Sotaro Fujisawa, Tomohiro Okagawa, Naoya Maekawa, Carlos Logullo, Itabajara da Silva Vaz, Shiro Murata, Kazuhiko Ohashi

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/638fdda85f414409bc159c27d999af7e

In vitro evaluation of a cysteine protease from poultry red mites, Demanyssus gallinae, as a vaccine antigen for chickens

Authors: Takuma Ariizumi, Shiro Murata, Sotaro Fujisawa, Masayoshi Isezaki, Takumi Sato, Eiji Oishi, Akira Taneno, Osamu Ichii, Naoya Maekawa, Tomohiro Okagawa, Satoru Konnai, Kazuhiko Ohashi

Source: Poultry Science, Vol 101, Iss 3, Pp 101638- (2022)

Subject Terms: poultry red mite, cysteine protease, vaccine candidate, Deg-CPR-2, Dermanyssus gallinae, Animal culture, SF1-1100

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0032579121006593; https://doaj.org/toc/0032-5791

Access URL: https://doaj.org/article/98d808a9d4c74707b8c4686e796cfaae

Estradiol-induced immune suppression via prostaglandin E2 during parturition in bovine leukemia virus-infected cattle

Authors: Yamato Sajiki, Satoru Konnai, Tomohiro Okagawa, Naoya Maekawa, Shinya Goto, Junko Kohara, Atsushi Nitanai, Hirofumi Takahashi, Kentaro Kubota, Hiroshi Takeda, Shiro Murata, Kazuhiko Ohashi

Source: PLoS ONE, Vol 17, Iss 3 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906636/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/1fc529d9dc554e37891e8707f6dd9ce1